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1. 发明授权

US10058681B2 Low profile instrument immobilizer 有权
公开(公告)号：US10058681B2
公开(公告)日：2018-08-28
申请号：US13828136
申请日：2013-03-14
申请人： Medtronic, Inc.
发明人： James G. Skakoon , Matthew S. Solar , Thomas I. Miller , Patrick R. Helmer , Mark S. Freas
IPC分类号： A61M25/02 , A61B5/00 , A61B90/50 , A61B90/11 , A61B17/34 , A61N1/05 , A61B90/10
CPC分类号： A61M25/02 , A61B5/6864 , A61B17/3415 , A61B17/3423 , A61B90/11 , A61B90/50 , A61B2017/347 , A61B2090/103 , A61M2025/024 , A61N1/0536 , A61N1/0539
摘要： This document discusses, among other things, examples of a low profile instrument immobilizer and means for positioning the same. In one example, the low profile instrument immobilizer grasps, secures, and immobilizes an electrode or other instrument that extends through a burr hole in a skull to a target location in a patient's brain.

2. 发明授权

US09878147B2 Microelectrode and multiple microelectrodes 有权
公开(公告)号：US09878147B2
公开(公告)日：2018-01-30
申请号：US14616122
申请日：2015-02-06
申请人： Fredrik Ek , Nils Danielsen , Jenny Eriksson Linsmeier , Per Petersson , Jens Schouenborg
发明人： Fredrik Ek , Nils Danielsen , Jenny Eriksson Linsmeier , Per Petersson , Jens Schouenborg
IPC分类号： A61N1/05 , A61L31/14 , A61L31/16 , A61B5/04 , A61N1/04 , A61N1/30 , A61N1/32 , A61N1/372 , A61B5/00
CPC分类号： A61N1/0531 , A61B5/04001 , A61B5/4094 , A61L31/148 , A61L31/16 , A61L2300/604 , A61N1/0412 , A61N1/0476 , A61N1/05 , A61N1/0536 , A61N1/0551 , A61N1/306 , A61N1/325 , A61N1/327 , A61N1/37205
摘要： A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.

3. 发明授权

US09731122B2 Electroosmotic tissue treatment 有权
公开(公告)号：US09731122B2
公开(公告)日：2017-08-15
申请号：US13872794
申请日：2013-04-29
申请人： RAINBOW MEDICAL LTD.
发明人： Yossi Gross
IPC分类号： A61N1/32 , A61N1/36 , A61N1/05 , A61N1/30
CPC分类号： A61N1/327 , A61N1/0536 , A61N1/306 , A61N1/36082 , A61N1/36139
摘要： Apparatus for driving fluid between first and second anatomical sites of a subject is provided, comprising (1) a first electrode, configured to be coupled to the first anatomical site of the subject; (2) a second electrode, configured to be coupled to the second anatomical site of the subject; and (3) a control unit, configured to (i) detect a pressure difference between the first and second anatomical sites, and (ii) in response to the detected pressure difference, drive fluid between the first and second anatomical sites by applying a treatment voltage between the first and second electrodes. Other embodiments are also described.

4. 发明授权

US09533150B2 Methods and associated neural prosthetic devices for bridging brain areas to improve function 有权
标题翻译：用于桥接脑部区域以改善功能的方法和相关神经假体装置
公开(公告)号：US09533150B2
公开(公告)日：2017-01-03
申请号：US14630375
申请日：2015-02-24
申请人： UNIVERSITY OF KANSAS , CASE WESTERN RESERVE UNIVERSITY
发明人： Randolph J. Nudo , Pedram Mohseni , David Guggenmos , Meysam Azin
IPC分类号： A61N1/05 , A61N1/36 , A61B5/00 , A61B5/04
CPC分类号： A61N1/36103 , A61B5/04001 , A61B5/6868 , A61N1/0529 , A61N1/0531 , A61N1/0536 , A61N1/36139
摘要： Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.
摘要翻译：提供了桥接基本上没有有效通信的脑部位置和相关联的神经修复装置的方法。检测受试者中第一神经位点中的神经尖峰，并且在检测到神经穗之后的确定的时间段内传递对受试者中的第二神经部位的刺激，其中基本上没有有效的通信第一和第二神经位点。该方法在两个神经位点之间形成人造桥梁，并建立了两个站点之间的持久通信。本公开尤其提供了包括集成电路的神经假体装置，所述集成电路包括包括多个记录通道的记录前端; 处理器单元; 以及传送后端的刺激物，其包括多个刺激通道。

