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1. 发明申请

US20170340207A1 USING LOCATION AND FORCE MEASUREMENTS TO ESTIMATE TISSUE THICKNESS 审中-公开
公开(公告)号：US20170340207A1
公开(公告)日：2017-11-30
申请号：US15678714
申请日：2017-08-16
申请人： BIOSENSE WEBSTER (ISRAEL) LTD.
发明人： DORON MOSHE LUDWIN , Assaf Govari , Aharon Turgeman , Yohai Makbily , Eliahu Zino
IPC分类号： A61B5/00 , A61B5/02 , A61B5/107 , A61B5/0215
CPC分类号： A61B5/0053 , A61B5/02007 , A61B5/02156 , A61B5/062 , A61B5/1075 , A61B5/1076 , A61B5/6847 , A61B5/6852 , A61B5/6869 , A61B5/6876 , A61B5/6885 , A61B2560/0223 , A61B2562/0247
摘要： A method, including pressing a distal end of a medical probe against a wall of a body cavity, and receiving from the probe first measurements of a force exerted by the distal end on the wall. The method also includes receiving from the probe second measurements indicating a displacement of the wall in response to the force. The method further includes estimating a thickness of the wall based on the first and the second measurements.

2. 发明申请

US20160287101A1 BIOCOMPATIBLE PACKAGING FOR LONG TERM IMPLANTABLE SENSORS AND ELECTRONICS 审中-公开
标题翻译：用于长期可植入式传感器和电子产品的生物易燃包装
公开(公告)号：US20160287101A1
公开(公告)日：2016-10-06
申请号：US15076184
申请日：2016-03-21
申请人： California Institute of Technology
发明人： Yu-Chong Tai , Yang Liu , Aubrey M. Shapero
IPC分类号： A61B5/0215 , A61B5/021
CPC分类号： A61B5/02156 , A61B5/02141 , A61B5/0215 , A61B2562/0247 , A61B2562/12 , A61B2562/162 , A61B2562/168 , G01L9/00
摘要： An implantable medical device is described. In an example, the implantable medical device includes an electromechanical substrate and sensor, such as a pressure sensor, disposed on the substrate. At least a portion of the sensor is packaged via a liquid encapsulation. The packaging includes a shaped flexible outer membrane that surrounds at least the portion of the sensor. The packaging also includes a hydrophobic liquid disposed between at least the portion of the pressure sensor and the flexible outer membrane. The implantable medical device can be a part of a medical system used for monitoring medical conditions or performing medical operations based on the implantable medical device. Additionally, manufacturing methods are described for packaging the sensor in a liquid encapsulation.
摘要翻译：描述了可植入医疗装置。在一个示例中，可植入医疗装置包括设置在基底上的机电衬底和诸如压力传感器的传感器。传感器的至少一部分通过液体封装进行封装。该包装包括至少围绕传感器的该部分的成形的柔性外膜。该包装还包括设置在压力传感器的至少部分与柔性外膜之间的疏水性液体。可植入医疗装置可以是用于监视医疗状况或基于可植入医疗装置执行医疗操作的医疗系统的一部分。另外，描述了用于将传感器封装在液体封装中的制造方法。

