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1. 发明申请

US20180246176A1 IDENTIFICATION OF MOLECULES BASED ON FREQUENCY RESPONSES USING ELECTROMAGNETIC WRITE-HEADS AND MAGNETO-RESISTIVE SENSORS 审中-公开
公开(公告)号：US20180246176A1
公开(公告)日：2018-08-30
申请号：US15963006
申请日：2018-04-25
申请人： International Business Machines Corporation
发明人： Allen K. Bates , Anna W. Topol , Daniel J. Winarski
IPC分类号： G01R33/09 , G01R33/12 , G01N27/72
CPC分类号： G01R33/091 , G01N27/72 , G01R33/093 , G01R33/1269
摘要： The inventive concepts presented herein relate to methods of identifying molecules identification of molecules using apparatuses including: electromagnetic write-head(s); magneto-resistive read sensor(s), and processor(s). An exemplary method includes magnetically exciting a molecule to be identified using an alternating magnetic field generated by an electromagnetic write-head, measuring a resonant response of the molecule to be identified using a magneto-resistive read sensor; and comparing, using a processor, the resonant response of the molecule to be identified with a table of known resonant responses to identify a chemical composition of the molecule to be identified. The molecule to be identified may optionally be disposed on a biosample substrate which comprises, or is coupled to, a plurality of servo-alignment marks; and the plurality of servo-alignment marks are configured to facilitate alignment of the electromagnetic write-head with the biosample tracks of the biosample substrate.

2. 发明授权

US09958510B2 Integrated magnetic spectrometer for multiplexed biosensing 有权
公开(公告)号：US09958510B2
公开(公告)日：2018-05-01
申请号：US14028484
申请日：2013-09-16
申请人： California Institute of Technology
发明人： Constantine Sideris , Seyed Ali Hajimiri
IPC分类号： G01R33/28 , G01R33/02 , G01R33/12
CPC分类号： G01R33/02 , G01R33/1269
摘要： A magnetic spectrometer is integrated in a semiconductor substrate and provides high sensitivity without using an external magnet field. The spectrometer includes one or more highly stable on-chip oscillator and LC resonator. A current caused to pass through the inductor generates a magnetic field and polarizes the nanoparticles placed in its proximity, thereby changing the effective inductance of the inductor, and in turn, modifying the oscillation frequency of the LC resonator. The shift in the oscillation frequency is used to characterize the nanoparticles and measure their magnetic susceptibility frequency profile. The spectrometer operates at multiple frequencies over a diverse range without using a reference sensor thereby effectively increasing its spatial multiplexing density. The magnetic spectrometer uses the relationship between the sizes of the particles and the resonance frequency Fres and/or the magnetic frequency spectrum of the particles as a spectroscopic means of differentiating between the particles.

3. 发明申请

US20170342478A1 MAGNETIC FLUX DENSITY BASED DNA SEQUENCING 审中-公开
公开(公告)号：US20170342478A1
公开(公告)日：2017-11-30
申请号：US15163735
申请日：2016-05-25
申请人： International Business Machines Corporation
发明人： Samuel Mathew Jawaharlal , Arunachalam Narayanan , Sathya Santhar , Balamurugaramanathan Sivaramalingam
IPC分类号： C12Q1/68 , G01R33/04 , G01N27/72
CPC分类号： C12Q1/6869 , G01N27/72 , G01R33/02 , G01R33/04 , G01R33/12 , G01R33/1269 , C12Q2563/116 , C12Q2563/143 , C12Q2565/631
摘要： In an approach to magnetic flux density based DNA sequencing, a static magnetic field is provided. A chain of nucleotides is passed through the magnetic field. A change in magnetic flux density of the static magnetic field due to an ionic voltage associated with an individual nucleotide or base pair of the chain of nucleotides is measured. An identity of the nucleotide is determined based on the change in magnetic flux density.

