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1. 发明申请

US20190189416A1 SPRAY CHAMBERS AND METHODS OF USING THEM 审中-公开
公开(公告)号：US20190189416A1
公开(公告)日：2019-06-20
申请号：US16146752
申请日：2018-09-28
申请人： PERKINELMER HEALTH SCIENCES CANADA, INC.
发明人： Chady Stephan , Hamid Badiei , Serguei Savtchenko , Samad Barzagan
IPC分类号： H01J49/10 , H01J49/04 , G01N30/72 , H01J49/16
CPC分类号： H01J49/107 , G01N30/7273 , H01J49/045 , H01J49/049 , H01J49/167
摘要： Devices, systems and methods including a spray chamber are described. In certain examples, the spray chamber may be configured with an outer chamber configured to provide tangential gas flows. In other instances, an inner tube can be positioned within the outer chamber and may comprise a plurality of microchannels. In some examples, the outer chamber may comprise dual gas inlet ports. In some instances, the spray chamber may be configured to provide tangential gas flow and laminar gas flows to prevent droplet formation on surfaces of the spray chamber. Optical emission devices, optical absorption devices and mass spectrometers using the spray chamber are also described.

2. 发明申请

US20190122878A1 LASER ABLATION SPECTROMETRY SYSTEM 审中-公开
公开(公告)号：US20190122878A1
公开(公告)日：2019-04-25
申请号：US16170434
申请日：2018-10-25
申请人： Hoi-Ying N. Holman , Antoine Masson , Evan Williams
发明人： Hoi-Ying N. Holman , Antoine Masson , Evan Williams
IPC分类号： H01J49/16 , H01J49/00 , H01J49/04
CPC分类号： H01J49/164 , H01J49/0004 , H01J49/0009 , H01J49/0422 , H01J49/0463 , H01J49/167
摘要： This disclosure provides systems, methods, and apparatus related to laser ablation spectrometry systems. In one aspect, a system comprises a microscope, a laser, a continuous flow probe, and a gas confinement device. The laser is positioned to emit light through an objective lens of the microscope. The continuous flow probe is coupled to a spectrometer. An end of the continuous flow probe is positioned proximate a sample and between the sample and the objective lens. The gas confinement device defines a gas inlet, a chamber, a platform, a wall surrounding the platform, a plurality of vents, and a plurality of channels. Each of the plurality of vents is positioned to direct a gas substantially parallel to the platform, and each of the plurality of vents is defined in the wall. The plurality of channels is operable to provide fluid communication between the chamber and the plurality of vents.

3. 发明申请

US20180188217A1 SIMPLIFIED SOURCE CONTROL INTERFACE 审中-公开
公开(公告)号：US20180188217A1
公开(公告)日：2018-07-05
申请号：US15394240
申请日：2016-12-29
申请人： Thermo Finnigan LLC
发明人： Joshua T. MAZE , Scott T. QUARMBY
IPC分类号： G01N30/86 , H01J49/00 , G01N30/72 , H01J49/16
CPC分类号： G01N30/8658 , G01N30/7266 , H01J49/00 , H01J49/0036 , H01J49/167
摘要： A mass spectrometry system having a simplified control interface includes a processor and a memory. The memory includes instructions that when executed cause the processor to perform the steps of providing a user interface including a plurality of adjustment elements for adjusting at least one results effective parameter and at least one sample descriptive parameter; determining a plurality of instrument control parameters based on the at least one results effective parameter and the at least one sample descriptive parameter; and analyzing a sample while operating according to the plurality of instrument control parameters.

4. 发明授权

US09805921B2 Ambient infrared laser ablation mass spectrometry (AIRLAB-MS) with plume capture by continuous flow solvent probe 有权
公开(公告)号：US09805921B2
公开(公告)日：2017-10-31
申请号：US14740176
申请日：2015-06-15
申请人： Jeremy T. O'Brien , Evan R. Williams , Hoi-Ying N. Holman
发明人： Jeremy T. O'Brien , Evan R. Williams , Hoi-Ying N. Holman
IPC分类号： H01J49/00 , H01J49/04 , H01J49/16
CPC分类号： H01J49/0463 , H01J49/167
摘要： A new experimental setup for spatially resolved ambient infrared laser ablation mass spectrometry (AIRLAB-MS) that uses an infrared microscope with an infinity-corrected reflective objective and a continuous flow solvent probe coupled to a Fourier transform ion cyclotron resonance mass spectrometer is described. The efficiency of material transfer from the sample to the electrospray ionization emitter was determined using glycerol/methanol droplets containing 1 mM nicotine and is ˜50%. This transfer efficiency is significantly higher than values reported for similar techniques.

