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1. 发明授权

US09980908B2 Liposome and method for producing liposome 有权
公开(公告)号：US09980908B2
公开(公告)日：2018-05-29
申请号：US14598603
申请日：2015-01-16
申请人： Konica Minolta, Inc.
发明人： Takeshi Isoda
IPC分类号： A61K9/127 , A61K8/14 , A61K8/41 , A61K8/49 , A61K8/63 , A61K8/68 , A61K31/7105 , A61K31/713 , A61K49/04 , A61Q11/00 , A61Q19/00 , B01J13/02 , C12N15/88 , A61K31/7088 , A61K49/00 , A23P10/30 , A61K47/62 , A61K47/69
CPC分类号： A61K9/1277 , A23P10/30 , A61K8/14 , A61K8/416 , A61K8/4986 , A61K8/63 , A61K8/68 , A61K9/1271 , A61K9/1272 , A61K31/7088 , A61K31/7105 , A61K31/713 , A61K47/62 , A61K47/6911 , A61K49/0002 , A61K49/0466 , A61Q11/00 , A61Q19/00 , B01J13/02 , C12N15/88 , C12N2810/85
摘要： It is intended to provide a liposome preparation which is a liposome, has a lipid bilayer membrane composed of an inner membrane constituted by a lipid including one or more types of functional lipids (a lipid capable of chemically interacting with another compound such as a charged lipid, a polarizable lipid, a lipid-soluble lipid or a water-soluble lipid) and an outer membrane constituted by a lipid with or without including one or more types of functional lipids, and is characterized in that at least a condition that the amount of any one type of functional lipid contained in the inner membrane is larger than in the outer membrane is satisfied. The liposome preparation is suitable as a liposome for encapsulating a contrast agent (a neutral substance having a hydroxy group), siRNA (an anionic substance) having an anticancer activity or the like. Its encapsulation ratio of drug agents, dispersion stability, control release and the like have been improved.

2. 发明授权

US09816080B2 Delivery of CAS9 via ARRDC1-mediated microvesicles (ARMMs) 有权
公开(公告)号：US09816080B2
公开(公告)日：2017-11-14
申请号：US14929177
申请日：2015-10-30
申请人： President and Fellows of Harvard College , The Board of Trustees of the Leland Stanford Junior University
发明人： Quan Lu , Qiyu Wang , Stanley N. Cohen
IPC分类号： C07K14/47 , C07K19/00 , C12N9/16 , C12N15/87 , C12N9/22 , C07K7/06 , C12N9/00 , A61K9/127
CPC分类号： C12N9/16 , A61K9/1272 , C07K7/06 , C07K14/4718 , C07K2319/00 , C07K2319/01 , C07K2319/03 , C07K2319/70 , C07K2319/85 , C12N9/22 , C12N9/93 , C12N2810/85
摘要： Methods, systems, compositions and strategies for the delivery of WW domain-containing fusion proteins into cells in vivo, ex vivo, or in vitro via ARMMs are provided. Methods, systems, compositions and strategies for the delivery of Cas9 proteins and/or Cas9 variants into cells in vivo, ex vivo, or in vitro via fusion to ARMM associated proteins (e.g., ARRDC1 or TSG101) are also provided.

3. 发明授权

US09744199B2 Herpes simplex virus (HSV) with modified tropism, uses and process of preparation thereof 有权
公开(公告)号：US09744199B2
公开(公告)日：2017-08-29
申请号：US14864098
申请日：2015-09-24
申请人： ALMA MATER STUDIORUM—UNIVERSITA DI BOLOGNA
发明人： Gabriella Campadelli , Laura Menotti
IPC分类号： A61K35/00 , A61K35/76 , A61K49/04 , C07K14/005 , C12N7/00 , A61K39/245 , C07K14/035 , A61K35/763
CPC分类号： A61K35/763 , A61K49/04 , C07K14/005 , C07K2317/622 , C07K2319/33 , C07K2319/61 , C07K2319/74 , C12N7/00 , C12N2710/16621 , C12N2710/16622 , C12N2710/16632 , C12N2710/16633 , C12N2710/16651 , C12N2710/16722 , C12N2810/85 , Y02A50/407
摘要： A modified Herpes Simplex Virus (HSV), which has a portion of gD (glycoprotein D) of the glycoproteic envelope deleted and a heterologous single chain antibody inserted in place of such deleted portion; the modified HSV is capable of infecting cells through receptor HER2/ErbB2 but not through receptors HVEM/HveA and nectin1/HveC; uses of the modified HSV and a process of the preparation thereof are also disclosed.