4. 发明授权

US09702748B2 Graphene-based magnetic hall sensor for fluid flow analysis at nanoscale level 有权
公开(公告)号：US09702748B2
公开(公告)日：2017-07-11
申请号：US14944766
申请日：2015-11-18
申请人： International Business Machines Corporation
发明人： Michael Engel , Rodrigo Neumann Barros Ferreira , Mathias Steiner
IPC分类号： G01N27/08 , G01F1/708 , H01L43/04 , H01L43/06 , H01L43/10
CPC分类号： G01R33/072 , G01F1/708 , G01F1/7088 , G01N27/745 , G01R33/07 , G01R33/1269 , H01L43/04 , H01L43/06 , H01L43/10 , H01L43/14
摘要： A method of detecting a particle comprises magnetizing a particle using an AC magnetic field; generating an AC voltage in a sensing device having a conductive substantially 2-dimensional lattice structure from the magnetized particle; superimposing a DC magnetic field on the generated AC voltage in the sensing device; and measuring an AC Hall voltage at the sensing device.

5. 发明申请

US20170108495A1 SAMPLE ANALYZER 审中-公开
公开(公告)号：US20170108495A1
公开(公告)日：2017-04-20
申请号：US15293806
申请日：2016-10-14
申请人： Toshiba Medical Systems Corporation
发明人： Naru IKEDA , Motoji Haragashira , Shoichi Kanayama
IPC分类号： G01N33/543 , G01R33/12
CPC分类号： G01N33/54333 , G01N33/54326 , G01N33/54366 , G01R33/1269 , G01R33/1276
摘要： According to one embodiment, a sample analyzer includes a detector, a first generator and a second generator. The detector detects a target substance bonded to a magnetic particle collected to a sensing area in the cartridge. The first generator applies a magnetic field for releasing the magnetic particles from the sensing area. The second generator includes a permanent magnet configured to generate a magnetic field for attracting the magnetic particles to the sensing area, a first soft magnetic material, and a second magnetic material. The second generator switches application and shut-off of a magnetic field by moving the permanent magnet relative to the first soft magnetic material and the second soft magnetic material.

6. 发明申请

US20170082701A1 METHOD FOR CALCULATING THE CHANGE OF TEMPORAL SIGNALS 审中-公开
公开(公告)号：US20170082701A1
公开(公告)日：2017-03-23
申请号：US14857685
申请日：2015-09-17
申请人： MAGQU CO. LTD.
发明人： Shieh-Yueh Yang , Yen-Fu Lee , Ming-Hung Hsu
IPC分类号： G01R33/12
CPC分类号： G01R33/1276 , G01R33/1269
摘要： The present invention relates to a method for calculating the change of signals starting from the originally detected temporal signals (_102 ), comprising the following steps: (a) eliminating the drift in the originally detected temporal signals with time to get χi signals; (b) removing the xi signals existing outside the range of 80% to 120% of the averaged value of all the χi signals to get residual signals as x 2 signals; (c) dividing the χ2 signals into 14-100 sections; (d) finding the averaged value of the χ2 signals in each section to get χ3 signals; (e) optionally neglecting one or two of the first χ3 signals and selecting six to nine χ3 signals with the smallest value of standard deviation in initial sections, wherein the initial sections are the first one-fourth part to half part of all sections; (f) eliminating the drift in the selected χ3 signals of step (e) with time to get χ4 signals; (g) selecting six to nine χ3 signals with the smallest value of standard deviation in terminal sections, wherein the terminal sections are the last one-fourth part to half part of all sections; (h) eliminating the drift in the selected χ3 signals of step (g) with time to get χ5 signals; and (i) finding the difference between the mean values of the χ4 and χ5 signals.

