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1. 发明申请

US20180272009A1 NON-HUMAN PRIMATE MODEL OF AGE-RELATED MACULAR DEGENERATION AND METHOD FOR PRODUCING SAME 审中-公开
公开(公告)号：US20180272009A1
公开(公告)日：2018-09-27
申请号：US15853190
申请日：2017-12-22
申请人： Hideaki HARA , Masamitsu SHIMAZAWA , Hamamatsu Pharma Research, Inc.
发明人： Hiroyuki TAKAMATSU
IPC分类号： A61K49/00 , A01K67/027
CPC分类号： A61K49/0008 , A01K67/027 , A01K2207/20 , A01K2227/106 , A01K2267/035
摘要： An object of the present invention is to provide a method for producing a non-human primate model of AMD, a method for evaluating the efficacy of a test substance in the prevention or treatment of AMD using the AMD animal model produced according to this method, and a method for screening substances effective in the prevention or treatment of AMD using the aforementioned AMD animal model. The method for preparing the AMD animal model consists of administering sodium iodate into a vitreous body of a non-human primate, and the method for evaluating the efficacy of a test substance in the prevention or treatment of AMD consists of preparing a non-human primate model of AMD according to the aforementioned method for preparing an AMD animal model, and evaluating the efficacy of the test substance in the prevention or treatment of AMD using the resulting AMD animal model.

2. 发明申请

US20150212069A1 SPERM-SPECIFIC CATION CHANNEL, CATSPER4, AND USES THEREFOR 审中-公开
公开(公告)号：US20150212069A1
公开(公告)日：2015-07-30
申请号：US14458643
申请日：2014-08-13
申请人： CHILDREN'S MEDICAL CENTER CORPORATION
发明人： Magdalene M. MORAN , Jayhong A. CHONG , Ian S. RAMSEY , David CLAPHAM
IPC分类号： G01N33/50
CPC分类号： A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2227/106 , A01K2267/03 , C07K14/47 , C07K14/705 , C12Q1/6881 , C12Q2600/158 , G01N33/5014 , G01N33/5023 , G01N33/5044 , G01N2500/04 , G01N2800/367
摘要： Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.

3. 发明授权

US09005982B2 Biomarkers associated with autoimmune diseases of the lung 有权
标题翻译：与肺部自身免疫性疾病相关的生物标记物
公开(公告)号：US09005982B2
公开(公告)日：2015-04-14
申请号：US13703617
申请日：2011-06-10
申请人： Mark S. Anderson , Anthony K. Shum
发明人： Mark S. Anderson , Anthony K. Shum
IPC分类号： G01N33/00 , G01N33/48 , G01N33/50 , G01N33/68 , A01K67/027 , G01N33/564
CPC分类号： G01N33/6884 , A01K67/027 , A01K2227/101 , A01K2227/105 , A01K2227/106 , A01K2267/0325 , G01N33/564 , G01N2800/12 , G01N2800/50
摘要： The present disclosure is generally related to pulmonary autoantigens. The disclosure provides methods and kits for assessing whether a subject has or is predisposed to interstitial lung disease. Additionally the present disclosure provides methods of treatment and animal models of interstitial lung disease.
摘要翻译：本公开一般涉及肺自身抗原。本公开提供了用于评估受试者是否患有间质性肺病的方法和试剂盒。此外，本公开提供了间质性肺疾病的治疗方法和动物模型。

4. 发明授权

US08852860B2 Sperm-specific cation channel, CatSper1 and uses therefor 有权
标题翻译：精子特异性阳离子通道，CatSper1及其用途
公开(公告)号：US08852860B2
公开(公告)日：2014-10-07
申请号：US13484061
申请日：2012-05-30
申请人： David Clapham , Dejian Ren
发明人： David Clapham , Dejian Ren
IPC分类号： C12Q1/00 , C12Q1/68 , G01N27/00 , G01N33/68 , C07K14/705 , C07K14/00
CPC分类号： C07K14/705 , A01K67/0278 , A01K2217/052 , A01K2227/105 , A01K2227/106 , A01K2267/03 , G01N33/5029 , G01N33/5041 , G01N33/5044 , G01N33/68
摘要： Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper1) are disclosed. The CatSper1 protein is shown to be specifically expressed in sperm and to be necessary for sperm motility. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper1 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper1 activity, methods of genotyping subjects with respect to CatSper1, and methods of diagnosing and treating CatSper1-mediated disorders, including infertility.
摘要翻译：公开了与精子特异性的阳离子通道相关的核酸和蛋白质序列（CatSper1）。显示CatSper1蛋白在精子中特异性表达，并且对于精子活力是必需的。公开了与CatSper1基因和蛋白相关的核酸，载体，转化细胞，转基因动物，多肽和抗体。还提供了体外受精和避孕方法，鉴定CatSper1活性的调节剂的方法，与CatSper1相关的受试者的基因分型方法，以及诊断和治疗CatSper1介导的疾病包括不孕症的方法。

