专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09808540B2 Contrast agent for nuclear magnetic resonance imaging comprising melanin nanoparticles stably dispersed in water 有权
公开(公告)号：US09808540B2
公开(公告)日：2017-11-07
申请号：US14391217
申请日：2013-04-09
申请人： SNU R&DB FOUNDATION , RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
发明人： Jin Kyu Lee , Kuk Youn Ju , Jung Hee Lee
IPC分类号： A61K49/18 , A61K49/10 , A61K49/16 , A61K49/12
CPC分类号： A61K49/1818 , A61K49/103 , A61K49/106 , A61K49/126 , A61K49/16 , A61K49/186
摘要： The present invention relates to a contrast agent for nuclear magnetic resonance imaging, and more particularly, to a contrast agent for nuclear magnetic resonance imaging containing melanin nanoparticles having a uniform shape and size, thereby providing good dispersibility in water, no cell toxicity, and a long retention time in vivo.

2. 发明授权

US09744251B2 MRI imaging of amyloid plaque using liposomes 有权
公开(公告)号：US09744251B2
公开(公告)日：2017-08-29
申请号：US14878745
申请日：2015-10-08
申请人： Texas Children's Hospital
发明人： Ananth V. Annapragada , Eric A. Tanifum , Mayank Srivastava
IPC分类号： A61K9/00 , A61K49/18 , A61K49/00 , A61K49/10 , A61K49/12
CPC分类号： A61K49/1812 , A61K49/0034 , A61K49/0084 , A61K49/10 , A61K49/126
摘要： Provided are aromatic compounds, phospholipid-polymer-aromatic conjugates comprising the aromatic compounds, and liposome compositions including the phospholipid-polymer-aromatic conjugates. The liposomal compositions may be useful for imaging of Alzheimer's Disease, for example, imaging of the amyloid-β plaque deposits characteristic of Alzheimer's Disease.

3. 发明授权

US09642875B2 Compounds and their effects on appetite control and insulin sensitivity 有权
公开(公告)号：US09642875B2
公开(公告)日：2017-05-09
申请号：US14418448
申请日：2013-07-31
申请人： Imperial Innovations Limited , The University Court of the University of Glasgow
发明人： Gary Frost , Douglas Morrison , Thomas Preston
IPC分类号： A23L1/30 , A61K31/733 , A61K45/06 , C08B37/00 , C08L5/00 , A61K49/12 , A23L33/10 , A23L33/21
CPC分类号： A61K31/733 , A23L33/10 , A23L33/21 , A23V2002/00 , A61K45/06 , A61K49/126 , C08B37/0054 , C08L5/00 , A61K2300/00
摘要： The invention provides a propionate inulin ester for the reduction of appetite, food intake and/or calorie intake and/or to improve insulin sensitivity in a subject, and for the treatment or prevention of obesity or diabetes. The invention also provides compositions comprising a propionate inulin ester, methods using propionate inulin esters, functional food containing propionate inulin ester and methods of making propionate inulin esters.

4. 发明申请

US20160235872A1 Compositions and Methods to Image and Quantify Inflammation 审中-公开
标题翻译：图像和量化炎症的组成和方法
公开(公告)号：US20160235872A1
公开(公告)日：2016-08-18
申请号：US15043004
申请日：2016-02-12
申请人： Celsense, Inc.
发明人： Brooke M. Helfer , Anthony G. Balducci , Charles F. O'Hanlon, III
IPC分类号： A61K51/12 , A61B5/055 , A61K51/04
CPC分类号： A61K49/126 , A61B5/055 , A61K49/12 , A61K49/1896 , A61K51/0423 , A61K51/1203
摘要： Compositions and methods for assessing inflammation in a subject. The preset disclosure provides compositions for labeling leukocytes with a 19F-containing perfluoropolyether molecule ex vivo. In some examples, the leukocytes are obtained from the patient, enriched in a whole blood fraction, and then labeled. The labeled cells may be re-introduced into the patient. The leukocytes may accumulate at a site of inflammation, thus permitting non-invasive evaluation of inflammation in patients. The present methods provide a tool for assessing inflammation in a wide variety of autoimmune diseases and may have particular utility in intestinal diseases such as Crohn's disease, ulcerative colitis, inflammatory bowel disease, and cardio myositis.
摘要翻译：用于评估受试者炎症的组合物和方法。该预设的公开内容提供了用离子标记含有19F的全氟聚醚分子标记白细胞的组合物。在一些实例中，从患者获得白细胞，富集全血分数，然后标记。可以将标记的细胞重新导入患者体内。白细胞可能积聚在炎症部位，从而允许对患者的炎症进行非侵入性评估。本发明的方法提供了用于评估多种自身免疫疾病中的炎症的工具，并且可以在诸如克罗恩病，溃疡性结肠炎，炎性肠病和心脏肌炎的肠道疾病中具有特别的用途。

