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1. 发明授权

US09861725B2 Multilayer protein films, methods of making, and drug delivery devices and biomedical implants employing the films 有权
公开(公告)号：US09861725B2
公开(公告)日：2018-01-09
申请号：US13319327
申请日：2010-05-24
申请人： Ella Cathrine Vikinge , Elin Engström , Henrik Aronsson , Oskar Axelsson
发明人： Ella Cathrine Vikinge , Elin Engström , Henrik Aronsson , Oskar Axelsson
IPC分类号： A61L27/54 , A61L27/34 , A61C8/00
CPC分类号： A61L27/54 , A61C8/0013 , A61L27/34 , A61L2300/112 , A61L2300/252 , A61L2300/406 , A61L2300/422 , A61L2300/608 , Y10T428/273 , C08L89/00
摘要： A multilayer protein film has a mass of greater than 0.5 μg/cm2 and consists essentially of protein. A drug delivery device comprises the multilayer protein film onto which a pharmaceutically active agent can be loaded. A biomedical implant comprises an implant substrate and the multilayer protein film on at least a portion of the implant substrate surface. A method of making a multilayer protein film having a mass of greater than 0.5 μg/cm2 comprises contacting a substrate with a protein solution at a temperature of from about 30° C. to about 95° C, wherein a multilayer protein film having a mass of greater than 0.5 μg/cm2 is formed on the substrate.

2. 发明授权

US09629941B2 Hydrogel coated scaffold 有权
公开(公告)号：US09629941B2
公开(公告)日：2017-04-25
申请号：US14427853
申请日：2013-09-18
申请人： CORTICALIS AS
发明人： S. Petter Lyngstadaas , Havard J. Haugen , Hanna Tiainen
IPC分类号： A61L27/34 , A61L27/06 , A61L27/10 , A61L27/54 , A61L27/56 , A61L27/38 , A61L27/42 , A61L27/52
CPC分类号： A61L27/34 , A61L27/06 , A61L27/10 , A61L27/3821 , A61L27/3834 , A61L27/425 , A61L27/52 , A61L27/54 , A61L27/56 , A61L2300/25 , A61L2300/412 , A61L2300/422 , A61L2300/64 , A61L2400/18 , A61L2420/02 , A61L2420/04 , A61L2420/06 , A61L2430/02 , A61L2430/12
摘要： The present document is directed to a titanium dioxide scaffold comprising a hydrogel coating comprising a biologically active substance. Also disclosed is a method for producing a thin hydrogel coating on a titanium dioxide scaffold and uses of the hydrogel coated scaffolds as medical implants.

3. 发明授权

US08992471B2 Coated devices and method of making coated devices that reduce smooth muscle cell proliferation and platelet activity 有权
公开(公告)号：US08992471B2
公开(公告)日：2015-03-31
申请号：US12740890
申请日：2008-11-05
申请人： Tammy R. Dugas , Alok Khandelwal , James John Kleinedler, III , John Devlin Foley
发明人： Tammy R. Dugas , Alok Khandelwal , James John Kleinedler, III , John Devlin Foley
IPC分类号： A61F2/82 , A61L31/16 , A61L31/10 , A61L31/14 , A61F2/915
CPC分类号： A61F2/82 , A61F2/915 , A61F2002/91508 , A61F2002/91558 , A61F2210/0076 , A61F2250/0067 , A61L31/10 , A61L31/146 , A61L31/16 , A61L2300/416 , A61L2300/422 , A61L2300/608
摘要： The present invention relates generally to the maintenance of blow flood using drug eluting stents and/or other coated medical devices to increased length of time of blood flow. Further, the present invention relates to drug-releasing coated devices for reducing smooth muscle cell proliferation and platelet activity to further limit restenosis utilizing resveratrol and quercetin, polyphenols that are linked to the cardioprotection of red wine consumption. The present invention also provides products and methods for treating or preventing atherosclerosis, stenosis, restenosis, smooth muscle cell proliferation, platelet cell activation and other clotting mechanisms, occlusive disease, or other abnormal lumenal cellular proliferation condition in a location within the body of a patient.

