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1. 发明申请

US20190233882A1 COMPETITIVE PROBES FOR ENGINEERING SIGNAL GENERATION 审中-公开
公开(公告)号：US20190233882A1
公开(公告)日：2019-08-01
申请号：US16376411
申请日：2019-04-05
申请人： ChromaCode, Inc.
发明人： Lucien A.E. JACKY , Aditya RAJAGOPAL , Karen L. MENGE , Gregory GOSCH
IPC分类号： C12Q1/6818 , C12Q1/686 , C12Q1/6816 , G01N33/58 , C12Q1/6804 , G01N21/64 , C12Q1/6888 , C12Q1/6827
CPC分类号： C12Q1/6818 , C12Q1/6804 , C12Q1/6816 , C12Q1/6827 , C12Q1/686 , C12Q1/6888 , C12Q2537/143 , G01N21/6428 , G01N33/58 , C12Q2545/107 , C12Q2563/107 , C12Q2565/519
摘要： A method of identifying a first target nucleic acid comprising, providing a sample comprising the first target nucleic acid, providing a first set of paired oligonucleotides with complementarity to the first target nucleic acid, the first set of paired oligonucleotides comprising a first ratio of (a) first competitive oligonucleotides to (b) first signal oligonucleotides comprising a signal tag, wherein the competitive oligonucleotides compete with the signal oligonucleotides for binding to the first target nucleic acid, amplifying the first target nucleic acid with the polymerase chain reaction, thereby degrading the first signal oligonucleotide and permitting generation of a first signal, generating the first signal, measuring intensity of the first signal, and correlating the intensity of the first signal to the first ratio, thereby identifying the first target nucleic acid.

2. 发明授权

US09845496B2 Multiplexed digital assay with specific and generic reporters 有权
公开(公告)号：US09845496B2
公开(公告)日：2017-12-19
申请号：US14977573
申请日：2015-12-21
申请人： Bio-Rad Laboratories, Inc.
发明人： John F. Regan , Svilen S. Tzonev , Yann Jouvenot , Claudia Litterst , Dianna Maar , Geoff McDermott
IPC分类号： C07H21/04 , C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2537/143 , C12Q2537/165 , C12Q2545/107
摘要： Digital assay system, including methods, apparatus, and compositions, for performing target assays in partitions each containing a generic reporter and a specific reporter for target amplification.

3. 发明授权

US09777330B2 mPCR methods for analyzing repeat sequences 有权
公开(公告)号：US09777330B2
公开(公告)日：2017-10-03
申请号：US13284328
申请日：2011-10-28
申请人： Gary J. Latham , Liangjing Chen , Andrew Hadd , Sachin Sah , Ru Cao
发明人： Gary J. Latham , Liangjing Chen , Andrew Hadd , Sachin Sah , Ru Cao
IPC分类号： C12P19/34 , C12Q1/68
CPC分类号： C12Q1/6883 , C12Q1/6858 , C12Q2600/154 , C12Q2600/166 , C12Q2565/125 , C12Q2545/107 , C12Q2521/331
摘要： Methods are provided for determining the methylation status of GC-rich templates. The methods include use of GC reference standards that allow simultaneous characterization of methylation status and CGG repeat length. The methods are useful for detecting genotypes associated with GC-rich repeats, including Fragile X Syndrome.

4. 发明授权

US09777316B2 Amplification of complex nucleic acids 有权
公开(公告)号：US09777316B2
公开(公告)日：2017-10-03
申请号：US13375046
申请日：2010-06-03
申请人： Christian Korfhage , Evelyn Fisch
发明人： Christian Korfhage , Evelyn Fisch
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2545/107 , C12Q2531/119
摘要： What is described is a method for quantitative and qualitative analysis of complex template nucleic acids to be analyzed. The method comprises the co-amplification of a control nucleic acid with the complex template nucleic acid by means of isothermal strand displacement reaction. The method of the invention further comprises the determination of the amount of amplified control nucleic acid as measure for the determination of the quantity and/or quality of the complex template nucleic acid used. The present invention also relates to a kit for carrying out a method of the invention. Furthermore, the use of the method of the invention or the kit of the invention for standardization of whole-genome, whole-transcriptome and whole-bisulfitome analyses is described.

