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1. 发明授权

US10748289B2 Coregistration of endoluminal data points with values of a luminal-flow-related index 有权
公开(公告)号：US10748289B2
公开(公告)日：2020-08-18
申请号：US14109058
申请日：2013-12-17
申请人： SYNC-RX, LTD.
发明人： David Tolkowsky , Ran Cohen , Alexander Steinberg , Eldad Klaiman
IPC分类号： A61B6/00 , A61B5/026 , G06T7/00 , A61B5/021 , G16H50/50 , G06T5/50 , G06T7/20 , A61B5/0275
摘要： Apparatus and methods are described for use with an endoluminal data-acquisition device configured to be moved through a lumen of a subject's body, and a two-dimensional angiographic image of the lumen. A value of a luminal-flow-related index of the subject is determined non-invasively at a plurality of locations along the lumen, at least partially by performing image processing on the angiographic image. While the endoluminal data-acquisition device is being moved through the lumen, a set of endoluminal data points of the lumen at a plurality of locations within the lumen is acquired, using the endoluminal data-acquisition device. It is determined that respective endoluminal data points correspond to respective locations along the lumen, and, in response thereto, it is determined that respective endoluminal data points correspond to respective values of the luminal flow-related index. Other applications are also described.

2. 发明授权

US09888969B2 Automatic quantitative vessel analysis 有权
公开(公告)号：US09888969B2
公开(公告)日：2018-02-13
申请号：US14145612
申请日：2013-12-31
申请人： SYNC-RX, LTD.
发明人： Ran Cohen , Eldad Klaiman , Alexander Steinberg , Yoav Stein , Sagiv Philipp , David Tolkowsky
IPC分类号： A61B5/05 , A61B19/00 , G06T5/00 , A61B5/02 , A61F2/06 , A61M25/09 , A61B34/20 , G06T7/12 , A61B90/00
CPC分类号： A61B5/0044 , A61B5/02007 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61B2090/3735 , A61B2090/374 , A61B2090/3762 , A61B2090/3782 , A61B2576/00 , A61F2/06 , A61F2/958 , A61M25/09 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T5/003 , G06T7/0012 , G06T7/0014 , G06T7/12 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10016 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101 , G06T2207/30172
摘要： Apparatus and methods are described including designating within an image of blood vessels of a subject, a target portion of the blood vessels. In response to a first input from a user that designates a single point on the image, a first location within the blood vessels in a vicinity of the designated point is designated. In response to second and third inputs from the user, proximal and distal locations within the target portion are designated. The target portion is designated such that the target portion passes from the proximal location of the target portion to the distal location of the target portion, and such that the target portion includes the first location. Quantitative vessel analysis is performed on the target portion of the blood vessels, and an output is generated based upon the quantitative vessel analysis. Other applications are also described.

3. 发明授权

US09717415B2 Automatic quantitative vessel analysis at the location of an automatically-detected tool 有权
公开(公告)号：US09717415B2
公开(公告)日：2017-08-01
申请号：US12649944
申请日：2009-12-30
申请人： Ran Cohen , Eldad Klaiman , Alexander Steinberg , Sagiv Philipp , David Tolkowsky
发明人： Ran Cohen , Eldad Klaiman , Alexander Steinberg , Sagiv Philipp , David Tolkowsky
IPC分类号： A61B5/00 , A61B34/20 , A61B6/12 , A61B6/00 , G06K9/00 , G06T7/00 , A61B17/12 , G06T11/60 , G06T5/00 , G06T7/13 , G06T7/246 , G06T7/62 , A61B34/10 , A61B8/08 , A61B8/00 , A61B17/00 , A61B17/22 , A61F2/958 , A61B18/02 , A61B18/14 , A61B18/24 , A61B34/00 , A61B90/00
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described including inserting a tool into a blood vessel, and, while the tool is within the blood vessel, acquiring an extraluminal image of the blood vessel. In the extraluminal image of the blood vessel, a location of a portion of the tool with respect to the blood vessel is detected automatically. In response to detecting the location of the portion of the tool, a target portion of the blood vessel that is in a vicinity of the portion of the tool is designated automatically. Using the extraluminal image, quantitative vessel analysis is performed on the target portion of the blood vessel. Other embodiments are also described.

