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1. 发明授权

US09842194B2 Simplified method for robust estimation of parameter values 有权
公开(公告)号：US09842194B2
公开(公告)日：2017-12-12
申请号：US14375810
申请日：2013-02-08
申请人： KONINKLIJKE PHILIPS N.V.
发明人： Jeffrey Allan Kolthammer , Raymond Frank Muzic, Jr.
IPC分类号： G06F7/60 , G06F17/10 , G06F19/00 , A61B6/00 , G06T7/00 , G06F17/50 , A61B6/03
CPC分类号： G06F19/3437 , A61B6/032 , A61B6/037 , A61B6/503 , A61B6/507 , A61B6/5217 , G06F17/5009 , G06F19/00 , G06T7/0016 , G06T2207/10016 , G06T2207/10081 , G06T2207/10084 , G06T2207/10104 , G06T2207/30104 , G16H50/50
摘要： A method for estimating parameter values includes acquiring image data with an imaging apparatus, deriving a parameter model function from the image data, generating a N-dimensional grid, wherein N is a number of values of one or more non-linear terms of the derived model function, pre-calculating the one or more non-linear terms given the parameter model function and the designated values of the non-linear parameters, calculating one or more remaining model terms of the parameter model function, and displaying at least one of the one or more non-linear terms and remaining linear model terms.

2. 发明授权

US09754082B2 Systems and methods for reporting blood flow characteristics 有权
公开(公告)号：US09754082B2
公开(公告)日：2017-09-05
申请号：US14480870
申请日：2014-09-09
申请人： HeartFlow, Inc.
发明人： Charles A. Taylor , Gregory R. Hart
IPC分类号： A61B5/02 , G06F19/00 , A61B5/026 , A61B5/00
CPC分类号： G06F19/3437 , A61B5/02007 , A61B5/026 , A61B5/743 , A61B5/7475 , G06F19/00 , G06F19/321 , G16H10/60 , G16H50/50
摘要： Embodiments include a system for displays cardiovascular information for a patient. The system may include at least one computer system configured to receive patient-specific data regarding a geometry of the patient's heart and create a model representing at least a portion of the patient's heart based on the patient-specific data. The computer system may determine at least one value of the blood flow characteristic within the patient's heart based on the model. The computer system may also display a report comprising a representation of at least one artery corresponding to at least a portion the model, and display one or more indicators of the value of the blood flow characteristic on a corresponding portion of the at least one artery.

3. 发明授权

US09684768B2 System and method for determining an optimal type and position of an implant 有权
公开(公告)号：US09684768B2
公开(公告)日：2017-06-20
申请号：US14666001
申请日：2015-03-23
申请人： OMNIlife science, Inc.
发明人： Stephane Lavallee , Carinne Granchi , Laurence Vertallier , Christopher Plaskos
IPC分类号： G06F19/00 , G06F17/50 , A61B34/10 , A61B34/20 , A61B34/00 , A61B90/00
CPC分类号： G06F19/3437 , A61B34/10 , A61B34/20 , A61B34/25 , A61B2034/102 , A61B2034/105 , A61B2034/108 , A61B2034/2055 , A61B2034/256 , A61B2090/365 , G06F17/50 , G06F19/00 , G16H50/50
摘要： A computer-assisted orthopedic surgery system includes a device for generating a three dimensional geometrical surface model of a first bone and a database containing three 3 dimensional implant models of a plurality of available implants. The system includes a computer that is configured to permit a user to select from the database a first implant and display on a screen the three dimensional implant model of the first implant. The computer superimposes on the screen the implant model on top of the model of the first bone such that the two models are visually identifiable from one another.

4. 发明授权

US09659152B2 Computer-implemented technique for defining a bone cut 有权
公开(公告)号：US09659152B2
公开(公告)日：2017-05-23
申请号：US14249695
申请日：2014-04-10
申请人： CADFEM GmbH
发明人： Christoph Mueller
IPC分类号： A61B19/00 , G06F19/00 , A61B34/20 , A61B34/10
CPC分类号： G06F19/3437 , A61B34/10 , A61B34/20 , A61B2034/105 , A61B2034/107 , G06F19/00 , G16H50/50
摘要： A technique for generating a data set that geometrically defines a bone cut configuration for transverse maxillary distraction is using a computer-implemented method. An aspect of the technique comprises creating a numeric model of a maxilla based on patient-specific data of the maxilla. The numeric model is representative of mechanical properties of the maxilla. Based on the numeric model thus generated, one or more cut configurations for one or more bone cuts on at least one of a left hand side and a right hand side of the maxilla are determined. Each cut configuration has been determined to compensate for asymmetric mechanical properties of the maxilla. In a further step, a data set indicative of the one or more cut configurations thus determined is generated. The data set may be used to create a surgical template or jig, for computer-assisted surgery or a surgical navigation system.

