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1. 发明申请

US20190216735A1 LIPOSOMAL FORMULATIONS 审中-公开
公开(公告)号：US20190216735A1
公开(公告)日：2019-07-18
申请号：US16332725
申请日：2017-09-14
申请人： NANYANG TECHNOLOGICAL UNIVERSITY , SINGAPORE HEALTH SERVICES PTE LTD
发明人： Subramanian VENKATRAMAN , Yingying HUANG , Amrita NAGLE , Jayaganesh V. NATARAJAN , Nicolas Daniel Marie FOIN , Tze Tec CHONG , Jie Liang PHUA
IPC分类号： A61K9/127 , A61K9/00 , A61K31/337 , A61K31/436 , A61P9/00 , A61M25/10 , A61M25/00
CPC分类号： A61K9/127 , A61K9/0019 , A61K9/1278 , A61K31/337 , A61K31/436 , A61K47/24 , A61M25/0084 , A61M25/104 , A61P1/00 , A61P9/00 , A61P11/00 , A61P35/00
摘要： According to the present disclosure, a liposomal formulation comprising at least one uncharged phospholipid without cholesterol and at least one pharmaceutical agent, wherein the at least one uncharged phospholipid forms one or more lipid bilayers without cholesterol encapsulating the at least one pharmaceutical agent, is provided. The use(s) of such a liposomal formulation and method of producing such a liposomal formulation are also provided.

2. 发明申请

US20180296483A1 MICROVESICLES DERIVED FROM NUCLEATED, MAMMALIAN CELLS AND USE THEREOF 审中-公开
公开(公告)号：US20180296483A1
公开(公告)日：2018-10-18
申请号：US15959521
申请日：2018-04-23
申请人： MDIMUNE INC.
发明人： Yong Song Gho , Yoon Keun Kim , Su Chul Jang , Oh Youn KIM , Dong-Sic CHOI , Yae Jin YOON
IPC分类号： A61K9/127 , A61K35/545 , A61K45/06 , A61K35/15 , A61K9/50
CPC分类号： A61K9/127 , A61K9/1278 , A61K9/5068 , A61K35/15 , A61K35/545 , A61K45/06 , A61K2300/00
摘要： The present invention relates to a microvesicle that is derived from nucleated mammalian cells, which are smaller than the nucleated cells. The microvesicles of the present invention can be used in the delivery of a therapeutic or diagnostic substance to specific tissues or cells, and more particularly, relates to microvesicles derived from monocytes, macrophages, dendritic cells, stem cells or the like, which can be used to deliver specific therapeutic or diagnostic substances for treating and/or diagnosing tissue associated with cancer, diseased blood vessels, inflammation, or the like.

3. 发明授权

US09974744B2 Sustained release formulation of a non-steroidal anti-inflammatory drug 有权
公开(公告)号：US09974744B2
公开(公告)日：2018-05-22
申请号：US13787265
申请日：2013-03-06
申请人： PACIRA PHARMACEUTICALS, INC.
发明人： Louie Daniel Garcia , Liangjin Zhu , William Joseph Lambert , Gary Patou
IPC分类号： A61K9/127 , A61K31/196 , A61K31/407 , A61K31/5415
CPC分类号： A61K9/1272 , A61K9/127 , A61K9/1277 , A61K9/1278 , A61K31/196 , A61K31/407 , A61K31/5415
摘要： Disclosed are formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs which minimize the side effects of unencapsulated non-steroidal anti-inflammatory drugs while maintaining or improving efficacy. Methods of making and administering the formulations comprising multivesicular liposomes and one or more non-steroidal anti-inflammatory drugs and their use as medicaments are also provided.

4. 发明授权

US09730891B2 Liposomes useful for drug delivery 有权
公开(公告)号：US09730891B2
公开(公告)日：2017-08-15
申请号：US14879302
申请日：2015-10-09
申请人： Ipsen Biopharm Ltd.
发明人： Keelung Hong , Daryl C. Drummond , Dmitri Kirpotin
IPC分类号： A61K9/127 , A61K9/00 , A61K31/4745 , A61K31/475 , A61K31/704 , A61K31/337 , A61K31/4375 , A61K47/26 , A61K47/48 , A61K47/10 , A61K47/24 , A61K47/28 , C07H13/12
CPC分类号： A61K31/4745 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K9/1278 , A61K31/337 , A61K31/4375 , A61K31/475 , A61K31/704 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/60 , A61K47/6913 , C07H13/12 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.

