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1. 发明授权

US10052388B2 Compositions and methods for delivering an agent to a wound 有权
公开(公告)号：US10052388B2
公开(公告)日：2018-08-21
申请号：US15483686
申请日：2017-04-10
申请人： UNIVERSITY OF MEMPHIS RESEARCH FOUNDATION
发明人： Warren O. Haggard , Scott P. Noel , Joel D. Bumgardner
IPC分类号： A61K47/36 , A61K9/70 , A61K31/7036 , A61L29/14 , A61L29/16 , A61L31/04 , A61L31/14 , A61L31/16 , C08B37/08 , C08J5/18 , A61L29/04 , A61K38/14
CPC分类号： A61K47/36 , A61K9/0024 , A61K9/7007 , A61K31/00 , A61K31/7036 , A61K38/14 , A61L15/28 , A61L15/44 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/146 , A61L29/148 , A61L29/16 , A61L31/042 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/232 , A61L2300/25 , A61L2300/406 , C08B37/003 , C08J5/18 , C08J2305/08 , C08L5/08 , A61K2300/00
摘要： The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

2. 发明申请

US20180133366A1 FLOWABLE TISSUE COMPOSITIONS WITH ENHANCED BUOYANCY PROPERTIES CONTAINING ANTIBIOTICS AND DERIVATIVES THEREOF 审中-公开
公开(公告)号：US20180133366A1
公开(公告)日：2018-05-17
申请号：US15814247
申请日：2017-11-15
申请人： Neil RIORDAN
发明人： Neil RIORDAN
IPC分类号： A61L27/36 , A61L27/50 , A61L27/38 , A61K35/39 , A61K35/407 , A61K35/35 , A61K35/50 , A61K35/51 , A61K9/00
CPC分类号： A61L27/3687 , A01N1/021 , A61K9/0019 , A61K35/35 , A61K35/39 , A61K35/407 , A61K35/50 , A61K35/51 , A61L27/3604 , A61L27/3691 , A61L27/3804 , A61L27/50 , A61L2300/214 , A61L2300/232 , A61L2300/406 , A61L2400/06
摘要： Disclosed are compositions of matter, protocols, and treatment means for generation of tissues capable of administration in a flowable manner through contain with one or more antibiotics, or derivatives of said antibiotics. In one embodiment the invention provides the treatment of morselized amniotic membranes with antibiotics in a manner as to increase buoyancy of morselized components of said amniotic membranes in order to prevent gravity based accumulation of said morselized tissue. In another embodiment buoyancy of morselized tissue is modulated by contacting said tissue with an antibiotic or derivative thereof in a manner to allow for increased uniformity of said morselized tissue components throughout a vessel. In another embodiment, pancreatic islets are isolated and stored in a manner to prevent gravity based aggregation. The invention pertains to all tissues, with emphasize in a preferred embodiment to tissues which are useful when administered in a flowable manner.

3. 发明申请

US20180071430A1 INJECTABLE COLLAGEN SUSPENSIONS, THE PREPARATION METHOD THEREOF, AND THE USES THEREOF, PARTICULARLY FOR FORMING DENSE COLLAGEN MATRICES 审中-公开
公开(公告)号：US20180071430A1
公开(公告)日：2018-03-15
申请号：US15558787
申请日：2016-03-17
申请人： UNIVERSITE PIERRE ET MARIE CURIE (PARIS 6) , CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE
发明人： Nadine NASSIF , Francisco Miguel MOREIRA MARTINS FERNANDES , Cedric BOISSIERE , Clement SANCHEZ , Marie-Madeleine GIRAUD-GUILLE
IPC分类号： A61L27/24 , A61L27/50 , A61L27/54 , A61L27/52
CPC分类号： A61L27/24 , A61K8/022 , A61K8/025 , A61K8/14 , A61K8/606 , A61K8/65 , A61K38/39 , A61K2800/412 , A61K2800/654 , A61K2800/91 , A61L27/50 , A61L27/52 , A61L27/54 , A61L2300/232 , A61L2300/236 , A61L2300/252 , A61L2300/402 , A61L2300/428 , A61L2400/06 , A61L2430/06 , A61L2430/34 , A61L2430/38 , A61Q19/08 , C08J3/122 , C08J2389/00
摘要： Disclosed is the preparation of injectable collagen suspensions, to the method for preparing the suspensions, and to the uses thereof, particularly for forming dense collagen matrices.