7. 发明授权

US09488649B2 Imaging method using magnetic small particles and corresponding device 有权
标题翻译：成像方法采用磁性小粒子及相应装置
公开(公告)号：US09488649B2
公开(公告)日：2016-11-08
申请号：US13638624
申请日：2011-04-01
申请人： Martin Rueckert , Volker C. Behr
发明人： Martin Rueckert , Volker C. Behr
IPC分类号： A61B5/05 , G01N33/569 , A61B5/055 , G01N33/543 , G01R33/12 , A61B5/00 , C12Q1/04 , G01N33/68
CPC分类号： G01N33/569 , A61B5/0035 , A61B5/0515 , A61B5/055 , C12Q1/04 , G01N33/54326 , G01N33/5695 , G01N33/56983 , G01N33/6854 , G01R33/1269
摘要： The invention relates to a method for imaging from a distribution of small magnetic particles. According to said method, the magnetisation of the small particles is rotated asynchronously to the magnetic field by means of an outer magnetic field of suitable field intensity and rotational frequency, which rotates about a longitudinal axis (z), whereby an asynchronous average rotational frequency is generated for a set of particles according to the field intensity; a spatial dependence is impressed on each set of particles by means of a magnetic gradient field of the asynchronous average rotational frequency; the frequency parts of the superpositioned transverse magnetisation (MQ) of the set of particles are detected; and a spatially resolved distribution of the transverse magnetisation (MQ) determines the small particles and emits same by means of the frequency parts. The invention also relates to a suitable device (1). An improved spatial resolution can be obtained, compared to the previous magnetic particle imaging methods, with essentially lower field intensities.
摘要翻译：本发明涉及一种从小磁性颗粒分布成像的方法。根据所述方法，通过围绕纵轴（z）旋转的合适的场强和旋转频率的外磁场，使小颗粒的磁化与磁场异步旋转，从而异步平均转动频率为根据场强产生一组粒子; 通过异步平均旋转频率的磁梯度场对每组粒子施加空间依赖性; 检测该组颗粒的叠加横向磁化（MQ）的频率部分; 并且横向磁化（MQ）的空间分辨分布决定了小颗粒并通过频率部分发射它们。本发明还涉及合适的装置（1）。与以前的磁粉成像方法相比，可以获得改善的空间分辨率，具有实质上较低的场强度。

8. 发明授权

US09411022B2 Calibration correlation for calibration assembly having electromagnetic read head 有权
标题翻译：具有电磁读头的校准组件的校准相关性
公开(公告)号：US09411022B2
公开(公告)日：2016-08-09
申请号：US14569376
申请日：2014-12-12
申请人： GLOBALFOUNDRIES U.S. 2 LLC
发明人： David Berman , Dylan J. Boday , Icko E. T. Iben , Wayne I. Imaino , Stephen L. Schwartz , Anna W. Topol , Daniel J. Winarski
IPC分类号： G01R35/00 , G01N27/72 , G01R33/00 , G01R33/12 , G01R33/09 , G01N27/74
CPC分类号： G01R33/0035 , G01N27/72 , G01N27/745 , G01R33/09 , G01R33/1269 , G01R35/00 , G01R35/005
摘要： According to one embodiment a method of performing a calibration correlation test for a calibration assembly includes sweeping a head module having a magnetic read sensor along a y-axis of the calibration assembly. The calibration assembly has at least one calibration trench having at least one nanoparticle at a known y-axis location in the calibration trench and the magnetic properties are known for the at least one nanoparticle. A read response of the at least one nanoparticles is obtained from the magnetic read sensor and a correlation is determined from the read response. The correlation of the read response is compared to a correlation threshold. The read response correlation is stored in memory in response to determining that the correlation of the read response is greater than the correlation threshold. When the correlation of the read response is not greater than the correlation threshold, a correlation test error is indicated.
摘要翻译：根据一个实施例，对校准组件执行校准相关性测试的方法包括沿着校准组件的y轴扫描具有磁读取传感器的头模块。校准组件具有至少一个在校准沟槽中已知的y轴位置处具有至少一个纳米颗粒的校准沟槽，并且至少一个纳米颗粒的磁特性是已知的。从磁读取传感器获得至少一种纳米颗粒的读取响应，并根据读取响应确定相关性。将读取响应的相关性与相关阈值进行比较。响应于确定读响应的相关性大于相关阈值，读响应相关被存储在存储器中。当读取响应的相关性不大于相关阈值时，指示相关测试误差。

