专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US10080730B2 Treatment of vasculopathy with prostacyclin and mesenchymal stem cells 有权
公开(公告)号：US10080730B2
公开(公告)日：2018-09-25
申请号：US14149929
申请日：2014-01-08
申请人： United Therapeutics Corporation
发明人： Roger Jeffs , Thomas Petersen , Roger M. Ilagan , Michael Wade
IPC分类号： C12N5/00 , A61K31/192 , A61K35/28 , A61K31/557 , C12N5/0775
CPC分类号： A61K31/192 , A61K31/557 , A61K35/28 , C12N5/0663 , C12N2501/00 , C12N2501/02
摘要： Provided are methods for treating or preventing vasculopathy in a subject in need thereof, comprising administering to the subject a prostacyclin and a mesenchymal stem cell (MSC) or a MSC-conditioned culture medium or administering to the subject a MSC or a MSC-conditioned culture medium that has treated with prostacyclin. Pharmaceutical compositions suitable for such treatments are also provided.

2. 发明申请

US20170298347A1 NOVEL FUSION-CIRCULAR RNAs AND USES THEREOF 审中-公开
公开(公告)号：US20170298347A1
公开(公告)日：2017-10-19
申请号：US15417868
申请日：2017-01-27
申请人： BETH ISRAEL DEACONESS MEDICAL CENTER
发明人： Pier Paolo Pandolfi , Jlenia Guarnerio
IPC分类号： C12N15/11 , C12Q1/68 , C12N5/073 , C12N15/113
CPC分类号： C12N15/11 , C12N5/0603 , C12N15/1135 , C12N2310/113 , C12N2310/14 , C12N2310/531 , C12N2310/532 , C12N2320/33 , C12N2330/10 , C12N2501/00 , C12Q1/6886 , C12Q2600/158 , C12Q2600/178
摘要： Novel fusion-circular RNAs (f-circRNAs) and complements thereof are provided. Diagnostic and treatment methods using f-circRNA inhibitors are provided. Non-human animals expressing exogenous f-circRNA and complements thereof are also provided.

3. 发明申请

US20170152472A1 HEPATIC STELLATE CELL PRECURSORS AND METHODS OF ISOLATING SAME 审中-公开
公开(公告)号：US20170152472A1
公开(公告)日：2017-06-01
申请号：US15205908
申请日：2016-07-08
申请人： University of North Carolina at Chapel Hill
发明人： Hiroshi KUBOTA , Lola M. REID
IPC分类号： C12N5/00 , C12N5/071
CPC分类号： C12N5/0018 , C12N5/067 , C12N5/0672 , C12N2500/00 , C12N2500/05 , C12N2500/20 , C12N2500/25 , C12N2500/32 , C12N2500/36 , C12N2500/38 , C12N2500/90 , C12N2501/00 , C12N2501/11 , C12N2501/235 , C12N2501/33 , G01N33/56966
摘要： The present invention relates to precursor cells to hepatic stellate cells, compositions comprising same and methods of isolating same. The surface antigenic profile of the precursors is MHC class Ia negative, ICAM-1+, VCAM-1+, β3-integrin+. In addition to expression of these surface markers, the cells also express the intracellular markers desmin, vimentin, smooth muscle α-actin, nestin, hepatocyte growth factor, stromal derived factor-1α and Hlx homeobox transcriptional factor.

4. 发明申请

US20170013795A1 METHODS AND SYSTEMS FOR EXTRACTING DICOT EMBRYOS 审中-公开
标题翻译：提取DICOT EMBRYOS的方法和系统
公开(公告)号：US20170013795A1
公开(公告)日：2017-01-19
申请号：US15123971
申请日：2015-03-09
申请人： PIONEER HI-BRED INTERNATIONAL, INC.
发明人： CLIFFORD P. HUNTER , JEFFREY DALE WILLE
IPC分类号： A01H4/00 , G01N35/00 , G01N1/08 , C12Q1/68 , C12N5/04
CPC分类号： A01H4/008 , A01H4/001 , C12N5/04 , C12N2501/00 , C12Q1/6895 , G01N1/08 , G01N35/00 , G01N2001/045
摘要： Methods and systems are provided which permit extraction of a dicot embryo of a dicot seed without damage to the dicot embryo. Methods disclosed herein provide embryos for uses in plant breeding and research procedures.
摘要翻译：提供了允许提取双子叶植物种子的双子叶植物胚胎而不损害双子叶植物胚胎的方法和系统。本文公开的方法提供用于植物育种和研究程序的胚胎。