4. 发明授权

US09878019B2 Hyaluronic acid containing compositions for prevention of the formation of post-surgical scars and post-surgical adhesions 有权
公开(公告)号：US09878019B2
公开(公告)日：2018-01-30
申请号：US14458637
申请日：2014-08-13
申请人： PERGAMUM AB
发明人： Margit Mahlapuu , Mattias Münnich , Veronika Sjöstrand
IPC分类号： A61K38/40 , A61K9/00 , A61K9/06 , A61K31/728 , A61K45/06 , A61K47/36 , A61L31/16 , A61K38/08 , A61K38/10
CPC分类号： A61K38/40 , A61K9/0014 , A61K9/06 , A61K31/728 , A61K38/08 , A61K38/10 , A61K45/06 , A61K47/36 , A61L31/16 , A61L2300/232 , A61L2300/252 , A61K2300/00
摘要： The present invention relates to pharmaceutical compositions enhancing the therapeutic effect of biologically active peptides, especially peptides derived from human lactoferrin. The compositions are useful for the treatment and/or prevention of wounds, scars, and post surgical adhesions.

5. 发明授权

US09731044B2 Biopolymer system for tissue sealing 有权
公开(公告)号：US09731044B2
公开(公告)日：2017-08-15
申请号：US15003367
申请日：2016-01-21
申请人： Endomedix, Inc.
发明人： Weiliam Chen , John M. Abrahams
IPC分类号： A61L26/00 , A61K38/18 , A61K47/48 , A61K48/00 , A61K49/00 , A61K49/04 , A61K51/12 , A61L24/00 , A61L24/04 , A61L24/08 , A61L24/10 , A61K31/721 , A61K31/722 , A61K9/00 , A61K9/06
CPC分类号： A61L26/0052 , A61K9/0085 , A61K9/06 , A61K31/721 , A61K31/722 , A61K38/1875 , A61K47/60 , A61K47/6903 , A61K48/00 , A61K49/0002 , A61K49/0457 , A61K51/1213 , A61L24/0031 , A61L24/043 , A61L24/08 , A61L24/104 , A61L26/0066 , A61L26/008 , A61L26/009 , A61L2300/232 , A61L2300/236 , C08L89/00 , C08L5/08
摘要： A tissue sealant for use in surgical and medical procedures for sealing the tissues of a living mammal is provided. The tissue sealant comprises a hydrogel which is formed by gelation of a premix disposed on the tissue to be sealed. The premix comprises alkylated chitosan or a gelatin, and a polybasic carboxylic acid or an oxidized polysaccharide, in an aqueous medium. The premix can also include a dehydrating reagent, a carboxyl activating reagent, or both. A specific use of the tissue sealant is in the repair of the dura mater after brain surgery to prevent leakage of cerebrospinal fluid. The tissue sealant may include a therapeutic or protective agent such as an antibiotic or an anti-inflammatory drug.

6. 发明授权

US09642948B2 Compositions and methods for delivering an agent to a wound 有权
公开(公告)号：US09642948B2
公开(公告)日：2017-05-09
申请号：US14618722
申请日：2015-02-10
申请人： University of Memphis Research Foundation
发明人： Warren O. Haggard , Scott P. Noel , Joel D. Bumgardner
IPC分类号： A61L31/04 , A61L31/14 , A61L31/16 , A61L15/28 , A61L15/44 , A61K31/00 , A61K47/36 , A61L27/20 , A61L27/58 , C08B37/08 , C08L5/08 , A61K9/00 , A61K9/70
CPC分类号： A61K47/36 , A61K9/0024 , A61K9/7007 , A61K31/00 , A61K31/7036 , A61K38/14 , A61L15/28 , A61L15/44 , A61L27/20 , A61L27/58 , A61L29/043 , A61L29/146 , A61L29/148 , A61L29/16 , A61L31/042 , A61L31/146 , A61L31/148 , A61L31/16 , A61L2300/232 , A61L2300/25 , A61L2300/406 , C08B37/003 , C08J5/18 , C08J2305/08 , C08L5/08 , A61K2300/00
摘要： The invention provides compositions featuring chitosan and methods for using such compositions for the local delivery of biologically active agents to an open fracture, complex wound or other site of infection. Advantageously, the degradation and drug elution profiles of the chitosan compositions can be tailored to the needs of particular patients at the point of care (e.g., in a surgical suite, clinic, physician's office, or other clinical setting).