4. 发明授权

US09315547B2 Nuclear targeting sequences 有权
标题翻译：核靶向序列
公开(公告)号：US09315547B2
公开(公告)日：2016-04-19
申请号：US14243923
申请日：2014-04-03
申请人： Yeda Research and Development Co. Ltd.
发明人： Rony Seger , Dana Chuderland
IPC分类号： A61K38/00 , A61K47/00 , C07K7/08 , C07K14/47 , C07K16/28 , C07K16/18 , C12N15/113
CPC分类号： C12N15/87 , A61K48/0041 , C07K7/08 , C07K14/47 , C07K16/18 , C07K16/2866 , C07K2319/09 , C12N15/113 , C12N2810/85
摘要： Isolated peptides comprising nuclear targeting activity or being capable of preventing endogenous nuclear targeting activity are disclosed. Polynucleotides encoding same, pharmaceutical compositions comprising same, as well as uses thereof are also disclosed.
摘要翻译：公开了包含核靶向活性或能够预防内源性核靶向活性的分离的肽。编码相同的多核苷酸，包含其的药物组合物及其用途也被公开。

5. 发明申请

US20140017201A1 VIRAL VECTORS FOR THE TREATMENT OF RETINAL DYSTROPHY 有权
标题翻译：用于治疗视神经病变的病毒载体
公开(公告)号：US20140017201A1
公开(公告)日：2014-01-16
申请号：US13873558
申请日：2013-04-30
申请人： Vivian Choi , Chad Eric Bigelow , Thaddeus Peter Dryja , Seshidhar Reddy Police
发明人： Vivian Choi , Chad Eric Bigelow , Thaddeus Peter Dryja , Seshidhar Reddy Police
IPC分类号： C12N15/86 , C07K14/47 , A61K48/00 , A61K38/17
CPC分类号： C12N15/86 , A61K38/1709 , A61K48/005 , A61K48/0058 , C07H21/04 , C07K14/47 , C12N7/00 , C12N15/79 , C12N2750/14143 , C12N2750/14171 , C12N2750/14343 , C12N2750/14345 , C12N2750/14371 , C12N2800/22 , C12N2810/6027 , C12N2810/85
摘要： The present invention relates to viral vectors that are capable of delivering a heterologous gene to the retina and in particular delivering RLBP1 to RPE and Müller cells of the retina. The invention also relates nucleic acids useful for producing viral vectors, compositions comprising the viral vectors and uses of the compositions and viral vectors. The invention also relates to methods of delivering and/or expressing a heterologous gene to the retina, improving the rate of dark adaption in a subject and treating RLBP1-associated retinal dystrophy.
摘要翻译：本发明涉及能够将异源基因递送至视网膜，特别是将RLBP1递送至视网膜的RPE和Müller细胞的病毒载体。本发明还涉及可用于产生病毒载体的核酸，包含病毒载体的组合物和组合物和病毒载体的用途。本发明还涉及向视网膜递送和/或表达异源基因的方法，改善受试者中暗适应的速率并治疗RLBP1相关的视网膜营养不良症。