5. 发明授权

US09434926B1 Graphene hydrogel and methods of using the same 有权
标题翻译：石墨烯水凝胶及其使用方法
公开(公告)号：US09434926B1
公开(公告)日：2016-09-06
申请号：US14627671
申请日：2015-02-20
申请人： Subhra Mohapatra , Chunyan Wang
发明人： Subhra Mohapatra , Chunyan Wang
IPC分类号： A01N63/00 , A01N65/00 , C12N5/00 , C12N5/02 , C12N5/0775 , A61K35/28 , A61K9/06 , A61K47/02 , A61K47/36 , A61K47/14
CPC分类号： C12N5/0663 , A61K9/06 , A61K35/28 , A61K47/02 , A61K47/14 , A61K47/36 , A61L27/20 , A61L27/3821 , A61L27/52 , C08B37/003 , C08F220/54 , C08F222/1006 , C08F251/00 , C08F290/062 , C08F292/00 , C08G65/3322 , C08G83/001 , C08J3/075 , C08J2387/00 , C08L5/08 , C08L71/02 , C12N5/0068 , C12N2501/00 , C12N2533/20 , C12N2533/30 , C12N2533/72 , A61L27/443 , C08L33/00 , A61L15/60 , C08F220/52 , C08F220/06 , C08F2222/1013
摘要： Provided herein are hydrogel compositions containing graphene, chitosan, a polyethylene (glycol) diacrylate (PEGDA). The hydrogel can optionally contain an N-isopropylacrylamide (NIPAM) (TPCG hydrogel). Also provided are methods for differentiating a cell on the hydrogels described herein. Further provided herein are methods for delivering a compound via the hydrogels described herein.
摘要翻译：本文提供含有石墨烯，壳聚糖，聚乙二醇（二醇）二丙烯酸酯（PEGDA）的水凝胶组合物。水凝胶可任选地含有N-异丙基丙烯酰胺（NIPAM）（TPCG水凝胶）。还提供了用于区分本文所述的水凝胶上的细胞的方法。本文还提供了通过本文所述的水凝胶递送化合物的方法。

6. 发明申请

US20160220477A1 COSMETIC OR DERMATOLOGICAL USE OF AN EXTRACT OF TAPIRIRA GUIANENSIS 审中-公开
标题翻译：化妆品或皮肤用药提取物
公开(公告)号：US20160220477A1
公开(公告)日：2016-08-04
申请号：US15021292
申请日：2014-09-11
申请人： BASF Beauty Care Solutions France SAS , Centre National de la Recherche Scientifique , Universite Claude Bernard Lyon I
发明人： Valérie ANDRE-FREI , Nicolas BECHETOILLE , Morgan DOS SANTOS , Patricia ROUSSELLE
IPC分类号： A61K8/97 , C12N5/071 , A61Q19/08
CPC分类号： A61K8/97 , A61K36/22 , A61Q19/08 , C12N5/0629 , C12N2500/76 , C12N2501/00
摘要： The present invention relates to the cosmetic use by the topical route of a Tapirira guianensis extract, for stimulating the expression of perlecan and/or dystroglycan and/or VE-cadherin and/or claudin-5, in particular in the extracellular matrix and/or in the epithelial basement membrane, especially the dermoepidermal junction.It also relates to a cosmetic care method comprising the application, to at least one concerned area of healthy skin and/or healthy mucous membrane and/or healthy scalp, of a Tapirire guianensis extract or of a cosmetic composition comprising such an extract for stimulating the expression of perlecan and/or dystroglycan and/or VE-cadherin and/or claudin-5, in particular in the extracellular matrix and/or in the epithelial basement membrane, especially the dermoepidermal junction.In addition, it relates to a cosmetic composition comprising a Tapirira guianensis extract and a topically acceptable cosmetic excipient.Finally, it relates to a Tapirira guianensis extract or a dermatological composition comprising a Tapirira guianensis extract and a dermatologically acceptable excipient for use by the topical route in the treatment and/or prevention of rosacea, telangiectasia and/or pathologies of the oral and/or ocular mucous membranes.
摘要翻译：本发明涉及通过局部路线提取的丝瓜提取物的化妆品用途，用于刺激perlecan和/或dystroglycan和/或VE-钙粘蛋白和/或claudin-5，特别是在细胞外基质和/或在上皮基底膜，特别是皮肤表皮交界处。本发明还涉及一种美容护理方法，该方法包括向拟南芥提取物的健康皮肤和/或健康的头皮和/或健康头皮的至少一个有关区域应用包含这样的提取物的化妆品组合物，所述化妆品组合物用于刺激特别是在细胞外基质和/或上皮基底膜，特别是皮肤表皮连接处表达perlecan和/或dystroglycan和/或VE-钙粘蛋白和/或claudin-5。另外，本发明涉及一种化妆品组合物，其包含天麻提取物和局部可接受的化妆品赋形剂。最后，本发明涉及一种丝Tap提取物或皮肤病学组合物，其包含刺槐提取物和皮肤病学上可接受的赋形剂，用于局部途径用于治疗和/或预防酒渣鼻，毛细血管扩张症和/或口腔和/ 眼粘膜。