4. 发明授权

US09216065B2 Forming and displaying a composite image 有权
标题翻译：形成和显示合成图像
公开(公告)号：US09216065B2
公开(公告)日：2015-12-22
申请号：US12781366
申请日：2010-05-17
申请人： Ran Cohen , Zohar Barzelay , Eldad Klaiman , Alexander Steinberg
发明人： Ran Cohen , Zohar Barzelay , Eldad Klaiman , Alexander Steinberg
IPC分类号： A61B5/05 , A61B19/00 , A61B6/12 , A61B6/00 , G06K9/00 , G06T7/00 , A61B17/12 , G06T7/20 , G06T7/60 , G06T11/60 , G06T5/00 , A61B5/00 , A61B8/08 , A61B8/00 , A61B17/00 , A61B17/22 , A61F2/958 , A61B18/02 , A61B18/14 , A61B18/24
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described including acquiring a plurality of image frames of a portion of a subject's body. At least one of the image frames is designated as a baseline image frame, a shape of the portion in the first baseline image frame being designated as a baseline shape. A non-baseline-shape image frame is deformed, such that the shape of the portion becomes more similar to the baseline shape of the portion than when the portion in the non-baseline-shape image frame is not deformed. A composite image is formed that is of higher clarity with respect to anatomy of the portion, relative to each of the acquired image frames, by averaging at least the deformed non-baseline-shape image frame with the baseline image frame. The composite image is displayed on a display. Other applications are also described.
摘要翻译：描述的装置和方法包括获取被检体的一部分的多个图像帧。将至少一个图像帧指定为基线图像帧，将第一基线图像帧中的部分的形状指定为基线形状。非基线形状的图像帧变形，使得该部分的形状变得与非基线形状图像帧中的部分不变形时相比该部分的基线形状更相似。通过至少将变形的非基线形状图像帧与基线图像帧进行平均，形成相对于每个获取的图像帧对该部分的解剖结构具有更高清晰度的合成图像。合成图像显示在显示屏上。还描述了其它应用。

5. 发明申请

US20140114184A1 DETERMINING A LUMINAL-FLOW-RELATED INDEX USING BLOOD VELOCITY DETERMINATION 审中-公开
标题翻译：使用血液速度测定法确定与流体相关的指标
公开(公告)号：US20140114184A1
公开(公告)日：2014-04-24
申请号：US14141955
申请日：2013-12-27
申请人： SYNC-RX, LTD.
发明人： Eldad KLAIMAN , Ran COHEN , David TOLKOWSKY , Alexander STEINBERG
IPC分类号： A61B6/00 , G06T7/00 , G06T7/20
CPC分类号： G06T7/0016 , A61B5/021 , A61B5/0275 , A61B6/469 , A61B6/481 , A61B6/487 , A61B6/504 , A61B6/507 , A61B6/5217 , G06T5/50 , G06T7/20 , G06T2207/20224 , G06T2207/30104 , G16H50/50
摘要： Apparatus and methods are described for use with an imaging device (12) configured to acquire a set of angiographic images of a lumen. At least one processor (10) determines blood velocity within the lumen, via image processing. The processor determines a value of a flow-related parameter at the location based upon the determined blood velocity. The processor additionally receives an indication of a value of a second flow-related parameter of the subject, and determines a value of a luminal-flow-related index of the subject at the location, by determining a relationship between the value of the current flow-related parameter and the value of the second flow-related parameter. Other applications are also described.
摘要翻译：描述了与被配置为获取一组管腔的血管造影图像的成像装置（12）一起使用的装置和方法。至少一个处理器（10）经由图像处理来确定内腔内的血液速度。处理器基于所确定的血液速度来确定位置处的流量相关参数的值。处理器另外接收对象的第二流相关参数的值的指示，并且通过确定当前流的值之间的关系来确定该位置处的对象的与管腔相关的索引的值相关参数和第二个流相关参数的值。还描述了其它应用。

