专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20190201340A1 METHODS FOR PRODUCING LIPOSOMES 审中-公开
公开(公告)号：US20190201340A1
公开(公告)日：2019-07-04
申请号：US16052510
申请日：2018-08-01
申请人： Statens Serum Institut
发明人： Lars Vibe Andreasen , Grith Wood , Dennis Christensen
IPC分类号： A61K9/127 , A61K39/12 , A61K39/39 , A61K39/04 , A61K39/118
CPC分类号： A61K9/127 , A61K9/1272 , A61K9/1277 , A61K39/04 , A61K39/118 , A61K39/12 , A61K39/39 , A61K2039/55555 , C12N2740/16234 , C12N2760/16134
摘要： The invention discloses a method for the formation of liposomes by using high shear mixing of aqueous solution of lipid powder; the lipid powder can be produced by any known technique. Components of the liposomes include but are not limited to cationic lipids, immunostimulators/immunopotentiators and macromolecules as components for the liposome formation. The disclosed method describes the formulation of stable liposomes solitary or complexing high concentrations of macromolecules such as proteins, DNA and RNA having opposite charge of the liposomes by high shear mixing where aggregation is avoided due to the formulation method.

2. 发明申请

US20170072051A1 PARTICULATE VACCINE FORMULATIONS FOR INDUCING INNATE AND ADAPTIVE IMMUNITY 审中-公开
标题翻译：用于诱导放射免疫和适应性免疫的颗粒疫苗制剂
公开(公告)号：US20170072051A1
公开(公告)日：2017-03-16
申请号：US15332308
申请日：2016-10-24
申请人： Auburn University
发明人： Bernhard Kaltenboeck , Ram B. Gupta , Erfan U. Chowdhury , Courtney A. Ober
IPC分类号： A61K39/39 , C12N7/00 , A61K9/16 , A61K39/12 , A61K39/118 , A61K31/472
CPC分类号： A61K39/39 , A61K9/0043 , A61K9/10 , A61K9/1641 , A61K9/1647 , A61K31/47 , A61K31/472 , A61K39/118 , A61K39/12 , A61K2039/552 , A61K2039/55511 , A61K2039/55555 , A61K2039/57 , A61K2039/572 , C12N7/00 , C12N2720/10034 , C12N2740/10034
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against an infection or a disease. The compositions typically include biodegradable particles having an average effective diameter that such that the biodegradable particles are phagocytosed by antigen presenting cells when the biodegradable particles are administered to a subject in need thereof. Optionally, the compositions include one or more of an adjuvant, an apoptosis inhibitor, and an antigen. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
摘要翻译：公开了用于诱导针对感染或疾病的免疫应答的组合物，试剂盒和方法。组合物通常包括具有平均有效直径的可生物降解的颗粒，使得当可生物降解的颗粒施用于有需要的受试者时，可生物降解的颗粒被抗原呈递细胞吞噬。任选地，组合物包括一种或多种佐剂，凋亡抑制剂和抗原。组合物，试剂盒和方法可用于诱导细胞介导的应答，例如T辅助细胞应答和/或针对病原体或疾病的体液应答。在一些实施方案中，可以利用组合物，试剂盒和方法优先诱导Th1应答与其他类型的免疫应答如Th2应答。

3. 发明申请

US20170043005A1 CHLAMYDIA ANTIGENS AND USES THEREOF 审中-公开
标题翻译： CHLAMYDIA抗原及其用途
公开(公告)号：US20170043005A1
公开(公告)日：2017-02-16
申请号：US15080324
申请日：2016-03-24
申请人： Genocea Biosciences, Inc.
发明人： Jessica Baker Flechtner , Kenya Prince Cohane , Todd Gierahn , Alexander Yao-Hsein Lee , George Rainer Siber
IPC分类号： A61K39/118 , A61K39/39
CPC分类号： A61K39/118 , A61K39/39 , A61K2039/55505 , A61K2039/55561 , A61K2039/55566 , A61K2039/55577 , A61K2039/572 , A61K2039/575
摘要： The present invention provides novel chlamydia antigens, nucleic acids encoding the antigens, and immunogenic compositions including the antigens. The present invention further provides methods of using the antigens to elicit immune responses (e.g., T cell-mediated and/or B cell-mediated immune responses). The present invention provides methods of prophylaxis and/or treatment of chlamydia-mediated diseases comprising administering an immunogenic composition including one or more of the novel antigens described herein.
摘要翻译：本发明提供新颖的衣原体抗原，编码抗原的核酸和包含抗原的免疫原性组合物。本发明还提供了使用抗原引发免疫应答（例如T细胞介导的和/或B细胞介导的免疫应答）的方法。本发明提供了预防和/或治疗衣原体介导的疾病的方法，包括施用包含本文所述的一种或多种抗原的免疫原性组合物。