7. 发明授权

US09334498B2 Methods and compositions for modulating MIR-204 activity 有权
标题翻译：用于调节MIR-204活性的方法和组合物
公开(公告)号：US09334498B2
公开(公告)日：2016-05-10
申请号：US14400292
申请日：2013-05-10
申请人： UAB Research Foundation
发明人： Anath Shalev , Guanlan Xu
IPC分类号： C12N15/113 , A61K31/70
CPC分类号： C12N15/113 , A61K31/70 , C12N2310/113 , C12N2310/141 , C12N2501/00
摘要： The present invention provides compositions and methods for regulating insulin production.
摘要翻译：本发明提供了调节胰岛素生产的组合物和方法。

8. 发明申请

US20150209387A1 Method for Inducing Immune Tolerance Using Non-Proliferative Polymer-Modified Allogeneic Leukocytes 审中-公开
标题翻译：使用非增殖型聚合酶修饰的同种异体白细胞诱导免疫耐受的方法
公开(公告)号：US20150209387A1
公开(公告)日：2015-07-30
申请号：US14414396
申请日：2013-07-12
申请人： CANADIAN BLOOD SERVICES
发明人： Mark D. Scott , Duncheng Wang , Wendy M. Toyofuku
IPC分类号： A61K35/17 , A61K47/48 , C12N5/0783
CPC分类号： A61K35/17 , A61K9/0019 , A61K35/00 , A61K35/14 , A61K39/0008 , A61K39/001 , A61K47/60 , A61K47/69 , A61K47/6901 , A61K2035/122 , A61K2035/124 , A61K2039/515 , A61K2039/577 , C12N5/0637 , C12N5/0638 , C12N15/113 , C12N2310/141 , C12N2500/50 , C12N2501/00 , C12N2501/65 , C12N2502/1114
摘要： This invention relates to cellular-based therapies for increasing the level of regulatory T cells (Treg) and/or decreasing the level of pro-inflammatory T cells (Th17) to induce anergy or immune tolerance. To provide these therapeutic effects, a non-proliferative allogeneic leukocyte population is contacted with another leukocyte population. The non-proliferative allogeneic leukocyte population is modified to bear on its surface a low-immunogenic biocompatible polymer so as to prevent pro-inflammatory allo-recognition with the latter leukocyte population. Cellular-based preparations and processes for achieving cellular therapy are also provided.
摘要翻译：本发明涉及用于增加调节性T细胞（Treg）水平和/或降低促炎T细胞（Th17）的水平以诱导无反应性或免疫耐受性的基于细胞的疗法。为了提供这些治疗效果，非增殖性同种异体白细胞群体与另一白细胞群体接触。非增殖性同种异体白细胞群体被修饰以在其表面上承载低免疫原性的生物相容性聚合物，以便防止后者白细胞群体的促炎同种异体识别。还提供了用于实现细胞治疗的基于细胞的制备和方法。

9. 发明申请

US20150119449A1 Methods and Compositions for Modulating MIR-204 Activity 有权
标题翻译：调节MIR-204活性的方法和组合
公开(公告)号：US20150119449A1
公开(公告)日：2015-04-30
申请号：US14400292
申请日：2013-05-10
申请人： UAB Research Foundation
发明人： Anath Shalev , Guanlan Xu
IPC分类号： C12N15/113
CPC分类号： C12N15/113 , A61K31/70 , C12N2310/113 , C12N2310/141 , C12N2501/00
摘要： The present invention provides compositions and methods for regulating insulin production.
摘要翻译：本发明提供了调节胰岛素产生的组合物和方法。

10. 发明申请

US20150064145A1 BONE MARROW-DERIVED MESENCHYMAL STEM CELLS AS A SOURCE OF NEURAL PROGENITORS 审中-公开
标题翻译：骨髓衍生的骨髓间充质干细胞作为神经原发肿瘤的来源
公开(公告)号：US20150064145A1
公开(公告)日：2015-03-05
申请号：US14525919
申请日：2014-10-28
申请人： MULTIPLE SCLEROSIS RESEARCH CENTER OF NEW YORK
发明人： Saud A. SADIQ , Violaine K. Harris
IPC分类号： A61K35/30 , C12N5/0797
CPC分类号： C12N5/0622 , A61K35/30 , C12N5/0619 , C12N5/0623 , C12N5/0663 , C12N2501/00 , C12N2501/11 , C12N2501/115 , C12N2501/13 , C12N2502/08 , C12N2506/1353
摘要： Methods are provided for treating and/or reducing the severity of multiple sclerosis in a human, by administering autologous mesenchymal stem cell-derived neural precursors. Also described is an in vitro method for differentiating mesenchymal stem-cell derived neural precursor oligodengroglial and neuronal cell types.
摘要翻译：通过施用自体间充质干细胞衍生的神经前体，提供了用于治疗和/或降低人类多发性硬化症的严重程度的方法。还描述了用于分化间充质干细胞衍生的神经前体少突胶质细胞和神经元细胞类型的体外方法。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式