5. 发明申请

US20170053788A1 PAPER CONE TIP, AND PAPER CONE SPRAY IONIZATION MASS SPECTROMETRY USING THE SAME 审中-公开
标题翻译： PAPER CONE TIP和PAPER CONE喷雾离子质谱法使用该方法
公开(公告)号：US20170053788A1
公开(公告)日：2017-02-23
申请号：US15091226
申请日：2016-04-05
申请人： HANKUK UNIVERSITY OF FOREIGN STUDIES RESEARCH & BUSINESS FOUNDATION
发明人： Sangwon Cha , Purum Kim
IPC分类号： H01J49/16 , H01J49/00
CPC分类号： H01J49/167
摘要： A paper cone tip, having a triangular-pyramidal shape with a vertex angle of 12.5° to 45°, and to a paper cone spray ionization mass spectrometry (PCSI MS) method using a paper cone tip, including: preparing the paper cone tip having a triangular-pyramidal shape; placing a measuring sample in the paper cone tip and locating the paper cone tip in front of a mass spectrometer; and adding a spraying solvent to the paper cone tip and applying a voltage thereto. The paper cone tip having a triangular-pyramidal shape is suitable for use in PCSI MS for the direct analysis of solid samples of raw materials, and the three-dimensional paper cone tip serves as a sample container, a solid-liquid extraction chamber, an analyte transport channel, and an electrospray tip.
摘要翻译：一种具有顶角为12.5°至45°的三角锥体形状的纸锥尖端和使用纸锥尖的纸锥喷雾电离质谱法（PCSI MS）方法，包括：准备具有三角锥形; 将测量样品放在纸锥尖端并将纸锥尖定位在质谱仪前面; 并向所述纸锥尖端添加喷雾溶剂并向其施加电压。具有三角锥形的纸锥尖适用于PCSI MS直接分析固体样品原料，三维纸锥尖作为样品容器，固液萃取室，分析物传输通道和电喷雾尖端。

6. 发明申请

US20160260599A1 ION FOCUSING MEMBER AND MASS SPECTROMETER USING THE SAME 有权
标题翻译：使用它的离子聚焦会员和质谱仪
公开(公告)号：US20160260599A1
公开(公告)日：2016-09-08
申请号：US15057596
申请日：2016-03-01
申请人： NATIONAL CHUNG HSING UNIVERSITY
发明人： Maw-Rong LEE , Yen-Hsien LI
IPC分类号： H01J49/16
CPC分类号： H01J49/167 , H01J49/06
摘要： An ion focusing member includes a ball having a surface with a plurality of dimples. The ion focusing member is adapted for being disposed in a mass spectrometer in a way that the ball is located at a spray path of analyte ions and located between a metal capillary and a mass analyzer. When the analyte ions pass through the ball, the analyte ions can be gathered at a downstream position of the ball, which in turn flow into the mass analyzer by a potential difference. Therefore, the ion focusing member of the present disclosure can effectively enhance the amount of the analyte ions entering into the mass analyzer, thereby improving ion transmission efficiency. As a result, a mass spectrometer equipped with the ion focusing member may have increased signal intensity of analyte, lowered limit of detection (LOD), and minimized detection error.
摘要翻译：离子聚焦构件包括具有多个凹坑的表面的球。离子聚焦构件适于以如下方式设置在质谱仪中：球位于分析物离子的喷射路径处并位于金属毛细管和质量分析器之间。当分析物离子通过球时，分析物离子可以聚集在球的下游位置，球的下游位置又通过电势差流入质量分析器。因此，本公开的离子聚焦构件可以有效地增加进入质量分析器的分析物离子的量，从而提高离子传递效率。结果，配备有离子聚焦构件的质谱仪可以具有增加的分析物的信号强度，降低的检测限（LOD）和最小化的检测误差。