4. 发明申请

US20160367655A1 Immunogenic Compositions 审中-公开
标题翻译：免疫原性组合物
公开(公告)号：US20160367655A1
公开(公告)日：2016-12-22
申请号：US15075279
申请日：2016-03-21
申请人： Sanofi Pasteur Limited , Sanofi Pasteur, S.A.
发明人： Scott Gallichan , Ausra Mancevski , Nathalie Reveneau , Jin Su , Francois Dalencon , Jean Haensler
IPC分类号： A61K39/118 , A61K39/39
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K39/118 , A61K47/44 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/572 , A61K2039/575
摘要： The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as “MOMP”), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of Chlamydia (e.g., C. trachomatis, C. pneumoniae, C. psittaci, or C. trachomatis MoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of C. trachomatis. The invention also provides methods of inducing an immune response to a Chlamydia species (e.g., C. trachomatis) in a subject, by administering to the subject a composition of the invention.
摘要翻译：本发明提供了包含来自至少一种衣原体血清型和佐剂的衣原体主要外膜蛋白（本文称为“MOMP”）的组合物，其特征在于所述佐剂包含具有CAS号287180-63-6的产物E6020。该组合物还可以包含至少一种载体体系（例如乳液，矿物颗粒）。 MOMP蛋白可以衍生自衣原体（例如沙眼衣原体，沙眼衣原体，肺炎衣原体，鹦鹉热鹦鹉或C.沙眼衣原体MoPn）的任何种类。在优选的实施方案中，组合物包含一种或多种主要的外膜蛋白，其各自衍生自沙眼衣原体的不同血清型。本发明还提供了通过向受试者施用本发明的组合物来诱导受试者对衣原体（例如沙眼衣原体）的免疫应答的方法。

5. 发明授权

US09327021B2 Immunogenic compositions 有权
标题翻译：免疫原性组成
公开(公告)号：US09327021B2
公开(公告)日：2016-05-03
申请号：US13885485
申请日：2011-11-15
申请人： Scott Gallichan , Ausra Mancevski , Nathalie Reveneau , Jin Su , Francois Dalencon , Jean Haensler
发明人： Scott Gallichan , Ausra Mancevski , Nathalie Reveneau , Jin Su , Francois Dalencon , Jean Haensler
IPC分类号： A61K6/00 , A61K39/39 , A61K38/00 , A61K39/02 , A61K9/00 , A61K9/107 , A61K39/118 , A61K47/44 , A61K39/00
CPC分类号： A61K39/39 , A61K9/0019 , A61K9/107 , A61K9/1075 , A61K39/118 , A61K47/44 , A61K2039/55505 , A61K2039/55511 , A61K2039/55561 , A61K2039/55566 , A61K2039/572 , A61K2039/575
摘要： The present invention provides compositions comprising a Chlamydial major outer membrane protein (referenced herein as “MOMP”), from at least one Chlamydial serovar and an adjuvant, characterized in that the adjuvant comprises the product E6020 having CAS Number 287180-63-6. The composition may further comprise at least one carrier system (e.g., emulsion, mineral particle). The MOMP protein may be derived from any species of Chlamydia (e.g., C. trachomatis, C. pneumoniae, C. psittaci, or C. trachomatis MoPn). In preferred embodiments, the composition comprises one or more major outer membrane proteins each derived from different serovars of C. trachomatis. The invention also provides methods of inducing an immune response to a Chlamydia species (e.g., C. trachomatis) in a subject, by administering to the subject a composition of the invention.
摘要翻译：本发明提供了包含来自至少一种衣原体血清型和佐剂的衣原体主要外膜蛋白（本文称为“MOMP”）的组合物，其特征在于所述佐剂包含具有CAS号287180-63-6的产物E6020。该组合物还可以包含至少一种载体体系（例如乳液，矿物颗粒）。 MOMP蛋白可以衍生自衣原体（例如沙眼衣原体，沙眼衣原体，肺炎衣原体，鹦鹉热鹦鹉或C.沙眼衣原体MoPn）的任何种类。在优选的实施方案中，组合物包含一种或多种主要的外膜蛋白，其各自衍生自沙眼衣原体的不同血清型。本发明还提供了通过向受试者施用本发明的组合物来诱导受试者对衣原体（例如沙眼衣原体）的免疫应答的方法。