5. 发明申请

US20170081710A1 METHODS FOR DETECTING MULTIPLE NUCLEIC ACIDS IN A SAMPLE 审中-公开
公开(公告)号：US20170081710A1
公开(公告)日：2017-03-23
申请号：US15116185
申请日：2015-02-23
申请人： ALERE TECHNOLOGIES GMBH
发明人： Thomas Ullrich
IPC分类号： C12Q1/68 , B01L3/00
CPC分类号： C12Q1/6818 , B01L3/502715 , B01L2300/0819 , B01L2400/0481 , C12Q1/6844 , G01N21/645 , G01N33/52 , G01N33/542 , C12Q2537/101 , C12Q2545/107 , C12Q2565/102 , C12Q2565/107 , C12Q2565/519
摘要： The present invention relates to methods for determining the presence and/or amount of multiple nucleic acids in a sample.

6. 发明授权

US09523116B2 Multiplexed digital assay with data exclusion for calculation of target levels 有权
标题翻译：用于计算目标水平的数据排除的多重数字化验
公开(公告)号：US09523116B2
公开(公告)日：2016-12-20
申请号：US14171754
申请日：2014-02-03
申请人： Bio-Rad Laboratories, Inc.
发明人： Svilen S. Tzonev , Claudia Litterst
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q2537/143 , C12Q2537/165 , C12Q2545/107
摘要： Digital assay system, including methods and apparatus, for calculating a level of one or more targets. In an exemplary method, data for amplification of a plurality of targets including a first target may be collected from partitions. A level of the first target may be calculated from only a subset of the data that excludes partitions according to target content.
摘要翻译：数字测定系统，包括用于计算一个或多个目标的水平的方法和装置。在示例性方法中，可以从分区收集用于放大包括第一目标的多个目标的数据。可以仅从根据目标内容排除分区的数据的子集计算第一目标的级别。

7. 发明申请

US20150218627A1 SINGLE LABEL COMPARATIVE HYBRIDIZATION 审中-公开
标题翻译：单标签比较混合
公开(公告)号：US20150218627A1
公开(公告)日：2015-08-06
申请号：US14564342
申请日：2014-12-09
申请人： Quest Diagnostics Investments Incorporated
发明人： Mansoor S. Mohammed , Natasa Dzidic , Christopher McCaskill , Jaeweon Kim
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6837 , C12Q1/6823 , C12Q1/6825 , C12Q1/6841 , C12Q1/6883 , C12Q2600/16 , C12Q2565/501 , C12Q2539/101 , C12Q2537/155 , C12Q2545/107
摘要： The present invention provides methods of detecting and mapping chromosomal or genetic abnormalities associated with various diseases or with predisposition to various diseases, or to detecting the phenomena of large scale copy number variants. In particular, the present invention provides advanced methods of performing array-based comparative hybridization that allow reproducibility between samples and enhanced sensitivity by using the same detectable label for both test sample and reference sample nucleic acids. Invention methods are useful for the detection or diagnosis of particular disease conditions such as cancer, and detecting predisposition to cancer based on detection of chromosomal or genetic abnormalities and gene expression level. Invention methods are also useful for the detection or diagnosis of hereditary genetic disorders or predisposition thereto, especially in prenatal samples. Moreover, invention methods are also useful for the detection or diagnosis of de novo genetic aberrations associated with post-natal developmental abnormalities.
摘要翻译：本发明提供了检测和映射与各种疾病相关的染色体或遗传异常或具有各种疾病倾向的方法，或者检测大规模拷贝数变体的现象。特别地，本发明提供了进行基于阵列的比较杂交的先进方法，其通过使用相同的可检测标记用于测试样品和参照样品核酸，从而允许样品之间的再现性和增强的灵敏度。本发明方法可用于检测或诊断特定的疾病状况如癌症，并且基于染色体或遗传异常和基因表达水平的检测来检测癌症易感性。本发明的方法也可用于遗传性遗传疾病或其易感性的检测或诊断，特别是在产前样品中。此外，发明方法也可用于检测或诊断与产后发育异常相关的从头遗传畸变。

