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1. 发明申请

US20150140609A1 Anti-alpha(v)beta(6) Antibodies 有权
标题翻译：抗α（v）beta（6）抗体
公开(公告)号：US20150140609A1
公开(公告)日：2015-05-21
申请号：US14444701
申请日：2014-07-28
申请人： BIOGEN IDEC MA INC. , THE REGENTS OF THE UNIVERSITY OF CALIFORNIA
发明人： Shelia M. Violette , Paul H. Weinreb , Kenneth J. Simon , Dean Sheppard , Diane R. Leone
IPC分类号： C07K16/28
CPC分类号： C07K16/2839 , A61K47/48507 , A61K47/48561 , A61K47/48623 , A61K47/68 , A61K47/6835 , A61K47/6849 , A61K47/6851 , A61K47/6865 , A61K51/1027 , A61K51/1066 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , G01N33/57492 , G01N33/6893 , G01N2333/70546 , G01N2800/085 , G01N2800/205
摘要： Monoclonal antibodies that specifically bind to M.96. Also included are methods of using these antibodies to treat mammals having or at risk of having 006-mediated diseases, or to diagnose % Q mediated diseases.
摘要翻译：特异性结合M.96的单克隆抗体。还包括使用这些抗体治疗具有或具有006介导的疾病的风险的哺乳动物或诊断％Q介导的疾病的方法。

2. 发明申请

US20140235835A1 CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES 有权
标题翻译：卡利辛胺衍生物载体结合物
公开(公告)号：US20140235835A1
公开(公告)日：2014-08-21
申请号：US14201184
申请日：2014-03-07
申请人： WYETH HOLDINGS LLC
发明人： ARTHUR KUNZ , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
IPC分类号： A61K47/48 , A61K31/704
CPC分类号： A61K31/704 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/48561 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译：描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。

3. 发明授权

US08445644B2 ErbB interface peptidomimetics and methods of use thereof 有权
公开(公告)号：US08445644B2
公开(公告)日：2013-05-21
申请号：US12787594
申请日：2010-05-26
申请人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
发明人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
IPC分类号： C07K16/00
CPC分类号： C07K14/71 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/48238 , A61K47/4833 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/62 , A61K47/646 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K51/10 , C07K7/06 , C07K7/08 , C07K14/7151 , C07K14/82
摘要： Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.

4. 发明申请

US20110054151A1 COMPOSITIONS AND METHODS FOR SIMULTANEOUS BIVALENT AND MONOVALENT CO-ENGAGEMENT OF ANTIGENS 有权
标题翻译：同时双因素和单因素共同参与抗原的组合物和方法
公开(公告)号：US20110054151A1
公开(公告)日：2011-03-03
申请号：US12875015
申请日：2010-09-02
申请人： Gregory A. Lazar , Gregory L. Moore
发明人： Gregory A. Lazar , Gregory L. Moore
IPC分类号： C07K16/00
CPC分类号： C07K16/468 , A61K47/48507 , A61K47/6835 , C07K16/2809 , C07K16/283 , C07K16/2863 , C07K16/32 , C07K2317/31 , C07K2317/52 , C07K2317/64 , C07K2317/732 , C07K2317/92
摘要： Immunoglobulin compositions that simultaneously co-engage antigens, where one of the antigens is bound bivalently and the other antigen is bound monovalently. The novel immunoglobulins described preferably utilize heterodimeric Fc regions.
摘要翻译：同时共同参与抗原的免疫球蛋白组合物，其中一种抗原二价结合，另一种抗原是单价结合的。所述的新型免疫球蛋白优选利用异二聚体Fc区。

