专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20190247390A1 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS 审中-公开
公开(公告)号：US20190247390A1
公开(公告)日：2019-08-15
申请号：US16276540
申请日：2019-02-14
申请人： Satiogen Pharmaceuticals, Inc.
发明人： Bronislava GEDULIN , Andrew A. YOUNG , Howard E. GREENE
IPC分类号： A61K31/496 , C07D487/08 , A61K9/00 , C07D401/12 , C07C279/14 , A61K45/06 , A61K31/7042 , A61K31/655 , A61K31/575 , A61K31/554 , A61K31/55 , A61K31/5377 , A61K31/513 , A61K31/4995 , A61K31/4985 , A61K31/495 , A61K31/454 , A61K31/452 , A61K31/42 , A61K31/40 , A61K31/38 , A61K31/216 , A61K31/191 , A61K31/19 , A61K31/18 , A61K31/16 , A61K31/155 , A61K9/28 , A61K9/02 , C07D295/13
CPC分类号： A61K31/496 , A61K9/0031 , A61K9/02 , A61K9/286 , A61K31/155 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/191 , A61K31/216 , A61K31/38 , A61K31/40 , A61K31/42 , A61K31/452 , A61K31/454 , A61K31/495 , A61K31/4985 , A61K31/4995 , A61K31/513 , A61K31/5377 , A61K31/55 , A61K31/554 , A61K31/575 , A61K31/655 , A61K31/7042 , A61K45/06 , C07C279/14 , C07D295/13 , C07D401/12 , C07D487/08 , A61K2300/00
摘要： Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.

2. 发明申请

US20170152222A1 COMPOUNDS AND METHODS FOR INHIBITING PRODUCTION OF TRIMETHYLAMINE 审中-公开
公开(公告)号：US20170152222A1
公开(公告)日：2017-06-01
申请号：US15366940
申请日：2016-12-01
申请人： The Procter & Gamble Company
发明人： Jose Carlos GARCIA-GARCIA , Stanley Leon HAZEN , John August WOS
IPC分类号： C07C331/20 , A61K31/26 , A61K31/336 , C07D303/36 , A61K31/4425 , C07D213/04 , C07D213/65 , C07D213/30 , A61K31/452 , C07D295/13 , C07D211/46 , A61K31/5375 , A61K31/439 , C07D453/02 , A61K45/06
CPC分类号： A61K31/26 , A61K31/04 , A61K31/095 , A61K31/145 , A61K31/166 , A61K31/216 , A61K31/22 , A61K31/27 , A61K31/275 , A61K31/325 , A61K31/336 , A61K31/351 , A61K31/439 , A61K31/4425 , A61K31/4453 , A61K31/452 , A61K31/5375 , A61K45/06 , C07C331/20 , C07D211/46 , C07D213/04 , C07D213/30 , C07D213/65 , C07D295/13 , C07D303/36 , C07D453/02 , Y02A50/473
摘要： The invention provides a method of inhibiting the conversion of choline or carnitine to trimethylamine (TMA) and lowering TMAO in an individual comprising administering to the individual a composition comprising a compound set forth in FORMULA (I): The invention also provides for a method of inhibiting the production of TMA by bacteria comprising administering to the individual a composition comprising a compound set forth in FORMULA (I) wherein the compound is administered in an amount effective to inhibit formation of trimethylamine (TMA) from choline or carnitine in the individual.

3. 发明申请

US20150231127A1 BITOPIC MUSCARINIC AGONISTS AND ANTAGONISTS AND METHODS OF SYNTHESIS AND USE THEREOF 有权
标题翻译：双极肌肉激素和拮抗剂及其合成和使用方法
公开(公告)号：US20150231127A1
公开(公告)日：2015-08-20
申请号：US14628760
申请日：2015-02-23
申请人： BARRY UNIVERSITY, INC.
发明人： John BOULOS
IPC分类号： A61K31/452 , A61K45/06 , A61K31/4439 , A61K31/5375 , A61K31/443
CPC分类号： A61K31/452 , A61K31/443 , A61K31/4439 , A61K31/5375 , A61K45/06 , C07D295/104 , C07D295/14 , C07D405/06 , C07D417/06
摘要： Compositions for treating a condition associated with activity of a muscarinic receptor (e.g., one or more of M1, M2, M3, M4, M5) and for anesthetizing a subject include a bitopic muscarinic antagonist or agonist. A bitopic muscarinic antagonist named JB-D4 was discovered. This bitopic ligand and its structural analogs, as well as bitopic muscarinic agonists, may be used as neuromuscular blocking agents (e.g., for use in compositions for anesthetizing a subject) and for the treatment of central nervous system disorders (e.g., Parkinson's disease, Schizophrenia, etc.), Overactive Bladder Syndrome, Chronic Obstructive Pulmonary Disease, asthma, and many other diseases associated with the activation or inhibition of M1-M5 acetylcholine receptors.
摘要翻译：用于治疗与毒蕈碱受体（例如，M1，M2，M3，M4，M5中的一种或多种）的活性相关的病症的组合物和用于麻醉受试者的组合物包括苦味毒蕈碱性拮抗剂或激动剂。发现了一种名为JB-D4的苦涩毒蕈碱拮抗剂。这种比特配位体及其结构类似物以及苦味碱激动剂可用作神经肌肉阻滞剂（例如用于麻醉受试者的组合物）和治疗中枢神经系统疾病（例如，帕金森病，精神分裂症等），过度活动性膀胱综合征，慢性阻塞性肺疾病，哮喘和许多其他与M1-M5乙酰胆碱受体活化或抑制相关的疾病。

