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1. 发明授权

US09795325B1 Auditory perceptual systems 有权
公开(公告)号：US09795325B1
公开(公告)日：2017-10-24
申请号：US14211164
申请日：2014-03-14
申请人： POSIT SCIENCE CORPORATION
发明人： Michael M. Merzenich , Wesley Marshall Jackson
IPC分类号： A61B5/00 , A61B5/12 , H04R25/00 , G09B19/04
CPC分类号： A61B5/123 , G09B5/06 , G09B19/04 , H04R25/70 , H04R2225/55
摘要： A new hearing profile assessment plays each of a plurality of frequency tones multiple times at a plurality of loudness levels. For each frequency, the patient indicates which tones that they can hear, establishing minimum-amplitude thresholds for each frequency. The assessment adapts loudness levels until the patient indicates consistent minimum-amplitude thresholds for each frequency. Also, a new system for training the hearing of a subject is disclosed. The system instructs the subject to vocalize various sound items and remember the sounds that they vocalize. The system plays either recorded samples of the subject's own voice, or comparison samples of a synthesized voice or other's vocalizations of the same sound items. The system prompts the subject to compare the played samples with the sounds they remembered vocalizing. The system uses the feedback to adjust sound processing parameters for a hearing aid, cochlear implant, sound output devices, or a training program.

2. 发明授权

US09601026B1 Neuroplasticity games for depression 有权
公开(公告)号：US09601026B1
公开(公告)日：2017-03-21
申请号：US14201689
申请日：2014-03-07
申请人： POSIT SCIENCE CORPORATION
发明人： Michael M. Merzenich , Chung-Hay Luk , Mor Nahum , Thomas Matthew Van Vleet
IPC分类号： A63F9/24 , G09B5/02
CPC分类号： G09B19/00 , A63F13/10 , A63F13/537 , A63F13/67 , A63F13/80 , G09B5/00 , G09B5/02 , G09B5/06 , G09B5/065
摘要： A training program is configured to systematically drive neurological changes to treat depression, mood and anxiety disorders. In one embodiment, a reward renormalization game presents a plurality of stimuli, a subset of which are positively affective, and the remainder of which are neutral or negatively affective, and prompts a game participant to respond to the positively affective stimuli and ignore the remainder of the stimuli. In another embodiment, an inference renormalization game presents a plurality of stimuli, a subset of which are positively affective, a second subset of which are negatively affective, and a third subset of which are neutral and prompts a game participant to respond to both the positively affective stimuli and the negatively affective stimuli and ignore the neutral stimuli.

3. 发明授权

US07773097B2 Visual emphasis for cognitive training exercises 有权
标题翻译：视觉强调认知训练
公开(公告)号：US07773097B2
公开(公告)日：2010-08-10
申请号：US11611318
申请日：2006-12-15
申请人： Michael M. Merzenich , Peter B. Delahunt , Joseph L. Hardy , Henry W. Mahncke , Donald Richards
发明人： Michael M. Merzenich , Peter B. Delahunt , Joseph L. Hardy , Henry W. Mahncke , Donald Richards
IPC分类号： G09G5/00 , G09B19/00 , G06K9/00
CPC分类号： G09B19/00 , G09B5/02
摘要： Computer-implemented method for enhancing cognition of a participant using visual emphasis. One or more scenes are provided and are available for visual presentation to the participant, each scene having a background and at least one foreground object. A scene is visually presented to the participant with a specified visual emphasis that enhances visual distinction of the at least one foreground object with respect to the background, where the foreground object(s) and/or the background are modified or selected to achieve the specified visual emphasis. The participant is required to respond to the scene, and a determination made as to whether the participant responded correctly. The visual emphasis may be modified based on whether or not the participant responded correctly a specified number of times. The presenting, requiring, and determining (and possibly the modifying) are repeated in an iterative manner to improve the participant's cognition.
摘要翻译：使用视觉强调增强参与者认知的计算机实现方法。提供一个或多个场景并且可用于向参与者进行视觉呈现，每个场景具有背景和至少一个前景对象。以指定的视觉强调将场景视觉呈现给参与者，其增强相对于背景的至少一个前景对象的视觉区别，其中前景对象和/或背景被修改或选择以实现指定的视觉强调。参与者必须对场景做出响应，并确定参与者是否正确响应。可以基于参与者是否正确响应指定次数来修改视觉强调。以迭代的方式重复呈现，要求和确定（以及可能的修改），以改善参与者的认知。

