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1. 发明申请

US20190247637A1 MULTI-SITE INJECTION SYSTEM 审中-公开
公开(公告)号：US20190247637A1
公开(公告)日：2019-08-15
申请号：US16391147
申请日：2019-04-22
申请人： Allergan, Inc.
发明人： Steven D. Kimmell , Scott J. Gerondale
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M5/14593 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： A multi-site injection system includes a plurality of medicament delivering needles/microprotrusions, a needle/microprotrusion support, a supply of medicament, and a mechanism for providing the medicament to the plurality of needles/microprotrusions in order to effect delivery into a stratum corneum of a user.

2. 发明申请

US20190240469A1 MICRONEEDLE PATCHES AND METHODS 审中-公开
公开(公告)号：US20190240469A1
公开(公告)日：2019-08-08
申请号：US16384665
申请日：2019-04-15
申请人： Georgia Tech Research Corporation
发明人： Devin McAllister , Mark R. Prausnitz , Sebastien Henry , James J. Norman
IPC分类号： A61M37/00
CPC分类号： A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061 , A61M2205/581 , A61M2205/582 , A61M2205/583 , A61M2205/586
摘要： Microneedle patches and systems, and methods for use of such patches and systems. In one aspect, a microneedle patch is provided including a tab portion for handling the microneedle patch. In another aspect, a system is provided including a microneedle patch and a tray for housing the microneedle patch. In still another aspect, various indicators providing for providing feedback prior to, during, and after administration of the microneedle patch are provided. Advantageously, the described microneedle patches and systems provide improved handling and ease of application of the microneedle patches to skin for the delivery of therapeutic agents.

3. 发明申请

US20190240208A1 METHODS AND DEVICES FOR THE TREATMENT OF OCULAR DISEASES IN HUMAN SUBJECTS 审中-公开
公开(公告)号：US20190240208A1
公开(公告)日：2019-08-08
申请号：US16124407
申请日：2018-09-07
申请人： CLEARSIDE BIOMEDICAL, INC.
发明人： Vladimir ZARNITSYN , Samirkumar PATEL , Daniel WHITE , Glenn NORONHA , Brian BURKE
IPC分类号： A61K31/4439 , A61K47/26 , A61K9/00 , A61K9/10 , A61K47/38 , A61K45/06 , A61K47/12 , A61M37/00 , A61K9/16 , C07K16/22 , A61K31/573
CPC分类号： A61K31/4439 , A61K9/0019 , A61K9/0048 , A61K9/10 , A61K9/16 , A61K31/573 , A61K45/06 , A61K47/12 , A61K47/26 , A61K47/38 , A61K2039/505 , A61K2039/54 , A61K2300/00 , A61M37/0015 , A61M2037/0023 , A61M2037/0061 , C07K16/22
摘要： Methods and devices are provided for targeted non-surgical administration of a drug formulation to the suprachoroidal space (SCS) of the eye of a human subject for the treatment of a posterior ocular disorder or a choroidal malady. In one embodiment, the method comprises inserting a hollow microneedle into the eye at an insertion site and infusing a drug formulation through the inserted microneedle and into the suprachoroidal space of the eye, wherein the infused drug formulation flows within the suprachoroidal space away from the insertion site during the infusion. In one embodiment, the fluid drug formulation comprises drug nanoparticles or microparticles.

4. 发明申请

US20190209820A1 CLINICAL AND/OR CONSUMER TECHNIQUES AND DEVICES 审中-公开
公开(公告)号：US20190209820A1
公开(公告)日：2019-07-11
申请号：US16048722
申请日：2018-07-30
申请人： Seventh Sense Biosystems, Inc.
发明人： Donald E. Chickering, III , Douglas A. Levinson , Shawn Davis , Ramin Haghgooie , Howard Bernstein , David R. Walt
IPC分类号： A61M37/00 , A61B5/15 , A61B5/145 , A61B5/00 , A61M5/142 , A61N1/32 , A61B90/96 , A61B90/98
CPC分类号： A61M37/0015 , A61B5/117 , A61B5/14514 , A61B5/150984 , A61B5/415 , A61B5/417 , A61B5/418 , A61B90/96 , A61B90/98 , A61B2560/0412 , A61M5/14248 , A61M37/00 , A61M2037/0023 , A61M2037/0061 , A61M2205/3576 , A61M2205/6009 , A61M2205/6072 , A61N1/30 , A61N1/325
摘要： The present invention generally relates to systems and methods for delivering and/or receiving a substance or substances such as blood, from subjects, e.g., from the skin and/or from other tissues of the body. In some cases, the device may contain a substance transfer component such as needles or microneedles, which can be inserted into the skin or another organ to deliver and/or receiving fluid or other substances from the subject. In some embodiments, the device may include an activator constructed and arranged to insert one or more substance transfer components into the skin or other organ. In certain cases, the device may also include a storage chamber for receiving a fluid received from the subject.

5. 发明申请

US20180344860A1 MEDICATION SYSTEM 审中-公开
公开(公告)号：US20180344860A1
公开(公告)日：2018-12-06
申请号：US16054440
申请日：2018-08-03
申请人： Shabana Naheed
发明人： Shabana Naheed
IPC分类号： A61K47/36 , A61M37/00 , A61K36/185 , A61K9/00
CPC分类号： A61K47/36 , A61K9/0021 , A61K36/185 , A61K47/32 , A61M37/0015 , A61M2037/0023 , A61M2037/0061
摘要： A method for delivering therapeutics includes infusing medication with cannabis.