3. 发明申请

US20150025397A1 SYSTEM AND METHOD FOR ESTIMATING CARDIAC PRESSURE BASED ON CARDIAC ELECTRICAL CONDUCTION DELAYS USING AN IMPLANTABLE MEDICAL DEVICE 审中-公开
标题翻译：基于使用可植入医疗器械的心脏电导延迟的心脏压力估计系统和方法
公开(公告)号：US20150025397A1
公开(公告)日：2015-01-22
申请号：US13943680
申请日：2013-07-16
申请人： Pacesetter, Inc.
发明人： Brian J. Wenzel , Dan E. Gutfinger , Mihir Naware , Xiaoyi Min , Jeffery Siou , Anders Bjorling , Dorin Panescu
IPC分类号： A61B5/0215 , A61B5/00
CPC分类号： A61B5/02156 , A61B5/0215 , A61B5/72 , A61N1/365 , A61N1/36564 , A61N1/36578 , A61N1/3682 , A61N1/3684 , A61N1/37258
摘要： Techniques are provided for estimating left atrial pressure (LAP) or other cardiac performance parameters based on measured conduction delays. In particular, LAP is estimated based interventricular conduction delays. Predetermined conversion factors stored within the device are used to convert the various the conduction delays into LAP values or other appropriate cardiac performance parameters. The conversion factors may be, for example, slope and baseline values derived during an initial calibration procedure performed by an external system, such as an external programmer. In some examples, the slope and baseline values may be periodically re-calibrated by the implantable device itself. Techniques are also described for adaptively adjusting pacing parameters based on estimated LAP or other cardiac performance parameters. Still further, techniques are described for estimating conduction delays based on impedance or admittance values and for tracking heart failure therefrom.
摘要翻译：提供了基于测量的传导延迟来估计左心房压力（LAP）或其他心脏性能参数的技术。特别地，LAP是基于室间传导延迟估计的。存储在装置内的预定转换因子用于将各种导通延迟转换为LAP值或其他适当的心脏性能参数。转换因子可以是例如由外部系统（诸如外部编程器）执行的初始校准过程期间导出的斜率和基线值。在一些示例中，可以通过可植入装置本身周期性地重新校准斜率和基线值。还描述了基于估计的LAP或其他心脏性能参数自适应地调整起搏参数的技术。此外，描述了用于基于阻抗或导纳值估计导通延迟并用于跟踪其心力衰竭的技术。

4. 发明授权

US08926520B2 Transducer interface system and method 有权
标题翻译：传感器接口系统及方法
公开(公告)号：US08926520B2
公开(公告)日：2015-01-06
申请号：US13946646
申请日：2013-07-19
申请人： The Board of Regents of the University of Texas System
发明人： Phillip Douglas Purdy , Ronald Bruce Jennings
IPC分类号： A61B5/0215 , G01L9/00 , A61B5/03 , G01L19/12 , G01L27/00 , A61B5/00
CPC分类号： A61B5/02154 , A61B5/02156 , A61B5/02158 , A61B5/024 , A61B5/031 , A61B5/032 , A61B5/6853 , A61B5/72 , A61B5/7225 , A61B5/742 , G01L9/00 , G01L19/12 , G01L27/007
摘要： A transducer interface system/method allowing conversion from an analog sensor input to a standardized analog output interface is disclosed. In some preferred embodiments the system/method permits a fiber optic pressure sensor to be interfaced to a standard patient care monitor (PCM) system using standardized Wheatstone Bridge analog interface inputs. Within this context the Wheatstone Bridge sensed output is defined by stimulus from the PCM and modulation of bridge element values by the conditioned output of an analog pressure sensor. The use of analog-to-digital-to-analog conversion in this transducer interface permits retrofitting of PCM devices having analog Wheatstone Bridge inputs with advanced patient monitoring sensors without the need for specialized modifications to the baseline PCM data collection framework. Methods disclosed herein include techniques to connect arbitrary types/numbers of analog sensors to traditional PCM systems without the need for PCM system hardware/software modifications.
摘要翻译：公开了一种允许从模拟传感器输入到标准化模拟输出接口的转换的传感器接口系统/方法。在一些优选实施例中，系统/方法允许使用标准化的惠斯通电桥模拟接口输入将光纤压力传感器接口到标准的病人护理监视器（PCM）系统。在这种情况下，惠斯通电桥感测输出由PCM的激励定义，并通过模拟压力传感器的调节输出调制桥元件值。在该传感器接口中使用模拟到数模转换可以对具有模拟惠斯通电桥输入的PCM器件进行改进，并具有先进的患者监控传感器，而无需对基线PCM数据采集框架进行专门修改。本文公开的方法包括将任意类型/数量的模拟传感器连接到传统PCM系统而不需要PCM系统硬件/软件修改的技术。