4. 发明申请

US20070299319A1 Cognitive Training Using A Continuous Performance Adaptive Procedure 审中-公开
标题翻译：使用连续性能自适应过程的认知训练
公开(公告)号：US20070299319A1
公开(公告)日：2007-12-27
申请号：US11760413
申请日：2007-06-08
申请人： Samuel Chan , Joseph Hardy
发明人： Samuel Chan , Joseph Hardy
IPC分类号： A61B5/00
CPC分类号： A61B5/16 , A61B5/486 , G09B7/00
摘要： A computer-implemented method for enhancing cognition, e.g., for improving cognitive ability and memory of a subject using continuous performance with respect to a stimulus stream. A target descriptor is presented to the subject after which, a continuous sequence of stimulus groups from a stimulus set is presented one stimulus at a time, each stimulus presented for a specified duration, and separated by a specified inter-stimulus-interval (ISI). For each stimulus in the sequence: the subject is required to respond to the stimulus, indicating when the stimulus corresponds to the target descriptor, and the duration and/or the ISI adjusted accordingly, using an adaptive procedure. The presenting the target descriptor(s), presenting the continuous sequence, and requiring/determining/adjusting for each stimulus, are repeated iteratively to improve the cognition of the subject.
摘要翻译：一种用于增强认知的计算机实现的方法，例如用于使用针对刺激流的连续性能来改善受试者的认知能力和记忆。目标描述符被呈现给受试者，在此之后，来自刺激组的刺激组的连续序列一次呈现一个刺激，每个刺激呈现指定的持续时间，并被指定的刺激间隔（ISI）分开，。对于序列中的每个刺激：受试者需要响应刺激，指示刺激何时对应于目标描述符，并且使用自适应过程相应地调整持续时间和/或ISI。呈现呈现连续序列的目标描述符，以及需要/确定/调整每种刺激的方法被重复地重复以改善对象的认知。

5. 发明申请

US20070134635A1 COGNITIVE TRAINING USING FORMANT FREQUENCY SWEEPS 审中-公开
标题翻译：使用强制性扫描的认知训练
公开(公告)号：US20070134635A1
公开(公告)日：2007-06-14
申请号：US11610432
申请日：2006-12-13
申请人： Joseph Hardy , Henry Mahncke , Travis Wade
发明人： Joseph Hardy , Henry Mahncke , Travis Wade
IPC分类号： G09B19/00
CPC分类号： G09B5/04
摘要： A method on a computing device for enhancing the memory and cognitive ability of a participant by requiring the participant to differentiate between rapidly presented aural stimuli. The method trains the time order judgment of the participant by iteratively presenting sequences of upward and downward formant frequency sweeps, in random order, separated by an inter-stimulus interval (ISI). The upward and downward formant frequency sweeps utilize frequencies common in formants, i.e., the characteristic frequency components common in human speech. Icons are associated with the upward and downward formant frequency sweeps to allow the participant to indicate an order in which the sweeps are presented (i.e., UP-UP, UP-DOWN, DOWN-UP, and DOWN-DOWN). Correct/incorrect selection of an order causes the ISI and/or the duration of the frequency sweeps to be adaptively shortened/lengthened. A maximum likelihood procedure may be used to dynamically modify the stimulus presentation, and/or, to assess the participant's performance in the exercise.
摘要翻译：一种用于通过要求参与者区分快速呈现的听觉刺激来增强参与者的记忆和认知能力的计算设备上的方法。该方法通过以随机顺序迭代地呈现由刺激间间隔（ISI）间隔的向上和向下共振峰频率扫描的序列来训练参与者的时间顺序判断。向上和向下的共振峰频率扫描利用共振峰中常见的频率，即人类语音中常见的特征频率分量。图标与向上和向下的共振峰频率扫描相关联，以允许参与者指示呈现扫描的顺序（即，UP-UP，UP-DOWN，DOWN-UP和DOWN-DOWN）。订单的正确/不正确的选择导致ISI和/或频率扫描的持续时间被自适应地缩短/延长。可以使用最大似然程序来动态地修改刺激呈现，和/或评估参与者在演习中的表现。

