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1. 发明授权

US08449524B2 Fluid component analysis systems and methods for glucose monitoring and control 有权
标题翻译：用于葡萄糖监测和控制的流体成分分析系统和方法
公开(公告)号：US08449524B2
公开(公告)日：2013-05-28
申请号：US13174610
申请日：2011-06-30
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/168
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

2. 发明授权

US08417311B2 Fluid component analysis system and method for glucose monitoring and control 有权
标题翻译：用于葡萄糖监测和控制的流体成分分析系统和方法
公开(公告)号：US08417311B2
公开(公告)日：2013-04-09
申请号：US12559328
申请日：2009-09-14
申请人： Peter Rule
发明人： Peter Rule
IPC分类号： A61B5/05
CPC分类号： A61M5/1723 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150305 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/4839 , A61B5/7475 , A61M5/1415 , A61M5/142 , A61M5/16827 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/18 , A61M2205/3313 , A61M2205/3569 , A61M2205/502 , A61M2205/52 , A61M2230/005 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

3. 发明申请

US20110060199A1 DETERMINATION OF BLOOD PUMP SYSTEM PERFORMANCE AND SAMPLE DILUTION USING A PROPERTY OF FLUID BEING TRANSPORTED 审中-公开
标题翻译：使用流体输送物质确定血液泵系统性能和样品浓度
公开(公告)号：US20110060199A1
公开(公告)日：2011-03-10
申请号：US12884175
申请日：2010-09-16
申请人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Greg Knipstein , Dan Welsh
发明人： Mark Ries Robinson , Mike Borrello , Richard P. Thompson , Stephen Vanslyke , Shonn Hendee , Greg Knipstein , Dan Welsh
IPC分类号： A61B5/157
CPC分类号： A61B5/14557 , A61B5/14532 , A61B5/15003 , A61B5/150213 , A61B5/150221 , A61B5/150229 , A61B5/150946 , A61B5/150961 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61M1/1692 , A61M1/34 , A61M1/341 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2205/3368 , A61M2230/201
摘要： The use of an optical or other measurement in a blood access system enables the determination of a fluid sample appropriate for measurement on a real time basis. This information can be used to control the blood access system and related measurement processes. The determination can be based on, for example, at least one of: optical density, optical scatter, analyte level, temperature, the absolute level of any of the preceding, the stability of any of the preceding, the rate of change of any of the preceding, or the value of any of the preceding relative to another determination. The determination can be made using, for example, at least one of: electrochemical sensor, ion specific electrode, capacitance measurement, impedance measurement, inductance measurement, conductivity measurement, optical measurement, and ultrasound measurement. The present invention relates to determination of the quality of a biological sample in which determination of an analyte concentration is to be made, and various methods and apparatuses related thereto. An evaluation of sample quality can be made by monitoring the temporal changes in the sample properties or characteristics as the biological sample is procured or measured. The methods and apparatuses described herein can be used to evaluate the temporal characteristics of a sample during sample acquisition and/or during determination of the sample analyte or parameter of interest. The sample quality assurance methods and apparatuses described herein can thus be used to ensure that a valid sample has been procured by or presented to an instrument or measurement system for analyte determination, thereby preventing the measurement and reporting of analyte values for a sample that is unstable or otherwise non-representative of the biological system from which the sample was obtained.
摘要翻译：在血液存取系统中使用光学或其他测量能够实时地确定适于测量的流体样品。该信息可用于控制血液存取系统和相关测量过程。该测定可以基于例如光密度，光学散度，分析物水平，温度，前述任一项的绝对水平，前述任一项的稳定性，任何变化率前一个或前一个相对于另一个确定的任何值的值。可以使用例如电化学传感器，离子专用电极，电容测量，阻抗测量，电感测量，电导率测量，光学测量和超声测量中的至少一个来进行确定。本发明涉及要进行测定分析物浓度的生物样品的质量的确定以及与其相关的各种方法和装置。通过监测采购或测量生物样品的样品性质或特性的时间变化，可以对样品质量进行评估。本文描述的方法和装置可以用于在样品获取期间和/或在样品分析物或感兴趣的参数的确定期间评估样品的时间特征。因此，本文所述的样品质量保证方法和装置可以用于确保有效样品已经由用于分析物测定的仪器或测量系统获得或呈现给样品，从而防止对不稳定的样品的分析物值的测量和报告或以其他方式代表获得样品的生物系统。

