专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US09510593B2 S-benzylthiouracil compounds and methods of enhancing plant root growth 有权
标题翻译： S-苄基硫尿嘧啶化合物和增强植物根生长的方法
公开(公告)号：US09510593B2
公开(公告)日：2016-12-06
申请号：US14596687
申请日：2015-01-14
申请人： Valent BioSciences Corporation
发明人： Asako Nagasawa , Franklin Paul Silverman , Daniel F. Heiman , Dale O. Wilson, Jr. , Peter D. Petracek , Fujio Mukumoto , Hiroaki Tamaki , Takashi Moriwaki
IPC分类号： A01N43/54 , A01N43/90 , C07D239/47 , C07D239/52 , C07D239/56 , C07D473/22 , C07D239/60
CPC分类号： A01N43/54 , A01N43/90 , C07D239/47 , C07D239/52 , C07D239/56 , C07D239/60 , C07D473/22
摘要： The present invention is directed to methods for enhancing root growth comprising applying a S-Benzylthiouracil compound, or a salt thereof, to a plant, plant propagation material, root zone, or root of a plant. The invention also relates to methods for reducing the harmful effects of environmentally stressful conditions on plants, such as drought, or intense temperatures, by application of a S-Benzylthiouracil compound, or a salt thereof, to a plant, plant propagation material, root zone, or root of a plant. The invention further relates to new S-Benzylthiouracil derivatives, and salts thereof.
摘要翻译：本发明涉及用于增强根生长的方法，包括将S-苄基硫脲嘧啶化合物或其盐施用于植物的植物，植物繁殖材料，根部或根部。本发明还涉及通过向植物，植物繁殖材料，根部区域施用S-苄基硫脲嘧啶化合物或其盐来减少环境胁迫条件对植物如干旱或强烈温度的有害影响的方法，或植物的根。本发明还涉及新的S-苄基硫尿嘧啶衍生物及其盐。

2. 发明申请

US20150201620A1 S-BENZYLTHIOURACIL COMPOUNDS AND METHODS OF ENHANCING PLANT ROOT GROWTH 有权
标题翻译： S-苄基硫脲化合物和增强植物根系生长的方法
公开(公告)号：US20150201620A1
公开(公告)日：2015-07-23
申请号：US14596687
申请日：2015-01-14
申请人： Valent BioSciences Corporation
发明人： Asako Nagasawa , Franklin Paul Silverman , Daniel F. Heiman , Dale O. Wilson, JR. , Peter D. Petracek , Fujio Mukumoto , Hiroaki Tamaki , Takashi Moriwaki
IPC分类号： A01N43/54 , C07D473/22 , C07D239/52 , C07D239/60 , C07D239/47 , C07D239/56 , A01N43/90
CPC分类号： A01N43/54 , A01N43/90 , C07D239/47 , C07D239/52 , C07D239/56 , C07D239/60 , C07D473/22
摘要： The present invention is directed to methods for enhancing root growth comprising applying a S-Benzylthiouracil compound, or a salt thereof, to a plant, plant propagation material, root zone, or root of a plant. The invention also relates to methods for reducing the harmful effects of environmentally stressful conditions on plants, such as drought, or intense temperatures, by application of a S-Benzylthiouracil compound, or a salt thereof, to a plant, plant propagation material, root zone, or root of a plant. The invention further relates to new S-Benzylthiouracil derivatives, and salts thereof.
摘要翻译：本发明涉及用于增强根生长的方法，包括将S-苄基硫脲嘧啶化合物或其盐施用于植物的植物，植物繁殖材料，根部或根部。本发明还涉及通过向植物，植物繁殖材料，根部区域施用S-苄基硫脲嘧啶化合物或其盐来减少环境胁迫条件对植物如干旱或强烈温度的有害影响的方法，或植物的根。本发明还涉及新的S-苄基硫尿嘧啶衍生物及其盐。

