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1. 发明授权

US09783532B2 Molecules having certain pesticidal utilities, and intermediates, compositions, and processes related thereto 有权
公开(公告)号：US09783532B2
公开(公告)日：2017-10-10
申请号：US15453473
申请日：2017-03-08
申请人： Dow AgroSciences LLC
发明人： Natalie C. Giampietro , Lindsey G. Fischer , Erich W. Baum , Gary D. Crouse , Andrew L. Ward , Thomas C. Sparks , Jeff Petkus
IPC分类号： C07D417/12 , C07D249/08 , A01N47/42 , A01N47/36 , A01N47/34
CPC分类号： C07D417/12 , A01N25/00 , A01N25/32 , A01N43/653 , A01N47/12 , A01N47/34 , A01N47/36 , A01N47/40 , A01N47/42 , A01N53/00 , A01N55/08 , C07C211/45 , C07C267/00 , C07C335/02 , C07C335/16 , C07C335/26 , C07D249/08 , C07D277/54 , C07D285/01 , C07D403/10 , C07D405/10 , C07F5/04
摘要： This disclosure relates to the field of molecules having pesticidal utility against pests in phyla Nematoda, Arthropoda, and/or Mollusca, processes to produce such molecules and intermediates used in such processes, compositions containing such molecules, and processes of using such molecules against such pests. These molecules may be used, for example, as nematicides, acaricides, insecticides, miticides, and/or molluscicides. This document discloses molecules having the following formula (“Formula One”).

2. 发明授权

US09079869B2 Chiral disulfonimides 有权
标题翻译：手性二磺酰亚胺
公开(公告)号：US09079869B2
公开(公告)日：2015-07-14
申请号：US13203382
申请日：2010-03-02
申请人： Benjamin List , Frank Lay , Pilar Garcia Garcia
发明人： Benjamin List , Frank Lay , Pilar Garcia Garcia
IPC分类号： A61K31/554 , C07D285/36 , C07D285/01
CPC分类号： C07D285/01
摘要： Chiral disulfonimides having the formula I to III, wherein at least one of the groups A and B in the compound of formula I, C and D of the compound in formula II, and E and F of the compound in formula III is a chiral group, or E and F together form a chiral backbone, X is C, Si, O, N or S, and n is 0, 1, 2, 3, 4, 5 or 6, where n is >1 only if X is C, and G is as defined herein, and to the organic salts, metal salts and metal complexes thereof, are suited as NMR shift reagents and as reagents for racemate splitting, and also as chiral Brønsted acid catalysts or chiral Lewis acid catalysts for activating ketones, aldehydes and alkenes, and also as catalysts in the organic synthesis.
摘要翻译：具有式I至III的手性二磺酰亚胺，其中式I化合物中的基团A和B中至少一个，式II化合物中的C和D，以及式III中化合物的E和F是手性基团，或E和F一起形成手性主链，X为C，Si，O，N或S，n为0,1,2,3,4,5或6，其中只有X为C时，n为> 1 和G如本文所定义，并且其有机盐，金属盐和金属络合物适合用作NMR位移试剂和用作外消旋体分裂的试剂，以及用作活化酮的手性布朗斯台德酸催化剂或手性路易斯酸催化剂，醛和烯烃，以及有机合成中的催化剂。

3. 发明授权

US08003674B2 Flavivirus inhibition by sultams and related compounds 失效
标题翻译：苏氨酸和相关化合物的黄病毒抑制
公开(公告)号：US08003674B2
公开(公告)日：2011-08-23
申请号：US12279831
申请日：2007-03-15
申请人： Eric Barklis
发明人： Eric Barklis
IPC分类号： A61K31/41
CPC分类号： C07D285/01 , G01R33/5608 , G01R33/56341 , G06K9/4638 , G06K2009/366 , G06K2209/05 , G06T7/12 , G06T7/181 , G06T15/08 , G06T2207/10092 , G06T2207/20156 , G06T2207/30016
摘要： Disclosed herein are compounds, compositions and methods for treating or ameliorating flavivirus infections. This is particularly important because the present disclosure provides methods for treating flavivirus infections for which there is no effective vaccine.
摘要翻译：本文公开了用于治疗或改善黄病毒感染的化合物，组合物和方法。这是特别重要的，因为本公开提供了治疗没有有效疫苗的黄病毒感染的方法。