6. 发明申请

US20140112539A1 APPARATUS AND METHODS FOR REDUCING VISIBILITY OF A PERIPHERY OF AN IMAGE STREAM 审中-公开
标题翻译：用于降低图像周边的可见性的装置和方法
公开(公告)号：US20140112539A1
公开(公告)日：2014-04-24
申请号：US14143289
申请日：2013-12-30
申请人： SYNC-RX, LTD.
发明人： David TOLKOWSKY , Ran COHEN , Alexander STEINBERG , Sagiv PHILIPP , Eldad KLAIMAN
IPC分类号： G06T7/00
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described for imaging a portion of a body of a subject that undergoes a motion cycle, including acquiring a plurality of image frames of the portion of the subject's body. A given feature is identified in at least some of the image frames. At least some image frames are image tracked with respect to the feature, and the image frames that have been image tracked with respect to the given feature are displayed as a stream of image frames. Visibility of a periphery of the displayed stream of image frames is at least partially reduced. Other applications are also described.
摘要翻译：描述了用于对经历运动周期的对象的身体的一部分进行成像的装置和方法，包括获取对象身体的该部分的多个图像帧。在至少一些图像帧中识别给定特征。至少一些图像帧相对于特征被图像跟踪，并且已经相对于给定特征被图像跟踪的图像帧被显示为图像帧流。所显示的图像帧流的周边的可视性至少部分地减少。还描述了其它应用。

7. 发明授权

US08700130B2 Stepwise advancement of a medical tool 有权
标题翻译：逐步推进医疗工具
公开(公告)号：US08700130B2
公开(公告)日：2014-04-15
申请号：US12487315
申请日：2009-06-18
申请人： Gavriel Iddan , David Tolkowsky , Ran Cohen , Jacob Blank
发明人： Gavriel Iddan , David Tolkowsky , Ran Cohen , Jacob Blank
IPC分类号： A61B5/06 , A61M25/09 , A61B8/02
CPC分类号： A61B5/06 , A61B6/503 , A61B6/5217 , A61B6/541 , A61B8/02 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/22044 , A61B2017/22094 , A61F2/958 , A61F2002/9517 , A61M25/09041 , A61M2025/09116
摘要： Apparatus is provided, including a sensor for sensing a phase of cyclic activity of a subject's body system. A tool modulator includes a gate configured: in a first cycle of the cyclic activity, to allow movement of a tool, in response to the cyclic activity being at a first given phase thereof, following the given phase in the first cycle and prior to an occurrence of the given phase in a subsequent cycle of the cyclic activity, to inhibit the movement of the tool, and in a second cycle of the cyclic activity, subsequent to the inhibiting of the movement, to allow movement of the tool, in response to the second cycle of the cyclic activity being at the given phase thereof. An accumulation facilitator facilitates an accumulation of the tool in the tool modulator, and/or an accumulation of energy in the tool.
摘要翻译：提供了一种装置，包括用于感测被检体体系的循环活动的相位的传感器。工具调制器包括：门，其配置为：在循环活动的第一周期中，响应于循环活动处于其第一给定阶段，允许工具移动，遵循第一周期中的给定阶段，并且在在循环活动的随后循环中发生给定阶段，以抑制工具的移动，并且在停止运动之后的循环活动的第二循环中，以响应于循环活性的第二循环在其给定阶段。累积促进器促进工具在工具调制器中的积累和/或能量在工具中的累积。

8. 发明申请

US20120230565A1 AUTOMATIC QUANTITATIVE VESSEL ANALYSIS 有权
标题翻译：自动定量船舶分析
公开(公告)号：US20120230565A1
公开(公告)日：2012-09-13
申请号：US12666879
申请日：2009-11-18
申请人： Alexander Steinberg , Sagiv Philipp , David Tolkowsky , Ran Cohen , Eldad Klaiman , Jacob Blank
发明人： Alexander Steinberg , Sagiv Philipp , David Tolkowsky , Ran Cohen , Eldad Klaiman , Jacob Blank
IPC分类号： G06K9/00
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described for use with an image of blood vessels of a subject. In response to a user designating a single point on the image (a) a target portion of a blood vessel is automatically identified in the vicinity of the designated point, and (b) quantitative vessel analysis is performed on the target portion of the blood vessel. An output is generated based upon the quantitative vessel analysis. Other embodiments are also described.
摘要翻译：描述了与受试者的血管图像一起使用的装置和方法。响应于用户指定图像上的单个点（a），在指定点附近自动识别血管的目标部分，并且（b）对血管的目标部分进行定量血管分析。基于定量血管分析产生输出。还描述了其它实施例。

