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1. 发明申请

US20220034805A1 IMAGING AN OBJECT THROUGH A SCATTERING MEDIUM 有权
公开(公告)号：US20220034805A1
公开(公告)日：2022-02-03
申请号：US17277684
申请日：2019-09-17
申请人： University Court of the University of St Andrews
发明人： Kishan Dholakia , Mingzhou Chen , Adria Escobet-Montalban
IPC分类号： G01N21/47 , G01N21/64 , G02B21/00
摘要： A method for use in imaging an object through a scattering medium comprises illuminating the object sequentially point-by-point through the scattering medium with incident electromagnetic radiation propagating along an illumination direction so that the incident electromagnetic radiation interacts with the object to cause the object to generate and emit electromagnetic radiation, wherein the incident electromagnetic radiation is formed by spectrally dispersing initial electromagnetic radiation in a direction transverse to the illumination direction so as to form spectrally dispersed electromagnetic radiation and by spatially focusing the spectrally dispersed electromagnetic radiation through the scattering medium to the object. The method comprises measuring, for each illuminated point of the object, a corresponding value representative of a quantity of at least a portion of the corresponding emitted electromagnetic radiation and using, for each illuminated point of the object, position information for the illuminated point and the corresponding measured value to determine an image of the object.

2. 发明申请

US20220003980A1 LIGHT-SHEET IMAGING 有权
公开(公告)号：US20220003980A1
公开(公告)日：2022-01-06
申请号：US17280112
申请日：2019-09-24
申请人： University Court of the University of St Andrews
发明人： Kishan Dholakia , Mingzhou Chen , Adria Escobet-Montalban
IPC分类号： G02B21/06 , G02B21/36
摘要： A method for use in light-sheet imaging of an object through a scattering medium comprises illuminating the object through the scattering medium with incident electromagnetic radiation propagating along an illumination axis so that the incident electromagnetic radiation interacts with the object to cause the object to generate and emit electromagnetic radiation. The incident electromagnetic radiation is formed by spectrally dispersing initial electromagnetic radiation in a direction transverse to the illumination axis so as to form spectrally dispersed electromagnetic radiation and by spatially focusing the spectrally dispersed electromagnetic radiation through the scattering medium to the object. The method comprises forming an image of at least a portion of the emitted electromagnetic radiation propagating along a detection axis, wherein the detection axis and the illumination axis are non-collinear, and sensing the formed image. The object and/or the scattering medium may comprise biological material, for example human or animal tissue. The method may be used for light-sheet imaging in vivo or in vitro. A system for use in light-sheet imaging of an object through a scattering medium is configured to perform the method.

3. 发明申请

US20210355378A9 HETEROCYCLIC COMPOUNDS EXHIBITING THERMALLY ACTIVATED DELAYED FLUORESCENCE (TADF) AND THEIR USE IN ELECTROLUMINESCENT DEVICES 有权
公开(公告)号：US20210355378A9
公开(公告)日：2021-11-18
申请号：US17049304
申请日：2019-04-23
申请人： UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
发明人： Eli ZYSMAN-COLMAN , Dongyang CHEN , Rajamalli PACHAI GOUNDER
IPC分类号： C09K11/06 , C07D401/14 , H01L51/00 , C07D403/14 , C07F9/6558
摘要： An organic thermally activated delayed fluorescence (TADF) compound selected from the group consisting of compounds according to formula (Ia) and formula (Ib): wherein: Het is a heteroaryl group containing at least one heteroatom; n(D) denotes n donor groups D bonding to the heteroaryl group Het; n is at least 1; and -a and -b denotes bonding to another group.

4. 发明授权

US10994469B2 Dendrimer laser 有权
公开(公告)号：US10994469B2
公开(公告)日：2021-05-04
申请号：US15874498
申请日：2018-01-18
申请人： The University Court of the University of St. Andrews , Oxford University Innovation Limited
发明人： Paul Burn , Ifor Samuel , Justin Lawrence , Jonathan Markham
IPC分类号： B29C59/00 , C08G83/00 , H01S5/36 , H01S5/04 , H01S5/12 , B29C59/02
摘要： A distributed feedback laser having a conjugated dendrimer as the active lasing component, and a method for patterning conjugated dendrimers.

5. 发明申请

US20210053932A1 MANGANESE-CATALYSED HYDROGENATION OF ESTERS 有权
公开(公告)号：US20210053932A1
公开(公告)日：2021-02-25
申请号：US16960187
申请日：2019-01-08
申请人： University Court of the University of St Andrews
发明人： Magnus Widegren , Matthew Lee Clarke
IPC分类号： C07D307/77 , B01J31/18 , B01J31/22
摘要： The present invention relates to the field of catalytic hydrogenation and, more particularly, to methods of manganese-catalysed hydrogenation of esters to alcohols. Advantageously, where the esters are chiral, the hydrogenations proceed with high or complete stereochemical integrity.