5. 发明申请

US20160220705A1 BIODEGRADABLE ORGANIC RADICAL-FUNCTIONALIZED POLYCARBONATES FOR MEDICAL APPLICATIONS 有权
标题翻译：用于医疗应用的可生物降解的有机功能化的聚碳酸酯
公开(公告)号：US20160220705A1
公开(公告)日：2016-08-04
申请号：US14609778
申请日：2015-01-30
申请人： International Business Machines Corporation , AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH
发明人： Julian M. W. Chan , James L. Hedrick , Ashlynn L. Z. Lee , Rudy J. Wojtecki , Yi Yan Yang
IPC分类号： A61K49/00 , C08G64/18 , C08L69/00 , C08G64/02
CPC分类号： C08L69/00 , A61K49/085 , A61K49/126 , A61K49/1809 , A61K49/20 , C08G64/0241 , C08G64/183
摘要： Paramagnetic, amphiphilic, biocompatible polymers were prepared comprising a carbonate repeat unit bearing a paramagnetic organic radical, more specifically a nitroxyl radical. The radical polymers can be produced in one step from a precursor polymer bearing an active ester side chain by treating the precursor polymer with a radical-bearing nucleophile. The precursor polymer can be prepared by organocatalyzed catalyzed ring opening polymerization (ROP) of a cyclic carbonate monomer bearing an active ester side chain. The radical polymers can be non-toxic and partially biodegradable. The radical polymers have utility as contrast enhancing agents in a medical imaging application and/or as therapeutic agents for treating a medical condition. The radical polymers can also serve as carriers for therapeutic agents (e.g., drugs) and/or medical image enhancing agents (e.g., NIRF dyes).
摘要翻译：制备包含具有顺磁性有机基团，更具体地为硝酰基的碳酸酯重复单元的顺磁性，两亲性的生物相容性聚合物。自由基聚合物可以通过用带有自由基的亲核试剂处理前体聚合物，从一个带有活性酯侧链的前体聚合物一步制备。前体聚合物可以通过具有活性酯侧链的环状碳酸酯单体的有机催化的开环聚合（ROP）来制备。自由基聚合物可以是无毒的，部分可生物降解的。自由基聚合物在医学成像应用中可用作对比增强剂，和/或作为用于治疗医疗状况的治疗剂。自由基聚合物还可以用作治疗剂（例如药物）和/或医用图像增强剂（例如NIRF染料）的载体。

6. 发明申请

US20160200670A1 RADIOPAQUE MONOMERS, POLYMERS, MICROSPHERES, AND METHODS RELATED THERETO 审中-公开
标题翻译：放射性单体，聚合物，微球和与之相关的方法
公开(公告)号：US20160200670A1
公开(公告)日：2016-07-14
申请号：US14992580
申请日：2016-01-11
申请人： Biosphere Medical, Inc.
发明人： Philippe Reb
IPC分类号： C07C237/04 , A61K31/785 , A61K49/04 , A61K49/18 , C08F222/38 , C08F220/58 , A61K49/12 , A61K31/704 , C07C237/46
CPC分类号： A61K49/1818 , A61K9/0019 , A61K9/1635 , A61K31/704 , A61K47/02 , A61K49/0438 , A61K49/0442 , A61K49/048 , A61K49/126 , C07C231/08 , C08F220/58 , C08F222/385 , C07C237/52
摘要： Radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of using the radiopaque monomers, polymers, and microspheres are disclosed herein. Methods of manufacturing radiopaque monomers, polymers, and microspheres are disclosed herein.
摘要翻译：本文公开了不透射线单体，聚合物和微球。本文公开了使用不透射线单体，聚合物和微球的方法。本文公开了制造不透射线单体，聚合物和微球的方法。

