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1. 发明公开

US20240239809A1 THERAPEUTIC AGENTS FOR ENHANCING EPITHELIAL AND/OR ENDOTHELIAL BARRIER FUNCTION 审中-公开
公开(公告)号：US20240239809A1
公开(公告)日：2024-07-18
申请号：US18428542
申请日：2024-01-31
申请人： ARTUS THERAPEUTICS, INC. , INSTITUTE FOR STEM CELL SCIENCE AND REGENERATIVE MEDICINE
发明人： Praveen Kumar VEMULA , Nicholas Kenneth Terrett , Sakthimala Jagadeesan , Venkatesh Ravula
IPC分类号： C07D498/04 , A61K9/00 , A61K31/352 , A61K31/519 , A61P1/04 , C07D311/02
CPC分类号： C07D498/04 , A61K9/0053 , A61K31/352 , A61K31/519 , A61P1/04 , C07D311/02
摘要： The present invention relates to novel compounds and compositions thereof. The compositions are useful in the treatment of an epithelial or endothelial barrier dysfunction disorder in a subject.

2. 发明授权

US09987249B2 Substituted chroman compounds as calcium sensing receptor modulators 有权
公开(公告)号：US09987249B2
公开(公告)日：2018-06-05
申请号：US15416684
申请日：2017-01-26
申请人： LUPIN ATLANTIS HOLDINGS SA.
发明人： Manojkumar Ramprasad Shukla , Ankush Gangaram Sarde , Rajeshkumar Maganlal Loriya , Vipul Dilip Pachpute , Navnath Bajirao Walke , Talha Hussain Khan , Sanjeev Anant Kulkarni , Venkata P. Palle , Rajender Kumar Kamboj
IPC分类号： A61K31/352 , C07D311/02
CPC分类号： A61K31/352 , A61K31/353 , A61K31/4025 , C07D311/02 , C07D311/58 , C07D405/10
摘要： The present invention provides calcium sensing receptor modulators (CaSR). In particular, the compounds described herein are useful for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of calcium sensing receptors (CaSR). The invention also provides herein the pharmaceutical compositions thereof, and methods for treating, managing, and/or lessening the severity of diseases, disorders, syndromes and/or conditions associated with the modulation of CaSR. The invention also relates to process for the preparation of the compounds of the invention.

3. 发明申请

US20170368018A1 USE OF ELLAGIC ACID DIHYDRATE IN PHARMACEUTICAL FORMULATIONS TO REGULATE BLOOD GLUCOSE LEVELS 审中-公开
公开(公告)号：US20170368018A1
公开(公告)日：2017-12-28
申请号：US15536033
申请日：2015-12-04
申请人： HALO LIFE SCIENCE, LLC
发明人： Michael REYES
IPC分类号： A61K31/35 , C07D311/02 , A61K36/73 , A61K36/45 , A61K36/185 , C07D493/06 , A61K31/05
CPC分类号： A61K31/35 , A61K31/05 , A61K31/4375 , A61K31/66 , A61K36/185 , A61K36/45 , A61K36/73 , C07D311/02 , C07D493/06
摘要： The present invention relates generally to pharmaceutical compositions and methods of use that include an ellagic acid dihydrate compound that assists in increasing glucose uptake.

4. 发明申请

US20160038426A1 EXTENDED-RELEASE TOPIRAMATE CAPSULES 审中-公开
标题翻译：延伸释放的TOPIRAMATE CAPSULES
公开(公告)号：US20160038426A1
公开(公告)日：2016-02-11
申请号：US14775105
申请日：2014-01-06
申请人： UPSHER-SMITH LABORATORIES, INC.
发明人： Sarah Michelle Betterman , Jaidev Srinivas Tantry , Laura Marie Patrick
IPC分类号： A61K9/50 , A61K31/7048
CPC分类号： A61K9/50 , A61K9/16 , A61K9/28 , A61K9/2866 , A61K9/4891 , A61K9/5047 , A61K31/357 , A61K31/7048 , C07D311/02 , C07D493/12 , C07D493/14 , Y10S514/963 , Y10S514/964
摘要： An extended-release topiramate capsule that includes a capsule shell containing a single population of coated particles; wherein each coated particle includes a core and a coating thereon; wherein each particle core includes a homogeneous mixture comprising topiramate throughout its core; and wherein the coating includes one or more release controlling agent(s).
摘要翻译：一种延长释放托吡酯胶囊，其包含含有单一包衣颗粒群的胶囊壳; 其中每个涂覆的颗粒包括芯和其上的涂层; 其中每个颗粒核心包括均匀的混合物，其包含托吡酯整个其核心; 并且其中所述涂层包括一种或多种释放控制剂。

