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1. 发明申请

US20160176829A1 CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF 有权
标题翻译： CREATINE PRODRUGS，COMPOSITIONS AND METHODS OF USE THEREOF
公开(公告)号：US20160176829A1
公开(公告)日：2016-06-23
申请号：US14975950
申请日：2015-12-21
申请人： Farmington Pharma Development
发明人： William F. Brubaker
IPC分类号： C07D273/06 , C07D271/07 , C07D273/04 , C07C279/14
CPC分类号： C07D273/06 , C07B2200/05 , C07C279/14 , C07C279/24 , C07D271/07 , C07D273/04
摘要： The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.
摘要翻译：本发明描述了膜渗透性肌酸酐前药，包含膜可渗透性肌酸酐前药的药物组合物，以及治疗疾病如缺血，心力衰竭，神经变性疾病和影响肌酸激酶系统的遗传病症的方法，包括给予肌酸前药或其药物组合物。本发明还描述了治疗影响肌酸激酶系统的遗传疾病，例如肌酸转运蛋白紊乱或肌酸合成障碍，其包括施用肌酸前药或其药物组合物。

2. 发明申请

US20040235666A1 Substituted imidates as pesticidal agents 审中-公开
标题翻译：取代的亚胺酯作为杀虫剂
公开(公告)号：US20040235666A1
公开(公告)日：2004-11-25
申请号：US10478552
申请日：2004-04-07
发明人： Achim Hense , Rudiger Fischer , Ernst-Rudolf Gesing , Stefan Herrmann , Kristian Kather , Stefan Lehr , Katharina Jansen , Hans-Jochem Riebel , Peter Jeschke , Christoph Erdelen , Angelika Lubos-Erdelen , Wolfram Andersch , Peter Losel , Udo Reckmann
IPC分类号： A01N043/40 , A01N043/36 , C07D211/92 , C07D207/34
CPC分类号： C07D265/30 , A01N47/36 , A01N47/40 , C07D207/22 , C07D211/72 , C07D233/48 , C07D239/12 , C07D263/28 , C07D265/08 , C07D273/06 , C07D277/18 , C07D279/06
摘要： The present invention relates to novel substituted imidates of the formula (I) 1 in which Z, n, X, R1 and R2 have the meanings given in the disclosure, and to processes for their preparation, and to their use as pesticides.
摘要翻译：本发明涉及式（I）的新型取代酰亚胺盐，其中Z，n，X，R 1和R 2具有本公开中给出的含义，及其制备方法及其用途作为农药。

3. 发明授权

US06635637B2 Cyclic oxyguanidine protease inhibitors 有权
标题翻译：环氧基胍蛋白酶抑制剂
公开(公告)号：US06635637B2
公开(公告)日：2003-10-21
申请号：US09919815
申请日：2001-08-02
申请人： Aihua Wang , Tianbao Lu , Bruce Edward Tomczuk , Richard M. Soll , John Curtis Spurlino , Roger Francis Bone
发明人： Aihua Wang , Tianbao Lu , Bruce Edward Tomczuk , Richard M. Soll , John Curtis Spurlino , Roger Francis Bone
IPC分类号： C07D26502
CPC分类号： C07D273/06 , C07D265/02
摘要： Cyclic oxyguanidine compounds, including compounds of Formulae I and II: wherein R1, R3-R6, R21-R26, L, Y, Z, and A are set forth in the specification, as well as hydrates, solvates or pharmaceutically acceptable salts thereof, that inhibit proteolytic enzymes such as thrombin are described. Also described are methods for preparing the compounds of Formulae I and II. The novel compounds of the present invention are potent inhibitors of proteases, especially trypsin-like serine proteases, such as chymotrypsin, trypsin, thrombin, plasmin and factor Xa. Certain of the compounds exhibit antithrombotic activity via direct, selective inhibition of thrombin, or are intermediates useful for forming compounds having antithrombotic activity. The invention includes a composition for inhibiting loss of blood platelets, inhibiting formation of blood platelet aggregates, inhibiting formation of fibrin, inhibiting thrombus formation, and inhibiting embolus formation in a mammal, comprising a compound of the invention in a pharmaceutically acceptable carrier. Other uses of compounds of the invention are as anticoagulants either embedded in or physically linked to materials used in the manufacture of devices used in blood collection, blood circulation, and blood storage, such as catheters, blood dialysis machines, blood collection syringes and tubes, blood lines and stents.
摘要翻译：包括式I和II化合物的环状氧基胍化合物：其中R 1，R 3 -R 6，R 21 -R 26，L，Y，Z和A列于描述了抑制蛋白水解酶如凝血酶的说明书以及其水合物，溶剂合物或其药学上可接受的盐。还描述了制备式I和II化合物的方法。本发明的新型化合物是蛋白酶，特别是胰蛋白酶样丝氨酸蛋白酶的有效抑制剂，例如胰凝乳蛋白酶，胰蛋白酶，凝血酶，纤溶酶和因子Xa。某些化合物通过直接，选择性抑制凝血酶表现出抗血栓形成活性，或者是用于形成具有抗血栓形成活性的化合物的中间体。本发明包括用于抑制血小板损失，抑制血小板聚集体形成，抑制纤维蛋白形成，抑制血栓形成和抑制哺乳动物栓塞形成的组合物，其包含本发明化合物在药学上可接受的载体中。本发明化合物的其它用途是作为凝血剂或者物理上连接于用于血液收集，血液循环和血液储存（例如导管，血液透析机，采血注射器和管）中使用的装置的制造中使用的材料的抗凝剂，血线和支架。