4. 发明申请

US20080085894A1 ALPHA-(N-SULFONAMIDO)ACETAMIDE DERIVATIVES AS BETA-AMYLOID INHIBITORS 有权
标题翻译： ALPHA-（N-磺酰氨基）乙酰胺衍生物作为β-淀粉样抑制剂
公开(公告)号：US20080085894A1
公开(公告)日：2008-04-10
申请号：US11870595
申请日：2007-10-11
申请人： Michael Parker , Katharine McElhone , Robert Mate , Joanne Bronson , Yonghua Gai , Carl Bergstrom , Lawrence Marcin , John Macor
发明人： Michael Parker , Katharine McElhone , Robert Mate , Joanne Bronson , Yonghua Gai , Carl Bergstrom , Lawrence Marcin , John Macor
IPC分类号： A61K31/5375 , A61K31/145 , A61K31/195 , A61K31/21 , A61K31/351 , A61K31/4245 , A61P25/28 , A61K31/54 , A61K31/426 , A61K31/445 , A61K31/4545 , A61K31/495
CPC分类号： C07D207/325 , C07C311/19 , C07C317/32 , C07C323/49 , C07C323/60 , C07C2601/02 , C07C2601/14 , C07D211/28 , C07D211/60 , C07D213/42 , C07D213/74 , C07D215/06 , C07D217/04 , C07D231/12 , C07D233/56 , C07D235/14 , C07D249/08 , C07D257/04 , C07D261/08 , C07D271/06 , C07D271/10 , C07D277/28 , C07D285/01 , C07D295/13 , C07D295/135 , C07D307/68 , C07D333/20
摘要： There is provided a series of novel α-(N-sulfonamido)acetamide compounds of the Formula (I) wherein R, R1, R2 and R3 are defined herein, which are inhibitors of β-amyloid peptide (β-AP) production and are useful in the treatment of Alzheimer's Disease and other conditions affected by anti-amyloid activity.
摘要翻译：提供了一系列新的式（I）的α-（N-亚磺酰氨基）乙酰胺化合物，其中R 1，R 1，R 2和R 3 本文定义为β-淀粉样蛋白肽（β-AP）产生的抑制剂，并且可用于治疗阿尔茨海默病和受抗淀粉样蛋白活性影响的其它病症。

5. 发明授权

US07279470B2 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase 失效
标题翻译：用于降低激素敏感性脂肪酶活性的化合物及其用途
公开(公告)号：US07279470B2
公开(公告)日：2007-10-09
申请号：US10319885
申请日：2002-12-13
申请人： Soren Ebdrup , Johannes Cornelis de Jong , Poul Jacobsen , Holger Claus Hansen , Per Vedso
发明人： Soren Ebdrup , Johannes Cornelis de Jong , Poul Jacobsen , Holger Claus Hansen , Per Vedso
IPC分类号： C07D401/12 , C07D401/14 , A61K31/496 , A61K31/4523
CPC分类号： C07D207/404 , C07C39/367 , C07C233/25 , C07C233/26 , C07C233/60 , C07C307/06 , C07C311/04 , C07C311/17 , C07C311/21 , C07C311/29 , C07C311/40 , C07C317/22 , C07C323/20 , C07C2601/14 , C07D209/08 , C07D209/32 , C07D209/48 , C07D211/88 , C07D213/61 , C07D213/63 , C07D213/64 , C07D213/643 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/84 , C07D215/20 , C07D215/22 , C07D217/24 , C07D231/12 , C07D231/16 , C07D233/54 , C07D233/56 , C07D235/18 , C07D235/26 , C07D237/14 , C07D239/22 , C07D241/18 , C07D241/44 , C07D249/04 , C07D249/08 , C07D249/18 , C07D253/04 , C07D257/04 , C07D261/12 , C07D263/52 , C07D277/24 , C07D277/68 , C07D285/01 , C07D295/205 , C07D295/26 , C07D307/16 , C07D307/52 , C07D307/89 , C07D311/16 , C07D311/18 , C07D333/16 , C07D333/32 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/06 , C07D491/10
摘要： Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.
摘要翻译：使用化合物抑制激素敏感性脂肪酶，包含化合物的药物组合物，使用这些化合物和组合物的治疗方法以及新化合物。本发明化合物是激素敏感性脂肪酶的抑制剂，并且可用于治疗和/或预防需要激素敏感性脂肪酶活性降低的医学病症。