5. 发明申请

US20150309041A1 REACTIVE LABELLING COMPOUNDS AND USES THEREOF 有权
标题翻译：反应性标签化合物及其用途
公开(公告)号：US20150309041A1
公开(公告)日：2015-10-29
申请号：US14698660
申请日：2015-04-28
申请人： Academia Sinica
发明人： Chi-Huey WONG , Jim-Min FANG , Jiun-Jie SHIE
IPC分类号： G01N33/58 , C07D311/02 , C07D309/14 , C07F5/02
CPC分类号： G01N33/582 , C07D309/14 , C07D311/02 , C07F5/027 , C07K7/08 , G01N21/64 , G01N2333/924 , G01N2458/30
摘要： Provided are azido-BODIPY compounds of formula (I), cyclooctyne-based fluorogenic probes of formula (IV), and activity-based probes of formula (VI). These compounds undergo azide alkyne cycloadditions (AAC) with to form triazolyl products. The provided compounds are useful for detection and imaging of alkyne-, or azide-containing molecules. Methods for detection and imaging biomolecules using compounds of the present disclosure are disclosed.
摘要翻译：提供式（I）的叠氮基-BODIPY化合物，式（IV）的基于环辛烯的荧光探针和式（VI）的基于活性的探针。这些化合物经历叠氮炔环加成（AAC）以形成三唑基产物。所提供的化合物可用于检测和成像含炔或叠氮化物的分子。公开了使用本公开的化合物检测和成像生物分子的方法。

6. 发明授权

US08946455B2 Semi-synthetic small molecules for the treatment parasitic disease 有权
标题翻译：半合成小分子治疗寄生虫病
公开(公告)号：US08946455B2
公开(公告)日：2015-02-03
申请号：US14236030
申请日：2012-07-28
申请人： Roger Linington , Gabriel Navarro , Khanitha Pudhom , James McKerrow
发明人： Roger Linington , Gabriel Navarro , Khanitha Pudhom , James McKerrow
IPC分类号： C07D319/00 , C07D319/02 , C07D311/02 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
CPC分类号： C07D319/02 , C07D311/02 , C07D405/12 , C07D407/12 , C07D409/12 , C07D413/12 , C07D417/12
摘要： Small molecule therapeutics for the treatment of parasitic diseases, in particular, semi-synthetic derivatives of the fugally-derived natural product merulin A for the treatment of African Sleeping Sickness.
摘要翻译：用于治疗寄生虫病的小分子治疗剂，特别是用于治疗非洲睡眠疾病的假性天然产物Merulin A的半合成衍生物。

7. 发明申请

US20140323420A1 REDUCING TRANSMISSION OF SEXUALLY TRANSMITTED INFECTIONS 审中-公开
标题翻译：减少传染性传染性感染
公开(公告)号：US20140323420A1
公开(公告)日：2014-10-30
申请号：US14357037
申请日：2012-11-08
申请人： University of Rochester , Regents of the University of California
发明人： Stephen Dewhurst , David Easterhoff , Brad Nilsson , John Dimaio , Alan Smrcka , Jerry Yang , Christina Capule
IPC分类号： C07D471/04 , C07D277/66 , C07D311/02 , C07C317/28 , C07C317/24 , A61K31/167 , A61K31/122 , A61K31/352 , A61K31/473 , A61K31/437 , A61K31/427 , A61K45/06 , C07D221/06 , A61K31/428
CPC分类号： A61K31/167 , A61K31/122 , A61K31/352 , A61K31/427 , A61K31/428 , A61K31/437 , A61K31/473 , A61K31/4745 , A61K31/704 , A61K31/7072 , A61K45/06 , A61K47/60 , C07C317/24 , C07C317/28 , C07D221/06 , C07D277/66 , C07D311/02 , C07D417/12 , C07D417/14 , C07D471/04 , C07D491/04 , A61K2300/00
摘要： Described herein are compositions and methods for treating or preventing a sexually transmitted infection in a subject
摘要翻译：本文描述了用于治疗或预防受试者中性传播感染的组合物和方法

8. 发明申请

US20070123421A1 Imaging system 有权
标题翻译：成像系统
公开(公告)号：US20070123421A1
公开(公告)日：2007-05-31
申请号：US11656267
申请日：2007-01-22
申请人： Peter Chu , Chien Liu , Stephen Telfer
发明人： Peter Chu , Chien Liu , Stephen Telfer
IPC分类号： B41M5/20
CPC分类号： B41M5/385 , B41M5/1455 , B41M5/284 , B41M5/3275 , B41M5/34 , C07D311/02 , C07D493/10 , C09B11/24 , C09B67/006 , Y10S430/145 , Y10S430/146
摘要： There are disclosed imaging members wherein a chemical compound in a crystalline form is converted, at least partially, and preferably substantially completely or completely, to a liquid in the amorphous form, the liquid having intrinsically a different color from the crystalline form. Also described are imaging methods utilizing the imaging members. The conversion of the compound from the crystalline form to the liquid form can be effected by the application of thermal energy or by other imaging techniques.
摘要翻译：公开了成像构件，其中结晶形式的化合物至少部分地，优选地基本上完全或完全地转化为无定形形式的液体，该液体本质上与结晶形式不同。还描述了利用成像构件的成像方法。化合物从结晶形式转化为液体形式可以通过施加热能或通过其它成像技术来实现。

