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1. 发明授权

US11548901B2 Substituted 1,4-methanopyrido[1′,2′:4,5]pyrazino[1,2-a]pyrimidines for treating viral infections 有权
公开(公告)号：US11548901B2
公开(公告)日：2023-01-10
申请号：US16868119
申请日：2020-05-06
申请人： Gilead Sciences, Inc.
发明人： Elizabeth M. Bacon , Zhenhong R. Cai , Xiaowu Chen , Jeromy J. Cottell , Manoj C. Desai , Mingzhe Ji , Haolun Jin , Scott E. Lazerwith , Michael R. Mish , Philip Anthony Morganelli , Hyung-Jung Pyun , James G. Taylor , Teresa Alejandra Trejo Martin
IPC分类号： A61K31/4985 , C07D487/14 , C07D498/14 , A61K31/537 , C07D471/22 , A61K31/529 , A61K31/551 , A61K31/498 , C07D471/18 , A61K45/06 , C07D498/18 , A61K31/553
摘要： Compounds for use in the treatment of human immunodeficiency virus (HIV) infection are disclosed. The compounds have the following Formula (I): including stereoisomers and pharmaceutically acceptable salts thereof, wherein R1, X, W, Y1, Y2, Z1, and Z4 are as defined herein. Methods associated with preparation and use of such compounds, as well as pharmaceutical compositions comprising such compounds, are also disclosed.

2. 发明申请

US20220251197A1 ANTI-CD79B ANTIBODIES AND IMMUNOCONJUGATES AND METHODS OF USE 有权
公开(公告)号：US20220251197A1
公开(公告)日：2022-08-11
申请号：US17725417
申请日：2022-04-20
申请人： Genentech, Inc.
发明人： Yvonne CHEN , Mark DENNIS , David DORNAN , Kristi ELKINS , Jagat Reddy JUNUTULA , Andrew POLSON , Bing ZHENG
IPC分类号： C07K16/28 , A61K51/10 , A61K47/68 , A61K39/395 , A61K45/06 , A61K31/537 , A61K38/05 , C07K16/30 , G01N33/574
摘要： The present invention is directed to compositions of matter useful for the treatment of hematopoietic tumor in mammals and to methods of using those compositions of matter for the same.

3. 发明申请

US20220226334A1 ANTIBODY CONJUGATE AND APPLICATION OF PHARMACEUTICAL COMPOSITION THEREOF 有权
公开(公告)号：US20220226334A1
公开(公告)日：2022-07-21
申请号：US17612849
申请日：2019-05-21
申请人： SHANGHAI FUDAN-ZHANGJIANG BIO-PHARMACEUTICAL CO., LTD. , SHANGHAI JIAOLIAN MEDICINE RESEARCH AND DEVELOPMENT CO., LTD.
发明人： Yijun SHEN , Tong YANG , Yanjun LIU , Qingsong GUO , Xuemei CAO , Hua LI , Bei GAO , Guanghao WU , Likai MENG , Yanbo GAO , Yang ZHU
IPC分类号： A61K31/537 , A61K47/54 , A61K47/68
摘要： An application of an antibody conjugate in the preparation of a drug for treating CD30 positive tumors, which is characterized in that: the antibody conjugate is F0002-ADC; the general formula of the structural thereof is Ab-Lm-Yn; and the CD30-positive tumors are CD30-positive tumors that express a multidrug resistance gene 1. In addition, a pharmaceutical combination and a pharmaceutical composition containing the antibody conjugate, which may be applied to the preparation of a drug used for treating CD30-positive tumors.

4. 发明授权

US11332542B2 Anti-CEACAM5 antibodies and uses thereof 有权
公开(公告)号：US11332542B2
公开(公告)日：2022-05-17
申请号：US16558939
申请日：2019-09-03
申请人： SANOFI
发明人： Pierre-Francois Berne , Francis Blanche , Hervé Bouchard , Béatrice Cameron , Tarik Dabdoubi , Stéphanie Decary , Paul Ferrari , Alexey Rak
IPC分类号： C07K16/30 , A61K47/68 , A61K31/537 , C07K16/28 , C07K16/46 , G01N33/574
摘要： Disclosed are antibodies which bind human and Macaca fascicularis CEACAM5 proteins, as well as isolated nucleic acids, vectors and host cells comprising a sequence encoding the antibodies. Also disclosed are immunoconjugates comprising the antibodies conjugated or linked to a growth-inhibitory agent, and pharmaceutical compositions comprising the antibodies or immunoconjugates of the invention. The antibodies or immunoconjugates are used for the treatment of cancer or for diagnostic purposes.

5. 发明申请

US20220088112A1 FUNCTIONALIZED POLY-ADP-RIBOSE POLYMERS FOR DRUG DELIVERY 有权
公开(公告)号：US20220088112A1
公开(公告)日：2022-03-24
申请号：US17599309
申请日：2020-03-27
申请人： University of Southern California
发明人： Yong Zhang
IPC分类号： A61K38/07 , A61K47/64 , A61K47/60 , A61K47/68 , A61K47/54 , A61K31/704 , A61K31/537 , A61P35/00
摘要： Novel antibody-drug conjugates (ADCs) and methods of using such ADCs to treat proliferative disorders are described herein. The ADCs may comprise a PARP protein automodified with a plurality of poly-ADP-ribose polymers functionalized with novel NAD+ analogues. The automodified PARP with functionalized poly-ADP-ribose polymers provide a novel type of drug carrier, which allows facile conjugation of monoclonal antibodies and cytotoxic drug in high ratios.