6. 发明申请

US20070100141A1 SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR 有权
标题翻译：作为神经元Y2受体的调节剂的替代哌嗪和哌啶
公开(公告)号：US20070100141A1
公开(公告)日：2007-05-03
申请号：US11553556
申请日：2006-10-27
申请人： Pascal Bonaventure , Nicholas Carruthers , Wenying Chai , Curt Dvorak , Jill Jablonowski , Dale Rudolph , Mark Seierstad , Chandravadan Shah , Devin Swanson , Victoria Wong
发明人： Pascal Bonaventure , Nicholas Carruthers , Wenying Chai , Curt Dvorak , Jill Jablonowski , Dale Rudolph , Mark Seierstad , Chandravadan Shah , Devin Swanson , Victoria Wong
IPC分类号： C07D413/02 , C07D403/02 , C07D401/02
CPC分类号： C07D295/15 , C07D205/04 , C07D207/06 , C07D207/08 , C07D207/10 , C07D207/27 , C07D207/34 , C07D211/14 , C07D211/16 , C07D211/22 , C07D211/34 , C07D211/38 , C07D211/58 , C07D211/70 , C07D213/55 , C07D213/56 , C07D213/74 , C07D213/81 , C07D213/82 , C07D231/14 , C07D237/20 , C07D239/28 , C07D239/48 , C07D241/04 , C07D261/08 , C07D261/14 , C07D285/01 , C07D295/135 , C07D295/155 , C07D295/185 , C07D307/24 , C07D307/52 , C07D307/68 , C07D333/38 , C07D401/04 , C07D401/06 , C07D401/12 , C07D405/12 , C07D409/12 , C07D413/12 , C07D417/04 , C07D417/12 , C07D487/08
摘要： The invention provides novel non-peptidic NPY Y2 receptor inhibitors useful in treating or preventing: anxiolytic disorders or depression; injured mammalian nerve tissue; conditions responsive to treatment through administration of a neurotrophic factor; neurological disorders; bone loss; substance related disorders; sleep/wake disorders; cardiovascular disease; obesity; or an obesity-related disorder. Compounds of the invention are also useful in modulating endocrine functions, particularly endocrine functions controlled by the pituitary and hypothalamic glands, and are therefore useful in the treatment or prevention of inovulation and infertility.
摘要翻译：本发明提供了用于治疗或预防：抗焦虑障碍或抑郁症的新型非肽性NPY Y2受体抑制剂; 受伤的哺乳动物神经组织; 通过施用神经营养因子对治疗有反应的病症; 神经系统疾病; 骨质疏松物质相关疾病; 睡眠/觉醒障碍心血管疾病; 肥胖; 或肥胖相关疾病。本发明的化合物还可用于调节内分泌功能，特别是由垂体和下丘脑腺体控制的内分泌功能，因此可用于治疗或预防未排卵和不育症。

7. 发明授权

US06927215B2 Heterocyclic fluoroalkenyl thioethers and the use thereof as pesticides (I) 失效
标题翻译：杂环氟烯基硫醚及其作为农药的用途（I）
公开(公告)号：US06927215B2
公开(公告)日：2005-08-09
申请号：US10332645
申请日：2001-06-29
申请人： Udo Kraatz , Bernd Gallenkamp , Heiko Rieck , Albrecht Marhold , Peter Wolfrum , Wolfram Andersch , Christoph Erdelen , Peter Lösel , Andreas Turberg , Olaf Hansen , Achim Harder
发明人： Udo Kraatz , Bernd Gallenkamp , Heiko Rieck , Albrecht Marhold , Peter Wolfrum , Wolfram Andersch , Christoph Erdelen , Peter Lösel , Andreas Turberg , Olaf Hansen , Achim Harder
IPC分类号： A01N43/72 , A01N43/82 , A01N43/88 , C07D285/00 , C07D285/01 , C07D285/15 , C07D285/36
CPC分类号： C07D285/01 , A01N43/72 , A01N43/82 , A01N43/88 , C07D285/15 , C07D285/36
摘要： The present invention relates to novel heterocyclic fluoroalkenyl thioethers of the formula (I) in which X represents hydrogen, halogen or alkyl, m represents integers from 2 to 10, n represents 0, 1 or 2. y represents unsubstituted or substituted methylene and p represents 1, 2 or 3, and to processes for their preparation and to their use as pesticides.
摘要翻译：本发明涉及式（I）的新型杂环氟烯基硫醚，其中X表示氢，卤素或烷基，m表示2至10的整数，n表示0,1或2. y表示未取代或取代的亚甲基，p表示 1,2或3，以及其制备方法及其作为农药的用途。