9. 发明授权

US07176161B2 Imaging system 有权
公开(公告)号：US07176161B2
公开(公告)日：2007-02-13
申请号：US10789648
申请日：2004-02-27
申请人： Peter K. Chu , Chien Liu , Stephen J. Telfer
发明人： Peter K. Chu , Chien Liu , Stephen J. Telfer
IPC分类号： B41M5/30
CPC分类号： B41M5/385 , B41M5/1455 , B41M5/284 , B41M5/3275 , B41M5/34 , C07D311/02 , C07D493/10 , C09B11/24 , C09B67/006 , Y10S430/145 , Y10S430/146
摘要： There are disclosed imaging members wherein a chemical compound in a crystalline form is converted, at least partially, and preferably substantially completely or completely, to a liquid in the amorphous form, the liquid having intrinsically a different color from the crystalline form. Also described are imaging methods utilizing the imaging members. The conversion of the compound from the crystalline form to the liquid form can be effected by the application of thermal energy or by other imaging techniques.

10. 发明授权

US07169747B2 Bicyclic lactones, perfumery uses thereof, processes for preparing same and intermediates therefor 有权
标题翻译：双环内酯，其香料用途，其制备方法及其中间体
公开(公告)号：US07169747B2
公开(公告)日：2007-01-30
申请号：US10705786
申请日：2003-11-10
申请人： Richard A. Weiss , Mark A. Sprecker , Marie R. Hanna , Charles E. J. Beck , Harold W. Jackson
发明人： Richard A. Weiss , Mark A. Sprecker , Marie R. Hanna , Charles E. J. Beck , Harold W. Jackson
IPC分类号： A61K7/46
CPC分类号： A61K8/498 , A61L9/01 , A61L9/012 , A61Q13/00 , C07D311/02 , C07D311/74 , C11B9/008 , C11D3/2096 , C11D3/50
摘要： Described are bicyclic lactones, both fused ring lactones defined according to the generic structure: and spiro lactones defined according to the generic structure: uses thereof in augmenting, enhancing or imparting aromas in or to perfume compositions, perfumed articles, colognes and perfumed polymers; processes for preparing such bicyclic lactones and intermediates therefor. In the structure: Z is one of the moieties: one of R1 or R3 is methyl and the other is hydrogen; and R4, R5, R6, R7, R8 and R9 hydrogen or nonadjacent C1–C3 alkyl. In the structure: Y represents C2–C12 substituted or unsubstituted alkylidenyl, alkenylidenyl or alkadienylidenyl having the structure: and completes a C5–C15 cycloalkyl, cycloalkadienyl or cycloalkenyl ring moiety; and wherein R12, R13, R14, R16, R17, R28, R29, R30 and R31 represent hydrogen or C1–C3 nonadjacent alkyl; wherein s is an integer of from 0 up to 10; t is an integer of from 0 up to 10; and v is an integer of 1 or 2; with the proviso that the sum of s and t is between 0 and 10 according to the inequalities: 0≦s+t≦10; 0≦S≦10; and 0≦t≦10.
摘要翻译：描述的是双环内酯，根据通用结构定义的稠环内酯和根据通用结构定义的螺内酯：用于增强，增强或赋予香料组合物，香料制品，古龙水和加香聚合物中的香气; 制备此类双环内酯的方法及其中间体。在结构中：Z是部分之一：R 1或R 3中的一个是甲基，另一个是氢; 和R 4，R 5，R 6，R 7，R 8，和R 9的氢或不相邻的C 1 -C 3烷基。在结构中：Y表示具有以下结构的取代或未取代的亚烷基，亚烯基或链二烯基的取代或未取代的C 1 -C 12 - C 15环烷基，环链二烯基或环烯基环部分; 并且其中R 12，R 13，R 14，R 16，R 17， >，R 28，R 29，R 30和R 31表示氢或C 1〜 N 3 -C 3不相邻的烷基; 其中s为0至10的整数; t是0到10的整数; v为1或2的整数; 条件是根据不等式，s和t之和在0和10之间：0 <= s + t <= 10; 0 <= S <= 10; 0 <= t <= 10。

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