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1. 发明申请

US20170182486A1 METAL-ORGANIC FRAMEWORKS CONTAINING NITROGEN-DONOR LIGANDS FOR EFFICIENT CATALYTIC ORGANIC TRANSFORMATIONS 审中-公开
公开(公告)号：US20170182486A1
公开(公告)日：2017-06-29
申请号：US15129853
申请日：2015-03-30
申请人： The University of Chicago
发明人： Wenbin Lin, Ph.D. , Kuntal Manna , Teng Zhang
IPC分类号： B01J31/16 , C07F5/02 , C07F7/18 , C07C5/03 , C07C41/20 , C07D207/04 , C07D207/06 , C07C209/02 , B01J31/18 , C07C37/07
CPC分类号： B01J31/1691 , B01J31/18 , B01J31/1815 , B01J2531/16 , B01J2531/48 , B01J2531/824 , B01J2531/827 , B01J2531/842 , B01J2531/845 , B01J2531/847 , C07C5/03 , C07C37/07 , C07C41/20 , C07C209/02 , C07D207/04 , C07D207/06 , C07F5/025 , C07F7/1876 , Y02P20/544
摘要： Metal-organic framework (MOFs) compositions based on nitrogen donor-based organic bridging ligands, including ligands based on 1,3-diketimine (NacNac), bipyridines and salicylaldimine, were synthesized and then post-synthetically metalated with metal precursors, such as complexes of first row transition metals. Metal complexes of the organic bridging ligands could also be directly incorporated into the MOFs. The MOFs provide a versatile family of recyclable and reusable single-site solid catalysts for catalyzing a variety of asymmetric organic transformations. The solid catalysts can also be integrated into a flow reactor or a supercritical fluid reactor.

2. 发明申请

US20060161232A1 Phase-change particulate ice slurry coolant medical delivery tubing and insertion devices 审中-公开
标题翻译：相变微粒冰浆冷却液医疗输送管和插入装置
公开(公告)号：US20060161232A1
公开(公告)日：2006-07-20
申请号：US11038570
申请日：2005-01-18
申请人： Kenneth Kasza , John Oras , HyunJin Son , Lance Becker , Terrry Hoek
发明人： Kenneth Kasza , John Oras , HyunJin Son , Lance Becker , Terrry Hoek
IPC分类号： A61F7/00 , A61F7/12
CPC分类号： A61F7/0085 , A61F2007/0059
摘要： Various systems for delivering phase-change particulate ice slurries to targeted areas or organs of a patient are provided. Systems for delivering phase-change particulate ice slurries include a slurry reservoir and a conduit for delivering slurry from the reservoir to the patient. The conduit may include multiple components, including a section of medical tubing, an insertion tip for directing the out flow of slurry to the targeted area, and one or more transition fittings to adapt the tubing to the insertion tip. Interfaces between the various components that form the slurry flow path are configured so that there are no sudden reductions in the cross sectional area of the flow path. Any narrowing of the flow path occurs in a gradual tapered manner. The entire flow path remains substantially free of all obstacles that may tend to trap particles and lead to plugging of the flow path.
摘要翻译：提供用于将相变颗粒状冰浆递送到患者的目标区域或器官的各种系统。用于递送相变微粒冰浆的系统包括浆料储存器和用于将淤浆从储存器输送到患者的导管。导管可以包括多个部件，包括一部分医用管道，用于引导浆液流出到目标区域的插入尖端，以及一个或多个过渡配件以使管道适应插入尖端。形成浆料流动路径的各种部件之间的接口被构造成使得流动通道的横截面积没有突然减小。流动路径的任何变窄以渐变的方式发生。整个流动路径基本上没有可能倾向于捕获颗粒并导致流动路径堵塞的所有障碍物。

3. 发明授权

US11619660B2 Electrometry by optical charge conversion of defects in the solid-state 有权
公开(公告)号：US11619660B2
公开(公告)日：2023-04-04
申请号：US16968471
申请日：2019-02-13
申请人： The University of Chicago
发明人： Gary Wolfowicz , Samuel James Whiteley , David Daniel Awschalom
IPC分类号： G01R15/24
摘要： Methods and systems are disclosed for sensing an environment electric field. In one exemplary implementation, a method includes disposing a sensor in the environment, wherein the sensor comprising a crystalline lattice and at least one optically-active defect in the crystalline lattice; pre-exciting the crystalline lattice to prepare at least one defect in a first charge state using a first optical beam at a first optical wavelength; converting at least one defect from the first charge state to a second charge state using a second optical beam at a second optical wavelength; monitoring a characteristics of photoluminescence emitted from the defect during or after the conversion of the at least one defect from the first charge state to the second charge state; and determining a characteristics of the electric field in the environment according to the monitored characteristics of the photoluminescence.

4. 发明申请

US20230090706A1 METHODS AND COMPOSITIONS COMPRISING TRANS-ACTING TRANSLATIONAL ACTIVATORS 有权
公开(公告)号：US20230090706A1
公开(公告)日：2023-03-23
申请号：US17905116
申请日：2021-02-26
申请人： The University of Chicago
发明人： Bryan DICKINSON , Yang CAO
IPC分类号： C12N15/113 , C12N15/67
摘要： The current disclosure relates to nucleic acid therapeutics that target mRNA molecules and recruit translation machinery to increase the translation from the mRNA, thus increasing the protein product in a subject or cell. Accordingly, aspects of the disclosure relate to a chimeric nucleic acid comprising a targeting region and a translational activating region, wherein the translational activating region comprises at least one ribosome and/or translation factor binding site and wherein the targeting region comprises a region that is complementary to a target mRNA.

