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1. 发明授权

US09713654B2 Bone cement composition 有权
公开(公告)号：US09713654B2
公开(公告)日：2017-07-25
申请号：US14381922
申请日：2013-02-25
申请人： Ishihara Sangyo Kaisha, Ltd. , Kyoto University
发明人： Yoshimichi Ueda
IPC分类号： A61K9/16 , A61L24/00 , A61L27/44 , A61L27/50 , A61L24/06
CPC分类号： A61L24/001 , A61L24/0089 , A61L27/446 , A61L27/50 , A61L2430/02 , C08L33/10
摘要： The purpose of the present invention is to provide a bone cement composition which can have desired biological activity performance and desired radiolucency while enabling the strength of a cured product thereof to be kept. A titanium oxide coating is formed on radiolucent particles to thereby produce composite particles, and the composite particles are added to a bone cement composition. The bone cement composition thus produced can be used suitably for the filling of a bone defect portion and the fixation of an artificial joint and in percutaneous vertebroplasty. The shape of each of the radiolucent particles is preferably granular, and the titanium oxide is preferably of a rutile type.

2. 发明申请

US20170143869A1 Collagen Sponge Containing a Drug for Promoting Fracture Healing and Method for Preparing the Same 审中-公开
公开(公告)号：US20170143869A1
公开(公告)日：2017-05-25
申请号：US15307230
申请日：2015-12-17
申请人： WUHAN VSD MEDICAL SCIENCE & TECHNOLOGY CO., LTD.
发明人： Yansong Liu , Zhidao Xia , Hongxia Guan , Yingze Zhang
IPC分类号： A61L24/00
CPC分类号： A61L24/0036 , A61L24/0015 , A61L24/0084 , A61L24/0089 , A61L27/24 , A61L27/54 , A61L27/56 , A61L2300/102 , A61L2300/112 , A61L2300/412 , A61L2430/02
摘要： Provided are a collagen sponge containing a drug for promoting fracture healing and a method for preparing the same, the method comprises the steps of: 1) adding bisphosphonate containing phosphonate radical in an equivalent dosage of 70 to 140 mg and/or strontium salt in a dosage of 100 to 800 mg into 1 kg of the enzymolysis solution of collagen; 2) adding a crosslinking agent into the solution, the crosslinking agent being added in a proportion where 40 to 60 U of crosslinking agent is added per gram of enzymolysis solution; 3) stirring the mixed solution in step 2) uniformly, then putting it into a stainless steel tray, and placing the tray in a vacuum lyophilizer for lyophilizing for 10 to 16 hours so that it is lyophilized into a sponge-like shape; and 4) allowing the collagen sponge in step 3) to be cut, packaged and sealed, and sterilized by irradiation with cobalt 60.

3. 发明授权

US09044580B2 In-situ forming foams with outer layer 有权
标题翻译：外层原位成型泡沫
公开(公告)号：US09044580B2
公开(公告)日：2015-06-02
申请号：US13815910
申请日：2013-03-15
申请人： Arsenal Medical, Inc.
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号： A61F2/02 , A61M37/00 , A61L31/06 , A61L31/12 , A61L31/14 , A61L24/00 , A61L24/04 , A61F2/07 , A61B17/12 , A61J1/20 , A61F2/06
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译：公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。

