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1. 发明申请

US20170299532A1 DIFFERENTIAL SCANNING CALORIMETRY METHOD AND APPARATUS 审中-公开
公开(公告)号：US20170299532A1
公开(公告)日：2017-10-19
申请号：US15132859
申请日：2016-04-19
申请人： Malvern Instruments Incorporated
发明人： Vishal Patil , Ronan O'Brien , Edward A. Esposito , Ben E. Pattison
IPC分类号： G01N25/48
CPC分类号： G01N25/4866 , B01L3/502784 , B01L7/52 , B01L2300/14 , B01L2300/1822 , B01L2300/1827 , G01N25/4886 , G01N25/4893
摘要： A method of determining thermal properties of a sample using differential scanning calorimetry (DSC), the method comprises injecting a first separation fluid, a sample plug, and a second separation fluid into a sample cell. The first separation fluid and the sample plug have a first separation interface, and the sample plug and the second fluid have a second separation interface. The method further comprises injecting a reference fluid into a reference cell, heating the sample cell and reference cell, and determining thermal properties of the sample using DSC analysis.

2. 发明授权

US09851264B2 High-pressure colorimetric measurement cell 有权
公开(公告)号：US09851264B2
公开(公告)日：2017-12-26
申请号：US14417313
申请日：2013-07-26
申请人： UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR
发明人： Jean-Philippe Stephane Torre , Frederic Cedric Plantier , Laurent Christian Noel Marlin
IPC分类号： G01K17/00 , G01N25/48 , G01K1/14
CPC分类号： G01K17/00 , G01K1/14 , G01N25/4886 , G01N25/4893
摘要： The supporting device (10) includes: a body (14), designed to be mounted on an enclosure of a calorimeter, an end-fitting (34) for supporting the measurement cell (12), including elements (36) for fastening the measurement cell (12) on that supporting end-fitting (34), and fluid flow members in the measurement cell (12), able to control the pressure in that measurement cell (12).

3. 发明授权

US09285330B2 Calorimetric microfluidic sensor 有权
标题翻译：量热微流体传感器
公开(公告)号：US09285330B2
公开(公告)日：2016-03-15
申请号：US14230876
申请日：2014-03-31
申请人： Marquette University
发明人： Chung Hoon Lee , Benyamin Davaji
IPC分类号： G01N25/48 , G01N33/543 , C12Q1/54 , C12Q1/25 , G01K17/00 , G01K17/08 , B01L3/00
CPC分类号： G01N25/4886 , B01L3/5023 , B01L2200/147 , B01L2300/0627 , B01L2300/0825 , B01L2300/126 , B01L2400/0406 , C12Q1/25 , C12Q1/54 , G01K17/006 , G01K17/08 , G01N33/54373 , Y10T436/143333
摘要： A microfluidic sensor includes a microchannel that includes a reaction site with a reagent and a sample inlet. A liquid substance is received at the sample inlet and travels by capillary action to the reaction site. A temperature sensor measures a temperature as a result of a reaction between the reagent and a chemical in the liquid substance. A controller is communicatively connected to the temperature sensor, receives the temperature measured by the temperature sensor, and derives a concentration of the chemical in the liquid substance from the temperature.
摘要翻译：微流体传感器包括包含与试剂和样品入口的反应位点的微通道。在样品入口处接收液体物质并通过毛细管作用运动到反应部位。温度传感器由于试剂和液体物质中的化学物质之间的反应而测量温度。控制器通信连接到温度传感器，接收由温度传感器测量的温度，并从温度导出液体物质中化学物质的浓度。

4. 发明公开

US20230400426A1 CALORIMETER 审中-公开
公开(公告)号：US20230400426A1
公开(公告)日：2023-12-14
申请号：US18034096
申请日：2021-10-20
申请人： The Regents of the University of Michigan , Google LLC
发明人： EDGAR MEYHOFER , PRAMOD REDDY , DAVID FORK , JU WON LIM , AMIN REIHANI
IPC分类号： G01N25/48
CPC分类号： G01N25/484 , G01N25/4886 , G01N25/486 , G01N25/4826
摘要： Provided herein is technology relating to calorimetry and particularly, but not exclusively, to apparatuses, methods, and systems for making high-resolution thermodynamic measurements of reactions between gas phase reactants and nanomaterials. For example, the technology can provide thermodynamic measurements with a high heat flow resolution and long term stability at a wide range of temperatures and reaction pressures. The technology is used, for example, to study the thermodynamics of surface reactions and phase transformations in nanomaterials.