5. 发明授权

US08835105B2 Sperm-specific cation channel, CatSper4, and uses therefor 有权
标题翻译：精子特异性阳离子通道，CatSper4，并用于此
公开(公告)号：US08835105B2
公开(公告)日：2014-09-16
申请号：US13371033
申请日：2012-02-10
申请人： Magdalene M. Moran , Jayhong A. Chong , Ian S. Ramsey , David Clapham
发明人： Magdalene M. Moran , Jayhong A. Chong , Ian S. Ramsey , David Clapham
IPC分类号： C12Q1/00 , C12Q1/68 , G01N27/00 , C07K14/00
CPC分类号： A01K67/0278 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2227/106 , A01K2267/03 , C07K14/47 , C07K14/705 , C12Q1/6881 , C12Q2600/158 , G01N33/5014 , G01N33/5023 , G01N33/5044 , G01N2500/04 , G01N2800/367
摘要： Nucleic acid and protein sequences relating to a cation channel which is sperm-specific (CatSper4) are disclosed. The CatSper4 protein is shown to be specifically expressed in sperm. Nucleic acids, vectors, transformed cells, transgenic animals, polypeptides, and antibodies relating to the CatSper4 gene and protein are disclosed. Also provided are methods of in vitro fertilization and contraception, methods of identifying modulators of CatSper4 activity, methods of genotyping subjects with respect to CatSper4, and methods of diagnosing and treating CatSper4-mediated disorders, including infertility. Related business methods are also disclosed.
摘要翻译：公开了与精子特异性的阳离子通道相关的核酸和蛋白质序列（CatSper4）。显示CatSper4蛋白在精子中特异性表达。公开了与CatSper4基因和蛋白相关的核酸，载体，转化细胞，转基因动物，多肽和抗体。还提供了体外受精和避孕方法，鉴定CatSper4活性的调节剂的方法，关于CatSper4的受试者的基因分型方法，以及诊断和治疗CatSper4介导的疾病（包括不育症）的方法。还公开了相关业务方法。

6. 发明授权

US08502015B1 Method of inducing cancer 有权
标题翻译：诱导癌症的方法
公开(公告)号：US08502015B1
公开(公告)日：2013-08-06
申请号：US12831129
申请日：2010-07-06
申请人： Weidong Xu
发明人： Weidong Xu
IPC分类号： A01K67/00 , C12N15/00
CPC分类号： C12N15/1135 , A01K67/0275 , A01K2207/05 , A01K2217/052 , A01K2227/106 , A01K2267/0331 , C12N2310/111 , C12N2310/14 , C12N2320/10
摘要： A method induces cancer, such as ovarian cancer, in primates for testing of therapeutic treatments and preclinical research and development. A nanoparticle delivers plasmid DNA encoding oncogenes and siRNAs for tumor suppressor genes. For example, a biocompatible polymer, chitosan, is complexed with three plasmids including one that carries the cDNA encoding RAS oncogene and two plasmids encoding siRNAs for two tumor supressor genes p53 and Rb. Laproscopic delivery of these nanoparticles to the ovaries of non-human primates causes ovarian carcinoma, which is detected one month after delivery of the nanoparticles.
摘要翻译：一种方法在灵长类动物中诱导癌症，如卵巢癌，用于治疗治疗和临床前研究与开发的测试。纳米颗粒提供编码肿瘤抑制基因的癌基因和siRNA的质粒DNA。例如，生物相容性聚合物壳聚糖与三种质粒复合，包括携带编码RAS癌基因的cDNA和编码两种肿瘤抑制基因p53和Rb的siRNA的两种质粒。这些纳米颗粒向非人灵长类动物的卵巢的拉普拉斯递送导致卵巢癌，其在递送纳米颗粒后一个月检测到。