6. 发明申请

US20160015798A1 ATTENUATED CHLAMYDIA VACCINE 审中-公开
标题翻译：衰老的CHLAMYDIA VACCINE
公开(公告)号：US20160015798A1
公开(公告)日：2016-01-21
申请号：US14761520
申请日：2014-01-16
申请人： THE UNITED STATES OF AMERICA,AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH & HUMAN SERVICES
发明人： Harlan D. Caldwell
IPC分类号： A61K39/118 , C12N15/74
CPC分类号： A61K39/118 , A61K2039/522 , A61K2039/53 , C12N1/36 , C12N15/74
摘要： The invention provides vectors, attenuated pathogens, compositions, methods, and kits for use in preventing or treating infection by an infectious pathogen, especially Chlamydia trachomatis. The vectors comprise the plasmid encoded ppg genes from Chlamydia, ppg1, ppg2, ppg3, ppg5, ppg6, ppg7 and/or ppg8, but lack ppg4, a regulator of virulence associated genes. The application also provides attenuated pathogens, especially chlamydia, which are cured of their plasmid and have additional mutations to improve the attenuation, especially mutations in the CT135 gene or in the tryptophan operon (trp promoter, trpA, or trpB). Uses of said nucleic acids and attenuated pathogens for inducing or modulating an immune response in a subject, especially for prevention or treatment of infections, are proposed.
摘要翻译：本发明提供用于预防或治疗感染性病原体，特别是沙眼衣原体的感染的载体，减毒病原体，组合物，方法和试剂盒。载体包含来自衣原体，ppg1，ppg2，ppg3，ppg5，ppg6，ppg7和/或ppg8的质粒编码的ppg基因，但缺乏ppg4，是毒力相关基因的调节剂。该应用还提供减毒的病原体，特别是衣原体，其固化其质粒并具有额外的突变以改善衰减，特别是CT135基因或色氨酸操纵子（trp启动子，trpA或trpB）中的突变。提出了所述核酸和减毒病原体在受试者中诱导或调节免疫应答的用途，特别是用于预防或治疗感染。

7. 发明申请

US20160008452A1 Vault Compositions for Immunization 有权
公开(公告)号：US20160008452A1
公开(公告)日：2016-01-14
申请号：US14864186
申请日：2015-09-24
申请人： The Regents of the University of California
发明人： Valerie A. Kickhoefer , Leonard H. Rome , Kathleen A. Kelly , Cheryl Champion
IPC分类号： A61K39/118
CPC分类号： A61K39/118 , A61K39/385 , A61K2039/543 , A61K2039/57 , A61K2039/6031 , C07K14/295 , C07K14/47 , C07K2319/30 , C07K2319/33
摘要： Methods and compositions are provided herein for immunizing a subject by administering to the subject an effective amount of an immunogenic peptide or an immunogenic fragment or variant thereof incorporated within a vault-like particle carrier. The methods and compositions advantageously exhibit enhanced ability to induce cell-mediated immunity and/or antibody-based immunity.

8. 发明申请

US20160008451A1 NANOPARTICLE-BASED COMPOSITIONS 审中-公开
标题翻译：基于纳米材料的组合物
公开(公告)号：US20160008451A1
公开(公告)日：2016-01-14
申请号：US14772695
申请日：2014-03-14
申请人： PRESIDENT AND FELLOWS OF HARVARD COLLEGE , MASSACHUSETTS INSTITUTE OF TECHNOLOGY , THE BRIGHAM AND WOMEN'S HOSPITAL, INC
发明人： Georg STARY , Aleksandar Filip RADOVIC-MORENO , Pamela A. BASTO , Michael N. STARNBACH , Robert S. LANGER , Omid C. FAROKHZAD , Ulrich Von ANDRIAN
IPC分类号： A61K39/118 , A61K39/04 , A61K39/02
CPC分类号： A61K39/118 , A61K31/4745 , A61K31/711 , A61K39/0208 , A61K39/04 , A61K39/085 , A61K39/092 , A61K45/06 , A61K2039/521 , A61K2039/5252 , A61K2039/543 , A61K2039/55555 , A61K2039/55572 , C12N2740/16034 , C12N2760/16134 , C12N2760/18534 , C12N2770/16034 , C12N2770/20034 , Y02A50/386 , Y02A50/388 , Y02A50/403 , Y02A50/466 , Y02A50/478 , Y02A50/48 , Y02A50/484 , A61K2300/00
摘要： Provided herein are new compositions including an inactivated pathogen and one or more adjuvant-loaded polymeric nanoparticles, wherein the adjuvant-loaded nanoparticles are bound to the inactivated pathogen. These compositions are useful for preventing and/or treating diseases caused by the specific pathogens, especially when administered to a subject's mucosal membranes.
摘要翻译：本文提供了新的组合物，其包括灭活的病原体和一种或多种负载载体的聚合物纳米颗粒，其中所述佐剂负载的纳米颗粒结合于灭活的病原体。这些组合物可用于预防和/或治疗由特定病原体引起的疾病，特别是当施用于受试者的粘膜时。