4. 发明授权

US08936635B2 Bioresorbable nitric oxide agonist prodrug scaffolds for vascular stents 有权
标题翻译：用于血管支架的生物可再吸收一氧化氮激动剂前药支架
公开(公告)号：US08936635B2
公开(公告)日：2015-01-20
申请号：US13426948
申请日：2012-03-22
申请人： Wayne H Kaesemeyer
发明人： Wayne H Kaesemeyer
IPC分类号： A61F2/06 , A61L31/14 , A61L31/16
CPC分类号： A61L31/148 , A61L31/16 , A61L2300/422 , A61L2300/434
摘要： The present invention relates to a bioresorbable scaffold for a vascular stent comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone. The nitric oxide agonist is a statin or a HMG CoA reductase inhibitor. The nitric oxide agonist may be coated on the polymer, incorporated within the polymer or chemically bonded to the polymer. The invention also relates to a method for treating atherothrombosclerotic occlusive disease of an artery comprising implanting into the artery a stent with a bioresorbable scaffold comprising a nitric oxide agonist and a polymer comprising a lactide, a glycolide and a lactone, wherein the nitric oxide agonist is exuded from or released from the bioresorbable scaffold.
摘要翻译：本发明涉及包含一氧化氮激动剂和包含丙交酯，乙交酯和内酯的聚合物的血管支架的生物可再吸收支架。一氧化氮激动剂是他汀类或HMG辅酶A还原酶抑制剂。一氧化氮激动剂可以涂覆在聚合物上，并入聚合物中或化学键合到聚合物上。本发明还涉及用于治疗动脉粥样硬化性血管硬化闭塞性疾病的方法，其包括将包含一氧化氮激动剂的生物可再吸收支架和包含丙交酯，乙交酯和内酯的聚合物植入动脉内的支架，其中一氧化氮激动剂为从生物可吸收支架中渗出或释放。

5. 发明申请

US20140277398A1 DRUG DELIVERY DEVICE FOR PERIPHERAL ARTERY DISEASE 有权
标题翻译：用于外周动脉疾病的药物递送装置
公开(公告)号：US20140277398A1
公开(公告)日：2014-09-18
申请号：US13802098
申请日：2013-03-13
申请人： ABBOTT CARDIOVASCULAR SYSTEMS INC.
发明人： Yunbing Wang , James Oberhauser , Manish Gada
IPC分类号： A61F2/06
CPC分类号： A61F2/06 , A61L31/041 , A61L31/129 , A61L31/148 , A61L31/16 , A61L2300/422 , C08L67/04
摘要： A medical device implantable within a peripheral vessel of the body composed of a bioresorbable polymer is disclosed. The device has a high resistance to fracture, is very flexible, and has a high crush recovery when subjected to crushing, axial, or torsional forces.
摘要翻译：公开了一种可植入在由生物可再吸收的聚合物组成的身体的外周血管内的医疗装置。该装置具有高抗断裂性，非常柔软，并且当受到破碎，轴向或扭转力时具有高的压碎恢复性。

6. 发明申请

US20130095160A1 RESORBABLE POLYSTATIN BIOMATERIALS 审中-公开
标题翻译：可溶性聚苯乙烯生物材料
公开(公告)号：US20130095160A1
公开(公告)日：2013-04-18
申请号：US13612054
申请日：2012-09-12
申请人： Gautam S. Ghatnekar , Wayne H. Kaesemeyer
发明人： Gautam S. Ghatnekar , Wayne H. Kaesemeyer
IPC分类号： A61K31/765
CPC分类号： A61K31/765 , A61F2013/00221 , A61F2013/00927 , A61K9/0024 , A61K45/06 , A61K47/34 , A61K47/55 , A61K47/593 , A61K47/6957 , A61L31/041 , A61L31/06 , A61L31/10 , A61L2300/416 , A61L2300/422 , A61L2300/45 , A61L2300/60 , A61L2300/604 , A61L2420/06 , C08L67/04
摘要： Resorbable biomaterials including polystatin polymers and devices including the resorbable biomaterials are described. Methods of making the resorbable biomaterials and devices including resorbable biomaterials are also described.
摘要翻译：描述了包括聚合抑制剂聚合物和包括可再吸收的生物材料的装置的可吸收的生物材料。还描述了制备可再吸收的生物材料和包括可再吸收的生物材料的装置的方法。