4. 发明申请

US20020115657A1 Substituted hetero-polycyclic compounds as PPARalpha and PPARgamma 审中-公开
标题翻译：取代的杂多环化合物为PPARα和PPARγ
公开(公告)号：US20020115657A1
公开(公告)日：2002-08-22
申请号：US10076575
申请日：2002-02-08
发明人： Lone Jeppesen , Paul Stanley Bury , Per Sauerberg
IPC分类号： A61K031/55 , A61K031/5415 , A61K031/538 , A61K031/498 , A61K031/473
CPC分类号： C07D471/04 , C07D209/86 , C07D209/88 , C07D223/22 , C07D273/06 , C07D279/34
摘要： The present invention relates to compounds of the general formula (I) 1 The compounds are useful in the treatment and/or prevention of conditions mediated by nuclear receptors, in particular the Peroxisome Proliferator-Activated Receptors (PPAR).
摘要翻译：本发明涉及通式（I）的化合物。该化合物可用于治疗和/或预防由核受体介导的病症，特别是过氧化物酶体增殖物激活受体（PPAR）

5. 发明授权

US06423708B1 Aralkyl and aralkylidene heterocyclic lactams and imides 失效
标题翻译：芳烷基和芳烷基杂环内酰胺和酰亚胺
公开(公告)号：US06423708B1
公开(公告)日：2002-07-23
申请号：US09733346
申请日：2000-12-08
申请人： Megan Ann Gibbs , Harry Ralph Howard , Jeffrey Scott Sprouse , Joel Barry Schachter , Phillip Branch Chappell
发明人： Megan Ann Gibbs , Harry Ralph Howard , Jeffrey Scott Sprouse , Joel Barry Schachter , Phillip Branch Chappell
IPC分类号： A61K31538
CPC分类号： C07D277/20 , A61K31/135 , A61K31/496 , C07D233/70 , C07D233/96 , C07D241/08 , C07D265/32 , C07D267/10 , C07D273/06 , C07D277/34 , C07D279/12 , C07D281/06 , C07D417/04 , C07D417/10 , C07D417/12 , C07D471/04 , C07D487/04 , A61K2300/00
摘要： The present invention relates to compounds of the formula I wherein R1, R2, R3, X, Y and the dashed line are as defined in the specification, to intermediates for their preparation, to pharmaceutical compositions containing them and to their medicinal use as psychotherapeutic agents.
摘要翻译：本发明涉及式I化合物，其中R1，R2，R3，X，Y和虚线如本说明书中所定义，其制备中间体，含有它们的药物组合物和作为精神治疗药物的药物组合物。

6. 发明授权

US4020063A Oxadiazepine cationic dyestuffs 失效
标题翻译：恶二嗪阳离子染料
公开(公告)号：US4020063A
公开(公告)日：1977-04-26
申请号：US391298
申请日：1973-08-24
申请人： Uwe Mayer , Karl-Heinz Schundehutte
发明人： Uwe Mayer , Karl-Heinz Schundehutte
IPC分类号： C09B57/00 , C07D273/06 , C09B44/10
CPC分类号： C07D273/06 , C09B44/10
摘要： Cationic dyestuffs of the formula ##STR1## WHEREIN A and B denote aromatic-carbocyclic or aromatic-heterocyclic radicals,D denotes the groups --O--R.sub.2, ##STR2## R denotes hydrogen, alkyl, aralkyl, alkenyl, alkoxy or aryl, X denotes a bridge member andAn.sup.(.sup.-) denotes an anion,Are suitable for dyeing and printing of natural and synthetic materials, particularly of polyacrylonitrile, copolymers of acrylonitrile with other vinyl compounds, of acid modified polyesters and acid modified polyamides.
摘要翻译：式A和B表示芳族 - 碳环或芳族 - 杂环基的阳离子染料，D表示基团-O-R2，R表示氢，烷基，芳烷基，烯基，烷氧基或芳基，X表示桥联构件和An（ - ）表示阴离子，适用于天然和合成材料的染色和印刷，特别是聚丙烯腈，丙烯腈与其它乙烯基化合物的共聚物，酸改性聚酯和酸改性聚酰胺。

