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1. 发明申请

US20220090994A1 AUTOMATED STAINING SYSTEM AND REACTION CHAMBER 有权
公开(公告)号：US20220090994A1
公开(公告)日：2022-03-24
申请号：US17543672
申请日：2021-12-06
申请人： Sakura Finetek U.S.A., Inc.
发明人： Xuan S. Bui , Anthony L. Hartman , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
IPC分类号： G01N1/31 , B01L3/00 , B01L9/00 , G01N35/00 , G01N35/02
摘要： An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations. A method including determining an inventory of an automated sample processing system, downloading a processing protocol from a central controller to the automated sample processing system, operating the automated sample processing system based on the processing protocol and independently of the central controller and dispensing a reagent from the automated sample processing system.

2. 发明授权

US11193859B2 Automated staining system and reaction chamber 有权
公开(公告)号：US11193859B2
公开(公告)日：2021-12-07
申请号：US16417575
申请日：2019-05-20
申请人： Sakura Finetek U.S.A., Inc.
发明人： Xuan S. Bui , Anthony L. Hartman , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
IPC分类号： G01N1/31 , G01N35/00 , G01N35/02 , B01L3/00 , B01L9/00
摘要： An apparatus including a reagent cartridge and a reaction chamber, the reagent cartridge having a reagent capsule removably positioned therein for dispensing of a reagent onto the reaction chamber. A system including a linearly translatable mounting assembly having a plurality of mounting stations dimensioned to receive at least one fluid dispensing cartridge, a linearly translatable bulk reagent dispensing assembly having a plurality of bulk reagent dispensing nozzles coupled thereto and a receiving assembly positioned beneath the mounting assembly and the bulk reagent dispensing assembly, the receiving assembly including a plurality of reaction stations. A method including determining an inventory of an automated sample processing system, downloading a processing protocol from a central controller to the automated sample processing system, operating the automated sample processing system based on the processing protocol and independently of the central controller and dispensing a reagent from the automated sample processing system.

3. 外观设计

USD920121S1 Bottle 有权
公开(公告)号：USD920121S1
公开(公告)日：2021-05-25
申请号：US29670602
申请日：2018-11-16
申请人： SAKURA FINETEK U.S.A., INC.
设计人： Joseph T. Sestak

4. 发明授权

US10422724B2 Microtome waste removal assembly 有权
公开(公告)号：US10422724B2
公开(公告)日：2019-09-24
申请号：US15811447
申请日：2017-11-13
申请人： Sakura Finetek U.S.A., Inc.
发明人： Xuan S. Bui , Alyicia Marie Rios , Erico Von Bueren
IPC分类号： G01N1/06 , B26D7/01 , B26D7/27 , H05B33/08 , G01N1/31 , G01N21/25
摘要： A sample sectioning device including a housing having a base member, a cutting mechanism positioned on the base member and operable to cut sections from a sample, a sample holder dimensioned to hold a sample and operable to move with respect to the cutting mechanism during a cutting operation, and a waste removal assembly positioned below the cutting mechanism and the sample holder, the waste removal assembly having a first member and a second member that are dimensioned to remove waste produced during the cutting operation.

5. 发明授权

US10139613B2 Digital microscope and method of sensing an image of a tissue sample 有权
公开(公告)号：US10139613B2
公开(公告)日：2018-11-27
申请号：US13212955
申请日：2011-08-18
申请人： Paul Hing , Christian Romer , Sven Hensler
发明人： Paul Hing , Christian Romer , Sven Hensler
IPC分类号： H04N7/18 , H04N9/47 , G02B21/36
摘要： A method including sensing an image without magnification of a portion of a tissue sample; displaying the sensed image on a display; and performing at least one of the following: refreshing a sensed image at a predetermined rate, storing the sensed image, modifying the sensor to display pixel ratio, and sensing a magnified view of an area of the portion of the tissue sample. A digital microscope comprising: at least one image sensor; a first optic configured to project an image with a magnification of one or less; a second optic disposed between the at least one sensor and the stage, the second optic configured to project an image with a magnification greater than one; and a computer operable to direct an image capture by the at least one image sensor of a portion of a microslide on the stage projected through the first optic or the second optic.