7. 发明申请

US20130035755A1 MEDICAL DEVICE WITH COATING THAT PROMOTES ENDOTHELIAL CELL ADHERENCE 有权
公开(公告)号：US20130035755A1
公开(公告)日：2013-02-07
申请号：US13589907
申请日：2012-08-20
申请人： Michael John Bradley Kutryk , Robert John Cottone, JR. , Stephen Maxwell Rowland
发明人： Michael John Bradley Kutryk , Robert John Cottone, JR. , Stephen Maxwell Rowland
IPC分类号： A61F2/06
CPC分类号： A61L31/10 , A61F2/07 , A61F2/2412 , A61F2/82 , A61K38/363 , A61K38/39 , A61K39/39558 , A61L27/08 , A61L27/227 , A61L27/303 , A61L27/44 , A61L27/54 , A61L29/103 , A61L29/126 , A61L29/16 , A61L31/022 , A61L31/047 , A61L31/084 , A61L31/125 , A61L31/148 , A61L31/16 , A61L2300/256 , A61L2300/416 , A61L2300/422 , A61L2300/432 , A61L2300/606 , A61L2420/04 , B82Y30/00 , C07K16/2896 , C07K2317/55 , C12N5/0692 , C12N2510/00 , A61K2300/00
摘要： The invention relates to a method for healing blood vessels by stimulating the formation of a confluent endothelial autologous cell layer in vivo on an implantable metallic stent having a lumen and a luminal surface, and an exterior surface. More specifically, the method includes implanting the stent with a coating in a patient in need of thereof; wherein the coating includes one or more layers of a matrix covalently adherent on said luminal and exterior surface of said stent containing one or more pharmaceutical substances on said exterior surface and a therapeutically effective amount of a single type of antibody, antibody fragments or combinations thereof being compatible to binding selectively to a specific cell surface antigen of circulating autologous endothelial progenitor cells in peripheral blood. In addition, genetically engineered endothelial progenitor cells can be captured on said luminal surface of stent in vivo, to proliferate to form rapidly a confluent endothelium in situ.

8. 发明申请

US20090311301A1 COATING CONSTRUCT CONTAINING POLY(VINYL ALCOHOL) 有权
标题翻译：包含聚（乙烯醇）的涂料结构
公开(公告)号：US20090311301A1
公开(公告)日：2009-12-17
申请号：US12546534
申请日：2009-08-24
申请人： LOTHAR W. KLEINER , Jessica Reneé DesNoyer , Thierry Glauser , Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy
发明人： LOTHAR W. KLEINER , Jessica Reneé DesNoyer , Thierry Glauser , Stephen D. Pacetti , Syed Faiyaz Ahmed Hossainy
IPC分类号： A61L27/54
CPC分类号： A61L31/16 , A61L31/10 , A61L2300/416 , A61L2300/422 , A61L2300/606 , Y10T428/265 , Y10T428/31855 , Y10T428/31935 , Y10T428/31938 , C08L29/04
摘要： A method of forming a surface layer that includes a hydroxyl polymer on a substrate coating on a medical device is provided.
摘要翻译：提供了一种在医疗装置上的基底涂层上形成包含羟基聚合物的表面层的方法。

