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1. 发明授权

US06548552B1 Absorbent article, particularly a tampon having additives that reduce toxic shock syndrome toxin production 失效
标题翻译：吸收制品，特别是具有减少毒性休克综合征毒素生产的添加剂的卫生棉条
公开(公告)号：US06548552B1
公开(公告)日：2003-04-15
申请号：US09150373
申请日：1998-09-10
申请人： Robert L. Deresiewicz , Dennis L. Kasper
发明人： Robert L. Deresiewicz , Dennis L. Kasper
IPC分类号： A61K31095
CPC分类号： A61F13/2051 , A61F13/8405 , Y10S514/975
摘要： An absorbent article, particularly a tampon having additives that reduce toxic shock syndrome toxin (TST-1) production is disclosed. The tampon has a combination of an effective amount of at least one oxygen inhibiting agent and an effective amount of at least one surface active agent applied to: the surface of the absorbent tampon material; the surfaces of the fibers comprising the tampon; to the tampon applicator; or any combination of the foregoing. The effective amounts of the oxygen inhibiting agent and the surface active agent are sufficient to reduce the toxin production at lease about 50%, but do not negatively affect the wearer's normal vaginal flora.
摘要翻译：公开了一种吸收制品，特别是具有减少毒性休克综合征毒素（TST-1）生产的添加剂的卫生棉条。卫生棉条具有有效量的至少一种氧气抑制剂和有效量的至少一种表面活性剂的组合，其施加到吸收性棉塞材料的表面上; 纤维的表面包括棉条; 到棉塞上; 或上述的任何组合。氧抑制剂和表面活性剂的有效量足以将毒素产量降低至约50％，但不会对穿着者的正常阴道菌群产生不利影响。

2. 发明授权

US06444657B1 Methods for treating certain diseases using naaladase inhibitors 失效
标题翻译：使用奈拉替酶抑制剂治疗某些疾病的方法
公开(公告)号：US06444657B1
公开(公告)日：2002-09-03
申请号：US09425197
申请日：1999-10-22
申请人： Barbara S. Slusher , Xi-Chun May Lu , Krystyna Wozniak
发明人： Barbara S. Slusher , Xi-Chun May Lu , Krystyna Wozniak
IPC分类号： A61K31095
CPC分类号： A61K31/66 , A61K31/00
摘要： The present invention relates to methods of using NAALADase inhibitors to regulate TGF-&bgr; and to treat neurodegenerative disorders, extracellular matrix formation disorders, cell-growth related diseases, infectious diseases, immune related diseases, epithelial tissue scarring, collagen vascular diseases, fibroproliferative disorders, connective tissue disorders, inflammatory diseases, respiratory distress syndrome and infertility.
摘要翻译：本发明涉及使用NAALADase抑制剂调节TGF-β并治疗神经变性疾病，细胞外基质形成障碍，细胞生长相关疾病，感染性疾病，免疫相关疾病，上皮组织瘢痕形成，胶原血管疾病，纤维增生性疾病，结缔组织疾病，炎性疾病，呼吸窘迫综合征和不育症。

3. 发明授权

US06297289B2 Product for moisturizing an eye 有权
标题翻译：产品用于保湿眼睛
公开(公告)号：US06297289B2
公开(公告)日：2001-10-02
申请号：US09849367
申请日：2001-05-07
申请人： Elliott J. Siff
发明人： Elliott J. Siff
IPC分类号： A61K31095
CPC分类号： A61F9/0026 , A61K9/0048 , A61K31/095 , Y10S514/912
摘要： Substances, methods and devices for moisturizing the eye by stimulation of the lachrymatory glands to cause generation of tears.
摘要翻译：用于通过刺激泪液来滋润眼睛以引起眼泪的产生的物质，方法和装置。