6. 发明申请

US20180344631A1 MICRONEEDLE DEVICES AND METHODS 审中-公开
公开(公告)号：US20180344631A1
公开(公告)日：2018-12-06
申请号：US16059522
申请日：2018-08-09
申请人： 3M Innovative Properties Company
发明人： Ying Zhang , Kristen J. Hansen , Amy S. Determan
IPC分类号： A61K9/00 , A61M37/00
CPC分类号： A61K9/0021 , A61M37/0015 , A61M2037/0023 , A61M2037/0046 , A61M2037/0061
摘要： A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

7. 发明申请

US20180304063A1 HOLLOW MICRONEEDLE ARRAYS 审中-公开
公开(公告)号：US20180304063A1
公开(公告)日：2018-10-25
申请号：US16025141
申请日：2018-07-02
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： BERNARD A. GONZALEZ , SCOTT A. BURTON , JIA HU , CHIN-YEE NG , RYAN PATRICK SIMMERS , THOMAS J. GILBERT , SEAN M. BURKE , ROBERT A. HARKINS , LARRY A. SCHLEIF
IPC分类号： A61M37/00 , A61M5/20
CPC分类号： A61M37/0015 , A61M5/14248 , A61M5/1454 , A61M5/2033 , A61M2005/14252 , A61M2005/14506 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

8. 发明申请

US20180263641A1 MICROPROJECTION ARRAYS WITH MICROPROJECTIONS HAVING LARGE SURFACE AREA PROFILES 审中-公开
公开(公告)号：US20180263641A1
公开(公告)日：2018-09-20
申请号：US15760869
申请日：2016-09-16
申请人： Vaxxas Pty Limited
发明人： Michael CRICHTON , Mark Anthony Fernance KENDALL
IPC分类号： A61B17/20 , A61M37/00
CPC分类号： A61B17/205 , A61M37/0015 , A61M2037/0046 , A61M2037/0061
摘要： A microprojection array comprising a substrate with a plurality of microprojections protruding from the substrate wherein the microprojections have a tapering hexagonal shape and comprise a tip and a base wherein the base has two substantially parallel sides with a slight draught angle of approximately 1 to 20 degrees up to a transition point at which point the angle increases to from about 20 degrees to about 70 degrees.

9. 发明授权

US10010706B2 Hollow microneedle arrays 有权
公开(公告)号：US10010706B2
公开(公告)日：2018-07-03
申请号：US13386937
申请日：2010-07-27
申请人： Bernard A. Gonzalez , Scott A. Burton , Jia Hu , Chin-Yee Ng , Ryan Patrick Simmers , Thomas J. Gilbert , Sean M. Burke , Robert A. Harkins , Larry A. Schleif
发明人： Bernard A. Gonzalez , Scott A. Burton , Jia Hu , Chin-Yee Ng , Ryan Patrick Simmers , Thomas J. Gilbert , Sean M. Burke , Robert A. Harkins , Larry A. Schleif
IPC分类号： A61M37/00 , A61M5/20 , A61M5/142 , A61M5/145
CPC分类号： A61M37/0015 , A61M5/14248 , A61M5/1454 , A61M5/2033 , A61M2005/14252 , A61M2005/14506 , A61M2037/0023 , A61M2037/003 , A61M2037/0046 , A61M2037/0061
摘要： The present disclosure relates to apparatus, assemblies, combinations, and methods for infusing fluids by hollow microneedles.

10. 发明申请

US20180161252A1 MICRONEEDLE DELIVERY SYSTEM AND METHOD 审中-公开
公开(公告)号：US20180161252A1
公开(公告)日：2018-06-14
申请号：US15821314
申请日：2017-11-22
申请人： University Medical Pharmaceuticals Corp.
发明人： Raymond Joseph Francis , David Bardin , Gregory Lee Hunt
IPC分类号： A61K8/02 , A61K8/73 , A61K8/34 , A61Q19/08 , A61M37/00
CPC分类号： A61K8/0233 , A61K8/345 , A61K8/73 , A61K8/731 , A61K8/732 , A61K8/735 , A61K9/0021 , A61K47/26 , A61K47/36 , A61K2800/87 , A61K2800/91 , A61M37/0015 , A61M2037/0023 , A61M2037/0061 , A61Q19/08
摘要： A microneedle device suitable for application to the skin and methods for using the same. The microneedles are made of one or more biocompatible polymers that optionally provide a cosmetic benefit when dissolved within the skin. Optionally, the microneedles also may be used to deliver other active ingredients to the skin. The device is characterized by a microneedle layer, an intermediate layer of a liquid-soluble polymer, and an outer, liquid-permeable layer that is in fluid communication with the intermediate layer. In use, the device is applied to the skin such that the microneedles penetrate the skin surface. A liquid (e.g., water) is applied to the outer layer, causing dissolution of the intermediate layer, thereby detaching the microneedles within the skin from the device body. The remainder of the device is then removed and discarded.

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