6. 发明授权

US10593893B2 Light emitting devices and compouds 有权
公开(公告)号：US10593893B2
公开(公告)日：2020-03-17
申请号：US15569669
申请日：2015-12-29
申请人： UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
发明人： Eli Zysman-Colman , Michael Yin Wong
IPC分类号： H01L51/00 , C07D417/10 , C09K11/06 , C07D413/10 , C07F9/572 , C07D265/38 , C07D279/22 , C07D413/14 , H01L51/50
摘要： Thermally Activated Delayed Fluorescence (TADF) compounds wherein two aromatic heterocyclic moieties are provided as acceptor groups, spaced apart from two donor moieties by an aromatic spacer ring, are described. Charged organic TADF species having a similar structure are also described. The TADF compounds and charged organic TADF species may be employed as emitter material in light emitting devices such as OLEDs and LEECs. Also described TADF compounds wherein at least one donor moiety is substituted by at least one substituent that is a phosphine oxide or a phosphine sulphide.

7. 发明授权

US10588513B2 Optical apparatus for use with a medical imager 有权
公开(公告)号：US10588513B2
公开(公告)日：2020-03-17
申请号：US14650524
申请日：2014-01-20
申请人： University Court of the University of St Andrews
发明人： Kishan Dholakia , Praveen Cheriyan Ashok
IPC分类号： A61B5/00 , A61B1/07 , A61B10/04 , A61B5/055 , A61B10/02
摘要： An optical apparatus comprising a disposable non-magnetic optical fibre probe for coupling light into a sample and receiving light from the sample for performing Raman spectroscopy, and a non-magnetic optical extension releasably connected to the disposable non-magnetic optical probe for transmitting light into the disposable non-magnetic optical probe and receiving light from the disposable non-magnetic optical probe.

8. 发明申请

US20200041778A1 LIGHT SHEET IMAGING WITH ACOUSTIC TRAPPING 审中-公开
公开(公告)号：US20200041778A1
公开(公告)日：2020-02-06
申请号：US16339850
申请日：2017-10-05
申请人： UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
发明人： Kishan DHOLAKIA , Zhengyi YANG
IPC分类号： G02B21/32 , G02B21/08
摘要： A light sheet imaging system comprises an acoustic trapping arrangement for forming an acoustic trap using one or more acoustic beams and an optical system for light sheet imaging a sample positioned in the acoustic trap. A light sheet imaging method comprises forming an acoustic trap using one or more acoustic beams and light sheet imaging a sample positioned in the acoustic trap. The system and/or the method may be used for light sheet microscopy using acoustic trapping for the contactless confinement of a sample to be imaged such as a particle, a colloid, a cell, a conglomerate of cells (e.g. a cell biopsy), an embryo, a larva or an organism such as a complex organism or a plurality of such samples.

9. 发明授权

US10429245B2 Random wavelength meter 有权
公开(公告)号：US10429245B2
公开(公告)日：2019-10-01
申请号：US15977596
申请日：2018-05-11
申请人： University Court of the University of St Andrews
发明人： Kishan Dholakia , Michael Mazilu , Klaus Metzger
IPC分类号： G01J9/02 , G01J3/02 , G01J4/00 , G01J1/42 , G01J1/04
摘要： An optical system comprising a randomizer that has a plurality of randomly positioned scatterers for scattering and thereby randomizing light to generate a speckle pattern and a detector for detecting the speckle pattern to determine at least one property of the light and/or change in at least one property of the light.

10. 发明授权

US10363298B2 Immunomodulatory compounds 有权
公开(公告)号：US10363298B2
公开(公告)日：2019-07-30
申请号：US15113672
申请日：2015-01-23
申请人： University Court of the University of St Andrews
发明人： Garry Taylor , Helen Connaris
IPC分类号： A61K39/07 , A61K39/09 , A61K39/104 , A61K39/39 , A61K38/16 , A61K39/02 , G01N33/68 , A61K39/00
摘要： The present invention is based on the finding that in addition to interfering with or blocking, preventing and/or inhibiting the interaction between a pathogen and, for example, a sialic acid containing cell surface receptor, certain sialic acid binding molecules have immunomodulatory properties. The invention provides methods and uses which exploit sialic acid binding molecules in the treatment and/or prevention of disease by modulation and/or priming of the host immune response.

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