7. 发明申请

US20130111612A1 PRIMATE MODEL FROM THE FAMILY CERCOPITHECIDAE INFECTED BY A HBV STRAIN OF HUMAN GENOTYPE 有权
标题翻译：由人类基因组HBV病毒感染的家族性胚胎干细胞的初步模型
公开(公告)号：US20130111612A1
公开(公告)日：2013-05-02
申请号：US13636487
申请日：2011-03-24
申请人： Isabelle Chemin , Christian Trepo
发明人： Isabelle Chemin , Christian Trepo
IPC分类号： A01K67/027
CPC分类号： A01K67/027 , A01K2227/106 , A01K2267/0337 , C07K14/005 , C12N7/00 , C12N2730/10121
摘要： The invention relates to a non-human primate animal model for HBV infection, said animal model being of the Cercopithecidae family.
摘要翻译：本发明涉及用于HBV感染的非人灵长类动物模型，所述动物模型是Cercopithecidae家族。

8. 发明授权

US08097640B2 Prophylactic or therapeutic agent for diabetic maculopathy 失效
标题翻译：预防或治疗糖尿病性黄斑病变
公开(公告)号：US08097640B2
公开(公告)日：2012-01-17
申请号：US12842391
申请日：2010-07-23
申请人： Noriaki Kato , Hiroshi Nagano , Kaori Taniko , Takahito Jomori
发明人： Noriaki Kato , Hiroshi Nagano , Kaori Taniko , Takahito Jomori
IPC分类号： A01N43/50
CPC分类号： A61K31/4166 , A01K2227/106 , A01K2267/0362 , A01K2267/0375 , C07D491/10 , G01N33/5088 , G01N2800/042
摘要： A prophylactic or therapeutic agent for diabetic maculopathy, which can be administered for a long time and exhibits efficacy in a mechanism different from that of existing medicines. The invention relates to a prophylactic or therapeutic agent for diabetic maculopathy, comprising, as an active ingredient, a compound represented by the general formula: wherein X represents a halogen or a hydrogen atom, R1 and R2 concurrently or differently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or R1 and R2, together with a nitrogen atom bound thereto and optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle. Preferably, the compound is (2S,4S)-6-fluoro -2′,5′-dioxospiro chroman-4,4′-imidazolidine]-2-carboxamide. The invention also provides a model animal with diabetic maculopathy produced by subjecting a diabetic animal to intraocular ischemia/reperfusion to express edema in a retinal visual cell layer or in a macula lutea.
摘要翻译：用于糖尿病性黄斑病变的预防或治疗剂，其可以长时间施用并且以与现有药物不同的机制显示功效。本发明涉及一种糖尿病性黄斑病变的预防或治疗剂，其特征在于，作为活性成分，含有下列通式表示的化合物：其中，X表示卤素或氢原子，R 1和R 2可以同时或不同地表示氢原子或任选取代的C 1至C 6烷基，或R 1和R 2与连接的氮原子和任选另外的氮原子或氧原子一起形成5-至6-元杂环。优选地，该化合物是（2S，4S）-6-氟-2'，5'-二氧杂环苯并二氢吡喃-4,4'-咪唑烷] -2-甲酰胺。本发明还提供了一种通过使糖尿病动物进行眼内缺血/再灌注以在视网膜视细胞层或黄斑黄斑中表达水肿而产生的糖尿病性黄斑变性的模型动物。