8. 发明申请

US20140287422A1 Method for Selecting a Treatment for Non-Small Cell Lung Cancer Using Gene Expression Profiles 审中-公开
标题翻译：使用基因表达谱选择非小细胞肺癌治疗方法
公开(公告)号：US20140287422A1
公开(公告)日：2014-09-25
申请号：US14265593
申请日：2014-04-30
申请人： University of Toledo
发明人： Jeffrey P. Demuth , Erin L. Crawford , James C. Willey , David A. Weaver , Kristy A. Warner , Timothy G. Graves
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6851 , C12Q1/6886 , C12Q2565/501 , C12Q2600/106 , C12Q2600/112 , C12Q2600/136 , C12Q2600/158 , C12Q2600/16 , C12Q2600/178 , C12Q2545/107
摘要： The present invention identifies and quantifies changes in gene expression associated with non-small cell lung cancer NSCLC by examining gene expression in tissue from normal lung and diseased lung. The present invention also identifies and quantifies expression profiles which serve as useful diagnostic markers as well as markers that are useful to monitor disease states, disease progression, drug toxicity, drug efficacy and drug metabolism.
摘要翻译：本发明通过检查来自正常肺和患病肺的组织中的基因表达来鉴定和量化与非小细胞肺癌NSCLC相关的基因表达的变化。本发明还鉴定和量化用作有用的诊断标志物的表达谱以及可用于监测疾病状态，疾病进展，药物毒性，药物功效和药物代谢的标志物。

9. 发明授权

US08603745B2 Artificial mutation controls for diagnostic testing 有权
标题翻译：用于诊断测试的人工变异控制
公开(公告)号：US08603745B2
公开(公告)日：2013-12-10
申请号：US10598589
申请日：2005-03-11
申请人： Wayne W. Grody , Michael R. Jarvis , Ramaswamy K. Iyer , Laurina O. Williams
发明人： Wayne W. Grody , Michael R. Jarvis , Ramaswamy K. Iyer , Laurina O. Williams
IPC分类号： C12Q1/68 , C12P19/34 , C12N15/64 , C12N15/00 , C07H21/04
CPC分类号： C12N15/102 , C12Q1/6858 , C12Q1/6883 , C12Q2600/156 , C12Q2545/101 , C12Q2545/107
摘要： Disclosed are artificial compositions that can be used as positive controls in a genetic testing assay, such as a diagnostic assay for a particular genetic disease. Such controls can be used to confirm the presence or absence of a particular mutation. Also provided are methods of generating such compositions, and methods of their use.
摘要翻译：公开了可以在遗传测试测定中用作阳性对照的人造组合物，例如针对特定遗传疾病的诊断测定。这样的对照可用于确认特定突变的存在或不存在。还提供了产生这种组合物的方法及其使用方法。

10. 发明申请

US20120276542A1 QUANTIFICATION OF A MINORITY NUCLEIC ACID SPECIES 有权
公开(公告)号：US20120276542A1
公开(公告)日：2012-11-01
申请号：US13457978
申请日：2012-04-27
申请人： Anders NYGREN
发明人： Anders NYGREN
IPC分类号： C12Q1/68 , G01N27/26 , G01N21/64
CPC分类号： C12Q1/6851 , C12Q1/6879 , C12Q1/6881 , C12Q1/6883 , C12Q2600/118 , C12Q2600/154 , C12Q2600/16 , C12Q2600/166 , C12Q2521/331 , C12Q2525/204 , C12Q2537/16 , C12Q2545/107
摘要： The technology relates in part to quantification of a minority nucleic acid species from a nucleic acid sample. In some embodiments, methods for determining the amount of fetal nucleic acid (e.g. absolute amount, relative amount) in a maternal sample are provided.

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