4. 发明申请

US20150087642A1 BILE ACID RECYCLING INHIBITORS AND SATIOGENS FOR TREATMENT OF DIABETES, OBESITY, AND INFLAMMATORY GASTROINTESTINAL CONDITIONS 审中-公开
标题翻译：双酸回收抑制剂和治疗糖尿病，肥胖和炎症胃肠病症的患者
公开(公告)号：US20150087642A1
公开(公告)日：2015-03-26
申请号：US14555290
申请日：2014-11-26
申请人： SATIOGEN PHARMACEUTICALS, INC.
发明人： Bronislava GEDULIN , Andrew A. YOUNG , Howard E. GREENE
IPC分类号： C07D487/08 , C07D401/12 , C07C279/14 , A61K31/4995 , A61K45/06 , A61K31/454 , A61K31/40 , A61K31/496 , A61K31/155 , A61K31/5377 , C07D295/13 , A61K31/452
CPC分类号： A61K31/496 , A61K9/0031 , A61K9/02 , A61K9/286 , A61K31/155 , A61K31/16 , A61K31/18 , A61K31/19 , A61K31/191 , A61K31/216 , A61K31/38 , A61K31/40 , A61K31/42 , A61K31/452 , A61K31/454 , A61K31/495 , A61K31/4985 , A61K31/4995 , A61K31/513 , A61K31/5377 , A61K31/55 , A61K31/554 , A61K31/575 , A61K31/655 , A61K31/7042 , A61K45/06 , C07C279/14 , C07D295/13 , C07D401/12 , A61K2300/00
摘要： Provided herein are methods of utilizing bile acid transport inhibitors and/or enteroendocrine peptide enhancing agents for the treatment of obesity, diabetes, and inflammatory gastrointestinal conditions.
摘要翻译：本文提供了利用胆汁酸转运抑制剂和/或肠内分泌肽增强剂来治疗肥胖症，糖尿病和炎性胃肠病症的方法。

5. 发明申请

US20150038719A1 Agent for Ameliorating Chronic Obstructive Pulmonary Disease 审中-公开
标题翻译：改善慢性阻塞性肺疾病的药物
公开(公告)号：US20150038719A1
公开(公告)日：2015-02-05
申请号：US14385067
申请日：2013-02-28
申请人： LTT BIO-PHARMA CO., LTD.
发明人： Toru Mizushima , Hongxing Liu
IPC分类号： A61K31/452
CPC分类号： A61K31/452 , A61K9/0031 , A61K9/0053 , A61K9/007 , A61K9/0078 , A61K9/2018
摘要： This invention provides a safe and effective agent for ameliorating chronic obstructive pulmonary disease (COPD) that has both a bronchodilator effect and an anti-inflammatory effect. The agent for ameliorating chronic obstructive pulmonary disease contains mepenzolate bromide as an active ingredient. More preferably the mode of administration of the agent for ameliorating chronic obstructive pulmonary disease is airway administration or inhalation administration, and furthermore the mode of administration thereof is oral administration or rectal administration. This invention is a safe and effective agent for ameliorating chronic obstructive pulmonary disease (COPD) that has both a bronchodilator effect and an anti-inflammatory effect of mepenzolate bromide.
摘要翻译：本发明提供一种安全有效的改善慢性阻塞性肺疾病（COPD）的药物，其具有支气管扩张剂作用和抗炎作用。用于改善慢性阻塞性肺疾病的药物含有作为有效成分的溴苯甲酰溴。更优选地，用于改善慢性阻塞性肺疾病的药剂的给药方式是气道给药或吸入给药，此外，其给药方式是口服给药或直肠给药。本发明是一种缓解慢性阻塞性肺疾病（COPD）的安全有效的药物，其具有支气管扩张剂作用和溴苯酚溴化物的抗炎作用。