3. 发明申请

US20080221133A1 Compounds 失效
标题翻译：化合物
公开(公告)号：US20080221133A1
公开(公告)日：2008-09-11
申请号：US11756967
申请日：2007-06-01
申请人： Anna-Karin Tiden
发明人： Anna-Karin Tiden
IPC分类号： A61K31/522 , C07D473/22 , A61P29/00
CPC分类号： C07D473/22
摘要： The present invention relates to a compound according to Formula (I) wherein R1 is selected from C1-C6 alkyl, and said C1-C6 alkyl is substituted with C1-C6 alkoxy; and at least one of said C1-C6 alkyl or said C1-C6 alkoxy is branched; or a pharmaceutically acceptable salt thereof, solvate or solvate of a salt thereof, as well as, to compositions containing at least one compound according to Formula (I) and methods of treating at least one disease or condition therewith.
摘要翻译：本发明涉及式（I）化合物，其中R 1选自C 1 -C 6烷基，所述C C 1 -C 6烷基被C 1 -C 6烷氧基取代; C 1 -C 6烷基被C 1 -C 6烷氧基取代; 并且所述C 1 -C 6 - 烷基或所述C 1 -C 6烷氧基中的至少一个是支链 ; 或其药学上可接受的盐，其盐的溶剂合物或溶剂合物，以及含有至少一种根据式（I）的化合物的组合物和用其治疗至少一种疾病或病症的方法。

4. 发明授权

US6090816A Aryl thioxanthines 失效
标题翻译：芳基硫代黄嘌呤
公开(公告)号：US6090816A
公开(公告)日：2000-07-18
申请号：US911549
申请日：1997-08-14
申请人： David John Cavalla , Mark Chasin , Peter Hofer
发明人： David John Cavalla , Mark Chasin , Peter Hofer
IPC分类号： A61K31/52 , A61K31/522 , A61P11/06 , A61P25/24 , A61P25/26 , A61P25/28 , A61P29/00 , A61P37/08 , A61P43/00 , C07D473/18 , C07D473/22 , A61K473/22
CPC分类号： C07D473/18 , C07D473/22
摘要： Disclosed are compounds having the formulae: ##STR1## wherein: Q.sub.3,Q.sub.6a,Q.sub.6b and Q.sub.8 are independently a bond, C.sub.1-8 alkylene, C.sub.2-8 alkenylene and C.sub.2-6 alkynylene, andR.sub.3, R.sub.6a, R.sub.6b, and R.sub.8 are independently hydrogen, aryl or heteroaryl, optionally substituted by halogen, hydroxy, alkoxy, nitro, cyano and carboxy, provided that:Q.sub.3 R.sub.3 is not hydrogen or methyl in formulae (I) or (II); and at least one of R.sub.3 and R.sub.8 is aryl or heteroaryl in formula (I).The compounds are effective PDE IV inhibitors and possess improved PDE IV inhibition and improved selectivity with regard to PDE III inhibition.
摘要翻译：公开了具有下式的化合物：其中：Q 3，Q 6a，Q 6b和Q 8独立地是键，C 1-8亚烷基，C 2-8亚烯基和C 2-6亚炔基，R 3，R 6a，R 6b和R 8独立地是氢，任选被卤素，羟基，烷氧基，硝基，氰基和羧基取代的杂芳基，条件是：式（I）或（II）中的Q3R 3不是氢或甲基; 并且R 3和R 8中的至少一个是式（I）中的芳基或杂芳基。这些化合物是有效的PDE IV抑制剂，并具有改善的PDE IV抑制和改善PDE III抑制的选择性。

