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1. 发明公开

US20240285836A1 HEMODIALYSIS SYSTEM INCLUDING A DISPOSABLE SET AND A DIALYSIS INSTRUMENT 审中-公开
公开(公告)号：US20240285836A1
公开(公告)日：2024-08-29
申请号：US18656202
申请日：2024-05-06
申请人： BAXTER INTERNATIONAL INC. , BAXTER HEALTHCARE SA
发明人： Robert W. CHILDERS , Thomas D. KELLY , Rodolfo G. ROGER
IPC分类号： A61M1/16 , A61M1/14 , A61M1/28 , A61M1/34 , A61M1/36 , B01D61/24 , B01D61/30
CPC分类号： A61M1/16 , A61M1/14 , A61M1/153 , A61M1/155 , A61M1/1561 , A61M1/15625 , A61M1/1565 , A61M1/1601 , A61M1/1605 , A61M1/1621 , A61M1/1649 , A61M1/166 , A61M1/168 , A61M1/1686 , A61M1/1688 , A61M1/28 , A61M1/281 , A61M1/3465 , A61M1/36225 , A61M1/362261 , A61M1/362265 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3652 , B01D61/243 , B01D61/244 , B01D61/30 , A61M1/1524 , A61M1/362227 , A61M1/362262 , A61M2205/128 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3379 , A61M2205/6036 , Y10T29/49826 , Y10T137/0396 , Y10T137/87893
摘要： A hemodialysis system is disclosed. The hemodialysis system includes a dialyzer and an online dialysate generation system comprising a water inlet line and a drain line. The hemodialysis system also includes a disposable set comprising a supply tube fluidly connected to online dialysate generation system and a dialysate pumping tube fluidly connected to the dialyzer. The hemodialysis system further includes a dialysis instrument comprising a dialysate pump head and a motor positioned and arranged to operate the dialysate pump head. The dialysis instrument operates the dialysate pump head to move fresh dialysate from the online dialysate generation system through the dialysate pumping tube to the dialyzer.

2. 发明授权

US10010663B2 Fluid circuit for delivery of renal replacement therapies 有权
公开(公告)号：US10010663B2
公开(公告)日：2018-07-03
申请号：US13757693
申请日：2013-02-01
申请人： Medtronic, Inc.
发明人： Thomas E. Meyer , David B. Lura , Bryant J. Pudil , Martin T. Gerber
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36
CPC分类号： A61M1/1621 , A61M1/1601 , A61M1/1652 , A61M1/1656 , A61M1/1658 , A61M1/1664 , A61M1/1668 , A61M1/3465 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3649
摘要： A flow loop for hemodialysis, hemodiafiltration and hemofiltration for the treatment of pathological conditions such as End Stage Renal Disease (ESRD) that has a controlled compliant flow path for preparing fluids required for a hemodialysis therapy session from water. The controlled compliant flow path modifies water into any one of a solution for priming a hemodialysis system, a physiologically compatible solution for contacting blood, a physiologically compatible solution for infusion to a subject, and a solution for blood rinse back to a subject. The controlled compliant flow path has a means for selectively metering in and metering out fluid from the flow path.

3. 发明授权

US09968725B2 Priming system and method of dialysis systems 有权
公开(公告)号：US09968725B2
公开(公告)日：2018-05-15
申请号：US15044194
申请日：2016-02-16
申请人： Fresenius Medical Care Holdings, Inc.
发明人： Barry Neil Fulkerson , Martin Hering , Frank Isackson
IPC分类号： A61M1/36 , A61M1/34 , A61M1/16
CPC分类号： A61M1/3643 , A61M1/16 , A61M1/1696 , A61M1/342 , A61M1/3437 , A61M1/3465 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3672 , A61M2205/128 , A61M2205/3324 , A61M2205/3331 , A61M2205/3368 , A61M2205/3372 , Y10T137/0491
摘要： The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment.