7. 发明授权

US09155804B2 Contrast enhancement agents and method of use thereof 有权
标题翻译：对比增强剂及其使用方法
公开(公告)号：US09155804B2
公开(公告)日：2015-10-13
申请号：US13626942
申请日：2012-09-26
申请人： General Electric Company
发明人： Brian James Grimmond , Michael James Rishel , Jeannette Christine Roberts
IPC分类号： A61K51/00 , A61M36/14 , A61K49/12
CPC分类号： A61K49/126
摘要： A contrast agent composition and a method of diagnostic imaging are provided. The composition comprises a pharmaceutically acceptable carrier and a metal-complex comprising a ligand having structure (XXX): wherein R1, R2, R3, R7, R8, R′1, R′2, R′3, R7′ and R8′ are selected form hydrogen, a protected C1-C3 hydroxyalkyl group, or a C1-C3 alkyl group; R4, R′4 are selected from a hydrogen, a hydroxyl, a protected hydroxyl group, a protected C1-C3 hydroxyalkyl group, a C1-C3 alkyl group; n is an integer between 0 and 4; R5, R′5 are selected from a hydrogen, a protecting group comprising C1-C30 aliphatic radicals, C3-C30 cycloaliphatic radicals, C2-C30 aromatic radicals, m is an integer between 1 and 10; at least one of R7 and R′7 is acidic groups or protected acidic groups; Y comprises a protein or peptide moiety, a particle, a micelle, a liposome, an organic molecule, oligomer, polymer or a hydrophilic moiety.
摘要翻译：提供造影剂组合物和诊断成像方法。该组合物包含药学上可接受的载体和包含具有结构（XXX）的配体的金属络合物：其中R1，R2，R3，R7，R8，R'1，R'2，R'3，R7'和R8'是选自氢，受保护的C1-C3羟烷基或C1-C3烷基; R 4，R'4选自氢，羟基，被保护的羟基，保护的C 1 -C 3羟烷基，C 1 -C 3烷基; n是0和4之间的整数; R5，R'5选自氢，包含C1-C30脂族基团，C3-C30脂环族基团，C2-C30芳族基团的保护基，m是1-10之间的整数; R 7和R 7中的至少一个是酸性基团或被保护的酸性基团; Y包括蛋白质或肽部分，颗粒，胶束，脂质体，有机分子，低聚物，聚合物或亲水部分。

8. 发明申请

US20150196583A1 Compounds And Their Effects On Appetite Control And Insulin Sensitivity 有权
标题翻译：化合物及其对食欲控制和胰岛素敏感性的影响
公开(公告)号：US20150196583A1
公开(公告)日：2015-07-16
申请号：US14418448
申请日：2013-07-31
申请人： Imperial Innovations Limited , The University Court of the University of Glasgow
发明人： Gary Frost , Douglas Morrison , Thomas Preston
IPC分类号： A61K31/733 , A23L1/30 , A61K45/06
CPC分类号： A61K31/733 , A23L33/10 , A23L33/21 , A23V2002/00 , A61K45/06 , A61K49/126 , C08B37/0054 , C08L5/00 , A61K2300/00
摘要： The invention provides a propionate inulin ester for the reduction of appetite, food intake and/or calorie intake and/or to improve insulin sensitivity in a subject, and for the treatment or prevention of obesity or diabetes. The invention also provides compositions comprising a propionate inulin ester, methods using propionate inulin esters, functional food containing propionate inulin ester and methods of making propionate inulin esters.
摘要翻译：本发明提供了一种丙酸菊糖酯，用于减少食欲，食物摄取和/或卡路里摄取和/或改善受试者的胰岛素敏感性，以及用于治疗或预防肥胖或糖尿病。本发明还提供了包含丙酸菊糖酯酯的组合物，使用丙酸菊糖酯的方法，含有丙酸菊糖酯的功能性食品和制备丙酸菊糖酯的方法。