4. 发明申请

US20150056289A1 BONE CEMENT COMPOSITION 有权
标题翻译：骨水泥组合物
公开(公告)号：US20150056289A1
公开(公告)日：2015-02-26
申请号：US14381922
申请日：2013-02-25
申请人： Ishihara Sangyo Kaisha, Ltd. , Kyoto University
发明人： Yoshimichi Ueda
IPC分类号： A61L24/00
CPC分类号： A61L24/001 , A61L24/0089 , A61L27/446 , A61L27/50 , A61L2430/02 , C08L33/10
摘要： The purpose of the present invention is to provide a bone cement composition which can have desired biological activity performance and desired radiolucency while enabling the strength of a cured product thereof to be kept. A titanium oxide coating is formed on radiolucent particles to thereby produce composite particles, and the composite particles are added to a bone cement composition. The bone cement composition thus produced can be used suitably for the filling of a bone defect portion and the fixation of an artificial joint and in percutaneous vertebroplasty. The shape of each of the radiolucent particles is preferably granular, and the titanium oxide is preferably of a rutile type.
摘要翻译：本发明的目的是提供一种骨水泥组合物，其可以具有期望的生物活性性能和期望的放射性能，同时能够保持其固化产物的强度。在射线可透过性粒子上形成氧化钛被膜，从而制造复合粒子，将复合粒子添加到骨水泥组合物中。如此生产的骨水泥组合物可适用于骨缺损部分的填充和人造关节的固定以及经皮椎体成形术。每个射线可透微粒子的形状优选为粒状，氧化钛优选为金红石型。

5. 发明申请

US20140031450A1 BONE TREATMENT SYSTEMS AND METHODS 有权
标题翻译：骨治疗系统和方法
公开(公告)号：US20140031450A1
公开(公告)日：2014-01-30
申请号：US13921479
申请日：2013-06-19
申请人： DFINE, INC.
发明人： Csaba Truckai , Andrew Kohm , John Shadduck , Robert Luzzi
IPC分类号： A61K31/78
CPC分类号： A61L24/0094 , A61B17/7095 , A61B17/8822 , A61B17/8833 , A61B17/8836 , A61B2017/00022 , A61K31/78 , A61L24/001 , A61L24/0084 , A61L24/0089 , A61L24/06 , A61L27/46 , A61L27/50 , A61L2400/06 , A61L2430/02 , C08L33/12
摘要： The present disclosure relates to bone cement formulations that have an extended working time for use in vertebroplasty procedures and other osteoplasty procedures together with cement injectors that include energy delivery systems for on-demand control of cement viscosity and flow parameters. The bone cement formulations may include a liquid component having at least one monomer and a non-liquid component including polymer particles and benzoyl peroxide (BPO). The non-liquid component may be further configured to allow controlled exposure of the BPO to the liquid monomer so as to enable control of the viscosity of the bone cement composition.
摘要翻译：本公开内容涉及具有用于椎体成形术程序和其它骨成形术程序的延长工作时间的骨水泥制剂以及水泥注射器，其包括用于按需控制水泥粘度和流动参数的能量输送系统。骨水泥制剂可以包括具有至少一种单体和包含聚合物颗粒和过氧化苯甲酰（BPO））的非液体组分的液体组分。非液体组分可以进一步构造成允许BPO受控地暴露于液体单体，以便能够控制骨水泥组合物的粘度。

6. 发明申请

US20130317418A1 In-situ Forming foams with outer layer 有权
标题翻译：外层原位成型泡沫
公开(公告)号：US20130317418A1
公开(公告)日：2013-11-28
申请号：US13815910
申请日：2013-03-15
申请人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
发明人： Toby Freyman , Joseph Lomakin , John Marini , Jennifer Mortensen , Adam Rago , Rany Busold , Upma Sharma , Gregory T. Zugates
IPC分类号： A61M37/00
CPC分类号： A61B17/12181 , A61B17/12113 , A61B17/12118 , A61B17/1214 , A61B2017/1205 , A61F2/07 , A61F2002/065 , A61F2002/077 , A61F2210/0085 , A61J1/2093 , A61L24/0036 , A61L24/0089 , A61L24/046 , A61L31/06 , A61L31/128 , A61L31/146 , A61L2300/60 , A61L2400/06 , A61M37/00 , C08L67/04 , C08L83/04
摘要： Systems, methods and kits relating to in-situ forming polymer foams for the treatment of aneurysms or fluid filled spaces are disclosed. The systems include an insertable medical device and an in-situ forming foam of lava like materials with a fast forming outer skin and a slower hardening interior that is formed from a one-, two- or multi-part formulation. When used to treat an aneurysm, the foam is placed into contact with at least a portion of an exterior surface of the medical device and/or the tissue surface of the aneurysm.
摘要翻译：公开了与原位形成聚合物泡沫相关的用于治疗动脉瘤或填充液体的空间的系统，方法和试剂盒。这些系统包括可插入的医疗装置和具有快速成形外皮的熔岩状材料的原位成形泡沫体，以及由一部分，两部分或多部分制剂形成的较慢的硬化内部。当用于治疗动脉瘤时，将泡沫放置成与医疗装置的外表面的至少一部分和/或动脉瘤的组织表面接触。

