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1. 发明授权

US08045678B2 Dynamically-varied beam energy using a tunable monochromatic X-ray beam 有权
标题翻译：使用可调谐单色X射线束动态变化的束能
公开(公告)号：US08045678B2
公开(公告)日：2011-10-25
申请号：US12244219
申请日：2008-10-02
申请人： Frank E. Carroll
发明人： Frank E. Carroll
IPC分类号： A61N5/10
CPC分类号： A61N5/10 , A61N2005/1091 , A61N2005/1098
摘要： In one embodiment, a method includes applying an output of a substantially monochromatic x-ray beam source to a target tissue along a first path, tuning the output of the substantially monochromatic x-ray beam source, and applying an output of a substantially monochromatic x-ray beam source to a target tissue along a second path different from the first path. The energy of the output of the substantially monochromatic x-ray beam source at the target tissue substantially corresponds to a binding energy level of an electron shell in an atom within the target tissue along the first path. The tuning tunes the substantially monochromatic x-ray beam source such that an energy of the output of the substantially monochromatic x-ray beam source at the target tissue along the second path substantially corresponds to a binding energy level of an electron shell in an atom within the target tissue.
摘要翻译：在一个实施例中，一种方法包括将基本上单色的X射线束源的输出沿着第一路径施加到目标组织，调整基本上单色的X射线束源的输出，以及施加基本单色x射线源的输出将光束源沿着与第一路径不同的第二路径到目标组织。目标组织上的基本上单色X射线束源的输出能量基本上对应于沿着第一路径的靶组织内的原子中的电子壳的结合能级。调谐调谐基本上单色的X射线束源，使得沿着第二路径的目标组织处的基本上单色X射线束源的输出能量基本上对应于电子壳在其内的原子内的结合能级目标组织。

2. 发明授权

US07486984B2 System and method for monochromatic x-ray beam therapy 失效
标题翻译：单色x射线束治疗的系统和方法
公开(公告)号：US07486984B2
公开(公告)日：2009-02-03
申请号：US10848151
申请日：2004-05-19
申请人： Frank E. Carroll
发明人： Frank E. Carroll
IPC分类号： A61B6/00 , H01J35/14
CPC分类号： A61N5/10 , A61K41/0038 , A61K51/02 , A61N2005/1091 , A61N2005/1098 , H05G2/00
摘要： In embodiments of the invention, a radiosensitizer or other agent is relatively uniformly accumulated in the cells of a tumor. An external monochromatic x-ray beam, which is tuned to a predetermined energy level associated with k-edge effects in the agent, is then directed to the tumor. The monochromatic x-ray beam activates the release of additional localized radiation from the agent. The additional radiation destroys the DNA of at least some tumor cells, making those tumor cells incapable of reproduction and repair. In embodiments of the invention, a single monochromatic x-ray beam source is used for both imaging and radiotherapy.
摘要翻译：在本发明的实施方案中，放射增敏剂或其它药剂相对均匀地积聚在肿瘤的细胞中。调谐到与药剂中的k边缘效应相关联的预定能级的外部单色X射线束然后被引导到肿瘤。单色x射线束激活来自药剂的额外局部辐射的释放。另外的辐射破坏至少一些肿瘤细胞的DNA，使得这些肿瘤细胞不能繁殖和修复。在本发明的实施例中，单个单色x射线束源用于成像和放射治疗。

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