5. 发明申请

US20100239587A1 ErbB Interface Peptidomimetics And Methods Of Use Thereof 有权
标题翻译： ErbB接口肽模拟物及其使用方法
公开(公告)号：US20100239587A1
公开(公告)日：2010-09-23
申请号：US12787594
申请日：2010-05-26
申请人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
发明人： Mark I. Greene , Ramachandran Murali , Hongtao Zhang , Mark Richter , Alan Berezov , Qingdu Liu , Jinqiu Chen
IPC分类号： A61K39/395 , C07K16/00
CPC分类号： C07K14/71 , A61K38/00 , A61K39/00 , A61K39/0011 , A61K47/48238 , A61K47/4833 , A61K47/48384 , A61K47/48407 , A61K47/48507 , A61K47/62 , A61K47/646 , A61K47/6803 , A61K47/6809 , A61K47/6835 , A61K51/10 , C07K7/06 , C07K7/08 , C07K14/7151 , C07K14/82
摘要： Peptides, mimetics and antibodies of erbB, TNF, and IgSF receptors and pharmaceutical compositions comprising the same are described. Methods of using such antibodies, peptides, and mimetics in therapeutic, prophylactic, imaging and diagnostic applications are disclosed.
摘要翻译：描述了erbB，TNF和IgSF受体的肽，模拟物和抗体以及包含其的药物组合物。公开了在治疗，预防，成像和诊断应用中使用这些抗体，肽和模拟物的方法。

6. 发明申请

US20060198840A1 Molecules with extended half-lives, compositions and uses thereof 有权
公开(公告)号：US20060198840A1
公开(公告)日：2006-09-07
申请号：US11397328
申请日：2006-04-03
申请人： William Dall'Acqua , Leslie Johnson , Elizabeth Ward
发明人： William Dall'Acqua , Leslie Johnson , Elizabeth Ward
IPC分类号： A61K39/395 , C07K16/44
CPC分类号： C07K16/283 , A61K38/00 , A61K39/00 , A61K47/48507 , A61K47/6835 , A61K49/0002 , A61K49/0004 , A61K2039/505 , C07K2/00 , C07K14/70503 , C07K16/00 , C07K2317/14 , C07K2317/21 , C07K2317/24 , C07K2317/52 , C07K2317/53 , C07K2317/94 , C07K2319/00 , C07K2319/30 , Y10S435/81
摘要： The present invention provides molecules, including IgGs, non-IgG immunoglobulins, proteins and non-protein agents, that have increased in vivo half-lives due to the presence of an IgG constant domain, or a portion thereof that binds the FcRn, having one or more amino acid modifications that increase the affinity of the constant domain or fragment for FcRn. Such proteins and molecules with increased half-lives have the advantage that smaller amounts and or less frequent dosing is required in the therapeutic, prophylactic or diagnostic use of such molecules.

7. 发明授权

US5363846A Method for the diagnosis and treatment of inflammation 失效
标题翻译：炎症诊断和治疗方法
公开(公告)号：US5363846A
公开(公告)日：1994-11-15
申请号：US526002
申请日：1990-05-21
申请人： Robert H. Rubin , H. William Strauss
发明人： Robert H. Rubin , H. William Strauss
IPC分类号： A61K47/48 , A61K49/16 , A61K51/10 , C07K16/00 , A61B5/00 , G01N33/563
CPC分类号： C07K16/00 , A61K47/48438 , A61K47/48507 , A61K49/16 , A61K51/1018 , A61K2121/00 , A61K2123/00 , Y10T436/24
摘要： The invention relates to a method of detecting an inflammation site in an individual by administering to the individual a diagnostically effective amount of detectably labeled immunoglobulin or fragment thereof, wherein the immunoglobulin substantially accumulates at the site when the site is inflamed.
摘要翻译：本发明涉及一种通过向个体施用诊断有效量的可检测标记的免疫球蛋白或其片段来检测个体中的炎症部位的方法，其中所述免疫球蛋白在所述部位发炎时基本上累积在所述部位。