5. 发明授权

US09533140B2 Microelectrode and multiple microelectrodes 有权
标题翻译：微电极和多个微电极
公开(公告)号：US09533140B2
公开(公告)日：2017-01-03
申请号：US14329339
申请日：2014-07-11
申请人： Fredrik Ek , Nils Danielsen , Jenny Eriksson Linsmeier , Per Petersson , Jens Schouenborg
发明人： Fredrik Ek , Nils Danielsen , Jenny Eriksson Linsmeier , Per Petersson , Jens Schouenborg
IPC分类号： A61L31/16 , A61L31/14 , A61N1/00 , A61N1/05 , A61B5/04 , A61N1/04 , A61N1/30 , A61N1/32 , A61N1/372 , A61B5/00
CPC分类号： A61N1/0531 , A61B5/04001 , A61B5/4094 , A61L31/148 , A61L31/16 , A61L2300/604 , A61N1/0412 , A61N1/0476 , A61N1/05 , A61N1/0536 , A61N1/0551 , A61N1/306 , A61N1/325 , A61N1/327 , A61N1/37205
摘要： A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.
摘要翻译：医用微电极包括细长电极体，其包括尖端部分，主体部分和任选的耦合部分。尖端部分，主体部分和任选的联接部分嵌入第一电极矩阵元件中，该第一电极矩阵元件在体液中基本上是刚性的，生物相容的和可溶解的或可生物降解的。此外，微电极在第一电极矩阵元件上包括溶解阻滞层和/或设置在第一电极矩阵元件和电极之间的第二电极矩阵元件。在第一电极矩阵元件的溶解或生物降解时，由第一电极矩阵元件或第二电极矩阵元素包含的药物被释放到组织中。还公开了电极的束和阵列及其用途。

6. 发明申请

US20160287436A1 SYSTEMS, METHODS AND DEVICES FOR A SKULL/BRAIN INTERFACE 有权
公开(公告)号：US20160287436A1
公开(公告)日：2016-10-06
申请号：US15178525
申请日：2016-06-09
申请人： NeuroPace, Inc.
发明人： Brett WINGEIER , Benjamin PLESS
IPC分类号： A61F7/12 , A61F7/00 , A61N1/05 , A61B90/98 , A61N1/36 , A61N5/06 , A61N7/02 , A61B5/0478 , A61N1/30
CPC分类号： A61N1/0539 , A61B5/04 , A61B5/0478 , A61B18/02 , A61B18/14 , A61B90/98 , A61B2018/1807 , A61F7/0085 , A61F7/12 , A61F2007/0002 , A61F2007/0056 , A61F2007/126 , A61N1/0529 , A61N1/0531 , A61N1/0534 , A61N1/0536 , A61N1/20 , A61N1/303 , A61N1/36017 , A61N1/36025 , A61N1/36082 , A61N2/006 , A61N5/0601 , A61N5/0622 , A61N7/022 , A61N2007/0026
摘要： Systems, methods and devices are disclosed for directing and focusing signals to the brain for neuromodulation and for directing and focusing signals or other energy from the brain for measurement, heat transfer and imaging. An aperture in the skull and/or a channel device implantable in the skull can be used to facilitate direction and focusing. Treatment and diagnosis of multiple neurological conditions may be facilitated with the disclosed systems, methods and devices.