9. 发明申请

US20150139914A1 Contrast-Enhancing Agent for Nuclear Magnetic Resonance Imaging Comprising Melanin Nanoparticles Stably Dispersed in Water 有权
标题翻译：用于核磁共振成像的对比增强剂包括稳定分散在水中的黑色素纳米颗粒
公开(公告)号：US20150139914A1
公开(公告)日：2015-05-21
申请号：US14391217
申请日：2013-04-09
申请人： SNU R&DB FOUNDATION , RESEARCH & BUSINESS FOUNDATION SUNGKYUNKWAN UNIVERSITY
发明人： Jin Kyu Lee , Kuk Youn Ju , Jung Hee Lee
IPC分类号： A61K49/18 , A61K49/12 , A61K49/16 , A61K49/10
CPC分类号： A61K49/1818 , A61K49/103 , A61K49/106 , A61K49/126 , A61K49/16 , A61K49/186
摘要： The present invention relates to a contrast agent for nuclear magnetic resonance imaging, and more particularly, to a contrast agent for nuclear magnetic resonance imaging containing melanin nanoparticles having a uniform shape and size, thereby providing good dispersibility in water, no cell toxicity, and a long retention time in vivo.
摘要翻译：本发明涉及用于核磁共振成像的造影剂，更具体地，涉及含有具有均匀形状和大小的黑色素纳米颗粒的核磁共振成像造影剂，从而在水中提供良好的分散性，无细胞毒性和体内保留时间长。

10. 发明申请

US20140170077A1 HIGH-SENSITIVITY MAGNETIC RESONANCE IMAGING NANO-CONTRAST AGENT BASED ON AN ANIONIC POLYMER AND CATIONIC POLYMER ION COMPLEX, AND A PRODUCTION METHOD THEREFOR 有权
标题翻译：基于阴离子聚合物和阳离子聚合物复合物的高灵敏度磁共振成像纳米对比剂及其制备方法
公开(公告)号：US20140170077A1
公开(公告)日：2014-06-19
申请号：US14110138
申请日：2011-04-07
申请人： Moon-Hee Sung , Yong Taik Lim , Young-Woock Noh , Il Han Lee , Hyun Min Kim
发明人： Moon-Hee Sung , Yong Taik Lim , Young-Woock Noh , Il Han Lee , Hyun Min Kim
IPC分类号： A61K49/12
CPC分类号： A61K49/126 , A61K49/1863 , A61K49/1872
摘要： The present invention relates to a nano-composite containing anionic and cationic polymers and a method for preparing thereof, and more particularly to a poly-gamma-glutamic acid (γ-PGA)/chitosan/manganese iron oxide nanoparticle composite prepared by encapsulating iron oxide-based nanoparticles in a γ-PGA/chitosan polymer composite using the ionic self-assembly properties of poly-gamma-glutamic acid (γ-PGA) and chitosan, which are biocompatible polymer materials, and to a method for preparing thereof.The present invention provides a magnetic resonance imaging nano-contrast agent based on a nanoparticle composite including iron oxide-based nanoparticles encapsulated in a self-assembled composite of anionic poly-gamma-glutamic acid (γPGA) and cationic chitosan. The iron oxide-based nanoparticles encapsulated in the composite interact with each other to produce a synergistic effect on the amplification of magnetic resonance signals, and thus have an relatively excellent contrast effect compared to when they exist as single particles.
摘要翻译：本发明涉及含有阴离子和阳离子聚合物的纳米复合物及其制备方法，更具体地涉及通过包封氧化铁制备的聚-γ-谷氨酸（γ-PGA）/壳聚糖/锰铁氧体纳米颗粒复合材料基于聚-γ-谷氨酸（γ-PGA）和壳聚糖的离子自组装性质的γ-PGA /壳聚糖复合材料的生物相容性聚合物材料的制备方法。本发明提供一种基于纳米颗粒复合材料的磁共振成像纳米造影剂，其包括封装在阴离子聚-γ-谷氨酸（γPGA）和阳离子壳聚糖的自组装复合物中的基于氧化铁的纳米颗粒。封装在复合材料中的基于氧化铁的纳米颗粒彼此相互作用以对磁共振信号的扩增产生协同效应，因此与作为单个颗粒存在时相比具有相对优异的对比效果。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式