9. 发明申请

US20160223624A1 IDENTIFICATION OF MOLECULES BASED ON FREQUENCY RESPONSES USING ELECTROMAGNETIC WRITE-HEADS AND MAGNETO-RESISTIVE SENSORS 有权
标题翻译：基于使用电磁写头和磁电阻传感器的频率响应的分子鉴定
公开(公告)号：US20160223624A1
公开(公告)日：2016-08-04
申请号：US15093599
申请日：2016-04-07
申请人： International Business Machines Corporation
发明人： Allen K. Bates , Anna W. Topol , Daniel J. Winarski
IPC分类号： G01R33/09 , G01R33/12 , G01N27/72
CPC分类号： G01R33/091 , G01N27/72 , G01R33/093 , G01R33/1269
摘要： The invention relates to the identification of molecules using an apparatus which includes: a head module comprising: an electromagnetic write-head configured to magnetically excite the molecule to be identified with an alternating magnetic field; and a magneto-resistive read sensor for measuring a resonant response of the magnetically excited molecule to be identified. The apparatus also includes a processor coupled to the magneto-resistive sensor, the processor being configured to compare the resonant response to a table of known resonant responses to identify a chemical composition of the molecule to be identified.
摘要翻译：本发明涉及使用装置识别分子，该装置包括：头模块，其包括：电磁写入头，被配置为用交变磁场磁激发待识别的分子; 以及用于测量待鉴定的激发分子的共振响应的磁阻读取传感器。所述装置还包括耦合到所述磁阻传感器的处理器，所述处理器被配置为将所述谐振响应与已知谐振响应的表进行比较，以识别待识别的分子的化学组成。

10. 发明授权

US09372188B2 Integrated membrane sensor 有权
标题翻译：集成膜传感器
公开(公告)号：US09372188B2
公开(公告)日：2016-06-21
申请号：US14265666
申请日：2014-04-30
申请人： Mark Christopher Tondra
发明人： Mark Christopher Tondra
IPC分类号： G01N27/72 , G01N33/543 , G01R33/12 , G01N27/414
CPC分类号： G01N33/54373 , G01N27/4145 , G01R33/12 , G01R33/1269
摘要： An integrated microelectronic sensor is provided in a disposable flow membrane sensing device. The integrated sensors detect electromagnetic effect labels in flow detection zones above the sensor in the membrane. The labels are small particles that give off a detectable electromagnetic signal. They are commonly used for isolating and quantifying biochemical targets of interest. The sensors are fabricated using planar integrated circuit technologies. Sensors can detect labels of several types including magnetic, electric, and photonic. These types all have in common the fact that the sensor detects the label at a distance. Magnetoresistive sensors for detecting magnetic labels, and photodiodes for detecting photonic labels are described.A system for using the sensors is described. There are disposable cartridges with a backing that supports the sensors and membrane is described. The integrated sensor in the cartridge is designed to be discarded after use. Also, label excitation sources are provided. The multi sensor array chip can be configured in order to detect labels in multiple zones, and to monitor progress of flow down a strip of membrane. These multiple label detection zones, using sandwich assay techniques, can quantify analyte concentration for many types of analytical samples. Also, the membrane can be micropatterned in order to provide multiple or unusually shaped flow paths.
摘要翻译：在一次性流膜检测装置中提供集成的微电子传感器。集成传感器在膜中的传感器上方的流量检测区域中检测电磁效应标签。标签是发出可检测电磁信号的小颗粒。它们通常用于分离和定量感兴趣的生化指标。传感器采用平面集成电路技术制造。传感器可以检测包括磁，电和光子在内的几种类型的标签。这些类型都具有传感器在远处检测标签的事实。描述了用于检测磁性标签的磁阻传感器和用于检测光子标签的光电二极管。描述了使用传感器的系统。有一些带支持传感器的背衬的一次性盒，并描述膜。墨盒中的集成传感器设计为在使用后丢弃。此外，还提供了标签激励源。可以配置多传感器阵列芯片，以便检测多个区域中的标签，并监测膜条下流的进度。使用夹心测定技术的这些多个标签检测区域可以量化许多类型的分析样品的分析物浓度。此外，膜可以被微图案化，以便提供多个或异常形状的流动路径。

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