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1. 发明授权

US07229642B2 Amino acid modulated extended release dosage form 有权
标题翻译：氨基酸调制缓释剂型
公开(公告)号：US07229642B2
公开(公告)日：2007-06-12
申请号：US11158786
申请日：2005-06-22
申请人： A. Reza Fassihi , Thomas Dürig
发明人： A. Reza Fassihi , Thomas Dürig
IPC分类号： A61K9/26 , A61K9/16 , A61K47/00
CPC分类号： A61K9/2077 , A61K9/1617 , A61K9/1652 , A61K9/2013 , A61K9/205 , Y10S514/96 , Y10S514/961 , Y10S514/964 , Y10S514/965 , Y10S514/972
摘要： Disclosed herein is a oral extended release dosage form comprising a plurality of granules of an effective amount of a pharmaceutically active compound, at least one amino acid, and an intragranular polymer in which the granule is dispersed within a hydrophilic extragranular polymer matrix which is more rapidly hydrating than the intragranular polymer. The amino acid is selected for hydropathy characteristics depending on solubility characteristics of the active compound.
摘要翻译：本文公开了一种口服延长释放剂型，其包含多个有效量的药物活性化合物，至少一种氨基酸和颗粒内聚合物的颗粒，其中颗粒分散在亲水性颗粒外聚合物基质内，其更快速地水合比颗粒内聚合物。根据活性化合物的溶解度特性，选择氨基酸用于亲水性特征。

2. 发明申请

US20060128938A1 Lactic acid polymer and process for producing the same 审中-公开
公开(公告)号：US20060128938A1
公开(公告)日：2006-06-15
申请号：US11348464
申请日：2006-02-07
申请人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
发明人： Kohei Yamamoto , Tsutomu Tani , Takashi Aoki , Yoshio Hata
IPC分类号： C08G63/08
CPC分类号： A61K38/09 , A61K9/1647 , A61K9/5031 , A61K47/34 , C08G63/08 , C08G63/88 , C08G63/912 , Y10S514/963 , Y10S514/965
摘要： A process for producing a lactic acid polymer of 15,000 to 50,000 in weight-average molecular weight, the content of polymeric materials having not more than about 5,000 in weight-average molecular weight therein being not more than about 5% by weight, characterized by hydrolyzing a high molecular weight lactic acid polymer, placing the resultant solution comprising the hydrolyzed product under a condition capable of precipitating the objective lactic acid polymer, separating the precipitated lactic acid polymer and collecting them. The lactic acid polymer is useful as a matrix for sustained-release preparations. The sustained-release microcapsule preparation encapsulating a physiologically active substance can fully prevent the initial excessive release of the physiologically active substance from the microcapsules and keep a stable release rate over a long period of time.

3. 发明授权

US06979674B1 Polyol/oil suspensions for the sustained release of proteins 失效
标题翻译：用于持续释放蛋白质的多元醇/油悬浮液
公开(公告)号：US06979674B1
公开(公告)日：2005-12-27
申请号：US09728534
申请日：2000-11-28
申请人： Merrill Goldenberg , Daxian Shan , Alice Beekman , Tiansheng Li
发明人： Merrill Goldenberg , Daxian Shan , Alice Beekman , Tiansheng Li
IPC分类号： A61K9/06 , A61K38/00 , A61K38/18 , A61K38/21 , A61K38/24 , A61K47/34 , C07K1/00
CPC分类号： A61K9/0024 , A61K47/34 , Y10S514/964 , Y10S514/965
摘要： The present invention relates to the preparation of polyol/thickened oil suspensions containing a biologically active agent, for the sustained delivery of the biologically active agent. The described protein/glycerol/oil suspensions show sustained release of protein, e.g., G-CSF, of up to at least one week.
摘要翻译：本发明涉及含有生物活性剂的多元醇/增稠油悬浮液的制备，用于持续递送生物活性剂。所描述的蛋白质/甘油/油悬浮液显示蛋白质例如G-CSF的持续释放至多至少一周。