5. 发明授权

US5525607A Xanthine compounds 失效
标题翻译：黄嘌呤化合物
公开(公告)号：US5525607A
公开(公告)日：1996-06-11
申请号：US63684
申请日：1993-05-20
申请人： Fumio Suzuki , Junichi Shimada , Akio Ishii , Tetsuji Ohno , Akira Karasawa , Kazuhiro Kubo , Hiromi Nonaka , Fumio Suzuki , Junichi Shimada , Akio Ishii , Tetsuji Ohno , Akira Karasawa , Kazuhiro Kubo , Hiromi Nonaka
发明人： Fumio Suzuki , Junichi Shimada , Akio Ishii , Tetsuji Ohno , Akira Karasawa , Kazuhiro Kubo , Hiromi Nonaka , Fumio Suzuki , Junichi Shimada , Akio Ishii , Tetsuji Ohno , Akira Karasawa , Kazuhiro Kubo , Hiromi Nonaka
IPC分类号： C07D473/06 , C07D473/08 , C07D473/20 , C07D473/22 , A61K31/52 , C07D473/00
CPC分类号： C07D473/06 , C07D473/08 , C07D473/20 , C07D473/22
摘要： Novel xanthine compounds represented by the following formula: ##STR1## wherein each of R.sup.1, R.sup.2 and R.sup.3 independently represents hydrogen or lower alkyl;each of X.sup.1 and X.sup.2 independently represents oxygen or sulfur; and Q represents: ##STR2## The compounds are useful as a diuretic, a renal-protecting agent and bronchodilator.
摘要翻译：由下式表示的新型黄嘌呤化合物：其中R 1，R 2和R 3各自独立地表示氢或低级烷基; X1和X2各自独立地表示氧或硫; Q表示：该化合物可用作利尿剂，肾保护剂和支气管扩张剂。

6. 发明授权

US5068236A Xanthine derivatives 失效
标题翻译： XANTHINE DERIVATIVES
公开(公告)号：US5068236A
公开(公告)日：1991-11-26
申请号：US486831
申请日：1990-03-01
申请人： Fumio Suzuki , Junichi Shimada , Kazuhiro Kubo , Tetsuji Ohno , Akira Karasawa , Akio Ishii , Hiromi Nonaka
发明人： Fumio Suzuki , Junichi Shimada , Kazuhiro Kubo , Tetsuji Ohno , Akira Karasawa , Akio Ishii , Hiromi Nonaka
IPC分类号： A61K31/52 , A61K31/522 , A61P7/10 , A61P9/08 , A61P9/12 , A61P13/02 , A61P15/00 , C07D473/04 , C07D473/06 , C07D473/08 , C07D473/10 , C07D473/12 , C07D473/20 , C07D473/22
CPC分类号： C07D473/04 , C07D473/06 , C07D473/22
摘要： Novel xanthine compounds represented by the following formula: ##STR1## and pharmaceutically acceptable salts thereof have a diuretic action, a renal-protecting action and a vasodilative action.The compounds are useful as a diuretic, a renal-protecting agent and an antihypertensive agent.

7. 发明授权

US4925847A 6-thioxanthines 失效
标题翻译： 6-硫代黄嘌呤
公开(公告)号：US4925847A
公开(公告)日：1990-05-15
申请号：US78545
申请日：1987-07-28
申请人： Peter Hofer
发明人： Peter Hofer
IPC分类号： A61K31/52 , A61K31/522 , A61P11/08 , C07D473/22
CPC分类号： C07D473/22
摘要： A 6-thioxanthine of general formula I or a pharmaceutically acceptable salt thereof ##STR1## wherein R.sub.3 is a C.sub.2 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group and R.sub.8 is a C.sub.1 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group provided that when R.sub.3 is an ethyl, n-propyl or n-butyl group, R.sub.8 is a C.sub.3 to C.sub.6 alkyl, a C.sub.3 to C.sub.7 cycloalkyl group or a C.sub.4 to C.sub.8 cycloalkylalkyl group.These 3,8-disubstituted-6-thioxanthines have enhanced bronchodilator activity.
摘要翻译：通式I的6-硫代黄嘌呤或其药学上可接受的盐，其中R 3为C 2至C 6烷基，C 3至C 7环烷基或C 4至C 8环烷基烷基，R 8为C 1至C 6烷基， C3至C7环烷基或C4至C8环烷基烷基，条件是当R3为乙基，正丙基或正丁基时，R 8为C 3至C 6烷基，C 3至C 7环烷基或C 4至C 8环烷基烷基。这些3,8-二取代-6-硫代黄嘌呤具有增强的支气管扩张剂活性。