5. 发明申请

US20140187982A1 Intravascular Devices Having Information Stored Thereon And/Or Wireless Communication Functionality, Including Associated Devices, Systems, And Methods 审中-公开
公开(公告)号：US20140187982A1
公开(公告)日：2014-07-03
申请号：US14137436
申请日：2013-12-20
申请人： Volcano Corporation
发明人： Bret C. Millett , Paul Douglas Corl
IPC分类号： A61B5/0215 , A61B5/00
CPC分类号： A61B5/0215 , A61B5/0022 , A61B5/02156 , A61B5/6851 , G16H40/67
摘要： Intravascular devices, systems, and methods are disclosed. In some embodiments, the intravascular devices are guide-wires that include one or more sensing components and a sensor control module that stores information about the guide-wire. In some instances, the information about the guide-wire stored in the sensor control module is calibration information for a sensing component of the guide-wire. In some embodiments, the intravascular devices are guide-wires that include wireless communication functionality. In some instances, the guide-wires include one or more antennas adjacent a proximal portion of the guide-wire. In some instances, the guide-wires include passive radio frequency devices integrated into the guide-wire. Systems associated with such intravascular devices are disclosed. Methods of using such devices and systems are also disclosed.

6. 发明申请

US20140163392A1 Sheath with Optically Interrogatable Sensors 有权
标题翻译：带光学可询问传感器的护套
公开(公告)号：US20140163392A1
公开(公告)日：2014-06-12
申请号：US13712368
申请日：2012-12-12
申请人： AXSUN TECHNOLOGIES, INC.
发明人： Dale C. Flanders
IPC分类号： A61B5/0215 , A61B5/01
CPC分类号： A61B5/02154 , A61B1/04 , A61B5/0002 , A61B5/0066 , A61B5/0084 , A61B5/01 , A61B5/02156 , A61B5/02158 , A61B5/6852 , A61B2562/0247 , A61B2562/0271 , A61B2562/043 , A61B2562/12 , A61B2562/164
摘要： An intravascular sensor system including an array of pressure and/or temperature sensors for detecting pressure and/temperature. In one example, the sensors are interrogated with an optical catheter. In this example, the swept source is able to acquire both image and pressure/temperature data of a patient's vessel or artery. In another example, the intravascular pressure sensor system has a sheath embedded with pressure sensors in the sheath wall. Other examples include the process of making and using the intravascular pressure sensor system.
摘要翻译：包括用于检测压力和/温度的压力和/或温度传感器阵列的血管内传感器系统。在一个示例中，用光学导管询问传感器。在该示例中，扫掠源能够获取患者的血管或动脉的图像和压力/温度数据。在另一个实例中，血管内压力传感器系统具有在护壁内嵌有压力传感器的护套。其他实例包括制造和使用血管内压力传感器系统的过程。