4. 发明申请

US20100168535A1 METHODS AND APPARATUSES RELATED TO BLOOD ANALYTE MEASUREMENT SYSTEM 审中-公开
标题翻译：与血液分析仪测量系统相关的方法和装置
公开(公告)号：US20100168535A1
公开(公告)日：2010-07-01
申请号：US12714100
申请日：2010-02-26
申请人： Mark Ries Robinson , William R. Patterson , Richard P. Thompson , Shonn Hendee , James H. Macemon
发明人： Mark Ries Robinson , William R. Patterson , Richard P. Thompson , Shonn Hendee , James H. Macemon
IPC分类号： A61B5/00
CPC分类号： A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150236 , A61B5/150244 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150992 , A61B5/153 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2230/201
摘要： The present invention relates to a blood analyte measurement system for the procurement of blood samples for measurement of blood properties such as analyte concentration or analyte presence. A blood access system can be coupled with a measurement system such as an electrochemical sensor, and can also be used with other measurement modalities. Embodiments of the present invention can facilitate accurate measurement of blood glucose by the clinician in a sterile manner. Embodiments of the present invention can also enable the calibration of the sensor at one or more calibration points. One desired analyte of measurement is glucose for the effective implementation of glycemic control protocols. Embodiments of the present invention can also be used for the measurement of other analytes such as arterial blood gases, lactate, hemoglobin, potassium and urea. Additionally, embodiments of the present invention can function effectively on a variety of blood access points and specifically enables glucose monitoring in an existing arterial line that is already in place for hemodynamic monitoring. The present invention does not consume a significant amount of blood. Some embodiments of the present invention can re-infuse the blood into the patient, which can facilitate operation of the system in a sterile manner.
摘要翻译：本发明涉及一种用于血液分析物测量系统，用于采血用于测量血液特性如分析物浓度或分析物存在。血液存取系统可以与诸如电化学传感器的测量系统耦合，并且还可以与其它测量模式一起使用。本发明的实施方案可以促进临床医生以无菌方式精确测量血糖。本发明的实施例还可以实现在一个或多个校准点处的传感器的校准。一个期望的测量分析物是用于有效实施血糖控制方案的葡萄糖。本发明的实施方案也可用于测量其它分析物，例如动脉血气，乳酸，血红蛋白，钾和尿素。此外，本发明的实施例可以有效地在各种血液接入点上起作用，并且具体地实现已经存在于用于血液动力学监测的现有动脉管线中的葡萄糖监测。本发明不消耗大量的血液。本发明的一些实施例可以将血液重新注入患者体内，这可以以无菌的方式促进系统的操作。

5. 发明申请

US20090149745A1 KEEP VEIN OPEN METHOD AND INJECTOR WITH KEEP VEIN OPEN FUNCTION 审中-公开
标题翻译：保持开启方法和注射器保持开启功能
公开(公告)号：US20090149745A1
公开(公告)日：2009-06-11
申请号：US12369427
申请日：2009-02-11
申请人： Gary S. Wagner , Frank Fago
发明人： Gary S. Wagner , Frank Fago
IPC分类号： A61B6/00 , A61M5/32
CPC分类号： A61M5/007 , A61M5/14546 , A61M5/1456 , A61M5/31511 , A61M2005/1404 , A61M2005/3112
摘要： The present invention embodies a method and an injector adapted to incorporate this method, for keeping a patient's vein open during an intravenous contrast injector procedure without injecting a saline solution from a separate syringe. The injector includes a controller having a programmable software module to allow an operator to configure the injector to push some contrast media fluid through an injection site and then retract a plunger drive ram. A syringe is adapted to allow a patient's blood pressure to move the syringe plunger back towards its starting position, thus enabling a patient's blood to pass through the injection site. Alternatively, the syringe is adapted with an elastic plunger which as it enlarges and contracts facilitating fluid communication through the injection site. Additionally, the plunger drive ram can be adapted to gradually pull as well as push the plunger, thereby causing fluid to flow across the injection site.
摘要翻译：本发明体现了适用于该方法的方法和注射器，用于在静脉造影注射器程序期间保持患者的静脉打开，而不从单独的注射器注入盐水溶液。注射器包括具有可编程软件模块的控制器，以允许操作者配置注射器以将一些造影剂流体推入注射部位，然后缩回柱塞驱动柱塞。注射器适于允许患者的血压将注射器柱塞移回其起始位置，从而使患者的血液能够通过注射部位。或者，注射器适于具有弹性柱塞，随着弹性柱塞的扩大和收缩，便于通过注射部位的流体连通。此外，柱塞驱动柱塞可以适于逐渐拉动以及推动柱塞，从而使流体流过注射部位。