4. 发明申请

US20050037058A1 Method for producing a silver-containing wound care device 失效
标题翻译：含银伤口护理装置的制造方法
公开(公告)号：US20050037058A1
公开(公告)日：2005-02-17
申请号：US10640919
申请日：2003-08-14
申请人： T. Canada , Robert Schuette , Raymond Sturm , Kenneth Wiencek
发明人： T. Canada , Robert Schuette , Raymond Sturm , Kenneth Wiencek
IPC分类号： A61K33/38 , A61L15/18 , A61L15/44 , A61L15/46 , A61L15/00
CPC分类号： A61K33/38 , A61L15/18 , A61L15/44 , A61L15/46 , Y10S424/03 , Y10S514/944 , Y10S514/945 , Y10S514/964 , Y10S514/965 , Y10S514/97 , Y10T442/2525
摘要： Wound care devices having a topically applied silver-based antimicrobial finish are provided. The finish comprises at least one silver ion-containing compound and at least one binder compound. The finish may be applied to a target substrate, such as a fiber, fabric, film, foam, hydrogel, or hydrocolloid to provide a single layer antimicrobial wound care device. Alternatively, a silver-containing layer may be combined with one or more additional layers of target substrate to provide a composite antimicrobial wound care device. The device may also contain an odor-absorbing component capable of reducing or eliminating odors that are inherently associated with infectious wounds. Also provided is a method for making the wound care device and a composition of matter comprising the silver-based antimicrobial finish.
摘要翻译：提供具有局部应用的银基抗微生物整理剂的伤口护理装置。整理剂包含至少一种含银离子的化合物和至少一种粘合剂化合物。可以将光洁度施加到目标基底，例如纤维，织物，膜，泡沫，水凝胶或水胶体，以提供单层抗微生物伤口护理装置。或者，含银层可以与一个或多个另外的靶基底层组合以提供复合抗微生物伤口护理装置。该装置还可以含有能够减少或消除与感染性伤口固有相关的气味的气味吸收组分。还提供了制造伤口护理装置的方法和包含银基抗微生物整理剂的物质组合物。

5. 发明申请

US20040228905A1 Anti-inflammatory and antimicrobial uses for bioactive glass compositions 审中-公开
公开(公告)号：US20040228905A1
公开(公告)日：2004-11-18
申请号：US10865636
申请日：2004-06-10
发明人： David C. Greenspan , Jon K. West , Sean Lee , James L. Meyers , Mason Diamond
IPC分类号： A61K033/24 , A61K009/14 , A61K031/65
CPC分类号： A61Q1/02 , A61K8/25 , A61K45/06 , A61L15/18 , A61L15/44 , A61L15/46 , A61Q5/00 , A61Q17/005 , A61Q19/00 , C03C4/0007 , Y10S424/13 , Y10S514/829 , Y10S514/83 , Y10S514/831 , Y10S514/859 , Y10S514/861 , Y10S514/862 , Y10S514/863 , Y10S514/864 , Y10S514/886 , Y10S514/887 , Y10S514/951 , Y10S514/965
摘要： Compositions and methods for treating wounds to significantly reduce the healing time, reduce the incidence of scar formation, improve the success of skin grafts, reduce the inflammatory response and providing anti-bacterial treatments to a patient in need thereof, that include small non-interlinked particles of bioactive glass or highly porous bioactive glass, are disclosed. Anti-bacterial solutions derived from bioactive glass, and methods of preparation and use thereof, are also disclosed. The compositions include non-interlinked particles of bioactive glass, alone or in combination with anti-bacterial agents and/or anti-inflammatory agents. The compositions can include an appropriate carrier for topical administration. Anti-bacterial properties can be imparted to implanted materials, such as prosthetic implants, sutures, stents, screws, plates, tubes, and the like, by incorporating small bioactive glass particles or porous bioactive glass into or onto the implanted materials. Anti-bacterial properties can also be imparted to devices used for in vitro and ex vivo cell culture by incorporating non-interlinked particles of bioactive glass into the devices. Anti-bacterial compositions derived from aqueous extracts of bioactive glass are also disclosed. These compositions can be used, for example, in food preparation, solutions used for cell culture, and buffer solutions, such as i.v. solutions.