8. 发明授权

US5190865A Antibody-enhanced stereospecific hydrolyses 失效
标题翻译：抗体增强的立体特异性水解
公开(公告)号：US5190865A
公开(公告)日：1993-03-02
申请号：US574674
申请日：1990-08-29
申请人： Peter G. Schultz
发明人： Peter G. Schultz
IPC分类号： A61K47/48 , C07K16/00 , C12N9/00 , C12N9/86 , C12N15/10 , C12P21/08
CPC分类号： C07K16/00 , A61K47/48369 , A61K47/48507 , C12N15/10 , C12N9/0002 , C12N9/86
摘要： Hydrolyses of various chiral compounds are performed in stereospecific manner by antibodies generated from analogs of transition states of the compounds. The compounds susceptible to such hydrolysis include esters, thioesters and amides. In certain embodiments of the invention, antibodies with a strong selectivity toward one of the two enantiomers with respect to the chiral substrate are generated from haptens which is a mixture of enantiomers. A method of screening antibodies thus generated for those which are active towards the desired cleavage is also disclosed, using a test compound similar in structure to the intended substrate but which contains both a fluorescence donor group and a fluorescence quenching group, situated on opposite sides of the cleavage site. Cleavage by active antibodies results in separation of the groups and a resulting termination of the quenching effect.
摘要翻译：各种手性化合物的水解通过由化合物的过渡态的类似物产生的抗体以立体特异性方式进行。对这种水解敏感的化合物包括酯，硫酯和酰胺。在本发明的某些实施方案中，相对于手性底物，对于两种对映异构体之一具有强选择性的抗体是由对映异构体混合物的半抗原产生的。还公开了筛选针对对所需切割有活性的抗体的抗体的方法，其使用与预期底物相似结构的测试化合物，但同时含有荧光供体基团和荧光猝灭基团，位于切割位点。通过活性抗体切割导致基团的分离和终止猝灭效应。

9. 发明申请

US20160303252A1 CALICHEAMICIN DERIVATIVE-CARRIER CONJUGATES 审中-公开
标题翻译：卡利辛胺衍生物载体结合物
公开(公告)号：US20160303252A1
公开(公告)日：2016-10-20
申请号：US15145238
申请日：2016-05-03
申请人： Wyeth Holdings LLC
发明人： Arthur Kunz , Justin Keith Moran , Joseph Thomas Rubino , Neera Jain , Eugene Joseph Vidunas , John McLean Simpson , Nishith Merchant , John Francis Dijoseph , Mark Edward Ruppen , Nitin Krishnaji Damle , Paul David Robbins , Andrew George Popplewell
IPC分类号： A61K47/48 , C07K16/28
CPC分类号： A61K31/704 , A61K47/48507 , A61K47/64 , A61K47/6803 , A61K47/6809 , A61K47/6849 , C07K16/2803 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/76
摘要： Methods for preparing monomeric cytotoxic drug/carrier conjugates with a drug loading significantly higher than in previously reported procedures and with decreased aggregation and low conjugate fraction (LCF) are described. Cytotoxic drug derivative/antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described. Monomeric calicheamicin derivative/anti-CD22 antibody conjugates, compositions comprising the conjugates and uses of the conjugates are also described.
摘要翻译：描述了具有显着高于先前报道的程序并且具有降低的聚集和低共轭分数（LCF）的药物负载的单体细胞毒性药物/载体缀合物的方法。还描述了细胞毒性药物衍生物/抗体缀合物，包含缀合物的组合物和缀合物的用途。还描述了单体加利车霉素衍生物/抗-CD22抗体缀合物，包含缀合物的组合物和缀合物的用途。

10. 发明授权

US09352050B2 Processes for preparing peptide conjugates and linkers 有权
标题翻译：制备肽缀合物和接头的方法
公开(公告)号：US09352050B2
公开(公告)日：2016-05-31
申请号：US14367216
申请日：2012-12-10
申请人： PFIZER INC.
发明人： Javier Magano , Mark Thomas Maloney , Olivier J. Marcq , Durgesh Vasant Nadkarni , Mark John Pozzo , John Joseph Teixeira, Jr.
IPC分类号： A61K47/48 , C12N9/00 , C07D205/08
CPC分类号： A61K47/48507 , A61K47/64 , A61K47/6811 , A61K47/6835 , C07D205/08
摘要： The present invention provides a process for preparing a compound of Formula 5b, as well as intermediates thereof, and novel classes of compounds useful in process for preparing these and similar compounds.
摘要翻译：本发明提供一种制备式5b化合物及其中间体的方法，以及可用于制备这些和类似化合物的方法中的新类化合物。

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