7. 发明申请

US20130209526A1 Flexible Bone Composite 有权
标题翻译：柔性骨复合材料
公开(公告)号：US20130209526A1
公开(公告)日：2013-08-15
申请号：US13838629
申请日：2013-03-15
申请人： SYNTHES USA, LLC
发明人： Sean Kerr , James W. Dwyer
IPC分类号： A61L27/50
CPC分类号： A61L27/50 , A61F2/28 , A61F2/30767 , A61F2002/2817 , A61F2002/30062 , A61F2002/30064 , A61F2002/30113 , A61F2002/30153 , A61F2002/30293 , A61F2002/30677 , A61F2002/30769 , A61F2002/30785 , A61F2002/30971 , A61F2210/0004 , A61F2230/0006 , A61F2230/0019 , A61F2230/0091 , A61F2310/00293 , A61F2310/00796 , A61L24/0089 , A61L27/46 , A61L2430/02
摘要： The present invention relates in general to implantable flexible bone composites, and method for preparing the same. The flexible bone composite includes at least one polymeric layer and at least one calcium-containing layer. The polymeric layer can be a polymeric layer including a synthetic polymer. The calcium-containing layer can include a calcium compound such as β-Ca3(PO4)2. The flexible bone composites of the invention are useful as bone void fillers and have improved handling characteristics.
摘要翻译：本发明一般涉及可植入的柔性骨组合物及其制备方法。柔性骨复合材料包括至少一个聚合物层和至少一个含钙层。聚合物层可以是包含合成聚合物的聚合物层。含钙层可以包括钙化合物如β-Ca 3（PO 4）2。本发明的柔性骨复合材料可用作骨隙填料并且具有改进的处理特性。

8. 发明授权

US08414930B2 Surgical calcium phosphate citrate-containing cement and method of manufacturing the same 有权
标题翻译：手术中含磷酸钙的柠檬酸钙水泥及其制造方法相同
公开(公告)号：US08414930B2
公开(公告)日：2013-04-09
申请号：US13004560
申请日：2011-01-11
申请人： Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Kehsin Chien
发明人： Sung-Tsuen Liu , Sung-Ching Chen , Hui-Chun Lai , Kehsin Chien
IPC分类号： C04B35/00
CPC分类号： A61L24/0084 , A61L24/0015 , A61L24/0042 , A61L24/0089
摘要： The present invention discloses a surgical cement and a manufacturing method thereof. The surgical cement comprises a cementing component selected form the group of a basic calcium phosphate consisting of tetracalcium phosphate, alpha-tricalcium phosphate, decomposed hydroxyapatite, or a combination thereof; a setting reagent selected form the group of an acidic calcium citrate consisting of monocalcium citrate, dicalcium citrate, or a combination thereof; and water; wherein a weight ratio of the cementing component and the setting reagent ranges from about 1:1 to about 8:1. The surgical cement is bioresorbable and bioactive and is useful in orthopedic, maxillofacial and dental applications. In addition, the surgical cement of this invention has a good flow character and a relatively short setting time.
摘要翻译：本发明公开了一种外科手术水泥及其制造方法。手术水泥包括选自由磷酸四钙，磷酸α-磷酸三钙，分解羟基磷灰石或其组合组成的碱性磷酸钙组的粘合组分; 选自柠檬酸一柠檬酸钙，柠檬酸二钙或其组合的酸性柠檬酸钙组的凝固试剂; 和水; 其中所述粘合组分和凝固剂的重量比范围为约1:1至约8:1。手术水泥是生物可再吸收和生物活性的，可用于矫形，颌面和牙科应用。此外，本发明的外科手术水泥具有良好的流动特性和较短的凝固时间。