5. 发明授权

US09460263B2 Integrated health data capture and analysis system 有权
标题翻译：综合健康数据捕获与分析系统
公开(公告)号：US09460263B2
公开(公告)日：2016-10-04
申请号：US14511753
申请日：2014-10-10
申请人： Theranos, Inc.
发明人： Elizabeth A. Holmes , Ian Gibbons , Daniel L. Young , Seth G. Michelson
IPC分类号： G06F19/00
CPC分类号： G06F19/3437 , G06F19/00 , G06F19/3443 , G06F19/345 , G06F19/3493 , G16H50/20 , G16H50/50 , G16H50/70 , G16H50/80 , Y02A90/22 , Y02A90/24 , Y02A90/26
摘要： The present invention provides an integrated health care surveillance and monitoring system that provides real-time sampling, modeling, analysis, and recommended interventions. The system can be used to monitor infectious and chronic diseases. When faced with outbreak of an infectious disease agent, e.g., influenza virus, the system can identify active cases through pro-active sampling in high risk locations, such as schools or crowded commercial areas. The system can notify appropriate entities, e.g., local, regional and national governments, when an event is detected, thereby allowing for proactive management of a possible outbreak. The system also predicts the best response for deployment of scarce resources.
摘要翻译：本发明提供了综合的医疗保健监控和监测系统，其提供实时采样，建模，分析和推荐的干预措施。该系统可用于监测感染性和慢性疾病。当面对流行性感冒病毒等传染病发病时，系统可以通过在高风险地点（如学校或拥挤的商业区）进行主动抽样来识别活动病例。当检测到事件时，系统可以通知适当的实体，例如地方，区域和国家政府，从而允许主动管理可能的爆发。该系统还预测部署稀缺资源的最佳反应。

6. 发明授权

US09449144B2 Flux balance analysis with molecular crowding 有权
公开(公告)号：US09449144B2
公开(公告)日：2016-09-20
申请号：US13630650
申请日：2012-09-28
申请人： University of Pittsburgh—Of the Commonwealth System of Higher Education
发明人： Zoltan N. Oltvai , Alexei Vazquez
IPC分类号： G06G7/48 , G06G7/58 , G01N33/48 , G01N31/00 , G06F19/00 , G06F19/12 , C12M1/36
CPC分类号： G06F19/3437 , C12M41/48 , G06F19/00 , G06F19/12 , G16H50/50 , Y02A90/26
摘要： Methods are provided herein for: calculating cell growth rates in various environments and genetic backgrounds; calculating the order of substrate utilization from a defined growth medium; calculating metabolic flux reorganization in various environments and at various growth rates; and calculating the maximum metabolic rate and optimal metabolite concentrations and enzyme activities by applying a computational optimization method to a kinetic model of a metabolic pathway. The optimization methods use intracellular molecular crowding parameters and/or well as kinetic rates to assist in modeling metabolic activity.

7. 发明授权

US09384325B2 System and method for generating enhanced density distribution in a three dimensional model of a structure for use in skeletal assessment using a limited number of two dimensional views 有权
标题翻译：用于在使用有限数量的二维视图的骨骼评估中使用的结构的三维模型中生成增强密度分布的系统和方法
公开(公告)号：US09384325B2
公开(公告)日：2016-07-05
申请号：US14246281
申请日：2014-04-07
申请人： Hologic, Inc.
发明人： Krishna Ramamurthi , Kevin Wilson
IPC分类号： A61B6/03 , G06F19/00 , A61B6/00 , G06T19/20 , G06T11/00
CPC分类号： G06F19/3437 , A61B6/505 , A61B6/5247 , G06F19/00 , G06T11/006 , G06T19/20 , G06T2210/41 , G06T2211/436 , G16H50/50
摘要： A method of generating a density enhanced model of an object is described. The method includes generating a customized a model of an object using a pre-defined set of models in combination with at least one projection image of the object, where the customized model is formed of a plurality of volume elements including density information. A density map is generated by relating a synthesized projection image of the customized model to an actual projection image of the object. Gains from the density map are back-projected into the customized model to provide a density enhanced customized model of the object. Because the density map is calculated using information from the synthesized projection image in combination with actual projection images of the structure, it has been shown to provide spatial geometry and volumetric density results comparable to those of QCT but with reduced patient exposure, equipment cost and examination time.
摘要翻译：描述了生成对象的密度增强模型的方法。所述方法包括使用与所述对象的至少一个投影图像组合的预定义模型集来生成对象的定制模型，其中所述定制模型由包括密度信息的多个体积元素形成。通过将定制模型的合成投影图像与对象的实际投影图像相关联来生成密度图。来自密度图的收益被反投影到定制模型中，以提供对象的密度增强定制模型。由于使用来自合成投影图像的信息与结构的实际投影图像相结合的密度图计算，所以已经显示提供与QCT相当的空间几何形状和体积密度结果，但是减少了患者暴露，设备成本和检查时间。