7. 发明授权

US3502694A 1,3,5-benzoxadiazepines 失效
标题翻译： 1,3,5-苯并恶唑
公开(公告)号：US3502694A
公开(公告)日：1970-03-24
申请号：US3502694D
申请日：1967-09-05
申请人： HOFFMANN LA ROCHE
发明人： FIELD GEORGE FRANCIS , STERNBACH LEO HENRYK
IPC分类号： C07D273/06 , C07D51/00
CPC分类号： C07D273/06

8. 发明授权

US3244703A Thiazine, thiazoline, and thiazolinone compounds 失效
标题翻译：噻嗪，噻唑啉和噻唑啉酮化合物
公开(公告)号：US3244703A
公开(公告)日：1966-04-05
申请号：US23154962
申请日：1962-10-18
申请人： SHELL OIL CO
发明人： JOHN YATES , ROSINGER HERBERT P , TH HACKMANN JOHANNES
IPC分类号： C07D233/54 , C07D233/64 , C07D235/18 , C07D239/06 , C07D263/56 , C07D263/57 , C07D265/08 , C07D271/06 , C07D271/07 , C07D273/06 , C07D277/10 , C07D277/22 , C07D277/24 , C07D277/34 , C07D277/56 , C07D277/64 , C07D277/66 , C07D281/02 , C07D285/12 , C07D285/125 , C07D285/135
CPC分类号： C07D233/64 , C07D235/18 , C07D239/06 , C07D263/57 , C07D265/08 , C07D271/06 , C07D271/07 , C07D273/06 , C07D277/10 , C07D277/22 , C07D277/24 , C07D277/56 , C07D277/64 , C07D277/66 , C07D281/02 , C07D285/125 , C07D285/135

9. 发明申请

US20170342039A1 CREATINE PRODRUGS, COMPOSITIONS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20170342039A1
公开(公告)日：2017-11-30
申请号：US15481568
申请日：2017-04-07
申请人： Farmington Pharma Development
发明人： William F. Brubaker
IPC分类号： C07D273/06 , C07C279/14 , C07C279/24 , C07D273/04 , C07D271/07
CPC分类号： C07D273/06 , C07B2200/05 , C07C279/14 , C07C279/24 , C07D271/07 , C07D273/04
摘要： The invention describes membrane permeable creatine prodrugs, pharmaceutical compositions comprising membrane permeable creatine prodrugs, and methods of treating diseases such as ischemia, heart failure, neurodegenerative disorders and genetic disorders affecting the creatine kinase system comprising administering creatine prodrugs or pharmaceutical compositions thereof. The invention also describes treating a genetic disease affecting the creatine kinase system, such as, for example, a creatine transporter disorder or a creatine synthesis disorder comprising administering creatine prodrugs or pharmaceutical compositions thereof.

10. 发明申请

US20120208997A1 NOVEL COMPOUND HAVING HETEROCYCLIC RING 失效
标题翻译：具有杂环的新型化合物
公开(公告)号：US20120208997A1
公开(公告)日：2012-08-16
申请号：US13372848
申请日：2012-02-14
申请人： Hideyuki SUZUKI , Shoji HIZATATE , Iwao UTSUNOMIYA , Koichi SHUDO
发明人： Hideyuki SUZUKI , Shoji HIZATATE , Iwao UTSUNOMIYA , Koichi SHUDO
IPC分类号： C07D413/10 , C07D413/14 , C07D401/10 , C07D471/14 , C07D487/14 , C07D471/04 , C07D417/14 , C07D487/04
CPC分类号： C07D273/06 , C07D255/02 , C07D413/10 , C07D413/14 , C07D417/14 , C07D471/14 , Y02P20/55
摘要： The invention provides a novel oxazolidinone derivative represented by the formula (I): wherein Ring A, X1, Ring B and R1 are as described in the description, and an antibacterial agent containing the same.
摘要翻译：本发明提供由式（I）表示的新型恶唑烷酮衍生物：其中环A，X1，环B和R1如说明书所述，以及含有该恶唑烷酮衍生物的抗菌剂。

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