5. 发明授权

US09717723B2 Liposomes useful for drug delivery 有权
公开(公告)号：US09717723B2
公开(公告)日：2017-08-01
申请号：US14632422
申请日：2015-02-26
申请人： Ipsen Biopharm Ltd.
发明人： Keelung Hong , Daryl C. Drummond , Dmitri Kirpotin
IPC分类号： A61K9/127 , A61K31/4745 , A61K9/00 , A61K31/475 , A61K31/704 , A61K31/337 , A61K31/4375 , A61K47/26 , A61K47/48 , A61K47/10 , A61K47/24 , A61K47/28 , C07H13/12
CPC分类号： A61K31/4745 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K9/1278 , A61K31/337 , A61K31/4375 , A61K31/475 , A61K31/704 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/60 , A61K47/6913 , C07H13/12 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provides methods of making the liposome compositions provided by the present invention.

6. 发明授权

US09655846B2 Methods for the preparation of liposomes comprising drugs 有权
公开(公告)号：US09655846B2
公开(公告)日：2017-05-23
申请号：US14088657
申请日：2013-11-25
申请人： Indu Javeri
发明人： Indu Javeri , Kaliappanadar Nellaiappan
IPC分类号： A61K9/127 , A61K9/19 , A61K31/337 , A61K9/00
CPC分类号： A61K9/127 , A61K9/0095 , A61K9/1278 , A61K9/19 , A61K31/337
摘要： Provided herein are methods for preparing liposomes comprising docetaxel and uses thereof. In certain embodiments, liposomes are prepared without using heat, organic solvents, proteins, and/or inorganic salts in the process. In certain embodiments, the liposomal preparations are used in the treatment of diseases or disorders.

7. 发明申请

US20170079914A1 Liposomes Useful for Drug Delivery 审中-公开
公开(公告)号：US20170079914A1
公开(公告)日：2017-03-23
申请号：US15364021
申请日：2016-11-29
申请人： Merrimack Pharmaceuticals, Inc.
发明人： Keelung Hong , Daryl C. Drummond , Dmitri Kirpotin
IPC分类号： A61K9/127 , A61K31/4745
CPC分类号： A61K31/4745 , A61K9/0019 , A61K9/127 , A61K9/1271 , A61K9/1277 , A61K9/1278 , A61K31/337 , A61K31/4375 , A61K31/475 , A61K31/704 , A61K47/10 , A61K47/24 , A61K47/26 , A61K47/28 , A61K47/60 , A61K47/6913 , C07H13/12 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： The present invention provides liposome compositions containing substituted ammonium and/or polyanion, and optionally with a desired therapeutic or imaging entity. The present invention also provide methods of making the liposome compositions provided by the present invention.

8. 发明申请

US20170042813A1 LIPOSOME COMPOSITION AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：脂肪组合物及其生产方法
公开(公告)号：US20170042813A1
公开(公告)日：2017-02-16
申请号：US15336158
申请日：2016-10-27
申请人： FUJIFILM Corporation
发明人： Makoto ONO , Kohei ONO , Takeshi MATSUMOTO , Mikinaga MORI
IPC分类号： A61K9/127 , A61K31/7068
CPC分类号： A61K9/127 , A61K9/1278 , A61K31/7068 , A61K47/24 , A61K47/28 , B82Y5/00
摘要： Provided are a liposome composition in which an osmotic pressure of an inner water phase is 2-fold to 8-fold relative to the osmotic pressure of an outer water phase, and which encapsulates a water-soluble drug in a dissolved state, and also exhibits excellent preservation stability; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes obtained from lipids dissolved and emulsified in an organic solvent, each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which each of the liposomes encapsulates a water-soluble drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase; and a method for producing the same.
摘要翻译：提供一种脂质体组合物，其中内水相的渗透压相对于外部水相的渗透压为2倍至8倍，并且将水溶性药物包封在溶解状态，并且还显示出保存稳定性好; 及其制造方法。根据本发明，可以提供一种脂质体组合物，其包括由在有机溶剂中溶解和乳化的脂质获得的脂质体，每个脂质体具有构成外部水相的内部水相和水溶液，分散脂质体，其中每个脂质体包封溶解状态的水溶性药物，内部水相的渗透压相对于外部水相的渗透压为2倍至8倍; 及其制造方法。