6. 发明申请

US20030113374A1 Pulsatile release histamine H2 antagonist dosage form 有权
公开(公告)号：US20030113374A1
公开(公告)日：2003-06-19
申请号：US10057759
申请日：2002-01-25
发明人： Philip J. Percel , Nehal H. Vyas , Krishna S. Vishnupad , Gopi M. Venkatesh
IPC分类号： A61K009/20 , A61K009/26
CPC分类号： A61K9/5084 , A61K9/5026 , A61K9/5042 , A61K9/5047 , A61K9/5078 , Y10S514/965
摘要： A unit dosage form, such as a capsule or the like, for delivering drugs into the body in a circadian release fashion comprising one or more populations of drug-containing particles (beads, pellets, granules, etc.) is disclosed. Each bead population exhibits a pre-designed rapid or sustained release profile with or without a predetermined lag time of 3 to 5 hours. Such a circadian rhythm release drug delivery system is designed to provide a plasma concentration-time profile, which varies according to physiological need at different times during the dosing period, i.e., mimicking the circadian rhythm and severity/manifestation of gastric acid secretion (and/or midnight gerd), predicted based on pharmaco-kinetic and pharmaco-dynamic considerations and in vitro/in vivo correlations.

7. 发明申请

US20020192285A1 Controlled release pellet formulation 有权
标题翻译：控释丸剂配方
公开(公告)号：US20020192285A1
公开(公告)日：2002-12-19
申请号：US10165907
申请日：2002-06-10
申请人： Nostrum Pharmaceuticals, Inc.
发明人： Nirmal Mulye
IPC分类号： A61K009/00 , A61K009/32
CPC分类号： A61K9/5078 , A61K9/5026 , A61K9/5036 , A61K9/5042 , A61K9/5047 , Y10S514/965
摘要： The present invention describes an aqueous pharmaceutical coating formulation which can be used for coating core elements containing one or more medicaments to achieve controlled release. The coated pharmaceutical formulation provides a release of medicaments in a controlled manner at highly acidic environment such as that of stomach and shows relatively faster release in media with basic pH such as that of the intestine. The coating composition is a heterogenous mixture which comprises (a) at least 75% by weight of a water insoluble polymer which is insoluble in both acidic as well as basic pH; and (b) 1 to 25% by weight of an enteric polymer which is substantially insoluble in water at a pH below 4.5 and which is substantially soluble in water at a pH between above about 6.0, said enteric polymer and water insoluble polymer being present in an amount effective to control-the release of said medicament. The pharmaceutical composition comprises a solid medicament present in effective amounts and the coating composition thereover.
摘要翻译：本发明描述了一种水性药物涂料制剂，其可用于包含含有一种或多种药物的核心元件以实现控制释放。涂覆的药物制剂在高酸性环境例如胃的情况下以受控的方式提供药物释放，并且在碱性pH如肠的培养基中显示相对较快的释放。涂料组合物是一种异质混合物，其包含（a）至少75重量％的不溶于酸性和碱性pH的水不溶性聚合物; 和（b）1至25重量％的肠溶性聚合物，其在pH低于4.5时基本上不溶于水，并且其在约6.0之间的pH基本上可溶于水，所述肠溶聚合物和水不溶性聚合物存在于有效控制所述药物释放的量。药物组合物包含有效量的固体药物和其上的涂料组合物。

8. 发明授权

US06479040B1 Cosmetic formulation 失效
公开(公告)号：US06479040B1
公开(公告)日：2002-11-12
申请号：US09777611
申请日：2001-02-06
申请人： Salvatore Barone , Antonietta Corrigan , Mita Mody , Melizza Bautista , Ralph Macchio , Louis Veltry
发明人： Salvatore Barone , Antonietta Corrigan , Mita Mody , Melizza Bautista , Ralph Macchio , Louis Veltry
IPC分类号： A61K700
CPC分类号： A61Q19/001 , A61K8/025 , A61K8/31 , A61K8/375 , A61K8/60 , A61K8/645 , A61K8/8111 , A61K8/8182 , A61K8/922 , A61K8/925 , A61K8/927 , A61K2800/412 , A61Q1/02 , A61Q1/06 , A61Q1/10 , A61Q19/00 , A61Q19/08 , Y10S424/05 , Y10S514/847 , Y10S514/944 , Y10S514/952 , Y10S514/963 , Y10S514/965
摘要： The present invention includes a cosmetic formulation. The cosmetic formulation comprises a plurality of spheres having a first desiccated volume and having a second hydrated volume. The hydrated volume is greater than the desiccated volume.