4. 发明授权

US09925321B2 Apparatus for extracorporeal blood treatment 有权
公开(公告)号：US09925321B2
公开(公告)日：2018-03-27
申请号：US14654066
申请日：2013-12-16
申请人： GAMBRO LUNDIA AB
发明人： Alessandro Surace , Paolo Rovatti
IPC分类号： A61M1/16 , A61M1/34 , A61M1/36
CPC分类号： A61M1/1613 , A61M1/16 , A61M1/1603 , A61M1/1605 , A61M1/1611 , A61M1/34 , A61M1/3403 , A61M1/341 , A61M1/342 , A61M1/3434 , A61M1/3437 , A61M1/3441 , A61M1/3462 , A61M1/3465 , A61M1/36 , A61M1/3607 , A61M2205/3303 , A61M2205/3317 , A61M2205/3324 , A61M2205/3331 , A61M2205/3334 , A61M2205/3379 , A61M2205/3393 , A61M2205/502 , A61M2230/20 , A61M2230/65
摘要： It is disclosed an apparatus for extracorporeal blood treatment (1) having a control unit (15) connected to an ultrafiltration device (20) and to a fluid preparation section (30) of fresh dialysis liquid. The control unit (15) is configured to receive measured values of the change of blood volume, the amount of ultrafiltration volume, and conductivity or to the concentration for at least one substance in the blood (BV %mes(t); UFmes(t), WLmes(t); Cbmes(t)); the control unit (15) is also configured to receive prescription values for the same parameters and to control ultrafiltration and adjust conductivity in the fresh dialysis liquid based on the difference between said measured values and said prescription values.

5. 发明授权

US09855377B2 Dialysis system including heparin injection 有权
公开(公告)号：US09855377B2
公开(公告)日：2018-01-02
申请号：US14594349
申请日：2015-01-12
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Robert W. Childers , Thomas D. Kelly , Rodolfo Roger
IPC分类号： A61M1/16 , A61M1/28 , A61M1/34 , A61M1/36 , B01D61/30
CPC分类号： A61M1/16 , A61M1/14 , A61M1/1601 , A61M1/1605 , A61M1/1621 , A61M1/1649 , A61M1/166 , A61M1/168 , A61M1/1686 , A61M1/1688 , A61M1/28 , A61M1/281 , A61M1/3465 , A61M1/3643 , A61M1/3644 , A61M1/3649 , A61M1/3652 , A61M2205/128 , A61M2205/3313 , A61M2205/3331 , A61M2205/3334 , A61M2205/3344 , A61M2205/3379 , A61M2205/6036 , B01D61/243 , B01D61/30 , Y10T29/49826 , Y10T137/0396 , Y10T137/87893
摘要： A dialysis system includes a dialysis instrument including a blood pump actuator, a dialyzer, a heparin pump, and a disposable cassette including a blood pumping portion operable with the blood pump actuator of the dialysis instrument, the blood pumping portion including an inlet and an outlet, the inlet of the blood pumping portion of the disposable cassette positioned and arranged to receive blood from an arterial line of an extracorporeal circuit, the outlet of the blood pumping portion of the disposable cassette positioned and arranged to deliver the blood to the dialyzer and to receive heparin from the heparin pump.