7. 发明授权

US09220916B2 Methods for delivery of optical signals to tissue for the treatment of a disease or condition 有权
标题翻译：将光学信号传送到组织用于治疗疾病或病症的方法
公开(公告)号：US09220916B2
公开(公告)日：2015-12-29
申请号：US13710407
申请日：2012-12-10
申请人： InCube Labs, LLC
发明人： Mir Imran
IPC分类号： A61N1/00 , A61B5/02 , A61N5/06 , A61N1/36 , H01R13/52 , A61N1/375 , A61N1/05 , A61N1/37
CPC分类号： A61N5/0622 , A61N1/0529 , A61N1/0536 , A61N1/36 , A61N1/36064 , A61N1/37 , A61N1/375 , A61N1/3754 , A61N5/0601 , A61N2005/063 , H01R13/5224 , H01R2201/12
摘要： Embodiments described herein provide methods for treating various conditions and diseases using an optical signal. In one or more embodiments an apparatus is providing having an optical window, which is used to deliver an optical signal to provide stimulation to one or more tissue sites in the body such as the brain, optic nerve, eye, ganglia, spine, or other like site. The optical signals can be used to treat a variety of neurological diseases and conditions including epilepsy, migraine headaches and chronic pain. In particular applications the optical signals can be used to treat, inhibit or prevent epileptic or other neurological seizures by providing an optical input to a foci or surrounding tissue in the brain causing the seizure. The optical signal may also be combined with an electrical signal to produce an aggregate effect in tissue for treating the disease or condition such as a neurological disease or condition.
摘要翻译：本文所述的实施方案提供了使用光信号处理各种病症和疾病的方法。在一个或多个实施例中，装置提供具有光学窗口，其用于递送光学信号以向身体中的一个或多个组织部位提供刺激，例如脑，视神经，眼睛，神经节，脊柱或其它像网站。光信号可用于治疗各种神经疾病和病症，包括癫痫，偏头痛和慢性疼痛。在特定应用中，光学信号可用于通过向脑中的焦点或周围组织提供光学输入来引起癫痫发作，来治疗，抑制或预防癫痫或其它神经系统发作。光信号还可以与电信号组合以在组织中产生用于治疗疾病或病症如神经疾病或病症的聚集效应。

8. 发明申请

US20150231397A1 METHODS AND ASSOCIATED NEURAL PROSTHETIC DEVICES FOR BRIDGING BRAIN AREAS TO IMPROVE FUNCTION 有权
标题翻译：用于桥接脑区域以改善功能的方法和相关神经前体装置
公开(公告)号：US20150231397A1
公开(公告)日：2015-08-20
申请号：US14630375
申请日：2015-02-24
申请人： Randolph J. Nudo, JR. , Pedram Mohseni , David Guggenmos , Meysam Azin
发明人： Randolph J. Nudo, JR. , Pedram Mohseni , David Guggenmos , Meysam Azin
IPC分类号： A61N1/36
CPC分类号： A61N1/36103 , A61B5/04001 , A61B5/6868 , A61N1/0529 , A61N1/0531 , A61N1/0536 , A61N1/36139
摘要： Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.
摘要翻译：提供了桥接基本上没有有效通信的脑部位置和相关联的神经修复装置的方法。检测受试者中第一神经位点中的神经尖峰，并且在检测到神经穗之后的确定的时间段内传递对受试者中的第二神经部位的刺激，其中基本上没有有效的通信第一和第二神经位点。该方法在两个神经位点之间形成人造桥梁，并建立了两个站点之间的持久通信。本公开尤其提供了包括集成电路的神经假体装置，所述集成电路包括包括多个记录通道的记录前端; 处理器单元; 以及传送后端的刺激物，其包括多个刺激通道。