9. 发明授权

US06413533B1 Method for chemoprevention of prostate cancer 失效
公开(公告)号：US06413533B1
公开(公告)日：2002-07-02
申请号：US09531472
申请日：2000-03-20
申请人： Mitchell S. Steiner , Sharan Raghow
发明人： Mitchell S. Steiner , Sharan Raghow
IPC分类号： A61F1300
CPC分类号： A61K45/06 , A61K31/00 , A61K31/015 , A61K31/138 , A61K31/4535 , A61K31/565 , Y10S514/938 , Y10S514/944 , Y10S514/965
摘要： This invention provides the chemoprevention of prostate cancer and, more particularly, to a method of preventing prostate carcinogenesis comprising the steps of administering to a human subject having a precancerous precursor of prostate adenocarcinoma, a pharmaceutical preparation comprising a chemopreventive agent to prevent, prevent recurrence of, suppress or inhibit prostate carcinogenesis. The present invention provides a safe and effective method for suppressing or inhibiting latent prostate cancer and is particularly useful for treating subjects having elevated risk of developing prostate cancer, for example, those having benign prostatic hyperplasia, prostate intraepithelial neoplasia (PIN), or an abnormally high level of circulating prostate specific antibody (PSA), or who have a family history of prostate cancer.

10. 发明申请

US20020039571A1 COMPOSITIONS AND METHODS FOR TREATMENT OF TUMORS AND METASTATIC DISEASES 有权
标题翻译：用于治疗肿瘤和分化疾病的组合物和方法
公开(公告)号：US20020039571A1
公开(公告)日：2002-04-04
申请号：US09261816
申请日：1999-03-03
发明人： FRANK W. FALKENBERG , OLIVER C. KRUP
IPC分类号： A01N063/00 , A01N065/00 , A61K048/00 , A61K039/00 , A61K039/38 , C12N005/00 , C12N005/02 , C01F007/02
CPC分类号： A61K39/0011 , A61K2039/5152 , A61K2039/55505 , A61K2039/55522 , Y10S514/963 , Y10S514/965
摘要： Compositions and methods are provided which can be utilized in active immunization as a prophylactic treatment or a therapeutic treatment for tumors. The compositions are employed as injectable tumor vaccines or as preparations for intratumoral administration and are capable of stimulating immune responses to specific tumor antigens. The tumor vaccines are composed of an antigenic cellular material including a plurality of inactivated tumor cells or tumor cell portions, a depot material, and an immunostimulant adsorbed to the depot material. The depot material with absorbed immunostimulant is mixed with the tumor cells or tumor cell portions to form the vaccine compositions. The preparations for intratumoral administration include the depot material adsorbed immunostimulant without the antigenic cellular material. The immunostimulant adsorbed to the depot material permits release of biologically active quantities of the immunostimulant over a period of time rather than all at once.
摘要翻译：提供可用于主动免疫的组合物和方法作为肿瘤的预防治疗或治疗性治疗。该组合物用作可注射肿瘤疫苗或用于肿瘤内给药的制剂，并且能够刺激对特定肿瘤抗原的免疫应答。肿瘤疫苗由抗原性细胞材料组成，包括多个灭活的肿瘤细胞或肿瘤细胞部分，贮库材料和吸附于贮库材料的免疫刺激剂。将具有吸收的免疫刺激剂的储库材料与肿瘤细胞或肿瘤细胞部分混合以形成疫苗组合物。肿瘤内给药的制剂包括没有抗原性细胞材料的药物吸收的免疫刺激剂。吸附到贮库材料的免疫刺激剂允许在一段时间内而不是同时全部释放生物活性量的免疫刺激剂。

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