6. 发明申请

US20160310655A1 Apparatus for Extracorporeal Blood Treatment and Method for Operating An Extracorporeal Blood Treatment Apparatus 审中-公开
标题翻译：用于体外血液处理的装置和用于操作体外血液处理装置的方法
公开(公告)号：US20160310655A1
公开(公告)日：2016-10-27
申请号：US15104140
申请日：2014-12-02
申请人： FRESENIUS MEDICAL CARE DEUTSCHLAND GMBH
发明人： Christoph Wiktor , Arne Peters
IPC分类号： A61M1/34 , A61M1/16
CPC分类号： A61M1/3427 , A61M1/16 , A61M1/1601 , A61M1/1635 , A61M1/165 , A61M1/1672 , A61M1/342 , A61M1/3465 , A61M2205/50 , A61M2205/7554
摘要： A device for extracorporeal blood treatment and a method for operating an extracorporeal blood treatment device provide for an ultrafiltrate pump of an ultrafiltration apparatus to be operated in a first and second operating mode. The ultrafiltrate pump is operated in the first operating mode in such a way that the pressure on the blood-side of the semipermeable membrane is higher than the pressure on the dialysate-side of the semipermeable membrane of a dialyser, so that during the first operating mode a predetermined amount of fluid is removed from an extracorporeal blood circuit via the semipermeable membrane of the dialyser. In the second operating mode, the ultrafiltrate pump is operated in such a way that the pressure on the blood-side of the semipermeable membrane is, at successive intervals, alternately higher and lower than the pressure on the dialysate-side of the semipermeable membrane of the dialyser, so that fluid is continuously removed from and supplied to the extracorporeal blood circuit via the semipermeable membrane (push/pull mode). Additional components, in particular a separate push/pull pump, are not required for operation of the blood treatment device in push/pull mode. This results in both lower dimensions and lower weight. Operation in push/pull mode can increase the service life of the dialyser and the clearance of the dialysis treatment can also be increased for certain substances.
摘要翻译：用于体外血液处理的装置和用于操作体外血液处理装置的方法提供超滤装置的超滤泵，以在第一和第二操作模式下操作。超滤液泵以第一操作模式操作，使得半透膜的血液侧的压力高于透析器的半透膜的透析液侧的压力，使得在第一次操作期间通过透析器的半透膜从体外血液回路去除预定量的流体。在第二操作模式中，超滤泵以这样的方式操作，使得半透膜的血液侧的压力以连续的间隔交替地高于和低于半透膜的透析液侧的压力透析器，使得流体经由半透膜（推/拉模式）连续地从体外血液回路中提取并提供给体外血液回路。在推/拉模式下，不需要额外的部件，特别是单独的推/拉泵来操作血液处理装置。这导致了较小的尺寸和较低的重量。推/拉模式的操作可以增加透析器的使用寿命，同时也可以增加某些物质的透析处理清除率。

7. 发明申请

US20160106901A1 RENAL FAILURE THERAPY MACHINES AND METHODS INCLUDING CONVECTIVE AND DIFFUSIVE CLEARANCE 有权
标题翻译：肾衰竭治疗机制及方法，包括有针对性和差异性的清除
公开(公告)号：US20160106901A1
公开(公告)日：2016-04-21
申请号：US14976773
申请日：2015-12-21
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Thomas Kelly , Robert W. Childers , Don Busby , Rodolfo Roger , Waleed Musalem El Sayyid , Shahid Din
IPC分类号： A61M1/16 , A61M1/34
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1037 , A61M1/1039 , A61M1/1062 , A61M1/1081 , A61M1/1086 , A61M1/16 , A61M1/1601 , A61M1/1607 , A61M1/1613 , A61M1/1621 , A61M1/1629 , A61M1/1633 , A61M1/1635 , A61M1/1656 , A61M1/166 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/288 , A61M1/341 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3451 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/3472 , A61M1/3486 , A61M1/3624 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M2202/0413 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/276 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2205/3331 , A61M2205/3334 , A61M2205/3337 , A61M2205/3344 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/75
摘要： A renal failure therapy machine includes a blood cleaning filter, a sorbent device configured to regenerate used therapy fluid from the blood cleaning filter, a therapy fluid pump configured to pump regenerated therapy fluid from the sorbent device back to the blood cleaning filter, and a flow restrictor in fluid communication with the blood cleaning filter, the therapy fluid pump and the sorbent device, the flow restrictor configured to cause regenerated therapy fluid pumped by the therapy fluid pump from the sorbent device to the blood cleaning filter to be pressurized so that a first amount of the regenerated therapy fluid performs convective clearance and a second amount of the regenerated therapy fluid performs diffusive clearance.
摘要翻译：肾衰竭治疗机包括血液清洁过滤器，被配置为从血液清洁过滤器再生使用的治疗流体的吸附剂装置，被配置为将再生的治疗流体从吸附装置泵回到血液净化过滤器的治疗液泵，与血液净化过滤器，治疗流体泵和吸附剂装置流体连通的限流器，流量限制器构造成使由治疗流体泵从吸附装置泵送到血液净化过滤器的再生治疗液被加压，使得第一再生治疗液的量进行对流清除，第二量的再生治疗液进行扩散间隙。