9. 发明申请

US20150297706A1 Particulate Vaccine Formulations for Inducing Innate and Adaptive Immunity 审中-公开
标题翻译：用于诱导先天和适应性免疫的颗粒疫苗制剂
公开(公告)号：US20150297706A1
公开(公告)日：2015-10-22
申请号：US14674711
申请日：2015-03-31
申请人： Auburn University
发明人： Bernhard Kaltenboeck , Ram B. Gupta , Erfan U. Chowdhury , Courtney A. Ober
IPC分类号： A61K39/12 , C12N7/00 , A61K9/16 , A61K31/47 , A61K39/118
CPC分类号： A61K39/12 , A61K9/0043 , A61K9/16 , A61K9/1647 , A61K31/47 , A61K39/118 , A61K47/10 , A61K2039/552 , A61K2039/55555 , A61K2039/572 , C12N7/00 , C12N2720/10034 , C12N2740/10034
摘要： Disclosed are compositions, kits, and methods for inducing an immune response against an infection or a disease. The compositions typically include biodegradable particles having an average effective diameter of 0.5-20 μm, and optionally the compositions include one or more of an adjuvant, an apoptosis inhibitor, and an antigen. The compositions, kits, and methods may be utilized to induce a cell-mediated response, such as a T-helper cell response, and/or a humoral response against a pathogen or a disease. In some embodiments, the compositions, kits, and methods may be utilized to induce preferentially a Th1 response versus other types of immune responses such as a Th2 response.
摘要翻译：公开了用于诱导针对感染或疾病的免疫应答的组合物，试剂盒和方法。组合物通常包括平均有效直径为0.5-20μm的可生物降解的颗粒，任选的组合物包括一种或多种佐剂，凋亡抑制剂和抗原。组合物，试剂盒和方法可用于诱导细胞介导的应答，例如T辅助细胞应答和/或针对病原体或疾病的体液应答。在一些实施方案中，可以利用组合物，试剂盒和方法优先诱导Th1应答与其他类型的免疫应答如Th2应答。

10. 发明授权

US09138468B2 Modified pathogens for use as vaccines 有权
标题翻译：用作疫苗的改良病原体
公开(公告)号：US09138468B2
公开(公告)日：2015-09-22
申请号：US14306815
申请日：2014-06-17
申请人： University of Massachusetts
发明人： Egil Lien , Jon D. Goguen
IPC分类号： A61K48/00 , A01N63/00 , A61K39/02 , C12Q1/02 , G01N33/569 , A61K39/118 , A61K39/00
CPC分类号： A61K39/0291 , A61K39/0208 , A61K39/025 , A61K39/098 , A61K39/118 , A61K2039/55572 , C12Q1/025 , G01N33/56911 , Y02A50/407 , Y02A50/478
摘要： Described herein are microorganisms that are modified so that they have an increased ability to be recognized by the innate immune system of a eukaryote, relative to an unmodified microorganism. A microorganism may be a gram-negative bacterium that has been modified to produce high potency lipopolysaccharide, e.g., Yersinia pestis expressing LpxL. Such modified microorganisms may be used as vaccines for protection against an infection by the unmodified microorganism. They may also be used as delivery vehicles of one or more heterologous antigens, e.g., antigens from pathogens or those associated with a hyperproliferative eukaryotic cell.
摘要翻译：这里描述的是相对于未修饰的微生物进行修饰以使得它们具有增强的真核生物免疫系统识别能力的微生物。微生物可以是已被修饰以产生高效力脂多糖的革兰氏阴性细菌，例如表达LpxL的耶尔森氏菌。这种修饰的微生物可以用作防止未经修饰的微生物感染的疫苗。它们还可以用作一种或多种异源抗原的递送载体，例如来自病原体的抗原或与过度增殖的真核细胞相关的抗原。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式