6. 发明申请

US20140256632A1 METHODS USEFUL IN THE TREATMENT OF BONE RESORPTION DISEASES 审中-公开
标题翻译：有用的治疗骨质疏松症的方法
公开(公告)号：US20140256632A1
公开(公告)日：2014-09-11
申请号：US14285437
申请日：2014-05-22
申请人： NPS Pharmaceuticals, Inc.
发明人： John Dietrich , Sverker Ljunghall , Sven Sjorgen
IPC分类号： A61K38/29 , A61K45/06 , A61K31/663
CPC分类号： A61K38/29 , A61K31/138 , A61K31/452 , A61K31/56 , A61K31/59 , A61K31/66 , A61K31/663 , A61K31/675 , A61K45/06 , Y10S514/808 , A61K38/23 , A61K33/06 , A61K31/565 , A61K31/445 , A61K31/135 , A61K2300/00
摘要： The invention relates to a combined pharmaceutical preparation comprising parathyroid hormone and a bone resorption inhibitor, said preparation being adapted for (a) the administration of parathyroid hormone during a period of approximately 6 to 24 months; (b) after the administration of parathyroid hormone has been terminated, the administration of a bone resorption inhibitor during a period of approximately 12 to 36 months.
摘要翻译：本发明涉及包含甲状旁腺激素和骨吸收抑制剂的组合药物制剂，所述制剂适于（a）在约6至24个月的时间内施用甲状旁腺激素; （b）在甲状旁腺激素的给药已经终止之后，在约12至36个月的时间内施用骨吸收抑制剂。

7. 发明申请

US20140235864A1 BIPHENYL DERIVATIVES 有权
标题翻译：联苯衍生物
公开(公告)号：US20140235864A1
公开(公告)日：2014-08-21
申请号：US14087404
申请日：2013-11-22
申请人： Mathai Mammen , Adam Hughes , Yan Chen
发明人： Mathai Mammen , Adam Hughes , Yan Chen
IPC分类号： C07D211/46
CPC分类号： C07D211/46 , A61K31/445 , A61K31/452 , C07D211/48 , C07D211/58 , C07D401/06 , C07D401/12 , C07D401/14 , C07D405/12 , C07D409/06 , C07D409/12 , C07D453/02 , C07D471/08 , G01N33/9433
摘要： This invention provides biphenyl derivatives of formula I: wherein R1, R2, R3, R4, R5, R6, R7, W, a, b and c are as defined in the specification, or a pharmaceutically acceptable salt or solvate or stereoisomer thereof. The biphenyl derivatives of this invention possess both β2 adrenergic receptor agonist and muscarinic receptor antagonist activity and therefore, such biphenyl derivatives are useful for treating pulmonary disorders, such as chronic obstructive pulmonary disease and asthma.
摘要翻译：本发明提供式I的联苯衍生物：其中R1，R2，R3，R4，R5，R6，R7，W，a，b和c如说明书中所定义，或其药学上可接受的盐或溶剂合物或立体异构体。本发明的联苯衍生物具有二肾上腺素能受体激动剂和毒蕈碱受体拮抗剂活性，因此，这种联苯衍生物可用于治疗肺部疾病，如慢性阻塞性肺疾病和哮喘。

8. 发明申请

US20130116247A1 IRE-1alpha INHIBITORS 有权
标题翻译： IRE-1α抑制剂
公开(公告)号：US20130116247A1
公开(公告)日：2013-05-09
申请号：US13639734
申请日：2011-04-05
申请人： Qingping Zeng , Andras Toro , John Bruce Patterson , Warren Stanfield Wade , Zoltan Zubovics , Yun Yang , Zhipeng Wu
发明人： Qingping Zeng , Andras Toro , John Bruce Patterson , Warren Stanfield Wade , Zoltan Zubovics , Yun Yang , Zhipeng Wu
IPC分类号： A61K31/366 , A61K31/496 , A61K31/5377 , C07D405/04 , A61K31/4025 , C07D405/10 , A61K31/453 , C07D417/04 , A61K31/427 , A61K31/4155 , C07D401/04 , A61K31/4433 , C07D409/04 , C07D311/94 , A61K45/06 , C07D311/20
CPC分类号： A61K31/366 , A61K31/343 , A61K31/352 , A61K31/37 , A61K31/381 , A61K31/4025 , A61K31/404 , A61K31/4045 , A61K31/415 , A61K31/4155 , A61K31/4172 , A61K31/4184 , A61K31/423 , A61K31/427 , A61K31/4433 , A61K31/4439 , A61K31/452 , A61K31/453 , A61K31/454 , A61K31/4545 , A61K31/496 , A61K31/5377 , A61K45/06 , C07D217/02 , C07D217/08 , C07D311/12 , C07D311/16 , C07D311/20 , C07D311/22 , C07D311/94 , C07D401/04 , C07D401/12 , C07D405/04 , C07D405/10 , C07D409/04 , C07D417/04 , Y02A50/389 , Y02A50/393
摘要： Compounds which directly inhibit IRE-1α activity in vitro, prodrugs, and pharmaceutically acceptable salts there-of. Such compounds and prodrugs are useful for treating diseases associated with the unfolded protein response or with regulated IRE1-dependent decay (RIDD) and can be used as single agents or in combination therapies.
摘要翻译：直接抑制体外IRE-1α活性的化合物，其前体药物和药学上可接受的盐。这些化合物和前药可用于治疗与未折叠的蛋白质应答相关的疾病或者与调节的IRE1依赖性衰变（RIDD）相关的疾病，并可用作单一药物或联合疗法。