8. 发明授权

US06908935B2 Calcium receptor modulating agents 有权
标题翻译：钙受体调节剂
公开(公告)号：US06908935B2
公开(公告)日：2005-06-21
申请号：US10444946
申请日：2003-05-22
申请人： Michael G. Kelly , Shimin Xu , Ning Xi , Philip Miller , John F. Kincaid , Chiara Ghiron , Thomas Coulter
发明人： Michael G. Kelly , Shimin Xu , Ning Xi , Philip Miller , John F. Kincaid , Chiara Ghiron , Thomas Coulter
IPC分类号： A61K31/137 , A61K31/145 , A61K31/167 , A61K31/275 , A61K31/341 , A61K31/357 , A61K31/36 , A61K31/381 , A61K31/4045 , A61K31/417 , A61K31/4184 , A61K31/42 , A61K31/423 , A61K31/426 , A61K31/4418 , A61K31/443 , A61K31/4439 , A61K31/4465 , A61K31/47 , A61K31/4965 , A61K31/50 , A61K31/505 , A61K31/52 , A61K31/5377 , A61P3/14 , A61P5/18 , A61P5/20 , A61P19/10 , C07B53/00 , C07C209/28 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/55 , C07C215/46 , C07C217/54 , C07C217/58 , C07C229/38 , C07C233/43 , C07C235/20 , C07C237/30 , C07C255/58 , C07C255/59 , C07C275/40 , C07C311/08 , C07C317/32 , C07D207/26 , C07D207/32 , C07D207/325 , C07D209/08 , C07D209/10 , C07D209/44 , C07D211/22 , C07D211/26 , C07D211/70 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/62 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/73 , C07D213/74 , C07D213/75 , C07D213/82 , C07D215/12 , C07D231/56 , C07D233/22 , C07D235/06 , C07D235/08 , C07D235/10 , C07D235/12 , C07D235/14 , C07D237/14 , C07D239/26 , C07D239/34 , C07D239/42 , C07D239/47 , C07D241/12 , C07D241/42 , C07D249/18 , C07D261/08 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/10 , C07D271/12 , C07D277/24 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/66 , C07D277/78 , C07D285/00 , C07D285/01 , C07D295/096 , C07D295/135 , C07D295/185 , C07D295/26 , C07D307/42 , C07D307/52 , C07D307/68 , C07D317/46 , C07D317/54 , C07D317/58 , C07D319/18 , C07D321/10 , C07D333/16 , C07D333/20 , C07D333/56 , C07D401/12 , C07D405/12 , C07D471/04 , C07D473/00 , C07D487/04
CPC分类号： C07C233/36 , C07C211/27 , C07C211/29 , C07C211/30 , C07C211/55 , C07C215/46 , C07C217/54 , C07C217/58 , C07C229/38 , C07C233/43 , C07C233/46 , C07C235/20 , C07C237/30 , C07C255/58 , C07C255/59 , C07C275/40 , C07C311/08 , C07C317/32 , C07C2601/02 , C07D207/26 , C07D207/27 , C07D207/325 , C07D209/08 , C07D209/10 , C07D209/44 , C07D211/22 , C07D211/70 , C07D213/26 , C07D213/30 , C07D213/38 , C07D213/61 , C07D213/64 , C07D213/65 , C07D213/68 , C07D213/73 , C07D213/75 , C07D213/82 , C07D215/12 , C07D215/14 , C07D231/56 , C07D233/22 , C07D235/06 , C07D235/10 , C07D235/12 , C07D237/08 , C07D237/14 , C07D239/26 , C07D239/34 , C07D239/42 , C07D241/12 , C07D241/42 , C07D249/18 , C07D261/08 , C07D263/32 , C07D263/56 , C07D271/06 , C07D271/08 , C07D271/10 , C07D271/12 , C07D277/24 , C07D277/28 , C07D277/40 , C07D277/42 , C07D277/66 , C07D285/01 , C07D295/096 , C07D295/135 , C07D295/185 , C07D295/26 , C07D307/42 , C07D307/52 , C07D307/68 , C07D317/46 , C07D317/54 , C07D319/18 , C07D321/10 , C07D333/16 , C07D333/20 , C07D333/56 , C07D401/12 , C07D405/12 , C07D471/04 , C07D487/04
摘要： The compounds of the invention are represented by the following general structure or a pharmaceutically acceptable salt thereof, and compositions containing them, wherein the variables are defined herein, and their use to reduce or inhibit PTH secretion, including methods for reducing or inhibiting PTH secretion and methods for treatment or prophylaxis of diseases associated with bone disorders, such as osteoporosis, or associated with excessive secretion of PTH, such as hyperparathyroidism. The subject invention also relates to processes for making such compounds as well as to intermediates useful in such processes.
摘要翻译：本发明的化合物由以下一般结构或其药学上可接受的盐以及含有它们的组合物表示，其中变量在本文中定义，及其用于减少或抑制PTH分泌的用途，包括减少或抑制PTH分泌的方法，以及用于治疗或预防与骨疾病相关的疾病如骨质疏松症或与过度分泌的PTH相关的疾病如甲状旁腺功能亢进的方法。本发明还涉及制备这些化合物的方法以及在这些方法中有用的中间体。