5. 发明申请

US20150079583A1 DEVICE AND METHOD FOR DETECTING A TARGET ANALYTE 审中-公开
标题翻译：用于检测目标分析仪的装置和方法
公开(公告)号：US20150079583A1
公开(公告)日：2015-03-19
申请号：US14466305
申请日：2014-08-22
申请人： Vanderbilt University
发明人： Franz Baudenbacher , Raymond Mernaugh , John Mayo , Brad Lubbers
IPC分类号： G01N33/543 , G01N33/574 , B01L3/00 , G01N25/48
CPC分类号： G01N33/54373 , B01L3/502784 , B01L2300/0636 , B01L2300/0645 , B01L2300/0819 , B01L2300/0867 , B01L2300/0896 , G01K17/006 , G01N25/4806 , G01N25/4886 , G01N33/54306 , G01N33/57415
摘要： One aspect of the present disclosure relates to a calorimeter for detecting the presence of a target analyte in a fluid sample. The calorimeter can include a substrate, a hermetically-sealed, thermally decoupled central reaction zone associated with the substrate, at least one droplet transport region, and detection electronics. The at least one droplet transport region can be associated with the substrate and configured to merge a reagent droplet with a sample droplet including the fluid sample to form a reaction droplet in the central reaction zone. The detection electronics can be in electrical and/or thermal communication with the central reaction zone and associated with the substrate. The calorimeter can be configured to detect a heat of reaction produced by a reaction event between the target analyte and a capture reagent upon formation of the reaction droplet.
摘要翻译：本公开的一个方面涉及一种用于检测流体样品中目标分析物的存在的量热计。量热计可以包括基底，与基底相关联的气密密封的热解耦中心反应区，至少一个液滴传输区和检测电子。所述至少一个液滴传送区域可以与所述基底相关联并且被配置为将试剂液滴与包含所述流体样品的样品液滴合并以在所述中央反应区域中形成反应液滴。检测电子器件可以与中心反应区域电气和/或热连通并与衬底相关联。热量计可以被配置为在形成反应液滴时检测由目标分析物和捕获试剂之间的反应事件产生的反应热。

6. 发明申请

US20140273276A1 SYSTEM AND METHOD FOR A MICROFLUIDIC CALORIMETER 审中-公开
标题翻译：微流量计的系统和方法
公开(公告)号：US20140273276A1
公开(公告)日：2014-09-18
申请号：US14211486
申请日：2014-03-14
申请人： Northeastern University , The Charles Stark Draper Laboratory, Inc.
发明人： Jason O. Fiering , Dale Larson , Gregory Kowalski , Amy Taylor , Wajeeh M. Saadi , Mehmet Sen
IPC分类号： G01N25/48
CPC分类号： G01N25/4886 , B82Y15/00 , G01K17/006 , G01N21/05 , G01N21/554 , G01N25/4873 , G01N33/15
摘要： Systems and methods are disclosed herein for a microfluidic calorimeter apparatus. A microfluidic calorimeter system includes a calorimetry apparatus and a processor in connection with the apparatus. The apparatus includes a microfluidic laminar flow channel connected to two inlets for flowing fluid into the laminar flow channel. Below the laminar flow channel is a plurality of microscale temperature sensors at known positions in the channel. The processor is in connection with the discrete temperature sensors and determines a calorimetry measurement based on local temperatures derived from data output by the microscale temperature sensors and the respective positions of the sensors in the channel.
摘要翻译：本文公开了用于微流量计量计装置的系统和方法。微流量计量计系统包括量热法装置和与装置相关的处理器。该装置包括连接到两个入口的微流体层流通道，用于将流体流入层流通道。在层流通道下面是通道中已知位置处的多个微型温度传感器。该处理器与离散的温度传感器相关联，并且基于由微型温度传感器输出的数据和通道中传感器的相应位置导出的局部温度来确定量热测量。

7. 发明申请

US20170102346A1 MEMS Bio-DSC 审中-公开
公开(公告)号：US20170102346A1
公开(公告)日：2017-04-13
申请号：US14878443
申请日：2015-10-08
申请人： Richard Brown , William Buote , Ernesto Freire , Anthony Maletta , Thomas Denner
发明人： Richard Brown , William Buote , Ernesto Freire , Anthony Maletta , Thomas Denner
IPC分类号： G01N25/48 , B01L3/00
CPC分类号： G01N25/4886 , B01L3/502715 , B01L2200/027 , B01L2200/147 , B01L2300/0609 , B01L2300/0627 , B01L2300/0816 , B01L2300/0861 , B01L2300/12 , B01L2300/18 , B01L2300/1827 , G01N25/4833 , G01N25/4893
摘要： A MEMS cassette for insertion into a DSC calorimeter and a DSC calorimeter using MEMS cassettes to conduct DSC experiments. The MEMS cassette includes a chip configured to conduct DSC reactions of a sample and reference to derive information regarding the sample.