8. 发明授权

US09302039B2 Hemodialysis system including a disposable cassette 有权
标题翻译：血液透析系统包括一次性盒式磁带
公开(公告)号：US09302039B2
公开(公告)日：2016-04-05
申请号：US14549818
申请日：2014-11-21
申请人： Baxter International Inc. , Baxter Healthcare S.A.
发明人： Thomas Kelly , Robert W. Childers , Don Busby , Rodolfo Roger , Waleed Mutasem El Sayyid , Shahid Din
IPC分类号： A61M37/00 , A61M1/16 , A61M1/34 , A61M1/36 , A61M1/28
CPC分类号： A61M1/3621 , A61M1/1006 , A61M1/101 , A61M1/1012 , A61M1/1037 , A61M1/1039 , A61M1/1062 , A61M1/1081 , A61M1/1086 , A61M1/16 , A61M1/1601 , A61M1/1607 , A61M1/1613 , A61M1/1621 , A61M1/1629 , A61M1/1633 , A61M1/1635 , A61M1/1656 , A61M1/166 , A61M1/1668 , A61M1/167 , A61M1/1672 , A61M1/1696 , A61M1/267 , A61M1/288 , A61M1/341 , A61M1/3417 , A61M1/342 , A61M1/3427 , A61M1/3431 , A61M1/3434 , A61M1/3437 , A61M1/3444 , A61M1/3451 , A61M1/3458 , A61M1/3465 , A61M1/3468 , A61M1/3472 , A61M1/3486 , A61M1/3624 , A61M1/3626 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3656 , A61M2202/0413 , A61M2205/12 , A61M2205/13 , A61M2205/15 , A61M2205/18 , A61M2205/276 , A61M2205/3317 , A61M2205/3324 , A61M2205/3327 , A61M2205/3331 , A61M2205/3334 , A61M2205/3337 , A61M2205/3344 , A61M2205/3368 , A61M2205/3379 , A61M2205/3393 , A61M2205/3553 , A61M2205/3561 , A61M2205/3584 , A61M2205/502 , A61M2205/505 , A61M2205/52 , A61M2205/75
摘要： A dialysis system includes a dialyzer, a sorbent cartridge configured to clean used dialysate from the dialyzer, a dialysate pump actuator configured to pump dialysate to the dialyzer, and a conductivity sensor located adjacent to a temperature sensor. The dialysis system also includes a disposable cassette configured to carry dialysate pumped by the dialysate pump actuator. The disposable cassette includes a combined conductivity and temperature sensor fluid chamber separate from the conductivity sensor and the temperature sensor and located so as to operate with the conductivity sensor and the temperature sensor, respectively, when mounted for operation.
摘要翻译：透析系统包括透析器，配置成从透析器清洁用过的透析液的吸附剂盒，配置成将透析液泵送到透析器的透析泵致动器，以及位于温度传感器附近的电导率传感器。透析系统还包括被配置为承载由透析泵致动器泵送的透析液的一次性盒。一次性盒包括与电导率传感器和温度传感器分离的组合的电导率和温度传感器流体室，并分别安装在操作时，与电导率传感器和温度传感器一起工作。