6. 发明授权

US10107727B2 Tissue processing reagent 有权
公开(公告)号：US10107727B2
公开(公告)日：2018-10-23
申请号：US15371588
申请日：2016-12-07
申请人： Sakura Finetek U.S.A., Inc.
发明人： Amit D. Shah
IPC分类号： G01N1/30 , G01N1/36
摘要： A method including placing a biological sample taken from a body into a chamber; adding a composition including an acetal solvent to the chamber; and fixating the biological sample. A method including placing a tissue from a body into a chamber; and contacting the tissue with a composition including an acetal solvent as a fixating process.

7. 发明授权

US09032854B2 Reciprocating microtome drive system 有权
标题翻译：往复式切片机驱动系统
公开(公告)号：US09032854B2
公开(公告)日：2015-05-19
申请号：US13333942
申请日：2011-12-21
申请人： Hwai-Jyh Michael Yang , Xuan S. Bui
发明人： Hwai-Jyh Michael Yang , Xuan S. Bui
IPC分类号： B27B29/04 , B26D5/20 , B26D7/06 , G01N1/06
CPC分类号： G01N1/06 , G01N2001/065 , G05B15/02 , Y10S83/9155 , Y10T83/04 , Y10T83/50 , Y10T83/6475 , Y10T83/6512 , Y10T83/654 , Y10T83/6563 , Y10T83/6572
摘要： An apparatus having a sample sectioning device including a cutting mechanism that is operable to cut sections from a sample and a sample holder that is operable to hold the sample. The apparatus further includes a drive system coupled with the sample holder to drive movement of the sample holder and a reciprocating member coupled to the drive system to drive vertical movement of the drive system. The reciprocating member to move in a reciprocating manner within an angle of rotation of less than 180 degrees. A surface orientation sensor may further be provided that is operable to sense an orientation of a surface of the sample held by the sample holder.
摘要翻译：一种具有样品切片装置的装置，其包括切割机构，该切割机构可操作以切割来自样品的部分和可操作以保持样品的样品保持器。该装置还包括驱动系统，该驱动系统与样品保持器相连以驱动样品保持器的运动;以及耦合到驱动系统的往复运动构件以驱动驱动系统的垂直运动。往复运动构件以小于180度的旋转角度往复运动。可以进一步提供可操作以感测由样品架保持的样品的表面的取向的表面取向传感器。

8. 发明授权

US09016526B2 Fluid dispensing system 有权
标题翻译：流体分配系统
公开(公告)号：US09016526B2
公开(公告)日：2015-04-28
申请号：US14297537
申请日：2014-06-05
申请人： Sakura Finetek U.S.A., Inc.
发明人： Robert E. Evans , Wolfgang Mueller , Toshiyuki Fujimaki , Shinji Tokudaiji , Yoshitake Okabe , Yoshitada Mizusawa
IPC分类号： B65D37/00 , B05B11/04 , A47K5/12 , B01L3/00 , F04B43/08
CPC分类号： B05B11/048 , A47K5/1215 , B01L3/523 , B01L2200/0605 , B01L2200/141 , F04B43/08
摘要： An apparatus including a fluid reservoir and a compressible metering chamber including a first end coupled to the fluid reservoir and a second end. The apparatus further including a valve coupled to the second end of the metering chamber and a nozzle coupled to the valve. A system including linearly translatable cartridge mounting assembly having a plurality of fluid dispensing cartridge mounting stations and a plurality of fluid dispensing cartridges mounted to respective fluid dispensing cartridge mounting stations. The system further including a plurality of compression assemblies coupled to respective fluid dispensing cartridges and a receiving assembly positioned beneath the mounting assembly. A method includes positioning a fluid dispensing cartridge comprising a fluid reservoir and a metering chamber over a sample retaining member, applying a compressive force to the metering chamber to eject a predetermined amount of fluid and removing the compressive force to refill the metering chamber.
摘要翻译：一种包括流体储存器和可压缩计量室的装置，包括联接到流体储存器的第一端和第二端。该装置还包括联接到计量室的第二端的阀和连接到阀的喷嘴。一种包括具有多个流体分配盒安装台和安装到相应的流体分配盒安装台的多个流体分配盒的线性平移盒安装组件的系统。该系统还包括耦合到相应流体分配盒的多个压缩组件和位于安装组件下方的接收组件。一种方法包括将包括流体储存器和计量室的流体分配筒定位在样品保持构件上方，向计量室施加压缩力以排出预定量的流体并去除压缩力以重新填充计量室。