4. 发明授权

US06433023B1 Compositions having anti-leishmanial activity 失效
标题翻译：具有反利益相关活动的组合物
公开(公告)号：US06433023B1
公开(公告)日：2002-08-13
申请号：US09048334
申请日：1998-03-26
申请人： Heather Callahan , Colleen Kelley , Max Grogl , Brian G. Schuster
发明人： Heather Callahan , Colleen Kelley , Max Grogl , Brian G. Schuster
IPC分类号： A61K31095
CPC分类号： A61K31/095 , Y02A50/409 , Y02A50/411
摘要： This invention is directed to a composition comprising 4-chloro-3,6-dinitrobenzotrifluoride and related compounds and method for using it to treat infections caused by organisms that have microtubules.
摘要翻译：本发明涉及包含4-氯-3,6-二硝基三氟甲苯和相关化合物的组合物及其用于治疗由具有微管的生物引起的感染的方法。

5. 发明授权

US06426370B1 Use of thiol compounds in viral inactivation 失效
标题翻译：使用硫醇化合物进行病毒灭活
公开(公告)号：US06426370B1
公开(公告)日：2002-07-30
申请号：US09485793
申请日：2000-04-19
申请人： Peter Hofschneider
发明人： Peter Hofschneider
IPC分类号： A61K31095
CPC分类号： A61L2/0088 , A01N31/02 , A01N31/08 , A01N37/44 , A01N37/46 , A01N41/04 , A01N47/14 , A61L2/16 , C12N7/06
摘要： The invention relates to the use of thiol compounds in viral inactivation in a cell-free environment, especially in the blood, blood plasma, blood serum, conserved blood, blood products, cell culture liquids and nutrient media and to the application of said compounds on the surface of plants and animals. Viral inactivation occurs without requiring cell metabolism.
摘要翻译：本发明涉及硫醇化合物在无细胞环境，特别是血液，血浆，血清，保存血液，血液制品，细胞培养液和营养培养基中的病毒灭活中的用途以及所述化合物在植物和动物的表面。病毒灭活发生而不需要细胞新陈代谢。

6. 发明授权

US06592908B1 Nutritional or therapeutic compositions 有权
标题翻译：营养或治疗组合物
公开(公告)号：US06592908B1
公开(公告)日：2003-07-15
申请号：US10252957
申请日：2002-09-23
申请人： Albert Crum
发明人： Albert Crum
IPC分类号： A61K31095
CPC分类号： A61K31/197 , A23L33/16 , A23L33/175 , A23V2002/00 , A61K9/2018 , A61K31/095 , A61K31/198 , A61K33/04 , A61K45/06 , Y10S514/836 , Y10S514/905 , A61K2300/00 , A23V2250/1626 , A23V2250/06
摘要： Nutritional or therapeutic compositions containing glutamic acid, cystine, glycine and a selenium precursor and methods for their utilization to increase glutathione synthesis and thereby enhance the immune system are described.
摘要翻译：描述了包含谷氨酸，胱氨酸，甘氨酸和硒前体的营养或治疗组合物及其用于增加谷胱甘肽合成从而增强免疫系统的方法。

7. 发明授权

US06552089B1 Method of treating or preventing alopecia 失效
标题翻译：治疗或预防秃发的方法
公开(公告)号：US06552089B1
公开(公告)日：2003-04-22
申请号：US08758106
申请日：1996-11-29
申请人： Benjamin Sredni , Michael Albeck
发明人： Benjamin Sredni , Michael Albeck
IPC分类号： A61K31095
CPC分类号： A61K33/04 , A61K31/14 , A61K31/28 , A61K31/555 , A61K51/04 , A61K51/0491 , Y10S514/88 , Y10S514/922
摘要： The present application discloses a method of treating alopecia which is based on the use of a tellurium compound such as ammonium trichloro(dioxoethylene-O,O-tellurate).
摘要翻译：本申请公开了一种治疗秃发的方法，其基于使用碲化合物如三氯甲烷（二氧乙烯-O，碲化物）。