9. 发明授权

US07910615B2 Prophylactic or therapeutic agent for diabetic maculopathy 有权
标题翻译：预防或治疗糖尿病性黄斑病变
公开(公告)号：US07910615B2
公开(公告)日：2011-03-22
申请号：US10587320
申请日：2005-01-28
申请人： Noriaki Kato , Hiroshi Nagano , Kaori Taniko , Takahito Jomori
发明人： Noriaki Kato , Hiroshi Nagano , Kaori Taniko , Takahito Jomori
IPC分类号： A01N43/50
CPC分类号： A61K31/4166 , A01K2227/106 , A01K2267/0362 , A01K2267/0375 , C07D491/10 , G01N33/5088 , G01N2800/042
摘要： A prophylactic or therapeutic agent for diabetic maculopathy, which can be administered for a long time and exhibits efficacy in a mechanism different from that of existing medicines. The invention relates to a prophylactic or therapeutic agent for diabetic maculopathy, comprising, as an active ingredient, a compound represented by the general formula: wherein X represents a halogen or a hydrogen atom, R1 and R2 concurrently or differently represent a hydrogen atom or an optionally substituted C1 to C6 alkyl group, or R1 and R2, together with a nitrogen atom bound thereto and optionally another nitrogen atom or an oxygen atom, are combined to form a 5- to 6-membered heterocycle. Preferably, the compound is (2S,4S)-6-fluoro-2′,5′-dioxospiro[chroman-4,4′-imidazolidine]-2-carboxamide. The invention also provides a model animal with diabetic maculopathy produced by subjecting a diabetic animal to intraocular ischemia/reperfusion to express edema in a retinal visual cell layer or in a macula lutea.
摘要翻译：用于糖尿病性黄斑病变的预防或治疗剂，其可以长时间施用并且以与现有药物不同的机制显示功效。本发明涉及一种糖尿病性黄斑病变的预防或治疗剂，其特征在于，作为活性成分，含有下列通式表示的化合物：其中，X表示卤素或氢原子，R 1和R 2可以同时或不同地表示氢原子或任选取代的C 1至C 6烷基，或R 1和R 2与连接的氮原子和任选另外的氮原子或氧原子一起形成5-至6-元杂环。优选地，化合物是（2S，4S）-6-氟-2'，5'-二氧代螺[苯并二氢吡喃-4,4'-咪唑烷] -2-甲酰胺。本发明还提供了一种通过使糖尿病动物进行眼内缺血/再灌注以在视网膜视细胞层或黄斑黄斑中表达水肿而产生的糖尿病性黄斑变性的模型动物。

10. 发明授权

US07745688B2 Model mouse of Alzheimer's disease expressing FAD APP 716 and use thereof 有权
标题翻译：表达FAD APP 716的阿尔茨海默病模型小鼠及其用途
公开(公告)号：US07745688B2
公开(公告)日：2010-06-29
申请号：US11765730
申请日：2007-06-20
申请人： Takaomi Saido , Nobuhisa Iwata , Takashi Saito , Takahiro Suemoto , Jiro Takano
发明人： Takaomi Saido , Nobuhisa Iwata , Takashi Saito , Takahiro Suemoto , Jiro Takano
IPC分类号： A01K67/033 , G01N33/00
CPC分类号： C12N15/8509 , A01K67/0275 , A01K2207/15 , A01K2217/00 , A01K2217/05 , A01K2217/072 , A01K2227/105 , A01K2227/106 , A01K2267/0312
摘要： The present invention provides a non-human model mammal of Alzheimer's disease (AD) containing chimeric amyloid precursor protein (APP) gene capable of producing human amyloid β peptide (Aβ) or a living part thereof, characterized in that Aβ42/Aβ40 ratio at 8-weeks-old is about 7-fold or more (about 140-fold or more in homozygote) higher compared to that of a corresponding wild-type mammal. Moreover, the present invention provides the mammal or a living part thereof, further characterized in that the level of APP expression is not significantly different compared to the corresponding wild-type mammal, and a screening method for a prophylactic and/or therapeutic drug for AD, a biomarker in biological fluids and molecular imaging of amyloid deposition or other pathological changes in the brain for an early diagnosis of AD using the mammal or a living part thereof.
摘要翻译：本发明提供了含有能够产生人淀粉样蛋白的嵌合淀粉样蛋白前体蛋白（APP）基因的非人模型的阿尔茨海默病（AD）哺乳动物。肽（A＆bgr）或其活性部分，其特征在于8周龄的A / B比值与约7倍或更多（纯合子中约140倍或更多）相比较，相应的野生型哺乳动物。此外，本发明提供了哺乳动物或其生物体部分，其特征还在于，与相应的野生型哺乳动物相比，APP表达水平没有显着差异，以及用于AD的预防和/或治疗药物的筛选方法生物流体中的生物标志物和淀粉样蛋白沉积的分子成像或脑中的其它病理变化，以便使用哺乳动物或其生物部分进行AD的早期诊断。

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