6. 发明申请

US20070134632A1 Assessment in cognitive training exercises 审中-公开
标题翻译：认知训练中的评估
公开(公告)号：US20070134632A1
公开(公告)日：2007-06-14
申请号：US11465313
申请日：2006-08-17
申请人： Samuel Chan , Joseph Hardy , Henry Mahncke
发明人： Samuel Chan , Joseph Hardy , Henry Mahncke
IPC分类号： G09B19/00
CPC分类号： G09B7/02
摘要： A computer-implemented method is described for assessing an aging adult's ability to integrate visual-spatial and auditory memory by requiring the adult to spatially match pairs of graphically presented response buttons that are associated with aurally presented stimuli which is processed by a computing device. The adult is presented with a grid of response buttons, each associated with an aural stimulus. When the adult selects a response button, its aural stimulus is presented. The adult is required to consecutively select a response button having the same aural stimulus. As the adult sequentially selects response buttons having the same aural stimuli, the button pair is removed. First assessment trials are performed for a first plurality of grids, training trials are performed for a second plurality of grids, then second assessment trials performed for the first plurality of grids. The adult's performances in the two assessments are compared to determine the adult's improvement.
摘要翻译：描述了一种计算机实现的方法，用于通过要求成年人空间匹配由计算设备处理的与听觉呈现的刺激相关联的图形呈现的响应按钮对，来评估老化成年人整合视觉空间和听觉记忆的能力。成年人呈现出一个响应按钮网格，每个都与听觉刺激相关联。当成年人选择响应按钮时，会显示其听觉刺激。成人需要连续选择具有相同听觉刺激的响应按钮。随着成人依次选择具有相同听觉刺激的响应按钮，则移除按钮对。对于第一组多个网格进行第一次评估试验，对第二组网格进行训练试验，然后对第一组多个网格进行第二次评估试验。比较成人在两项评估中的表现，以确定成人的改善。

7. 发明申请

US20060177805A1 Method for enhancing memory and cognition in aging adults 审中-公开
公开(公告)号：US20060177805A1
公开(公告)日：2006-08-10
申请号：US11322199
申请日：2005-12-29
申请人： Daniel Goldman , Joseph Hardy , Henry Mahncke , Michael Merzenich , Jeffrey Zimman
发明人： Daniel Goldman , Joseph Hardy , Henry Mahncke , Michael Merzenich , Jeffrey Zimman
IPC分类号： G09B19/00
CPC分类号： G09B7/00
摘要： A method on a computing device is provided for enhancing the memory and cognitive ability of an older adult by requiring the adult to listen to two or more aurally processed syllables, presented serially, view the syllables graphically, and then designate the order in which the syllables were aurally presented. A number of trials are presented to the adult. As the adult correctly determines the syllable order in trials, the difficulty of the trials is increased by increasing the number of syllables presented, and by reducing the amount of processing that is applied to the syllables.

8. 发明申请

US20060051727A1 Method for enhancing memory and cognition in aging adults 审中-公开
标题翻译：增强老年成人记忆和认知的方法
公开(公告)号：US20060051727A1
公开(公告)日：2006-03-09
申请号：US11245253
申请日：2005-10-06
申请人： Daniel Goldman , Joseph Hardy , Henry Mahncke , Michael Merzenich , Jeffrey Zimman , Justin Char , Daniel Harrington
发明人： Daniel Goldman , Joseph Hardy , Henry Mahncke , Michael Merzenich , Jeffrey Zimman , Justin Char , Daniel Harrington
IPC分类号： G09B19/00 , G09B3/00
CPC分类号： G09B7/02
摘要： A method on a computing device is provided for enhancing the memory and cognitive ability of an older adult by requiring the adult to spatially match pairs of graphically presented response buttons that are associated with aurally presented stimuli which is processed by the computing device. An adult is presented with a grid of response buttons that have been paired with aural stimuli. As the adult selects a response button, its processed aural stimuli is presented. The adult is required to remember which response button is associated with which aural stimuli, and sequentially select response buttons having the same aural stimuli. As the adult sequentially selects response buttons having the same aural stimuli, the response button pair is removed. The number of response buttons presented in a trial, and the amount of processing applied to the stimuli adapts to the adults success or failure in completing trials. A method is provided for preventing chance sequential selection of response buttons having the same aural stimuli.
摘要翻译：提供了一种用于计算设备上的方法，用于通过要求成年人空间上匹配由计算设备处理的听觉呈现的刺激相关联的图形呈现的响应按钮对来增强老年人的记忆和认知能力。一名成年人被呈现出已经与听觉刺激配对的响应按钮网格。当成年人选择一个响应按钮时，呈现其处理的听觉刺激。成年人需要记住哪个响应按钮与哪个听觉刺激相关联，并且依次选择具有相同听觉刺激的响应按钮。随着成年人依次选择具有相同听觉刺激的响应按钮，消除了响应按钮对。在试验中呈现的反应按钮的数量以及应用于刺激的处理量适应成年人成功或失败的完成试验。提供了一种防止机会顺序选择具有相同听觉刺激的响应按钮的方法。

