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    • 8. 发明授权
    • Thermal responsive polymer siloxanes, compositions, and method and applications related thereto
    • 热响应聚合物硅氧烷,组合物以及与其有关的方法和应用
    • US09259509B2
    • 2016-02-16
    • US14286834
    • 2014-05-23
    • University of Massachusetts Medical School
    • Jie SongJianwen Xu
    • A61K31/74A61L27/18A61L31/06C08G18/61C08G63/695C08G77/04C08G77/38C08G77/445A61L27/50
    • A61L27/18A61L27/50A61L31/06A61L2400/16C08G18/61C08G63/6952C08G77/045C08G77/38C08G77/445C08L83/04
    • The invention relates to materials comprising siloxanes, preferably the materials have thermal-responsive properties. In some embodiments, the invention relates to silsesquioxane groups functionalized with polymers. In another embodiment, silsequioxane-polymer conjugates comprise polylactone segments. The silsequioxane-polymer conjugates may be crosslinked together to form a material, and these materials may be functionalized with bioactive compounds so that the materials have desirable biocompatibility or bioactivity when used in medical devices. In further embodiments, the invention relates to composite materials that contain a polymer matrix and aggregates, and in some embodiments, methods of making, and methods of using these materials. Preferably, the aggregates are calcium phosphate aggregates. Preferably, the material is resistant to fracture. In further embodiments, the materials are used in surgical procedures of bone replacement. In further embodiments, the materials contain polyhedral silsesquioxanes and/or biodegradable segments.
    • 本发明涉及包含硅氧烷的材料,优选该材料具有热响应特性。 在一些实施方案中,本发明涉及用聚合物官能化的倍半硅氧烷基团。 在另一个实施方案中,硅二恶烷 - 聚合物共轭物包含聚内酯片段。 硅氧烷 - 聚合物共轭物可以一起交联以形成材料,并且这些材料可以用生物活性化合物官能化,使得当用于医疗装置时,这些材料具有期望的生物相容性或生物活性。 在另外的实施方案中,本发明涉及包含聚合物基质和聚集体的复合材料,并且在一些实施方案中涉及制备方法和使用这些材料的方法。 优选地,聚集体是磷酸钙聚集体。 优选地,该材料耐断裂。 在另外的实施方案中,所述材料用于骨置换的外科手术中。 在另外的实施方案中,材料含有多面体倍半硅氧烷和/或可生物降解的片段。