9. 发明申请

US20170042811A1 LIPOSOME COMPOSITION AND METHOD FOR PRODUCING SAME 审中-公开
标题翻译：脂肪组合物及其生产方法
公开(公告)号：US20170042811A1
公开(公告)日：2017-02-16
申请号：US15336057
申请日：2016-10-27
申请人： FUJIFILM Corporation
发明人： Makoto ONO , Kohei ONO , Takeshi MATSUMOTO , Mikinaga MORI
IPC分类号： A61K9/127 , A61K31/7068
CPC分类号： A61K9/127 , A61K9/1278 , A61K31/7068 , A61K47/24 , A61K47/28 , B01J13/02 , B01J13/20 , Y10S977/773 , Y10S977/906 , Y10S977/907
摘要： Provided are a liposome composition which has a practically required long-term preservation stability, and which has a release rate of a drug on the order of several tens of hours due to releasability of a drug being able to be suitably controlled by rendering an inner water phase hyper-osmotic; and a method for producing the same. According to the present invention, it is possible to provide a liposome composition, including liposomes each of which has an inner water phase and an aqueous solution which constitutes an outer water phase and in which the liposomes are dispersed, in which the content of cholesterols is 10 mol % to 35 mol % with respect to the total amount of lipid components in the liposome composition, and each of the liposomes encapsulates a drug in a dissolved state, and an osmotic pressure of the inner water phase is 2-fold to 8-fold relative to the osmotic pressure of the outer water phase.
摘要翻译：本发明提供一种脂质体组合物，其具有实际上所需的长期保存稳定性，并且由于能够通过使内部水分适当地控制药物的释放性，其具有几十小时数量级的药物的释放速率相超渗透及其制造方法。根据本发明，可以提供一种脂质体组合物，其包括脂质体，其各自具有构成外部水相的内部水相和水溶液，并且其中分散有脂质体的胆固醇的含量为相对于脂质体组合物中的脂质成分的总量为10〜35摩尔％，并且每个脂质体将药物包封在溶解状态，内部水相的渗透压为2倍至8倍，相对于外部水相的渗透压折叠。

10. 发明申请

US20160038616A1 METHOD OF MONITORING THE RELEASE FROM LIPOSOMES OF A PRODUCT OF INTEREST USING SUPERPARAMAGNETIC NANOPARTICLES 审中-公开
标题翻译：使用超级纳米颗粒监测利益相关产品的释放物的方法
公开(公告)号：US20160038616A1
公开(公告)日：2016-02-11
申请号：US14886326
申请日：2015-10-19
申请人： NANOBIOTIX , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , UNIVERSITE DE BORDEAUX SEGALEN
发明人： AGNÈS POTTIER , LAURENT LEVY , MARIE-EDITH MEYRE , MATTHIEU GERMAIN , CYRIL LORENZATO , CHRIT MOONEN , PIERRE SMIRNOV
IPC分类号： A61K49/18 , G01R33/56 , A61K31/704 , G01N24/08 , A61K9/127 , A61K41/00
CPC分类号： A61K49/1812 , A61K9/0009 , A61K9/127 , A61K9/1271 , A61K9/1278 , A61K9/5094 , A61K9/5115 , A61K31/704 , A61K41/0028 , G01N24/088 , G01R33/5601
摘要： The present application relates to a method of monitoring the membrane permeabilization of liposome and the incidental release of a compound of interest.
摘要翻译：本申请涉及监测脂质体的膜透化和感兴趣的化合物的偶然释放的方法。

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