7. 发明申请

US20130085357A1 HAEMODYNAMIC MONITORING DEVICE 审中-公开
标题翻译： HAEMODYNAMIC监测装置
公开(公告)号：US20130085357A1
公开(公告)日：2013-04-04
申请号：US13628922
申请日：2012-09-27
申请人： Wolfgang Huber , Stephan Joeken , Martin Peterreins
发明人： Wolfgang Huber , Stephan Joeken , Martin Peterreins
IPC分类号： A61B5/0205 , A61B5/00 , A61B5/024 , A61B5/145 , A61B5/021 , A61B5/0402 , A61B5/01 , A61B5/02 , A61B5/029
CPC分类号： A61B5/0205 , A61B5/01 , A61B5/02 , A61B5/02055 , A61B5/021 , A61B5/02156 , A61B5/024 , A61B5/028 , A61B5/029 , A61B5/0402 , A61B5/14542 , A61B5/7278 , A61B2560/0223
摘要： A relation is formed between an n-tuple having n components and formed at a first point in time and at least one other n-tuple having n components formed at at least one corresponding later point in time, wherein n is a natural number equal to or greater than 1, and the components comprise at least one derived parameter and/or one read-in data value. If this relationship satisfies a predetermined calibration criterion, a calibration signal is triggered and is displayed, and/or automatically triggers a recalibration of the haemodynamic monitoring device. For example, the pulse contour cardiac output PCCO is derived from the arterial pressure curve as the constituent component of a 1-tuple. As long as this differs from the reference cardiac output CORef by less than a predefined threshold value, for example 101 or 15% of the reference cardiac output, parameter determination continues without initiating a new calibration. On the other hand, if the deviation exceeds PCCO-COref I, the calibration signal is triggered.
摘要翻译：在具有n个分量并在第一时间点形成的n元组和在至少一个对应的稍后时间点形成n个分量的至少一个其他n元组形成关系，其中n是等于或大于1，并且组件包括至少一个导出参数和/或一个读入数据值。如果该关系满足预定的校准标准，则触发并显示校准信号，和/或自动触发血液动力学监测装置的重新校准。例如，脉搏轮廓心输出量PCCO从作为1元组的构成成分的动脉压曲线导出。只要这不同于参考心输出量CORef小于预定阈值，例如参考心输出量的101或15％，参数确定将继续而不启动新的校准。另一方面，如果偏差超过PCCO-COref I，则校准信号被触发。

8. 发明申请

US20110208293A1 Catheter-Based Heart Valve Therapy System with Sizing Balloon 审中-公开
标题翻译：基于导管的心脏瓣膜治疗系统与放大气球
公开(公告)号：US20110208293A1
公开(公告)日：2011-08-25
申请号：US12710852
申请日：2010-02-23
申请人： Charles Tabor
发明人： Charles Tabor
IPC分类号： A61F2/82
CPC分类号： A61F2/2433 , A61B5/02156 , A61B5/023 , A61B5/1076 , A61B5/6853 , A61F2/2418 , A61F2/2496 , A61F2230/005 , A61F2230/0054 , A61F2230/008 , A61F2250/0039 , A61F2250/0097 , A61F2250/0098
摘要： A catheter-based heart valve therapy system, includes a stented heart valve prosthesis including a stent frame having a valvular contact region that is configured to make contact with a heart valve and nearby anatomy of a patient. A sizing balloon includes a first region having a shape in an inflated state that matches a shape of the valvular contact region of the stent frame in an expanded state. At least one catheter-based delivery system is configured to deliver the sizing balloon to the heart valve of the patient for a size determination, and deliver the prosthesis to the heart valve for implantation.
摘要翻译：基于导管的心脏瓣膜治疗系统，包括支架式心脏瓣膜假体，其包括支架框架，所述支架框架具有被配置为与心脏瓣膜接触并且与患者的附近解剖结构接触的瓣膜接触区域。定型气囊包括具有膨胀状态的膨胀状态的支架框架的瓣状接触区域的形状的扩张状态的第一区域。至少一个基于导管的递送系统构造成将尺寸气囊递送到患者的心脏瓣膜以进行尺寸确定，并将假体递送到用于植入的心脏瓣膜。