8. 发明授权

US4710503A 6-thioxanthine derivatives 失效
标题翻译： 6-硫代黄嘌呤衍生物
公开(公告)号：US4710503A
公开(公告)日：1987-12-01
申请号：US699254
申请日：1985-02-07
申请人： Peter Hofer
发明人： Peter Hofer
IPC分类号： A61K31/52 , A61K31/522 , A61P11/08 , C07D473/22 , C07D473/06
CPC分类号： C07D473/22
摘要： Compounds of the formula ##STR1## wherein R.sup.3 is ethyl, n-propyl or n-butyl, andR.sup.8 is hydrogen, methyl or ethyl,exhibit bronchodilating activity with reduced side effects and increased half-life. A method of achieving bronchodilation with reduced undesired effects (diuresis, CNS activity), by administering the said compounds to a patient, is also provided.
摘要翻译：其中R 3为乙基，正丙基或正丁基，且R 8为氢，甲基或乙基的式“IMAGE”化合物表现出支气管扩张活性，副作用减小且半衰期延长。还提供了通过向患者施用所述化合物来实现具有减少的不希望的作用（利尿，CNS活性）的支气管扩张的方法。

9. 发明授权

US08026244B2 Thioxanthine derivatives and their use as inhibitors of MPO 失效
标题翻译：硫代黄嘌呤衍生物及其作为MPO抑制剂的用途
公开(公告)号：US08026244B2
公开(公告)日：2011-09-27
申请号：US12295306
申请日：2007-04-12
申请人： Anna-Karin Tiden , Jenny Viklund
发明人： Anna-Karin Tiden , Jenny Viklund
IPC分类号： C07D473/22 , A61K31/522 , A61P9/10 , A61P11/00 , A61P11/08 , A61P25/16 , C07D401/06 , C07D401/12 , C07D403/06 , C07D403/12
CPC分类号： C07D473/20 , C07D473/22
摘要： There are disclosed novel compounds of Formula (I) wherein L, R1, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio- and cerebrovascular atherosclerotic disorders and peripheral artery disease and respiratory disorders.
摘要翻译：公开了式（I）的新化合物，其中L，R 1，X和Y如说明书中所定义，及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是MPO酶的抑制剂，因此特别可用于治疗或预防神经炎症性疾病，心脑血管动脉粥样硬化性疾病和外周动脉疾病和呼吸系统疾病。

10. 发明申请

US20090286813A1 Thioxanthine Derivatives and Their Use as Inhibitors of MPO 审中-公开
标题翻译：硫代黄嘌呤衍生物及其作为MPO抑制剂的用途
公开(公告)号：US20090286813A1
公开(公告)日：2009-11-19
申请号：US12296347
申请日：2007-04-12
申请人： Donald Pivonka , Anna-Karin Tiden , Jenny Viklund
发明人： Donald Pivonka , Anna-Karin Tiden , Jenny Viklund
IPC分类号： A61K31/52 , C07D473/00 , A61P29/00 , A61P9/00 , A61P11/00
CPC分类号： C07D473/20 , C07D473/22
摘要： There are disclosed novel compounds of Formula (I) wherein R1, X and Y are as defined in the specification, and pharmaceutically acceptable salts thereof; together with processes for their preparation, compositions containing them and their use in therapy. The compounds are inhibitors of the enzyme MPO and are thereby particularly useful in the treatment or prophylaxis of neuroinflammatory disorders, cardio- and cerebrovascular atherosclerotic disorders and peripheral artery disease and respiratory disorders.
摘要翻译：公开了式（I）的新化合物，其中R 1，X和Y如说明书中所定义，及其药学上可接受的盐; 以及其制备方法，含有它们的组合物及其在治疗中的用途。这些化合物是MPO酶的抑制剂，因此特别可用于治疗或预防神经炎症性疾病，心脑血管动脉粥样硬化性疾病和外周动脉疾病和呼吸系统疾病。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式