7. 发明申请

US20160225601A1 Miniature Ion Source of Fixed Geometry 审中-公开
标题翻译：固定几何微型离子源
公开(公告)号：US20160225601A1
公开(公告)日：2016-08-04
申请号：US15022396
申请日：2014-09-17
申请人： MICROMASS UK LIMITED
发明人： Stevan Bajic , David Gordon , Daniel James Kenny , Richard Barrington Moulds , Stephen O'Brien , Ian Trivett , Kate Whyatt
IPC分类号： H01J49/16 , H01J49/00 , H01J49/04
CPC分类号： H01J49/167 , H01J49/0027 , H01J49/044 , H01J49/165
摘要： A mass spectrometer is disclosed comprising an atmospheric pressure interface comprising a gas cone having an inlet aperture, wherein the gas cone has a first longitudinal axis arranged along an x-axis and an Electrospray ion source comprising a first capillary tube having an outlet and having a second longitudinal axis and a second capillary tube which surrounds the first capillary tube. The mass spectrometer further comprises a desolvation gas supply tube and a first device arranged and adapted to supply an analyte liquid via the first capillary tube so that the liquid exits the outlet of the first capillary tube at a flow rate >200 μL/min. The mass spectrometer further comprises a second device arranged and adapted to supply a nebuliser gas via the second capillary tube at a flow rate in the range 80-150 L/hr, wherein an outlet of the first capillary tube is arranged at a distance x mm along the x-axis as measured from the centre of the gas cone inlet aperture, a distance y mm along a y-axis as measured from the centre of the gas cone inlet aperture and a distance z mm along a z-axis as measured from the centre of the gas cone inlet aperture. The x-axis, the y-axis and the z-axis are mutually orthogonal. The desolvation gas supply tube surrounds the second capillary tube and the mass spectrometer further comprises a third device arranged and adapted to supply a desolvation gas via the desolvation gas supply tube at a flow rate in the range 400-1200 L/hr, a heater arranged and adapted to heat the desolvation gas to a temperature ≧100° C. and a fourth device arranged and adapted to supply a cone gas to the gas cone at a flow rate in the range 40-80 L/hr and wherein x is in the range 2.0-5.0 mm and wherein the ratio z/x is in the range 1-5:1.
摘要翻译：公开了一种质谱仪，其包括大气压力界面，其包括具有入口孔的气体锥体，其中所述气体锥体具有沿x轴布置的第一纵向轴线和电喷雾离子源，所述电喷雾离子源包括具有出口的第一毛细管，第二纵向轴线和围绕第一毛细管的第二毛细管。质谱仪还包括去溶剂化气体供应管和第一装置，其布置并适于经由第一毛细管供应分析物液体，使得液体以>200μL/ min的流速离开第一毛细管的出口。所述质谱仪还包括第二装置，其布置并适于经由所述第二毛细管以80-150L / hr的流速提供喷雾器气体，其中所述第一毛细管的出口以距离x mm 沿着从气体入口孔的中心测量的沿x轴的距离，沿着y轴的距离ymm，从气体锥入口孔的中心测量，并且沿z轴的距离z mm，从气锥入口孔的中心。 x轴，y轴和z轴相互正交。去溶剂化气体供应管围绕第二毛细管并且质谱仪还包括第三装置，其布置并适于经由去溶剂化气体供应管以400-1200L / hr的流量供应去溶剂化气体，并且适于将去溶剂化气体加热至≥100℃的温度;以及第四装置，其布置并适于以40-80L / hr的流速向锥形锥体供应锥形气体，并且其中x在范围2.0-5.0mm，并且其中z / x的比率在1-5:1的范围内。

8. 发明申请

US20160217994A1 Micro-Nozzle Array 审中-公开
标题翻译：微喷嘴阵列
公开(公告)号：US20160217994A1
公开(公告)日：2016-07-28
申请号：US15007708
申请日：2016-01-27
申请人： Queen's University at Kingston
发明人： Richard D. Oleschuk , Yueqiao Fu , Graham Gibson , Tim Hutama
IPC分类号： H01J49/16 , H01J49/00
CPC分类号： H01J49/167 , C03B37/01211 , C03B37/01228 , C03B37/01251 , C03B37/0756 , C03B37/14
摘要： The invention relates to a micro-nozzle array comprising a plurality of capillaries comprising a first silica-based material and a second silica-based material substantially surrounding the first silica-based material of the plurality of capillaries, and a plurality of nozzles extending beyond a face of the micro-nozzle array, each nozzle corresponding to a single capillary, wherein each nozzle comprises the first silica-based material. The micro-nozzle array may be used in hydrodynamic or electro-osmotic applications. In one embodiment the micro-nozzle array is a multiple electrospray emitter. The invention also relates to methods for preparing and using micro-nozzle arrays.
摘要翻译：本发明涉及一种微喷嘴阵列，其包括多个毛细管，其包括基本上围绕多个毛细管中的第一二氧化硅基材料的第一二氧化硅基材料和第二二氧化硅基材料，以及多个喷嘴，其延伸超过微喷嘴阵列的表面，每个喷嘴对应于单个毛细管，其中每个喷嘴包括第一基于二氧化硅的材料。微喷嘴阵列可用于流体动力学或电渗透应用。在一个实施例中，微喷嘴阵列是多个电喷雾发射器。本发明还涉及制备和使用微喷嘴阵列的方法。