9. 发明授权

US09308445B1 Neuroplasticity games 有权
标题翻译：神经可塑性游戏
公开(公告)号：US09308445B1
公开(公告)日：2016-04-12
申请号：US14201666
申请日：2014-03-07
申请人： POSIT SCIENCE CORPORATION
发明人： Michael M. Merzenich , Hyun Kyu Lee , Chung-Hay Luk , Mor Nahum , Jyoti Mishra Ramanathan , Thomas Matthew Van Vleet , Henry W. Mahncke , Travis William Wade , Peter Brendan Delahunt , Jefferson Arthur Dewey , Samuel Chungchi Chan , Gregory Michael Sabatini , Donald Kelly Richards , Wesley Marshall Jackson
IPC分类号： A63F9/24 , A63F13/40
CPC分类号： G09B19/00 , A63F13/10 , A63F13/537 , A63F13/67 , A63F13/80 , G09B5/00 , G09B5/02 , G09B5/06 , G09B5/065
摘要： A game delivery system delivers a plurality of games in a training program. The training program is configured to systematically drive neurological changes to overcome cognitive deficits associated with a neurological disorder. In one embodiment, the training program includes an initial batch of games that predominantly exercise elemental, lower-level cognitive processes and sensory deficits. After a game participant progresses through the initial batch of games, the training program provides games that impose comparatively greater higher-order cognitive processing requirements on the participant. A clinician portal provides remote access to a clinician to data about the game participant's compliance and performance with the training program. The clinician portal also enables the administrator to configure the training program.
摘要翻译：游戏传送系统在训练程序中传送多个游戏。训练计划被配置为系统地驱动神经变化以克服与神经障碍相关的认知缺陷。在一个实施例中，训练计划包括主要运动元素，较低级认知过程和感觉缺陷的初始游戏。在游戏参与者通过初始游戏进行游戏之后，训练计划提供对参与者施加相对较高的高阶认知处理要求的游戏。临床医生门户可以通过培训计划远程访问临床医生关于游戏参与者的合规性和绩效的数据。临床医生门户还使管理员能够配置培训计划。

10. 发明授权

US09302179B1 Neuroplasticity games for addiction 有权
标题翻译：神经可塑性游戏成瘾
公开(公告)号：US09302179B1
公开(公告)日：2016-04-05
申请号：US14201676
申请日：2014-03-07
申请人： POSIT SCIENCE CORPORATION
发明人： Michael M. Merzenich , Chung-Hay Luk , Mor Nahum , Jyoti Mishra Ramanathan , Thomas Matthew Van Vleet
IPC分类号： A63F9/24 , A63F13/40
CPC分类号： G09B19/00 , A63F13/10 , A63F13/537 , A63F13/67 , A63F13/80 , G09B5/00 , G09B5/02 , G09B5/06 , G09B5/065
摘要： A training program is configured to systematically drive neurological changes to treat an addiction, wherein a plurality of addiction-related stimuli stimulate craving for the object of the addiction. The training program comprises at least one computerized reverse conditioning game configured to present a plurality of target and distractor stimuli, wherein a subset of the distractor stimuli are addiction-related stimuli, and prompts a game participant to respond to the target stimuli and ignore the distractor stimuli.
摘要翻译：训练计划被配置为系统地驱动神经变化以治疗成瘾，其中多个成瘾相关刺激刺激对成瘾对象的渴望。所述训练程序包括至少一个计算机化的反向调节游戏，被配置为呈现多个目标和牵引器刺激，其中所述牵引器刺激的子集是成瘾相关的刺激，并且促使游戏参与者响应于所述目标刺激并忽略所述牵引器刺激。

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