9. 发明授权

US09008780B2 Methods and associated neural prosthetic devices for bridging brain areas to improve function 有权
标题翻译：用于桥接脑部区域以改善功能的方法和相关神经假体装置
公开(公告)号：US09008780B2
公开(公告)日：2015-04-14
申请号：US13523597
申请日：2012-06-14
申请人： Randolph J. Nudo , David Guggenmos , Pedram Mohseni , Meysam Azin
发明人： Randolph J. Nudo , David Guggenmos , Pedram Mohseni , Meysam Azin
IPC分类号： A61N1/05 , A61N1/36 , A61B5/00 , A61B5/04
CPC分类号： A61N1/36103 , A61B5/04001 , A61B5/6868 , A61N1/0529 , A61N1/0531 , A61N1/0536 , A61N1/36139
摘要： Methods for bridging brain sites between which there is substantially no effective communication, and associated neural prosthetic devices, are provided. A neural spike in a first neural site in a subject is detected, and a stimulus to a second neural site in the subject is delivered within a defined period of time after the detection of the neural spike, wherein there is substantially no effective communication between the first and second neural sites. The method forms an artificial bridge between the two neural sites, and establishes lasting communication between the two sites. The present disclosure provides, among other things, a neural prosthetic device comprising an integrated circuit that comprises a recording front-end comprising a plurality of recording channels; a processor unit; and a stimulus delivering back-end comprising a plurality of stimulation channels.
摘要翻译：提供了桥接基本上没有有效通信的脑部位置和相关联的神经修复装置的方法。检测受试者中第一神经位点中的神经尖峰，并且在检测到神经穗之后的确定的时间段内传递对受试者中的第二神经部位的刺激，其中基本上没有有效的通信第一和第二神经位点。该方法在两个神经位点之间形成人造桥梁，并建立了两个站点之间的持久通信。本公开尤其提供了包括集成电路的神经假体装置，所述集成电路包括包括多个记录通道的记录前端; 处理器单元; 以及传送后端的刺激物，其包括多个刺激通道。

10. 发明授权

US08954142B2 Microelectrode and multiple microelectrodes 有权
标题翻译：微电极和多个微电极
公开(公告)号：US08954142B2
公开(公告)日：2015-02-10
申请号：US13376910
申请日：2010-06-03
申请人： Fredrik Ek , Nils Danielsen , Jenny Eriksson Linsmeier , Per Petersson , Jens Schouenborg
发明人： Fredrik Ek , Nils Danielsen , Jenny Eriksson Linsmeier , Per Petersson , Jens Schouenborg
IPC分类号： A61M37/00 , A61N1/05 , A61B5/04 , A61N1/04 , A61N1/30 , A61N1/32 , A61N1/372
CPC分类号： A61N1/0531 , A61B5/04001 , A61B5/4094 , A61L31/148 , A61L31/16 , A61L2300/604 , A61N1/0412 , A61N1/0476 , A61N1/05 , A61N1/0536 , A61N1/0551 , A61N1/306 , A61N1/325 , A61N1/327 , A61N1/37205
摘要： A medical microelectrode includes an elongate electrode body including a tip section, a main body section and, optionally, a coupling section. The tip section, the main body section and, optionally, the coupling section are embedded in a first electrode matrix element, which is substantially rigid, biocompatible and soluble or biodegradable in a body fluid. Additionally the microelectrode includes a dissolution retarding layer on the first electrode matrix element and/or a second electrode matrix element disposed between the first electrode matrix element and the electrode. Upon dissolution or biodegradation of the first electrode matrix element a drug comprised by the first electrode matrix element or the second electrode matrix element is released into the tissue. Also disclosed are bundles and arrays of the electrodes and their use.
摘要翻译：医用微电极包括细长电极体，其包括尖端部分，主体部分和任选的耦合部分。尖端部分，主体部分和任选的联接部分嵌入第一电极矩阵元件中，该第一电极矩阵元件在体液中基本上是刚性的，生物相容的和可溶解的或可生物降解的。此外，微电极在第一电极矩阵元件上包括溶解阻滞层和/或设置在第一电极矩阵元件和电极之间的第二电极矩阵元件。在第一电极矩阵元件的溶解或生物降解时，由第一电极矩阵元件或第二电极矩阵元素包含的药物被释放到组织中。还公开了电极的束和阵列及其用途。

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