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    • 4. 发明授权
    • Glycidol functionalized anion exchange stationary phases
    • Glycidol官能化阴离子交换固定相
    • US09486799B2
    • 2016-11-08
    • US13610495
    • 2012-09-11
    • Christopher A. Pohl
    • Christopher A. Pohl
    • B01J41/08B01J20/32B01J41/20B01D15/36B01J20/288
    • B01J41/20B01D15/363B01J20/288B01J20/3251B01J20/3289B01J41/09
    • Treatment of anion exchange materials containing hydroxyl containing moieties in the beta position relative to the quaternary center in the hydroxide form with glycidol substantially alters the selectivity of the anion exchange material. Furthermore, sequential treatments of first a hydroxide containing solution to put the anion exchange material in the hydroxide form followed by treatment with glycidol in an alternating sequence progressively changes selectivity in a predictable manner allowing facile manipulation of selectivity. Unique to the selectivities achievable with this chemistry is the ability to reverse the elution order of sulfate and carbonate. With all other known systems, carbonate elutes ahead of sulfate and sometimes compromises the ability to quantitate sulfate. With glycidol treatment, carbonate can be moved after sulfate which eliminates interference issues for samples containing significantly more carbonate than sulfate. This modification is useful for columns operated with a hydroxide or carbonate eluent system.
    • 含有羟基的阴离子交换材料相对于具有缩水甘油的氢氧化物形式的季中心的β位置的处理基本上改变了阴离子交换材料的选择性。 此外,首先连续处理含氢氧化物溶液以将阴离子交换材料置于氢氧化物形式,然后以交替的顺序用缩水甘油处理,以可预测的方式逐渐改变选择性,从而容易地操纵选择性。 通过该化学可以实现的选择性独特的是反转硫酸盐和碳酸盐的洗脱顺序的能力。 使用所有其他已知的系统,碳酸盐在硫酸盐之前洗脱,有时会损害硫酸盐的定量能力。 通过缩水甘油处理,碳酸盐可以在硫酸盐之后移动,消除了含有比硫酸盐显着更多的碳酸盐的样品的干扰问题。 该修饰对于用氢氧化物或碳酸盐洗脱液系统操作的柱是有用的。