9. 发明授权

US09295772B2 Priming system and method for dialysis systems 有权
标题翻译：透析系统和方法
公开(公告)号：US09295772B2
公开(公告)日：2016-03-29
申请号：US13372202
申请日：2012-02-13
申请人： Barry Neil Fulkerson , Martin Hering , Frank Isackson
发明人： Barry Neil Fulkerson , Martin Hering , Frank Isackson
IPC分类号： A61M1/16 , A61M1/36 , A61M1/34
CPC分类号： A61M1/3643 , A61M1/16 , A61M1/1696 , A61M1/342 , A61M1/3437 , A61M1/3465 , A61M1/3644 , A61M1/3646 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M1/3652 , A61M1/3672 , A61M2205/128 , A61M2205/3324 , A61M2205/3331 , A61M2205/3368 , A61M2205/3372 , Y10T137/0491
摘要： The application is directed to an extracorporeal blood processing system capable of using dialysate to prime the system. A plastic molded compact manifold supports molded blood and dialysate fluidic pathways along with relevant sensors, valves and pumps. The compact manifold is also disposable in one embodiment and can be detachably installed in the dialysis machine. A two-way valve in the manifold is used to direct the dialysate flow through the blood circuit to prime the circuit for use in treatment.
摘要翻译：该应用针对能够使用透析液来引导系统的体外血液处理系统。塑料成型紧凑型歧管支持模制血液和透析液流通路以及相关的传感器，阀门和泵。紧凑型歧管在一个实施例中也是一次性的，并且可以可拆卸地安装在透析机中。歧管中的二通阀用于引导透析液流经血液循环以引导电路用于治疗。

10. 发明授权

US09233196B2 Method for pre-filling a hemodialysis apparatus 有权
标题翻译：预先填充血液透析装置的方法
公开(公告)号：US09233196B2
公开(公告)日：2016-01-12
申请号：US13889372
申请日：2013-05-08
申请人： D—MED CONSULTING AG
发明人： Gerd Breuch , Frank Biermann , Yoji Yanagimoto
IPC分类号： A61M1/14 , A61M1/34 , A61M1/30 , A61M1/36
CPC分类号： A61M1/30 , A61M1/3465 , A61M1/3621 , A61M1/3627 , A61M1/3643 , A61M1/3644 , A61M1/3647 , A61M1/3649 , A61M1/365 , A61M2205/3331 , A61M2205/3334 , A61M2205/3351 , A61M2205/3355
摘要： A method for pre-filling a hemodialysis apparatus includes providing a hemodialysis apparatus comprising a pre-filling liquid source which supplies a pre-filling liquid, a dialyzer, a dialysate side, a blood side. The dialysate side comprises a dialysate chamber, a dialysate pump to pump the pre-filling liquid to the dialysate chamber, and a waste pump to pump the pre-filling liquid away from the dialysate chamber. The blood side comprises an arterial line, a blood pump, a blood chamber of the dialyzer, and a venous line. A pressure sensor is arranged on the dialysate side or on the blood side. The arterial line and the venous line are pre-filled with the pre-filling liquid via the dialysate pump. A blood-side fluid pressure is continuously determined via the pressure sensor during the pre-filling. The pre-filling is stopped when the blood-side fluid pressure determined by the pressure sensor exceeds or falls below a defined limit pressure.
摘要翻译：一种用于预先填充血液透析装置的方法包括提供一种血液透析装置，其包括预充液体源，其供应预充液体，透析器，透析液侧，血液侧。透析液侧包括透析液室，用于将预充液体泵送到透析液室的透析泵，以及将预填充液体泵送离开透析液室的废水泵。血液侧包括动脉线，血液泵，透析器的血液室和静脉线。压力传感器布置在透析液侧或血液侧。动脉线和静脉线通过透析泵预填充预充液体。在预填充期间经由压力传感器连续地确定血液侧流体压力。当由压力传感器确定的血侧流体压力超过或低于规定的极限压力时，停止预填充。

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