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1. 发明申请

US20220357251A1 TESTING ASSEMBLY INCLUDING A MULTIPLE DEGREE OF FREEDOM STAGE 有权
公开(公告)号：US20220357251A1
公开(公告)日：2022-11-10
申请号：US17552665
申请日：2021-12-16
申请人： Bruker Nano, Inc.
发明人： Edward Cyrankowski , Syed Amanulla Syed Asif , Ryan Major , Derek Rasugu , Yuxin Feng
IPC分类号： G01N3/04 , G01N3/42 , G02B21/26 , G02B21/32 , G21K5/10 , H01J37/20
摘要： A multiple degree of freedom sample stage or testing assembly including a multiple degree of freedom sample stage. The multiple degree of freedom sample stage includes a plurality of stages including linear, and one or more of rotation or tilt stages configured to position a sample in a plurality of orientations for access or observation by multiple instruments in a clustered volume that confines movement of the multiple degree of freedom sample stage. The multiple degree of freedom sample stage includes one or more clamping assemblies to statically hold the sample in place throughout observation and with the application of force to the sample, for instance by a mechanical testing instrument. Further, the multiple degree of freedom sample stage includes one or more cross roller bearing assemblies that substantially eliminate mechanical tolerance between elements of one or more stages in directions orthogonal to a moving axis of the respective stages.

2. 发明授权

US11422504B2 Multiple laminar flow-based particle and cellular separation with laser steering 有权
公开(公告)号：US11422504B2
公开(公告)日：2022-08-23
申请号：US17458947
申请日：2021-08-27
申请人： ABS Global, Inc.
发明人： Daniel Mueth , Joseph Plewa , Jessica Shireman , Amy Anderson , Lewis Gruber , Neil Rosenbaum
IPC分类号： G03H1/00 , G02B21/32 , H05H3/04 , B01L3/00 , G01N15/02 , G01N33/49 , B01D21/01 , G01N33/487 , G01N21/64 , G01N33/50 , A61L2/08 , B01D21/26 , B03C1/00 , B04B13/00 , G01N27/447 , G21K5/08 , G01N15/04 , G01N15/05 , G01N15/06 , G01N15/14 , B03C1/28 , B03C5/00 , G03H1/08 , G03H1/22 , G01N15/00 , B01D21/00 , G01N15/10
摘要： The invention provides a method, apparatus and system for separating blood and other types of cellular components, and can be combined with holographic optical trapping manipulation or other forms of optical tweezing. One of the exemplary methods includes providing a first flow having a plurality of blood components; providing a second flow; contacting the first flow with the second flow to provide a first separation region; and differentially sedimenting a first blood cellular component of the plurality of blood components into the second flow while concurrently maintaining a second blood cellular component of the plurality of blood components in the first flow. The second flow having the first blood cellular component is then differentially removed from the first flow having the second blood cellular component. Holographic optical traps may also be utilized in conjunction with the various flows to move selected components from one flow to another, as part of or in addition to a separation stage.

3. 发明授权

US11293851B2 Controlling alkaline earth atoms for quantum computing and metrology applications 有权
公开(公告)号：US11293851B2
公开(公告)日：2022-04-05
申请号：US17019986
申请日：2020-09-14
申请人： California Institute of Technology
发明人： Alexandre Cooper-Roy , Jacob P. Covey , Ivaylo S. Madjarov , Jason R. Williams , Adam L. Shaw , Vladimir Schkolnik , Tai Hyun Yoon , Manuel Endres
IPC分类号： G01J3/30 , G01N15/14 , G01N21/64 , C09K11/55 , G06N10/00 , H03L7/26 , G04F5/14 , G02B21/32
摘要： An apparatus for individually trapping atoms, individually imaging the atoms, and individually cooling the atoms to prevent loss of the atoms from the trap caused by the imaging. The apparatus can be implemented in various quantum computing, sensing, and metrology applications (e.g., in an atomic clock).

4. 发明授权

US11162060B2 Self-locking optoelectronic tweezer and its fabrication 有权
公开(公告)号：US11162060B2
公开(公告)日：2021-11-02
申请号：US16667801
申请日：2019-10-29
申请人： The Regents of the University of California
发明人： Yajia Yang , Yufei Mao , Pei-Yu E. Chiou , Chi On Chui
IPC分类号： B03C5/00 , C12M1/42 , B03C5/02 , G02B21/32 , B01L3/00 , G01N15/10 , G01N35/10 , C12M3/00
摘要： A novel Self-Locking Optoelectronic Tweezers (SLOT) for single microparticle manipulation across a large area is provided. DEP forces generated from ring-shape lateral phototransistors are utilized for locking single microparticles or cells in the dark state. The locked microparticles or cells can be selectively released by optically deactivating these locking sites.