6. 发明申请

US20070244382A1 Blood Analyte Determinations 审中-公开
标题翻译：血液分析物测定
公开(公告)号：US20070244382A1
公开(公告)日：2007-10-18
申请号：US11679839
申请日：2007-02-28
申请人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
发明人： Mark Ries Robinson , Mike Borrello , Richard Thompson , Stephen Vanslyke , Steve Bernard , John O'Mahony
IPC分类号： A61B5/157
CPC分类号： A61B5/150961 , A61B5/14532 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150366 , A61B5/150992 , A61B5/153 , A61B5/155 , A61M1/1692 , A61M1/34 , A61M1/3621 , A61M1/3639 , A61M1/3663 , A61M5/16831 , A61M2005/1404 , A61M2205/3306 , A61M2205/331 , A61M2205/3331 , A61M2205/3334 , A61M2230/201
摘要： The present invention comprises methods and apparatuses that can provide measurement of glucose and other analytes with a variety of sensors without many of the performance-degrading problems of conventional approaches. An apparatus according to the present invention comprises a blood access system, adapted to remove blood from a body and infuse at least a portion of the removed blood back into the body. Such an apparatus also comprises an analyte sensor, mounted with the blood access system such that the analyte sensor measures the analyte in the blood that has been removed from the body by the blood access system. A method according to the present invention comprises removing blood from a body, using an analyte sensor to measure an analyte in the removed blood, and infusing at least a portion of the removed blood back into the body. The use of a non-contact sensor with a closed system creates a system will minimal infection risk.
摘要翻译：本发明包括可以提供葡萄糖和其他分析物与各种传感器的测量而不是常规方法的许多性能降级问题的方法和装置。根据本发明的装置包括血液存取系统，其适于从身体去除血液并且将至少一部分去除的血液注入体内。这种装置还包括安装有血液存取系统的分析物传感器，使得分析物传感器测量已经通过血液存取系统从体内除去的血液中的分析物。根据本发明的方法包括从身体去除血液，使用分析物传感器来测量去除的血液中的分析物，并将至少一部分去除的血液输入体内。使用具有封闭系统的非接触式传感器创建的系统将会最小的感染风险。

7. 发明申请

US20160317744A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 审中-公开
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20160317744A1
公开(公告)日：2016-11-03
申请号：US15089059
申请日：2016-04-01
申请人： Peter Rule
发明人： Peter Rule
IPC分类号： A61M5/172 , A61M5/14 , A61M5/142
CPC分类号： A61M5/1723 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150305 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/4839 , A61B5/7475 , A61M5/1415 , A61M5/142 , A61M5/16827 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/18 , A61M2205/3313 , A61M2205/3569 , A61M2205/502 , A61M2205/52 , A61M2230/005 , A61M2230/201 , G06F19/3468
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

8. 发明申请

US20130165900A1 FLUID COMPONENT ANALYSIS SYSTEMS AND METHODS FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20130165900A1
公开(公告)日：2013-06-27
申请号：US13619825
申请日：2012-09-14
申请人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
发明人： James R. Braig , Richard Keenan , Peter Rule , Gil Rivas , Mahesh Seetharaman
IPC分类号： A61M5/172
CPC分类号： A61B5/4839 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/1455 , A61B5/14557 , A61B5/1495 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150267 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/150992 , A61B5/153 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/7475 , A61M5/16827 , A61M5/1723 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/3303 , A61M2209/084 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatus for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment drug (e.g., insulin or glucose) and provide glycemic control. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗药物（例如胰岛素或葡萄糖）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。