6. 发明授权

US11202780B2 Crystalline forms of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide 有权
公开(公告)号：US11202780B2
公开(公告)日：2021-12-21
申请号：US16740174
申请日：2020-01-10
申请人： Gilead Sciences, Inc.
发明人： Ernest A. Carra , Irene Chen , Katie Ann Keaton , Scott E. Lazerwith , Vahid Zia
IPC分类号： A61K31/5365 , C07D498/18 , A61K45/06 , A61K9/20 , C07D498/14 , A61K31/513 , A61K31/553 , A61K31/675 , A61K31/683 , A61K31/537
摘要： The present invention relates to crystalline forms and co-crystals of (2R,5S,13aR)-8-hydroxy-7,9-dioxo-N-(2,4,6-trifluorobenzyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepine-10-carboxamide, the pharmaceutical formulations, and the therapeutic uses thereof. The present invention also relates to novel crystalline forms of sodium (2R,5S,13aR)-7,9-dioxo-10-(2,4,6-trifluorobenzyl)carbamoyl)-2,3,4,5,7,9,13,13a-octahydro-2,5-methanopyrido[1′,2′:4,5]pyrazino[2,1-b][1,3]oxazepin-8-olate Form I.

7. 发明授权

US11045560B2 Therapeutic conjugates with sulfated dendrimers for intracellular targeting 有权
公开(公告)号：US11045560B2
公开(公告)日：2021-06-29
申请号：US15313084
申请日：2015-05-21
申请人： IC DISCOVERY GMBH
发明人： Kai Licha , Michael Schirner
IPC分类号： A61K9/00 , A61K49/00 , C08G83/00 , A61K38/00 , A61K38/43 , A61K47/60 , A61K47/59 , A61K31/537 , A61K31/553 , A61K38/10 , A61K38/17 , A61K38/46 , A61K38/50 , A61K39/395 , A61K39/00
摘要： The present invention relates to novel dendrimer conjugates, methods for their preparation and their use for treatment of diseases. The invention discloses a new method for the delivery of dendrimer conjugates with therapeutically active molecules into the cell by utilizing transmembrane solute carrier proteins enabling uptake of the inventive dendrimer conjugates. Particular subject-matter of the present invention is a conjugate of the formula E-[G-L-D(OSO3−M+)n]m, wherein E is a therapeutic or diagnostic effector molecule, wherein D(OSO3−M+)n is a dendrimer D carrying a number n of sulfate groups OSO3−M+, wherein the number n of sulfate groups is selected from 6 to 96, wherein M is a cationic inorganic or organic counter ion to the anionic sulfate group, wherein L is a linker or spacer between D and E, wherein G is a connecting functional group forming the attachment between L and E, and wherein m is an integer from 1 to 20.

8. 发明申请

US20210113690A1 PHARMACEUTICAL COMBINATIONS 有权
公开(公告)号：US20210113690A1
公开(公告)日：2021-04-22
申请号：US17251718
申请日：2019-06-13
申请人： BERLIN-CHEMIE AG
发明人： Giuseppe MERLINO , Mario BIGIONI , Monica BINASCHI , Andrea PELLACANI
IPC分类号： A61K39/395 , A61K31/635 , A61K31/537 , A61K47/68 , C07K16/28 , A61P35/00 , A61P35/02
摘要： The present disclosure relates generally to the fields of immunology and molecular biology. More specifically, provided herein are pharmaceutical combinations comprising (A) antibodies, or antigen-binding portions thereof, directed against LY75, and (B) Venetoclax; methods for preparing pharmaceutical combinations; and methods for the treatment of diseases, such as cancers mediated by LY75 expression or activity.

9. 发明申请

US20200171039A1 COMBINATIONS AND USES AND TREATMENTS 审中-公开
公开(公告)号：US20200171039A1
公开(公告)日：2020-06-04
申请号：US16636452
申请日：2018-08-02
申请人： ViiV Healthcare Company
发明人： Mark I. COCKETT , Eugene L. STEWART , Mark Richard UNDERWOOD , Cindy L. VAVRO
IPC分类号： A61K31/537 , A61K31/513 , A61P31/18
摘要： Methods for treating or preventing HIV in a patient using a combination of bictegravir and emtricitabine and optionally with other anti-HIV agents are disclosed, as well as compositions containing such compounds.

10. 发明授权

US10525038B2 Combination therapy 有权
公开(公告)号：US10525038B2
公开(公告)日：2020-01-07
申请号：US15704713
申请日：2017-09-14
申请人： DIMERIX BIOSCIENCE PTY LTD
发明人： Kevin D. G. Pfleger , Elizabeth McCall , James Williams
IPC分类号： A61K31/537 , A61K9/00 , A61K9/20 , A61K31/28 , A61K31/4178 , A61K31/4184 , A61K31/80 , A61K45/06
摘要： The invention relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof, and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof. The invention also relates to pharmaceutical compositions comprising: (a) at least one angiotensin receptor blocker or a pharmaceutically acceptable salt thereof; and (b) at least one chemokine receptor pathway inhibitor or a pharmaceutically acceptable salt thereof which inhibits a component of the chemokine receptor pathway other than the chemokine receptor. Oral sustained release pharmaceutical compositions comprising the pharmaceutical composition, as well as injectable sustained release pharmaceutical compositions comprising the pharmaceutical composition are described. The invention further relates to tablets, capsules, injectable suspensions, and compositions for pulmonary or nasal delivery comprising the pharmaceutical composition. Also described are: methods for assessing the efficacy of the pharmaceutical composition; methods for assessing the inhibition or partial inhibition activity of the pharmaceutical composition; methods for the treatment, amelioration or prevention of a condition or disease comprising administering to a subject a therapeutically effective amount of the pharmaceutical composition; and the use of the pharmaceutical composition for the manufacture of a dosage form for the treatment of a disease.

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