5. 发明申请

US20210231936A1 SINGLE PLANE ILLUMINATION MICROSCOPE 有权
公开(公告)号：US20210231936A1
公开(公告)日：2021-07-29
申请号：US17230613
申请日：2021-04-14
申请人： Carl Zeiss Microscopy GmbH
发明人： Thomas Kalkbrenner , Ralf Netz , Helmut Lippert , Joerg Siebenmorgen
IPC分类号： G02B21/00 , G02B21/32
摘要： A single plane illumination microscope having an illumination optical system for illuminating a sample located on a sample carrier in a medium, and which is parallel to a planar reference surface. The sample is illuminated by a light sheet via an illumination light path. A detection optical system has a detection beam path. The optical axes of the illumination and detection optical systems each define an angle that is not equal to zero degrees along with the normal to the reference surface. A barrier layer system includes at least one layer of a given material having a given thickness and separates the medium from the illumination and detection optical systems. A base area of the barrier layer system is in contact with the region that is accessible for illumination and detection activities, said base area running parallel to the reference surface. At least one corrective element in the illumination beam path and/or the detection beam path allows those aberrations to be reduced which are created when light to be detected or light for illuminating the sample penetrates interfaces of the barrier layer system at an angle. The microscope has means, which are independent of the generation of the light sheet, for applying, via at least one manipulation beam path, light intensity to the sample in substantially point-shaped regions of the light sheet plane or in a given volume that at least temporarily encompasses the light sheet plane.

6. 发明申请

US20210196396A1 METHOD OF OPERATING A SURGICAL MICROSCOPE AND SURGICAL MICROSCOPE 有权
公开(公告)号：US20210196396A1
公开(公告)日：2021-07-01
申请号：US16732218
申请日：2019-12-31
申请人： Carl Zeiss Meditec AG
发明人： Fang You , David Dobbelstein , Stefan Saur
IPC分类号： A61B34/20 , A61B34/00 , G02B21/32 , G02B21/00 , A61B90/00 , A61B90/25
摘要： A method of operating a surgical microscope includes receiving an instruction to move the camera relative to the object, operating a zoom lens to zoom out and displaying images obtained by processing images recorded by the camera such that centers of the displayed images correspond to a target position within the recorded images and such that the magnification of the object displayed in the images is the initial magnification, wherein the target position is displaced within the recorded images relative to the first position, and operating actuators to move the camera.

7. 发明申请

US20210039102A1 METHODS AND SYSTEMS FOR DESIGNING AND PRODUCING NANO-STRUCTURED OPTICAL DEVICES 有权
公开(公告)号：US20210039102A1
公开(公告)日：2021-02-11
申请号：US16966841
申请日：2019-02-01
申请人： Arizona Board of Regents on Behalf of the University of Arizona
发明人： Euan McLeod , Weilin Liu , Jeffrey Melzer
IPC分类号： B01L3/00 , G02B1/00 , G02B21/32 , G21K1/00
摘要： A method of designing a nano-structured optical device includes: selecting a first nanoscale building block from a finite set of types of building blocks; placing the first nanoscale building block at a position and orientation in a three-dimensional optical device structure; optimizing the position, orientation, and type of the first nanoscale building block to obtain a preselected optical effect based on optical scattering from the first nanoscale building block; selecting a second nanoscale building block from the finite set of types of building blocks; placing the second nanoscale building block at a position and orientation in the three-dimensional optical device structure along with the first nanoscale building block; and optimizing the positions, orientations, and types of the first and second nanoscale building blocks to obtain the preselected optical effect based on optical scattering from the first and second nanoscale building blocks.

8. 发明申请

US20200333577A1 MICROMANIPULATION SYSTEM COMPRIMISING A PROTECTIVE SYSTEM FOR CAPILLARIES 审中-公开
公开(公告)号：US20200333577A1
公开(公告)日：2020-10-22
申请号：US16920158
申请日：2020-07-02
申请人： MMI AG
发明人： Peter Tschanz
IPC分类号： G02B21/32 , G01N1/28
摘要： A manipulation system for microscope applications comprises a micromanipulation tool and a protective device protecting the tool, wherein the tool and the protective device are movable relative to one another between a position protecting the tool in a contactless manner and a position releasing the tool for the manipulation.

9. 发明授权

US10809513B2 Functionalized optical lens and method of manufacturing 有权
公开(公告)号：US10809513B2
公开(公告)日：2020-10-20
申请号：US15615138
申请日：2017-06-06
申请人： United Arab Emirates University
发明人： Ebrahim Ghafar Zadeh , Falah Awwad
IPC分类号： G02B21/36 , G02B21/32 , G02B6/32 , G02B21/02 , G02B21/00 , G02B3/00 , C12N13/00
摘要： There is provided an optical lens having an optically transparent surface coated with transducers adapted to stimulate a stimulus signal in a sample, where the optical lens is adapted to enable an optical communication between an optical source from one side of the optically transparent surface and the transducers and the sample from another side of the optically transparent surface for enabling the optical source to conduct optical operations capturing both the transducers and the sample simultaneously during a stimulation process. There is also provided a method of manufacturing the optical lens.

10. 发明授权

US10682197B2 Systems and methods for optogenetic imaging 有权
公开(公告)号：US10682197B2
公开(公告)日：2020-06-16
申请号：US15964832
申请日：2018-04-27
申请人： INSCOPIX, INC.
发明人： Mark O. Trulson , Alice Stamatakis , Koen Visscher
IPC分类号： A61B90/20 , G01N21/64 , G02B21/16 , G02B21/06 , A61B5/00 , G02B21/02 , G02B21/00 , G02B21/32 , G02B3/14 , A61B5/04 , G01Q10/00 , G02B21/24
摘要： Provided herein are systems and methods for simultaneous imaging and stimulation using a microscope system. The microscope system can have a relatively small size compared to an average microscope system. The microscope can comprise in part an imaging light source and a stimulation light source. Light from the imaging light source and the stimulation light source can be spectrally separated to reduce cross talk between the stimulation light and the imaging light.

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