8. 发明申请

US20150204735A1 HIGH-PRESSURE COLORIMETRIC MEASUREMENT CELL 有权
标题翻译：高压彩色测量单元
公开(公告)号：US20150204735A1
公开(公告)日：2015-07-23
申请号：US14417313
申请日：2013-07-26
申请人： UNIVERSITE DE PAU ET DES PAYS DE L'ADOUR
发明人： Jean-Philippe Stéphane Torre , Frédéric Cédric Plantier , Laurent Christian Noël Marlin
IPC分类号： G01K17/00 , G01K1/14 , G01N25/48
CPC分类号： G01K17/00 , G01K1/14 , G01N25/4886 , G01N25/4893
摘要： The supporting device (10) includes: a body (14), designed to be mounted on an enclosure of a calorimeter, an end-fitting (34) for supporting the measurement cell (12), including elements (36) for fastening the measurement cell (12) on that supporting end-fitting (34), and fluid flow members in the measurement cell (12), able to control the pressure in that measurement cell (12).
摘要翻译：支撑装置（10）包括：设计成安装在量热计的外壳上的本体（14），用于支撑测量单元（12）的端部配件（34），包括用于紧固测量单元的元件（36）该支撑端配件（34）上的电池（12）以及能够控制该测量电池（12）中的压力的测量电池（12）中的流体流动元件。

9. 发明申请

US20150037902A1 NANOCALORIMETER DEVICE AND METHODS OF OPERATING THE SAME 审中-公开
标题翻译： NANOCALORIMETER设备及其操作方法
公开(公告)号：US20150037902A1
公开(公告)日：2015-02-05
申请号：US13955750
申请日：2013-07-31
申请人： Keysight Technologies, Inc.
发明人： Tirumala R. Ranganath , Carol J. Courville , Richard Michael Kinder
IPC分类号： G01N25/26
CPC分类号： G01N25/4886
摘要： A nanocalorimeter device includes a head that defines first dispensing regions configured to receive first drops of first liquids and a cover that defines second dispensing regions corresponding to the first dispensing regions and configured to receive second drops of second liquids. The first and second dispensing regions form corresponding nanocalorimeter cells when the cover is connected to the head, each nanocalorimeter cell thereby containing first and second drops which are combined during a measurement run into a merged drop. The nanocalorimeter device further includes mini-bars pre-dispensed in the second dispensing regions, respectively, each mini-bar including a high magnetic permeability material. A magnetic driver is configured to generate a rotating magnetic field around the nanocalorimeter cells, where the rotating magnetic field causes the mini-bars to spin, mixing the first and second liquids in the merged drop within each nanocalorimeter cell.
摘要翻译：纳米尺度计装置包括头部，其限定配置成接收第一液滴的第一液体的第一分配区域和限定对应于第一分配区域并且被配置为接收第二液滴的第二分配区域的盖子。当盖子连接到头部时，第一和第二分配区域形成相应的纳米光度计单元，每个纳米光度计单元由此包含在测量期间组合成合并液滴的第一和第二滴。纳米光度计装置还包括分别在第二分配区域中预分配的小型棒，每个迷你棒包括高磁导率材料。磁驱动器被配置为在纳米光度计单元周围产生旋转磁场，其中旋转磁场引起迷你棒旋转，将第一和第二液体混合在每个纳米光度计单元内的合并液滴中。

10. 发明申请

US20140303019A1 Calorimetric Microfluidic Sensor 有权
标题翻译：量热微流体传感器
公开(公告)号：US20140303019A1
公开(公告)日：2014-10-09
申请号：US14230876
申请日：2014-03-31
申请人： Marquette University
发明人： Chung Hoon Lee , Benyamin Davaji
IPC分类号： G01N25/48 , C12Q1/54 , G01N33/543
CPC分类号： G01N25/4886 , B01L3/5023 , B01L2200/147 , B01L2300/0627 , B01L2300/0825 , B01L2300/126 , B01L2400/0406 , C12Q1/25 , C12Q1/54 , G01K17/006 , G01K17/08 , G01N33/54373 , Y10T436/143333
摘要： A microfluidic sensor includes a microchannel that includes a reaction site with a reagent and a sample inlet. A liquid substance is received at the sample inlet and travels by capillary action to the reaction site. A temperature sensor measures a temperature as a result of a reaction between the reagent and a chemical in the liquid substance. A controller is communicatively connected to the temperature sensor, receives the temperature measured by the temperature sensor, and derives a concentration of the chemical in the liquid substance from the temperature.
摘要翻译：微流体传感器包括包含与试剂和样品入口的反应位点的微通道。在样品入口处接收液体物质并通过毛细管作用运动到反应部位。温度传感器由于试剂和液体物质中的化学物质之间的反应而测量温度。控制器通信连接到温度传感器，接收由温度传感器测量的温度，并从温度导出液体物质中化学物质的浓度。

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