9. 发明申请

US20110071407A1 DEVICE FOR ACQUIRING PHYSIOLOGICAL VARIABLES MEASURED IN A BODY 有权
标题翻译：用于获取身体中测量的生理学变量的设备
公开(公告)号：US20110071407A1
公开(公告)日：2011-03-24
申请号：US12562364
申请日：2009-09-18
申请人： Ulrik HÜBINETTE , Magnus SAMUELSSON
发明人： Ulrik HÜBINETTE , Magnus SAMUELSSON
IPC分类号： A61B5/021
CPC分类号： A61B5/0024 , A61B5/0002 , A61B5/0008 , A61B5/02007 , A61B5/02055 , A61B5/02141 , A61B5/02156 , A61B5/02158 , A61B5/026 , A61B5/6851 , A61B5/743 , A61B2560/0214 , A61B2562/222
摘要： The present invention relates to an eavesdropping device for monitoring measured physiological variables of an individual, which eavesdropping device comprises a receiver and a communication interface. The eavesdropping device of the present invention is typically applied in a system comprising a first sensor arranged to be disposed in or outside the body of the individual for measuring aortic blood pressure Pa, and a second sensor arranged for measuring distal blood pressure Pd. Further, the system comprises a central monitoring device for monitoring the measured physiological variables and a communication link between the sensors and the central monitoring device for communicating signals representing the measured physiological variables from the sensors to the central monitoring device. The eavesdropping device is configured such that the communication interface is arranged at the communication link to communicate at least the signal representing the aortic blood pressure to a monitor of the eavesdropping device. Moreover, the receiver of the eavesdropping device is connected to the communication link, in parallel with the central monitoring device. The signal representing the aortic blood pressure Pa is communicated to the receiver via a high-impedance connection at the communication interface, and the receiver of the eavesdropping device is further arranged to receive the signal representing the measured distal blood pressure Pd from the communication link. By means of the blood pressure signals of the respective sensor, FFR can be calculated.
摘要翻译：本发明涉及一种用于监测个人的测量生理变量的窃听装置，该窃听装置包括接收机和通信接口。本发明的窃听装置通常应用于包括布置成设置在个体体内或外部的用于测量主动脉血压Pa的第一传感器和布置成用于测量远端血压Pd的第二传感器的系统。此外，该系统包括用于监测所测量的生理变量的中央监控装置以及传感器与中央监测装置之间的通信链路，用于将表示所测量的生理变量的信号传递到中央监测装置。窃听装置被配置为使得通信接口被布置在通信链路处，以将至少表示主动脉血压的信号传送到窃听装置的监视器。此外，窃听设备的接收机与中央监控设备并行连接到通信链路。代表主动脉血压Pa的信号通过通信接口处的高阻抗连接传送给接收机，并且窃听设备的接收机进一步布置成从通信链路接收表示测量的远端血压Pd的信号。通过各传感器的血压信号，可以计算FFR。

10. 发明申请

US20110021887A1 METHOD FOR THE CALIBRATION OF AN IMPLANTABLE SENSOR 审中-公开
标题翻译：可植入式传感器校准方法
公开(公告)号：US20110021887A1
公开(公告)日：2011-01-27
申请号：US12509834
申请日：2009-07-27
申请人： Rocco CRIVELLI , Danillo ROTH , Alec GINGGEN
发明人： Rocco CRIVELLI , Danillo ROTH , Alec GINGGEN
IPC分类号： A61B5/07 , G01D18/00
CPC分类号： G01D11/245 , A61B5/0017 , A61B5/0031 , A61B5/02154 , A61B5/02156 , A61B5/686 , G01D5/353 , G01D18/008 , G01L19/086 , G01L19/149
摘要： An implant includes a processor, RF communication circuitry, optical communication circuitry, a power source and a memory, all of which being hermetically sealed within a housing having a transparent window. Sensor readings are transmitted by RF using the RF communication circuitry to a remote reader after receiving interrogation signals from the reader. During calibration of the sensor, corrective coefficients are calculated by comparing actual sensor pressure readings with known pressure readings. The corrective coefficients are transmitted to the memory of the control circuitry using optical communication wherein modulated light is transmitted through the transparent window of the housing to the photo-detector.
摘要翻译：植入物包括处理器，RF通信电路，光通信电路，电源和存储器，所有这些都被密封在具有透明窗口的壳体内。在从阅读器接收到询问信号之后，传感器读数通过RF通过RF通信电路传输到远程读取器。在校准传感器期间，通过将实际传感器压力读数与已知压力读数进行比较来计算校正系数。使用光通信将校正系数发送到控制电路的存储器，其中调制的光通过外壳的透明窗口传输到光电检测器。

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