7. 发明申请

US20160310631A1 ANTIMICROBIAL FIBROUS MATERIALS AND METHODS OF MAKING SAME 审中-公开
标题翻译：抗微生物纤维材料及其制备方法
公开(公告)号：US20160310631A1
公开(公告)日：2016-10-27
申请号：US15103896
申请日：2014-12-09
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： SHILPI K. SANGHI , ALI B. MAHFUZA
IPC分类号： A61L15/46 , C08B15/06 , A61L15/44 , A61L15/60 , A61L15/20 , A61L15/28
CPC分类号： A61L15/46 , A61L15/20 , A61L15/28 , A61L15/44 , A61L15/60 , A61L2300/208 , A61L2300/232 , A61L2300/404 , C08B15/06
摘要： Antimicrobial fibrous materials and methods of making same. The antimicrobial fibrous material can include a plurality of absorbent fibers; and a quaternary ammonium compound covalently grafted to the plurality of fibers. The quaternary ammonium compound can be derived from quaternary amine-functionalized ethylenically unsaturated monomers. The method can include providing a plurality of absorbent fibers; irradiating the plurality of fibers with high energy irradiation to generate a plurality of irradiated fibers; providing quaternary amine-functionalized ethylenically unsaturated monomers; and combining the plurality of irradiated fibers with the quaternary amine-functionalized ethylenically unsaturated monomers to form antimicrobial fibers with a quaternary ammonium compound covalently grafted thereto
摘要翻译：抗微生物纤维材料及其制造方法。抗微生物纤维材料可以包括多个吸收性纤维; 和共价接枝到多根纤维上的季铵化合物。季铵化合物可以衍生自季胺官能化的烯属不饱和单体。该方法可以包括提供多个吸收性纤维; 用高能量照射照射多根纤维以产生多根照射的纤维; 提供季胺官能化烯属不饱和单体; 并将多个经辐射的纤维与季胺官能化的烯属不饱和单体组合以形成具有共价接枝的季铵化合物的抗微生物纤维

8. 发明申请

US20160296658A1 NOVEL ACTIVE INGREDIENT IN CICATRIZATION AND USE THEREOF 审中-公开
标题翻译：在化学和其中使用的新的活性成分
公开(公告)号：US20160296658A1
公开(公告)日：2016-10-13
申请号：US15183310
申请日：2016-06-15
申请人： LABORATOIRES URGO
发明人： Christelle LAURENSOU
IPC分类号： A61L15/44 , A61L15/26
CPC分类号： A61L15/44 , A61K8/8158 , A61K31/7028 , A61K31/795 , A61L15/26 , A61L2300/232 , A61L2300/404 , A61L2300/41 , A61L2300/412 , A61Q19/00
摘要： The present invention relates to the use of a known compound as an agent for promoting and/or accelerating fibroblast proliferation and/or differentiation and, consequently, cicatrization. This compound is a copolymer of a 2-methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulphonic acid salt and of propenoic acid 2-hydroxyethyl ester. It may be used alone or in combination with other active substances for inducing or accelerating cicatrization. This compound, alone or in combination with another active substance, may be administered directly on the wound and the surrounding area or the mucous membranes, by topical application. It may also be used ex vivo, in particular for generating cells for skin grafts.
摘要翻译：本发明涉及已知化合物作为促进和/或促进成纤维细胞增殖和/或分化以及因此促进作用的药物的用途。该化合物是2-甲基-2 - [（1-氧代-2-丙烯基）氨基] -1-丙磺酸盐和丙烯酸2-羟基乙酯的共聚物。它可以单独使用或与其他活性物质组合用于诱导或加速瘢痕形成。该化合物单独或与另一种活性物质组合可以通过局部施用直接施用于伤口和周围区域或粘膜上。它也可以离体使用，特别是用于产生皮肤移植物的细胞。