9. 发明申请

US20050287184A1 Drug-delivery stent formulations for restenosis and vulnerable plaque 审中-公开
标题翻译：用于再狭窄和易损斑块的药物输送支架制剂
公开(公告)号：US20050287184A1
公开(公告)日：2005-12-29
申请号：US10881540
申请日：2004-06-29
申请人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
发明人： Syed Hossainy , Gordon Stewart , Deborah Kilpatrick , Jeffrey Ellis , Gene Park , Gina Zhang , Paul Consigny , Yiwen Tang
IPC分类号： A61K31/4745 , A61K31/56 , A61L31/10 , A61L31/16
CPC分类号： A61L31/10 , A61L31/16 , A61L2300/222 , A61L2300/416 , A61L2300/422 , A61L2300/43 , A61L2300/45
摘要： Drug-delivery stents capable of providing release of two or more drugs such as everolimus and estradiol are provided. The stents can be used for treating a disease such as restenosis and vulnerable plaque.
摘要翻译：提供能够释放两种或更多种药物如依维莫司和雌二醇的药物递送支架。支架可用于治疗诸如再狭窄和易损斑块的疾病。

10. 发明申请

US20050220836A1 Drug delivery device 审中-公开
标题翻译：给药装置
公开(公告)号：US20050220836A1
公开(公告)日：2005-10-06
申请号：US10813976
申请日：2004-03-31
申请人： Robert Falotico , Theresa Scheuble , Gregory Kopia
发明人： Robert Falotico , Theresa Scheuble , Gregory Kopia
IPC分类号： A61K45/00 , A61F2/00 , A61F2/82 , A61F2/84 , A61K31/436 , A61K31/4745 , A61K31/573 , A61L27/34 , A61L27/54 , A61L29/08 , A61L29/16 , A61L31/10 , A61L31/16 , A61M29/00 , A61M29/02 , A61M31/00 , A61M37/00 , A61P9/10
CPC分类号： A61L31/16 , A61L29/16 , A61L31/10 , A61L2300/41 , A61L2300/416 , A61L2300/42 , A61L2300/422 , C08L27/16
摘要： Medical devices, and in particular implantable medical devices, may be coated to minimize or substantially eliminate a biological organism's reaction to the introduction of the medical device to the organism. The medical devices may be coated with any number of biocompatible materials. Therapeutic drugs, agents or compounds may be mixed with the biocompatible materials and affixed to at least a portion of the medical device. These therapeutic drugs, agents or compounds may also further reduce a biological organism's reaction to the introduction of the medical device to the organism. In addition, these therapeutic drugs, agents and/or compounds may be utilized to promote healing, including the formation of blood clots. Therapeutic agents may also be delivered to the region of a disease site. Also, the devices may be modified to promote endothelialization. Various materials and coating methodologies may be utilized to maintain the drugs, agents or compounds on the medical device until delivered and positioned. In addition, the devices utilized to deliver the implantable medical devices may be modified to reduce the potential for damaging the implantable medical device during deployment. Medical devices include stents, grafts, anastomotic devices, perivascular wraps, sutures and staples. In addition, various polymer combinations may be utilized to control the elution rates of the therapeutic drugs, agents and/or compounds from the implantable medical devices.
摘要翻译：可以涂覆医疗装置，特别是可植入医疗装置，以最小化或基本上消除生物体对将生物体引入医疗装置的反应。医疗装置可以涂覆任何数量的生物相容性材料。治疗药物，药剂或化合物可以与生物相容性材料混合并固定在医疗装置的至少一部分上。这些治疗药物，药剂或化合物还可以进一步减少生物体对将生物体引入医疗装置的反应。此外，这些治疗药物，药剂和/或化合物可用于促进愈合，包括血块的形成。治疗剂也可以递送到疾病部位的区域。此外，可以修改装置以促进内皮化。可以使用各种材料和涂覆方法来将药物，试剂或化合物维持在医疗装置上，直到输送和定位。此外，可以修改用于递送可植入医疗装置的装置，以减少在展开期间损害可植入医疗装置的可能性。医疗器械包括支架，移植物，吻合装置，血管周围包裹物，缝线和钉。此外，可以使用各种聚合物组合来控制来自可植入医疗装置的治疗药物，药剂和/或化合物的洗脱速率。

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