9. 发明申请

US20100191218A1 INFUSION DEVICE AND METHOD FOR INFUSING MATERIAL INTO THE BRAIN OF A PATIENT 有权
标题翻译：用于将材料输入患者脑的输注装置和方法
公开(公告)号：US20100191218A1
公开(公告)日：2010-07-29
申请号：US12702470
申请日：2010-02-09
申请人： Michael G. Kaplitt , Matthew J. During
发明人： Michael G. Kaplitt , Matthew J. During
IPC分类号： A61M5/14 , A61M25/00
CPC分类号： A61M25/00 , A61M5/141 , A61M5/14244 , A61M25/0026 , A61M25/02 , A61M25/0662 , A61M2005/1404 , A61M2025/0213 , A61M2025/0681 , A61M2210/0693
摘要： A fluid infusion device and a method of using the same. The device includes an outer, flexible guide catheter having a distal end for introduction beneath the skull of a patient and a proximal end remaining external of the patient. A flexible infusion fiber is located within the guide catheter and has a distal end extending outwardly from the guide catheter to be located in a target area within the patient's brain. The infusion fiber can be fixed or axially movable within the guide catheter. In the latter embodiment, the proximal end of the infusion fiber extending outwardly from the guide catheter can be manipulated to locate the distal end of the infusion fiber in the target area. An infusion pump is connected to the proximal end of the infusion fiber to infuse a minute quantity of fluid at an extremely low flow rate into the brain of the patient.
摘要翻译：流体输注装置及其使用方法。该装置包括外部柔性引导导管，其具有用于引入患者头骨下方的远端以及残留在患者外部的近端。柔性输注纤维位于引导导管内，并且具有从引导导管向外延伸的远端，以位于患者脑内的目标区域中。输液纤维可以在引导导管内固定或轴向移动。在后一实施例中，可以操纵从引导导管向外延伸的输注纤维的近端，以将输注纤维的远端定位在目标区域中。输注泵连接到输注纤维的近端，以将极低流量的微量流体注入患者的脑中。

10. 发明申请

US20100121170A1 FLUID COMPONENT ANALYSIS SYSTEM AND METHOD FOR GLUCOSE MONITORING AND CONTROL 有权
标题翻译：流体组分分析系统和葡萄糖监测与控制方法
公开(公告)号：US20100121170A1
公开(公告)日：2010-05-13
申请号：US12559328
申请日：2009-09-14
申请人： Peter Rule
发明人： Peter Rule
IPC分类号： A61B5/145 , A61M5/14
CPC分类号： A61M5/1723 , A61B5/1427 , A61B5/14532 , A61B5/14535 , A61B5/14546 , A61B5/14557 , A61B5/15003 , A61B5/150221 , A61B5/150229 , A61B5/150305 , A61B5/150389 , A61B5/150503 , A61B5/150755 , A61B5/150786 , A61B5/150862 , A61B5/155 , A61B5/157 , A61B5/412 , A61B5/4839 , A61B5/7475 , A61M5/1415 , A61M5/142 , A61M5/16827 , A61M2005/1404 , A61M2005/14208 , A61M2005/1726 , A61M2205/12 , A61M2205/18 , A61M2205/3313 , A61M2205/3569 , A61M2205/502 , A61M2205/52 , A61M2230/005 , A61M2230/201 , G06F19/00 , G06F19/3468
摘要： Disclosed are methods and apparatuses for determining analyte concentration in a sample such as bodily fluid. Systems and methods disclosed herein can also include a treatment dosing system to infuse or inject a treatment dose (e.g. insulin, dextrose, etc.) and provide glycemic control. The dose of the treatment drug may be based on the patient's calculated sensitivity to treatment dosing, for example. The dose of the treatment drug may be based on the concentration of the analyte or the average value for the concentration of the analyte and/or the rate of change of the value of the concentration of the analyte. Delivery of the treatment drug can be cut off if the determined analyte concentration indicates that continued delivery would be harmful to the patient.
摘要翻译：公开了用于测定诸如体液的样品中的分析物浓度的方法和装置。本文公开的系统和方法还可以包括注射或注射治疗剂量（例如胰岛素，葡萄糖等）并提供血糖控制的治疗剂量系统。治疗药物的剂量可以基于例如患者对治疗剂量的计算灵敏度。治疗药物的剂量可以基于分析物的浓度或分析物浓度的平均值和/或分析物浓度值的变化率。如果确定的分析物浓度表明持续传递对患者有害，则可以切断治疗药物的递送。

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