9. 发明申请

US20160279284A1 TISSUE DRESSING KIT 有权
标题翻译：组织套装
公开(公告)号：US20160279284A1
公开(公告)日：2016-09-29
申请号：US15179045
申请日：2016-06-10
申请人： Medovent GmbH
发明人： Rivelino Montenegro , Thomas Freier
IPC分类号： A61L26/00
CPC分类号： A61L26/0023 , A61L15/28 , A61L26/0066 , A61L2300/232 , A61L2300/404 , C08L5/08
摘要： A kit comprising a tissue dressing material for being applied in contact with the tissue of a patient and a detachment solvent for removing the tissue dressing material from the tissue. A method of treating a tissue of a patient, the method comprising the steps of: applying a water-soluble tissue dressing material in contact with the patient's tissue; and applying an acidic detachment solvent to the tissue dressing material for removing the tissue dressing material from the tissue. A method of treating a tissue of a patient, the method comprising the steps of: applying a liquid tissue dressing material in contact with the patient's tissue; and applying a detachment solvent to the tissue dressing material for removing the tissue dressing material from the tissue. A method of treating a tissue of a patient, the method comprising the steps of: applying a water-soluble tissue dressing material in contact with the patient's tissue; and allowing the water-soluble tissue dressing material to convert into a form in which it is insoluble in water at neutral pH. And a solid material comprising a polymer salt and glycerol, the glycerol content being at least 10% of the polymer salt content by weight, for use in a method of treating a human or animal tissue.
摘要翻译：一种试剂盒，其包括用于与患者的组织接触的组织敷料材料和用于从组织去除组织敷料材料的脱离溶剂。一种治疗患者组织的方法，所述方法包括以下步骤：施加与患者组织接触的水溶性组织敷料; 以及向所述组织敷料材料施加酸性分离溶剂以从所述组织去除所述组织敷料材料。一种治疗患者组织的方法，所述方法包括以下步骤：施加与患者组织接触的液体组织敷料材料; 以及向所述组织敷料材料施加脱离溶剂，以从所述组织去除所述组织敷料材料。一种治疗患者组织的方法，所述方法包括以下步骤：施加与患者组织接触的水溶性组织敷料; 并且允许水溶性组织敷料在中性pH下转化为不溶于水的形式。和包含聚合物盐和甘油的固体材料，甘油含量为聚合物盐含量的至少10重量％，用于治疗人或动物组织的方法。

10. 发明授权

US09439998B2 Compositions and methods for disinfecting materials 有权
标题翻译：消毒材料的组成和方法
公开(公告)号：US09439998B2
公开(公告)日：2016-09-13
申请号：US13393520
申请日：2010-09-01
申请人： Karsten Henco , Thomas Freier , Rivelino Montenegro
发明人： Karsten Henco , Thomas Freier , Rivelino Montenegro
IPC分类号： A01N43/16 , C08B37/08 , A61P17/02 , A61K31/722 , A61L15/28 , A61L26/00
CPC分类号： A61L26/0023 , A61L15/28 , A61L26/0066 , A61L2300/232 , A61L2300/404 , C08L5/08
摘要： The present invention relates to methods for disinfecting or decontaminating a material or for preventing an infection or contamination of a material. The invention further relates to compositions which are suitable for disinfecting a material or for preventing an infection or contamination of a material and to uses of such compositions. The invention further relates to a medical use of chitosan and to a pharmaceutical composition comprising the chitosan. The invention further relates to a method of treating a microbial infection and to an aqueous solution comprising chitosan. The invention moreover relates to a chitosan or a pharmaceutical composition comprising a chitosan for an epithelial cell growth stimulating treatment of a patient's tissue and to a method of stimulating the growth of epithelial cells. The invention also relates to a tissue dressing material.
摘要翻译：本发明涉及消毒或净化材料或防止材料的感染或污染的方法。本发明还涉及适用于消毒材料或防止材料的感染或污染以及这些组合物的用途的组合物。本发明还涉及壳聚糖和包含壳聚糖的药物组合物的医学用途。本发明还涉及一种治疗微生物感染的方法和包含壳聚糖的水溶液。本发明还涉及壳聚糖或包含用于上皮细胞生长刺激治疗患者组织的壳聚糖和刺激上皮细胞生长的方法的药物组合物。本发明还涉及组织敷料材料。

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