9. 发明申请

US20120004529A1 AUTOMATIC DISPLAY OF PREVIOUSLY-ACQUIRED ENDOLUMINAL IMAGES 审中-公开
标题翻译：自动显示先前获得的内膜图像
公开(公告)号：US20120004529A1
公开(公告)日：2012-01-05
申请号：US13228185
申请日：2011-09-08
申请人： David TOLKOWSKY , Ran COHEN , Eldad KLAIMAN , Zohar BARZELAY
发明人： David TOLKOWSKY , Ran COHEN , Eldad KLAIMAN , Zohar BARZELAY
IPC分类号： A61B5/05
摘要： Apparatus and methods are provided for use with an endoluminal data-acquisition device that acquires a set of endoluminal data-points of a lumen of a subject's body at respective locations inside the lumen, a second endoluminal device, and a display configured to display images. At least one processor includes location-association functionality that associates a given data point acquired by the endoluminal data-acquisition device with a given location within the lumen. Location-determination functionality determines, by means of image processing, in an extraluminal image of the second endoluminal device, a current location of at least a portion of the second endoluminal device. Display-driving functionality drives the display to display an indication of the endoluminal data point associated with the location, in response to determining that the portion of the second device is currently at the location. Other applications are also described.
摘要翻译：提供了一种与内腔数据采集装置一起使用的装置和方法，所述装置和方法在管腔内的各个位置获取被检体的内腔的一组内腔数据点，第二腔室装置和被配置为显示图像的显示器。至少一个处理器包括将由内腔数据采集设备获取的给定数据点与管腔内的给定位置相关联的位置关联功能。位置确定功能通过图像处理确定第二腔室装置的外腔图像中第二腔内装置的至少一部分的当前位置。响应于确定第二设备的部分当前在该位置，显示驱动功能驱动显示器以显示与位置相关联的内腔数据点的指示。还描述了其它应用。

10. 发明申请

US20100220917A1 AUTOMATIC GENERATION OF A VASCULAR SKELETON 有权
标题翻译：血管生成自动生成
公开(公告)号：US20100220917A1
公开(公告)日：2010-09-02
申请号：US12781294
申请日：2010-05-17
申请人： Alexander STEINBERG , Sagiv PHILIPP , Ran COHEN , David TOLKOWSKY
发明人： Alexander STEINBERG , Sagiv PHILIPP , Ran COHEN , David TOLKOWSKY
IPC分类号： G06K9/00
CPC分类号： A61B5/0044 , A61B5/7285 , A61B5/7289 , A61B6/12 , A61B6/469 , A61B6/481 , A61B6/501 , A61B6/503 , A61B6/504 , A61B6/5217 , A61B6/5247 , A61B6/541 , A61B8/0883 , A61B8/0891 , A61B8/543 , A61B17/12036 , A61B17/1204 , A61B17/12136 , A61B18/02 , A61B18/1492 , A61B18/24 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2017/00252 , A61B2017/00694 , A61B2017/00703 , A61B2017/1205 , A61B2017/22044 , A61B2017/22094 , A61B2034/105 , A61B2034/107 , A61B2034/254 , A61B2090/365 , A61F2/958 , G06K9/00369 , G06K2209/057 , G06T5/001 , G06T7/0012 , G06T7/0014 , G06T7/13 , G06T7/246 , G06T7/62 , G06T11/60 , G06T2207/10121 , G06T2207/30048 , G06T2207/30101
摘要： Apparatus and methods are described for receiving into at least one processor at least one image of blood vessels of a subject. Using image processing, discontinuous lines that correspond to paths of at least a portion of the blood vessels in the image are automatically derived, the lines having end points at discontinuities in the lines. Continuous lines that correspond to the paths of the portion of the blood vessels in the image are automatically generated by bridging the discontinuities in the discontinuous lines. An output is generated by the processor, based on the continuous lines. Other embodiments are also described.
摘要翻译：描述了将受试者的血管的至少一个图像接收到至少一个处理器中的装置和方法。使用图像处理，自动导出与图像中的血管的至少一部分的路径相对应的不连续线，该线在线中的不连续点处具有终点。通过桥接不连续线中的不连续性，自动生成与图像中的血管部分的路径相对应的连续线。输出由处理器根据连续线生成。还描述了其它实施例。

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