9. 发明授权

US08747746B2 Automated system and method of processing biological specimens 有权
标题翻译：自动化系统及生物标本处理方法
公开(公告)号：US08747746B2
公开(公告)日：2014-06-10
申请号：US13768953
申请日：2013-02-15
申请人： Sakura Finetek U.S.A., Inc.
发明人： Gilles Lefebvre
IPC分类号： G01N21/00
CPC分类号： G01N35/00029 , G01N1/06 , G01N1/30 , G01N1/312 , G01N35/00732 , G01N35/00871 , G01N35/0092 , G01N35/04 , G01N2035/00039 , G01N2035/00138 , G01N2035/00851 , Y10T436/2575
摘要： An apparatus including at least one of a stainer module and a coverslipper module; an imaging module; a storage module; an automated transport module for transporting at least one slide between at least one of the stainer module and the coverslipper module, the imaging module and the storage module; and a controller. A method including processing at least one slide; determining whether an imaging module is available for imaging of a biological specimen on the at least one slide; transporting the at least one slide to the imaging module using an automated transport module; and transporting the at least one slide to a storage module using the automated transport module when it is determined that the imaging module is not available. A system including a processing module for processing at least one slide including a biological specimen thereon. A machine readable medium.
摘要翻译：一种包括染色器模块和盖玻片模块中的至少一个的装置; 成像模块; 存储模块; 用于在至少一个染色器模块和盖玻片模块，成像模块和存储模块之间传送至少一个滑块的自动传送模块; 和控制器。一种方法，包括处理至少一个幻灯片; 确定成像模块是否可用于所述至少一个载片上的生物样本的成像; 使用自动传送模块将所述至少一个幻灯片传送到所述成像模块; 以及当确定所述成像模块不可用时，使用所述自动运送模块将所述至少一个滑块运送到存储模块。一种系统，包括处理模块，用于在其上处理包括生物样本的至少一个载玻片。机器可读介质。

10. 发明申请

US20140108907A1 TRACEABILITY FOR AUTOMATED STAINING SYSTEM 有权
标题翻译：自动化污染系统的可追溯性
公开(公告)号：US20140108907A1
公开(公告)日：2014-04-17
申请号：US14057888
申请日：2013-10-18
申请人： SAKURA FINETEK U.S.A., INC.
发明人： Robert E. Evans , Anthony L. Hartman , Richard A. Suchter , Gilles Lefebvre
IPC分类号： G06F17/24
CPC分类号： G06F17/245 , G01N1/312 , G01N35/00732 , Y10T436/115831 , Y10T436/2575
摘要： A method including automatically displaying information obtained from a first identifier associated with a slide and a second identifier associated with a reagent cartridge. The method further including generating a staining log based on the information obtained from the first identifier and the second identifier. A further method includes displaying a location of a slide within a sample processing system and information obtained from a first identifier associated with the slide in a first table and displaying a location of a reagent cartridge within a sample processing system and information obtained from a second identifier associated with the reagent cartridge in a second table. The first table is then aligned with the second table.
摘要翻译：一种方法，包括自动显示从与幻灯片相关联的第一标识符获得的信息和与试剂盒相关联的第二标识符。该方法还包括基于从第一标识符和第二标识符获得的信息生成染色日志。另一种方法包括在样本处理系统内显示幻灯片的位置以及从第一表中与幻灯片相关联的第一标识符获得的信息，并显示样本处理系统内的试剂盒的位置以及从第二标识符获得的信息与第二表中的试剂盒相关联。然后将第一个表与第二个表对齐。

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