8. 发明授权

US09235686B2 Systems and methods for using adverse event data to predict potential side effects 有权
标题翻译：使用不良事件数据预测潜在副作用的系统和方法
公开(公告)号：US09235686B2
公开(公告)日：2016-01-12
申请号：US13446912
申请日：2012-04-13
申请人： David Jackson , Theodoros Soldatos , Guillaume Taglang , Alexander Zien , Stephan Brock
发明人： David Jackson , Theodoros Soldatos , Guillaume Taglang , Alexander Zien , Stephan Brock
IPC分类号： G01N33/48 , G06F19/00 , G06F19/18
CPC分类号： G06F19/345 , G06F19/00 , G06F19/18 , G06F19/326 , G06F19/3437 , G16H50/20 , G16H50/50
摘要： The present disclosure describes systems and methods for predicting a likely side effect profile for even new, untested medications. A predicted side effect profile may be generated based on intersections of side effect profiles of other medications that affect the same or related molecular entities, such as the nearby target proteins, involve the same pathways, or are otherwise similarly related. To generate a predicted side effect profile for a new drug targeting a novel or previously un-targeted protein target, an analyzer may query an adverse event database for records pertaining to patients who have taken drugs or combinations of drugs that target or affect molecular entities in the vicinity of the novel target within a global molecular entity graph, and, in some embodiments, may retrieve a plurality of adverse event records and generate an intersection of side effects associated with related targets to predict likely side effects for the novel target.
摘要翻译：本公开描述了用于预测甚至新的未经检验的药物的可能的副作用特征的系统和方法。可以基于影响相同或相关分子实体的其它药物（例如附近靶蛋白，涉及相同途径）的副作用分布的交叉点或者以其他方式相似的方式产生预测的副作用分布。为了产生针对新颖或先前未靶向的蛋白质靶标的新药物的预测副作用特征，分析器可以查询不良事件数据库以获得关于已经服用药物或靶向或影响分子实体的药物组合的患者的记录在全局分子实体图中的新靶标的附近，并且在一些实施例中，可以检索多个不利事件记录并产生与相关目标相关联的副作用的交集，以预测新颖目标的可能副作用。

9. 发明授权

US09202010B2 Systems and methods for modeling changes in patient-specific blood vessel geometry and boundary conditions 有权
标题翻译：用于建模患者特异性血管几何形状和边界条件变化的系统和方法
公开(公告)号：US09202010B2
公开(公告)日：2015-12-01
申请号：US14323201
申请日：2014-07-03
申请人： HeartFlow, Inc.
发明人： Charles A. Taylor , Hyun Jin Kim , Sethuraman Sankaran , Michiel Schaap , David Eberle , Gilwoo Choi , Leo Grady
IPC分类号： G06F19/00
CPC分类号： G06F19/3437 , G06F17/5009 , G06F19/00 , G16H50/50
摘要： Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.
摘要翻译：公开了系统和方法，用于模拟患者特异性血管几何形状和由血流或压力变化引起的边界条件的变化。一种方法包括使用处理器确定患者的一个或多个血管的第一解剖模型; 至少基于所述第一解剖模型确定所述一个或多个血管的生物力学模型; 确定与患者的生理状态相关联的一个或多个参数; 以及基于生物力学模型和与生理状态相关联的一个或多个参数创建第二解剖模型。

10. 发明申请

US20150269352A1 SYSTEMS AND METHODS FOR MODELING CHANGES IN PATIENT-SPECIFIC BLOOD VESSEL GEOMETRY AND BOUNDARY CONDITIONS 有权
公开(公告)号：US20150269352A1
公开(公告)日：2015-09-24
申请号：US14323201
申请日：2014-07-03
申请人： HeartFlow, Inc.
发明人： Charles A. TAYLOR , Hyun Jin KIM , Sethuraman SANKARAN , Michiel SCHAAP , David EBERLE , Gilwoo CHOI , Leo GRADY
IPC分类号： G06F19/00
CPC分类号： G06F19/3437 , G06F17/5009 , G06F19/00 , G16H50/50
摘要： Systems and methods are disclosed for modeling changes in patient-specific blood vessel geometry and boundary conditions resulting from changes in blood flow or pressure. One method includes determining, using a processor, a first anatomic model of one or more blood vessels of a patient; determining a biomechanical model of the one or more blood vessels based on at least the first anatomic model; determining one or more parameters associated with a physiological state of the patient; and creating a second anatomic model based on the biomechanical model and the one or more parameters associated with the physiological state.

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