9. 发明申请

US20120214809A1 Aminoindane Compounds and Use Thereof in Treating Pain 有权
标题翻译：氨基茚满化合物及其应用于治疗疼痛
公开(公告)号：US20120214809A1
公开(公告)日：2012-08-23
申请号：US13400039
申请日：2012-02-18
申请人： Scott Kevin Thompson , Tony Priestley , Roger Astbury Smith , Ashis K. Saha , Sonali Rudra , Arun Kuma Hajra , Dipanwita Chatterjee , Carl Henry Behrens , Yigang He , Hui-Yin Li
发明人： Scott Kevin Thompson , Tony Priestley , Roger Astbury Smith , Ashis K. Saha , Sonali Rudra , Arun Kuma Hajra , Dipanwita Chatterjee , Carl Henry Behrens , Yigang He , Hui-Yin Li
IPC分类号： A61K31/452 , C07D207/09 , A61K31/40 , C07D401/12 , A61K31/4545 , A61K31/506 , C07D417/12 , A61K31/454 , C07D498/10 , A61K31/5386 , C07D405/12 , A61K31/453 , C07D471/10 , A61K31/438 , A61P29/00 , A61P17/04 , C07D211/26
CPC分类号： C07D211/26 , A61K31/167 , A61K31/40 , A61K31/452 , A61K45/06 , C07D207/09 , C07D401/12 , C07D403/12 , C07D405/12 , C07D417/12 , C07D471/10 , C07D498/10 , A61K2300/00
摘要： The present application provides novel aminoindane compounds and methods for preparing and using these compounds. These compounds are useful in treating pain and/or itch in patients by administering one or more of the compounds to a patient. The methods include administering a compound of formula (I) or (II) and a TRPV 1 receptor activator. In one embodiment, the TRPV 1 receptor activator is lidocaine.
摘要翻译：本申请提供了新的氨基茚满化合物以及制备和使用这些化合物的方法。这些化合物可用于通过向患者施用一种或多种化合物来治疗患者的疼痛和/或瘙痒。所述方法包括施用式（I）或（II）化合物和TRPV 1受体激活剂。在一个实施方案中，TRPV 1受体激活剂是利多卡因。

10. 发明申请

US20120157399A1 BILE ACID RECYCLING INHIBITORS FOR TREATMENT OF OBESITY AND DIABETES 审中-公开
标题翻译：双酸回收抑制剂治疗肥胖和糖尿病
公开(公告)号：US20120157399A1
公开(公告)日：2012-06-21
申请号：US13402763
申请日：2012-02-22
申请人： Andrew A. Young , Bronislava Gedulin , Howard E. Greene
发明人： Andrew A. Young , Bronislava Gedulin , Howard E. Greene
IPC分类号： A61K31/4995 , A61K31/454 , A61K31/40 , A61K31/7042 , A61K31/155 , A61K31/5377 , A61K31/554 , A61P1/00 , A61K31/4453 , A61K31/495
CPC分类号： A61K31/5377 , A61K9/0053 , A61K9/4808 , A61K9/4825 , A61K9/485 , A61K9/4858 , A61K9/4866 , A61K31/155 , A61K31/16 , A61K31/40 , A61K31/452 , A61K31/454 , A61K31/495 , A61K31/4985 , A61K31/4995 , A61K31/554
摘要： Provided herein are methods of utilizing bile acid transport inhibitors for the treatment of obesity and diabetes.
摘要翻译：本文提供了利用胆汁酸转运抑制剂治疗肥胖和糖尿病的方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式