5. 发明申请

US20230073224A1 UNIVERSAL FAST-FLUX CONTROL OF LOW-FREQUENCY QUBITS 有权
公开(公告)号：US20230073224A1
公开(公告)日：2023-03-09
申请号：US17904377
申请日：2021-02-17
申请人： The University of Chicago
发明人： David I. Schuster , Helin Zhang
IPC分类号： H03K17/92 , G06N10/40
摘要： Methods for initializing a qubit into a pure state, reading the qubit, and arbitrarily rotating the qubit into any quantum state complete in times shorter than the qubit's typical dephasing and relaxation times. These methods provide universal single-qubit control and may be used to implement quantum gates with high fidelity. The methods may be implemented with superconducting qubits, such as heavy fluxonium, and do not rely on a three-dimensional cavity for suppressing spontaneous emission. Therefore, the methods may be implemented using smaller two-dimensional architectures commonly used for superconducting circuits. The methods also work with low-frequency qubits, i.e., qubits for which the energy spacing between the two quantum-computational states is less than the mean thermal energy of a surrounding bath. This reduces the cooling requirements of the qubit while maintaining fidelity.

6. 发明申请

US20230071166A1 ONE-STEP METHOD FOR PRODUCING ADENOVIRAL VECTORS 有权
公开(公告)号：US20230071166A1
公开(公告)日：2023-03-09
申请号：US17819539
申请日：2022-08-12
申请人： The University of Chicago
发明人： Tong-Chuan He
IPC分类号： C12N15/86 , C07K14/245
摘要： The disclosure is directed to a gene transfer vector which comprises (i) all or part of a viral genome and (ii) a suicide gene flanked by unique cloning sequences. The disclosure also is directed to a system for producing an adenoviral vector comprising a destination vector comprising (i) all or part of an adenoviral genome and (ii) a suicide gene flanked by unique cloning sequences; a transgene flanked by unique cloning sequences; and (c) reagents for Gibson DNA Assembly (GDA). A method of producing an adenoviral vector using the aforementioned system also is provided.

7. 发明授权

US11598780B2 Engineering lymphocytes with specific alpha and beta chains on their t-cell receptor 有权
公开(公告)号：US11598780B2
公开(公告)日：2023-03-07
申请号：US16753684
申请日：2018-10-05
申请人： The University of Chicago , OncoTherapy Science, Inc.
发明人： Yusuke Nakamura , Jae-Hyun Park , Sachiko Yoshimura , Tetsuro Hikichi
IPC分类号： G01N33/68 , A61K35/17 , C07K14/725 , C12N5/0783 , C12N15/85 , G01N33/50 , G01N33/569
摘要： Provided herein are methods to identify TCR-recognizing cancer-specific antigens, and TCR-engineered T cells having antigen-specific cytotoxic activity. Provided herein are engineered T lymphocytes produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the engineered T lymphocytes described herein. Provided herein are antibodies, or fragments thereof, produced by the methods described herein. Provided herein are methods of treating cancer in a subject comprising administering the antibodies described herein to a subject. In some embodiments, the therapeutic compositions (e.g., engineered lymphocytes, antibodies, etc.) and methods herein are provided as part of a kit or system.

8. 发明授权

US11575011B2 Superlattice structure including two-dimensional material and device including the superlattice structure 有权
公开(公告)号：US11575011B2
公开(公告)日：2023-02-07
申请号：US17515713
申请日：2021-11-01
申请人： Samsung Electronics Co., Ltd. , THE UNIVERSITY OF CHICAGO , Center for Technology Licensing at Cornell University
发明人： Minhyun Lee , Jiwoong Park , Saien Xie , Jinseong Heo , Hyeonjin Shin
IPC分类号： H01L29/15 , H01L29/10
摘要： Provided are a superlattice structure including a two-dimensional material and a device including the superlattice structure. The superlattice structure may include at least two different two-dimensional (2D) materials bonded to each other in a lateral direction, and an interfacial region of the at least two 2D materials may be strained. The superlattice structure may have a bandgap adjusted by the interfacial region that is strained. The at least two 2D materials may include first and second 2D materials. The first 2D material may have a first bandgap in an intrinsic state thereof. The second 2D material may have a second bandgap in an intrinsic state thereof. An interfacial region of the first and second 2D materials and an adjacent region may have a third bandgap between the first bandgap and the second bandgap.

9. 发明申请

US20230021795A1 METHODS OF PREPARING REGIOREGULAR CONJUGATED POLYMERS 有权
公开(公告)号：US20230021795A1
公开(公告)日：2023-01-26
申请号：US17778550
申请日：2020-11-11
申请人： THE UNIVERSITY OF CHICAGO
发明人： Xunshan LIU , Luping YU , Valerii SHARAPOV
IPC分类号： C08G61/12 , G03F7/11
摘要： Described herein is a novel polymerization method that is useful for synthesizing regioregular conjugated polymers from electron rich aromatic monomers and oligomers of electron rich aromatic monomers.

10. 发明申请

US20220383989A1 DEEP IMITATION LEARNING FOR MOLECULAR INVERSE PROBLEMS 有权
公开(公告)号：US20220383989A1
公开(公告)日：2022-12-01
申请号：US17773647
申请日：2020-11-03
申请人： The University of Chicago
发明人： Eric JONAS
IPC分类号： G16C20/30 , G16C20/20 , G16C20/70
摘要： A method of determining a molecular structure of a compound includes obtaining a known molecular formula of the compound based on at least one of an observed spectrum and stoichiometric calculations. Edges that meet per-vertex constraints of the molecular formula are determined, and a plurality of candidate structures is generated based on the determined edges. The plurality of candidate structures are evaluated, and one candidate structure of the plurality of candidate structures is determined as the molecular structure of the compound based on the evaluation of the plurality of candidate structures.

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