8. 发明授权

US06495607B2 Benzocycloheptenes, process for their production, pharmaceutical preparations that contain the latter as well as their use for the production of pharmaceutical agents 失效
标题翻译：苯并环庚三烯，其生产方法，含有后者的药物制剂及其制备药剂的用途
公开(公告)号：US06495607B2
公开(公告)日：2002-12-17
申请号：US09357239
申请日：1999-07-19
申请人： Rolf Bohlmann , Jorg Kroll , Hermann Kuenzer , Christa Hegele-Hartung , Monika Lessl , Rosemarie Lichtner , Yukishige Nishino
发明人： Rolf Bohlmann , Jorg Kroll , Hermann Kuenzer , Christa Hegele-Hartung , Monika Lessl , Rosemarie Lichtner , Yukishige Nishino
IPC分类号： A61K31095
CPC分类号： C07D307/38 , C07C217/20 , C07C317/18 , C07C317/28 , C07C317/44 , C07C323/12 , C07C323/25 , C07C323/60 , C07C327/28 , C07C2602/12 , C07D213/32 , C07D213/34 , C07D333/18
摘要： Benzocycloheptenes of general formula I in which R1, R2 and Y have the meanings indicated herein, have antiestrogenic activity on and are suitable for the production of pharmaceutical agents, especially for prophylaxis and therapy of osteoporosis.
摘要翻译：通式Iin的苯并环庚烯，其中R 1，R 2和Y具有本文所述的含义，具有抗雌激素活性并适于制备药剂，特别是用于预防和治疗骨质疏松症。

9. 发明授权

US06444709B1 Heteroethylene compounds and pharmaceutical and cosmetic compositions containing same 有权
标题翻译：异丙烯基化合物和含有它们的药物和化妆品组合物
公开(公告)号：US06444709B1
公开(公告)日：2002-09-03
申请号：US09424816
申请日：2000-02-07
申请人： Philippe Diaz , Jean-Michel Bernardon
发明人： Philippe Diaz , Jean-Michel Bernardon
IPC分类号： A61K31095
CPC分类号： C07C323/54 , C07C391/02 , Y10S514/824 , Y10S514/825 , Y10S514/859 , Y10S514/861 , Y10S514/863 , Y10S514/864 , Y10S514/866 , Y10S514/88 , Y10S514/885 , Y10S514/886 , Y10S514/887 , Y10S514/902 , Y10S514/909 , Y10S514/912
摘要： The invention relates to novel heteroethynylenic compounds having the general formula (I): as well as to the use of these compounds in pharmaceutical compositions intended for use in human or veterinary medicine (dermatological, rheumatic, respiratory, cardiovascular and ophthalmological complaints in particular), or alternatively in cosmetic compositions.
摘要翻译：本发明涉及具有通式（I）的新型异硫醚化合物：以及这些化合物在预期用于人类或兽医药物（特别是皮肤病学，风湿性，呼吸道，心血管和眼科投诉）的药物组合物中的用途，或者在化妆品组合物中。

10. 发明授权

US06355690B1 Remedy for CAG repeat expansion diseases 有权
标题翻译：补救CAG重复扩张疾病
公开(公告)号：US06355690B1
公开(公告)日：2002-03-12
申请号：US09236002
申请日：1999-01-22
申请人： Shoji Tsuji
发明人： Shoji Tsuji
IPC分类号： A61K31095
CPC分类号： A61K31/145
摘要： To elucidate the molecular mechanisms of “gain of toxic function” of expanded polyglutamine stretches in CAG repeat expansion diseases, the inventors established an expression system of full-length and truncated cDNAs for dentatorubral-pallidoluysian atrophy (DRPLA) and found that truncated DRPLA proteins containing the expanded polyglutamine stretch, but not the full-length protein, form peri- and intra-nuclear aggregates consisting of filaments and concomitant apoptosis. The apoptotic cell death was partially suppressed by transglutaminase inhibitors, cystamine and monodansyl cadaverine, raising the possibility of involvement of transglutaminase reaction. The results may provide a potential basis for the development of therapeutic measures for CAG repeat expansion diseases.
摘要翻译：为了阐明CAG重复扩张疾病中扩展的聚谷氨酰胺延伸的“获得有毒功能”的分子机制，本发明人建立了用于牙髓 - 苍白球囊肿萎缩（DRPLA）的全长和截短的cDNA的表达系统，并发现含有截短的DRPLA蛋白扩展的多聚谷氨酰胺拉伸，但不是全长蛋白，形成由细丝组成的周围和核内聚集体和伴随的凋亡。转谷氨酰胺酶抑制剂，胱氨酸和单睾酮尸胺部分抑制凋亡细胞死亡，提高转谷氨酰胺酶反应的可能性。结果可能为开发CAG重复扩张疾病的治疗措施提供潜在的依据。

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