9. 发明授权

US09362101B2 Plume collimation for laser ablation electrospray ionization mass spectrometry 有权
标题翻译：激光消融电喷雾电离质谱法的羽流准直
公开(公告)号：US09362101B2
公开(公告)日：2016-06-07
申请号：US14477112
申请日：2014-09-04
申请人： The George Washington University
发明人： Akos Vertes , Jessica A. Stolee
IPC分类号： H01J49/16 , H01J49/04 , H01J49/14
CPC分类号： H01J49/167 , H01J49/0404 , H01J49/0463 , H01J49/145 , H01J49/165
摘要： In various embodiments, a device may generally comprise a capillary having a first end and a second end; a laser to emit energy at a sample in the capillary to ablate the sample and generate an ablation plume in the capillary; an electrospray apparatus to generate an electrospray plume to intercept the ablation plume to produce ions; and a mass spectrometer having an ion transfer inlet to capture the ions. The ablation plume may comprise a collimated ablation plume. The device may comprise a flow cytometer. Methods of making and using the same are also described.
摘要翻译：在各种实施例中，装置通常可以包括具有第一端和第二端的毛细管; 在毛细管中的样品处发射能量的激光以烧蚀样品并在毛细管中产生消融羽流; 电喷射装置，用于产生电喷雾羽流以拦截消融羽流以产生离子; 和具有离子转移入口以捕获离子的质谱仪。消融羽流可以包括准直的消融羽流。该装置可以包括流式细胞仪。还描述了制备和使用它们的方法。

10. 发明申请

US20160126080A1 SYSTEM AND METHOD FOR LIQUID EXTRACTION ELECTROSPRAY-ASSISTED SAMPLE TRANSFER TO SOLUTION FOR CHEMICAL ANALYSIS 有权
标题翻译：用于液体萃取的系统和方法电泳辅助样品转移到化学分析方法
公开(公告)号：US20160126080A1
公开(公告)日：2016-05-05
申请号：US14529307
申请日：2014-10-31
申请人： UT-Battelle, LLC
发明人： Vilmos KERTESZ , Gary J. VAN BERKEL
IPC分类号： H01J49/16 , H01J49/04
CPC分类号： H01J49/167 , H01J49/04 , H01J49/0431 , H01J49/142 , H01J49/26
摘要： A system for sampling a surface includes a surface sampling probe comprising a solvent liquid supply conduit and a distal end, and a sample collector for suspending a sample collection liquid adjacent to the distal end of the probe. A first electrode provides a first voltage to solvent liquid at the distal end of the probe. The first voltage produces a field sufficient to generate electrospray plume at the distal end of the probe. A second electrode provides a second voltage and is positioned to produce a plume-directing field sufficient to direct the electrospray droplets and ions to the suspended sample collection liquid. The second voltage is less than the first voltage in absolute value. A voltage supply system supplies the voltages to the first electrode and the second electrode. The first electrode can apply the first voltage directly to the solvent liquid. A method for sampling for a surface is also disclosed.
摘要翻译：用于对表面进行采样的系统包括包括溶剂液体供应管道和远端的表面采样探针以及用于将样品收集液体悬挂在探针的远端附近的样品收集器。第一电极在探针的远端处向溶剂液体提供第一电压。第一电压产生足以在探针的远端产生电喷雾羽流的场。第二电极提供第二电压并且被定位成产生足以将电喷雾液滴和离子引导到悬浮样品收集液体的羽流引导场。第二电压小于绝对值中的第一电压。电压供应系统将电压提供给第一电极和第二电极。第一电极可以将第一电压直接施加到溶剂液体上。还公开了一种用于表面采样的方法。

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