9. 发明申请

US20040139562A1 7-Nitro-2,1,3-benzoxadiazole and 7-nitro-2,1,3-benzthiadiazole derivatives, as well dyeing agents for keratin fibers containing these compounds 失效
公开(公告)号：US20040139562A1
公开(公告)日：2004-07-22
申请号：US10752605
申请日：2004-01-07
发明人： Gisela Umbricht , Hans-Juergen Braun , Sylviane Oberson , Catherine Mueller
IPC分类号： A61K007/13
CPC分类号： C07D285/01 , C07D271/12
摘要： The object of the present invention are 4-nitro-2,1,3-benzoxadiazole derivatives and 4-nitro-2,1,3-benzthiadiazole derivatives of the general Formula (I) 1 as well as dyeing agents for keratin fibers, containing these compounds.

10. 发明申请

US20030166644A1 Compounds and uses thereof for decreasing activity of hormone-sensitive lipase 失效
标题翻译：用于降低激素敏感性脂肪酶活性的化合物及其用途
公开(公告)号：US20030166644A1
公开(公告)日：2003-09-04
申请号：US10319885
申请日：2002-12-13
发明人： Soren Ebdrup , Johannes Cornelis de Jong , Poul Jacobsen , Holger Claus Hansen , Per Vedso
IPC分类号： A61K031/541 , A61K031/5377 , A61K031/53 , A61K031/506 , A61K031/501 , A61K031/496 , A61K031/4545 , A61K031/325
CPC分类号： C07D207/404 , C07C39/367 , C07C233/25 , C07C233/26 , C07C233/60 , C07C307/06 , C07C311/04 , C07C311/17 , C07C311/21 , C07C311/29 , C07C311/40 , C07C317/22 , C07C323/20 , C07C2601/14 , C07D209/08 , C07D209/32 , C07D209/48 , C07D211/88 , C07D213/61 , C07D213/63 , C07D213/64 , C07D213/643 , C07D213/68 , C07D213/69 , C07D213/70 , C07D213/74 , C07D213/75 , C07D213/84 , C07D215/20 , C07D215/22 , C07D217/24 , C07D231/12 , C07D231/16 , C07D233/54 , C07D233/56 , C07D235/18 , C07D235/26 , C07D237/14 , C07D239/22 , C07D241/18 , C07D241/44 , C07D249/04 , C07D249/08 , C07D249/18 , C07D253/04 , C07D257/04 , C07D261/12 , C07D263/52 , C07D277/24 , C07D277/68 , C07D285/01 , C07D295/205 , C07D295/26 , C07D307/16 , C07D307/52 , C07D307/89 , C07D311/16 , C07D311/18 , C07D333/16 , C07D333/32 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/12 , C07D405/12 , C07D405/14 , C07D409/04 , C07D409/12 , C07D413/12 , C07D417/12 , C07D471/04 , C07D471/06 , C07D491/10
摘要： Use of compounds to inhibit hormone-sensitive lipase, pharmaceutical compositions comprising the compounds, methods of treatment employing these compounds and compositions, and novel compounds. The present compounds are inhibitors of hormone-sensitive lipase and may be useful in the treatment and/or prevention of medical disorders where a decreased activity of hormone-sensitive lipase is desirable.
摘要翻译：使用化合物抑制激素敏感性脂肪酶，包含化合物的药物组合物，使用这些化合物和组合物的治疗方法以及新化合物。本发明化合物是激素敏感性脂肪酶的抑制剂，并且可用于治疗和/或预防需要激素敏感性脂肪酶活性降低的医学病症。

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