6. 发明授权

US08071564B2 Regulation of angiogenesis with zinc finger proteins 失效
标题翻译：用锌指蛋白调节血管生成
公开(公告)号：US08071564B2
公开(公告)日：2011-12-06
申请号：US12553826
申请日：2009-09-03
申请人： Edward Rebar , Andrew Jamieson , Qiang Liu , Pei-Qi Liu , Alan Wolffe , Stephen P. Eisenberg , Eric Jarvis
发明人： Edward Rebar , Andrew Jamieson , Qiang Liu , Pei-Qi Liu , Alan Wolffe , Stephen P. Eisenberg , Eric Jarvis
IPC分类号： A61K48/00 , C07H21/02
CPC分类号： A61K48/005 , A61K38/00 , A61K48/00 , C07K14/47 , C07K14/4702 , C07K14/52 , C07K2319/00 , C12N15/86 , C12N2710/10343 , C12N2740/13043 , C12N2799/021 , C12N2810/85 , C12N2830/008
摘要： Provided herein are a variety of methods and compositions for regulating angiogenesis, such methods and compositions being useful in a variety of applications where modulation of vascular formation is useful, including, but not limited to, treatments for ischemia and wound healing. Certain of the methods and compositions accomplish this by using various zinc finger proteins that bind to particular target sites in one or more VEGF genes. Nucleic acids encoding the zinc finger proteins are also disclosed. Methods for modulating the expression of one or more VEGF genes with the zinc finger proteins and nucleic acids are also disclosed. Such methods can also be utilized in a variety of therapeutic applications that involve the regulation of endothelial cell growth. Pharmaceutical compositions including the zinc finger proteins or nucleic acids encoding them are also provided.
摘要翻译：本文提供了用于调节血管生成的各种方法和组合物，所述方法和组合物可用于血管形成调节是有用的多种应用，包括但不限于缺血和伤口愈合的治疗。某些方法和组合物通过使用结合一个或多个VEGF基因中的特定靶位点的各种锌指蛋白来实现。还公开了编码锌指蛋白的核酸。还公开了用锌指蛋白和核酸调节一种或多种VEGF基因的表达的方法。这些方法也可用于涉及内皮细胞生长调节的各种治疗应用中。还提供了包括锌指蛋白或编码它们的核酸的药物组合物。

7. 发明授权

US08052966B2 Methods and compositions for treating metastatic cancer 有权
标题翻译：用于治疗转移性癌症的方法和组合物
公开(公告)号：US08052966B2
公开(公告)日：2011-11-08
申请号：US10829926
申请日：2004-04-21
申请人： Frederick L. Hall , Erlinda M. Gordon
发明人： Frederick L. Hall , Erlinda M. Gordon
IPC分类号： A01N63/00 , A61K31/70 , A01K67/00
CPC分类号： C07K14/4738 , A61K48/00 , C12N15/85 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2800/108 , C12N2810/85
摘要： Methods and compositions for producing targeted delivery vectors are provided. Such vectors are useful for treating neoplastic disorders. Also provided are protocols for administering targeted delivery vectors in a clinical setting such that a therapeutic effect is achieved.
摘要翻译：提供了用于产生靶向递送载体的方法和组合物。这样的载体可用于治疗肿瘤性疾病。还提供了用于在临床环境中施用靶向递送载体的方案，使得实现治疗效果。

8. 发明申请

US20080032341A1 Method and kit for expressing protein under regulation of the expression from repeated sequence formed by gene amplification, and transformant 有权
标题翻译：用于通过基因扩增形成的重复序列表达调控表达蛋白质的方法和试剂盒，以及转化体
公开(公告)号：US20080032341A1
公开(公告)日：2008-02-07
申请号：US11889512
申请日：2007-08-14
申请人： Noriaki Shimizu
发明人： Noriaki Shimizu
IPC分类号： C12P21/00 , C12N5/10
CPC分类号： C12N15/67 , C12N15/85 , C12N2810/85 , C12N2820/85 , C12P21/02
摘要： A method is disclosed for releasing the transcriptional regulation caused by a repeated sequence in a gene, a kit therefor and so on to thereby establish a system capable of producing a protein in a large amount. At least one embodiment of the method can be achieved by any one or more of the following methods: (a) in the amplification of a gene encoding a target protein, co-amplifying a polynucleotide of 10 kbp or more such as a α-phage DNA or an insulator sequence; (b) selecting by culturing cells having undergone gene amplification in media containing a drug with a gradual increase in concentration; (c) elevating the promoter activity of inducing the expression of a gene encoding a target protein; (d) excising an amplified gene region from a chromosome with the use of Cre-LoxP System; (e) treating cells having undergone gene amplification with 5-aza-2′-deoxycytidine to thereby lower the methylation degree of DNA; and (f) selecting the mammalian cells having undergone gene amplification on double minute chromosomes.
摘要翻译：公开了一种用于释放由基因中的重复序列引起的转录调控的方法，其用于其的试剂盒等，从而建立能够大量产生蛋白质的系统。该方法的至少一个实施方案可以通过以下任何一种或多种方法来实现：（a）扩增编码靶蛋白的基因，共扩增10kbp或更多的多核苷酸，例如α-噬菌体 DNA或绝缘子序列; （b）通过培养在具有逐渐增加浓度的药物的培养基中培养经历基因扩增的细胞进行选择; （c）提高诱导编码靶蛋白的基因表达的启动子活性; （d）使用Cre-LoxP系统从染色体切除扩增的基因区域; （e）处理已经用5-氮杂-2'-脱氧胞苷进行基因扩增的细胞，从而降低DNA的甲基化程度; 和（f）选择在双分子染色体上经历基因扩增的哺乳动物细胞。