9. 发明申请

US20120195848A1 STRONTIUM-CONTAINING BIOACTIVE BONE CEMENT 审中-公开
标题翻译：含锶生物骨水泥
公开(公告)号：US20120195848A1
公开(公告)日：2012-08-02
申请号：US13326760
申请日：2011-12-15
申请人： William Weijia Lu , Raymond Wing Moon Lam , Keith Dip-Kei Luk , Zhao Yang Li
发明人： William Weijia Lu , Raymond Wing Moon Lam , Keith Dip-Kei Luk , Zhao Yang Li
IPC分类号： A61L24/04 , A61L24/06
CPC分类号： A61L24/0089 , A61L27/446 , A61L2430/02
摘要： The present invention provides bioactive bone cements that not only have sufficient radiopacity, low physiological toxicity, and requisite mechanism strength, but also promote local bone in-growth. The bone cement utilizes strontium salts as radiopacifiers, and comprises a powder component and a liquid component. In an embodiment, the powder component comprises a strontium salt, poly(methyl methacrylate) (PMMA), and a polymerization initiator; and the liquid component comprises methyl methacrylate (MMA) as reactive monomers and a polymerization accelerator.
摘要翻译：本发明提供生物活性骨水泥，其不仅具有足够的射线不透性，低生理毒性和必要的机制强度，而且还促进局部骨生长。骨水泥利用锶盐作为放射性填充剂，并且包含粉末组分和液体组分。在一个实施方案中，粉末组分包括锶盐，聚（甲基丙烯酸甲酯）（PMMA）和聚合引发剂; 并且液体组分包含作为反应性单体的甲基丙烯酸甲酯（MMA）和聚合促进剂。

10. 发明申请

US20110300194A1 Flexible Bone Composite 有权
标题翻译：柔性骨复合材料
公开(公告)号：US20110300194A1
公开(公告)日：2011-12-08
申请号：US13208837
申请日：2011-08-12
申请人： Sean Kerr , James W. Dwyer
发明人： Sean Kerr , James W. Dwyer
IPC分类号： A61K9/00 , B05D3/10 , A61P19/00
CPC分类号： A61L27/50 , A61F2/28 , A61F2/30767 , A61F2002/2817 , A61F2002/30062 , A61F2002/30064 , A61F2002/30113 , A61F2002/30153 , A61F2002/30293 , A61F2002/30677 , A61F2002/30769 , A61F2002/30785 , A61F2002/30971 , A61F2210/0004 , A61F2230/0006 , A61F2230/0019 , A61F2230/0091 , A61F2310/00293 , A61F2310/00796 , A61L24/0089 , A61L27/46 , A61L2430/02
摘要： The present invention relates in general to implantable flexible bone composites, and method for preparing the same. The flexible bone composite includes at least one polymeric layer and at least one calcium-containing layer. The polymeric layer can be a polymeric layer including a synthetic polymer. The calcium-containing layer can include a calcium compound such as β-Ca3(PO4)2. The flexible bone composites of the invention are useful as bone void fillers and have improved handling characteristics.
摘要翻译：本发明一般涉及可植入的柔性骨组合物及其制备方法。柔性骨复合材料包括至少一个聚合物层和至少一个含钙层。聚合物层可以是包含合成聚合物的聚合物层。含钙层可以包括钙化合物，例如-Ca 3（PO 4）2。本发明的柔性骨复合材料可用作骨隙填料并且具有改进的处理特性。

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