9. 发明申请

US20060286545A1 Viral vectors with improved properties 审中-公开
标题翻译：具有改善性质的病毒载体
公开(公告)号：US20060286545A1
公开(公告)日：2006-12-21
申请号：US10558394
申请日：2004-05-24
申请人： Thomas Weber , Laure Gigout
发明人： Thomas Weber , Laure Gigout
IPC分类号： C40B30/06 , C40B40/08 , C12N15/86
CPC分类号： C12N15/86 , A61K48/0091 , C12N7/00 , C12N2750/14123 , C12N2750/14143 , C12N2750/14145 , C12N2810/40 , C12N2810/405 , C12N2810/60 , C12N2810/6072 , C12N2810/80 , C12N2810/85 , C12N2810/851 , C12N2810/854 , C12N2810/859 , C12N2830/42 , C12N2840/44
摘要： Methods to improve the tropism or other features of a virus is disclosed. Such methods can be used to prepare, e.g., DNA or plasmid libraries of variants of a gene encoding a viral capsid or envelope restriction site, libraries of viral clones with such variant genes with a randon-dy inserted restriction site or polypeptide sequence targeting a receptor expressed by a specific type of mammalian cells. Described are also methods to prepare mosaic viruses, i.e., viral particles wherein copies of one or more capsid or envelope proteins originate from different sources. These methods can be used to prepare mosaic viruses of a specific mixture of wild-type and mutant proteins, or of different types of mutant proteins.
摘要翻译：公开了改善病毒的向性或其他特征的方法。这样的方法可以用于制备例如编码病毒衣壳或包膜限制性位点的基因的变体的DNA或质粒文库，具有这样的变体基因的病毒克隆的文库与插入限制性位点或靶向受体的多肽序列由特定类型的哺乳动物细胞表达。还描述了制备花叶病毒的方法，即病毒颗粒，其中一种或多种衣壳或包膜蛋白的拷贝来源于不同的来源。这些方法可用于制备野生型和突变蛋白或不同类型的突变蛋白的特异性混合物的花叶病毒。

10. 发明申请

US20040253215A1 Methods and compositions for treating disorders 有权
标题翻译：用于治疗疾病的方法和组合物
公开(公告)号：US20040253215A1
公开(公告)日：2004-12-16
申请号：US10829926
申请日：2004-04-21
发明人： Frederick L. Hall , Erlinda M. Gordon
IPC分类号： A61K048/00 , C12N015/85 , C12N015/867
CPC分类号： C07K14/4738 , A61K48/00 , C12N15/85 , C12N15/86 , C12N2740/13043 , C12N2740/13045 , C12N2800/108 , C12N2810/85
摘要： Methods and compositions for producing targeted delivery vectors are provided. Such vectors are useful for treating neoplastic disorders. Also provided are protocols for administering targeted delivery vectors in a clinical setting such that a therapeutic effect is achieved.
摘要翻译：提供了用于产生靶向递送载体的方法和组合物。这样的载体可用于治疗肿瘤性疾病。还提供了用于在临床环境中施用靶向递送载体的方案，使得实现治疗效果。

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