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1. 发明公开

US20230321202A1 AMERICAN CHESTNUT LEAF COMPOSITIONS COMPRISING OXALATE OXIDASE AND METHODS FOR TREATMENT OF OXALATE-RELATED DISORDERS 审中-公开
公开(公告)号：US20230321202A1
公开(公告)日：2023-10-12
申请号：US18185315
申请日：2023-03-16
申请人： UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INCORPORATED , The Research Foundation for The State University of New York (RFSUNY)
发明人： Paul R. Dominguez-Gutierrez , William L. Donelan , Tania Quesada , William A. Powell
IPC分类号： A61K38/44 , A61K36/49 , A61K47/46 , C07C51/43 , A61K9/00 , C12N9/02 , A23F3/14 , A23F3/16
CPC分类号： A61K38/44 , A61K36/49 , A61K47/46 , C07C51/43 , A61K9/0095 , C12N9/0008 , C12Y102/03004 , A23F3/14 , A23F3/166 , A61K2236/331 , A61K2236/15 , A61K2236/37
摘要： The invention provides American chestnut leaf compositions comprising oxalate oxidase. The compositions reduce oxalate levels in dietary sources of oxalate and are useful in reducing oxalate levels and reducing stone disease in patients. The invention provides methods of extracting and purifying oxalate oxidase from American chestnut leaf. The invention provides methods of extracting oxalate from biological samples.

2. 发明申请

US20220183339A1 ACETYLCHOLINESTERASE INHIBITOR 有权
公开(公告)号：US20220183339A1
公开(公告)日：2022-06-16
申请号：US17442203
申请日：2019-09-17
申请人： Taiko Pharmaceutical Co., Ltd.
发明人： Norio Ogata , Hideaki Tagishi
IPC分类号： A23L33/105 , A61K31/05 , A61K31/085 , A61K36/15 , A61K36/20 , A61K36/49 , A61P1/00 , A61P13/02 , A61P21/04 , A61P25/16 , A61P25/18 , A61P25/28 , A61P25/30 , A61P27/06 , A61P43/00
摘要： The object of the present invention is to search for and to provide a novel acetylcholinesterase inhibitor. An acetylcholinesterase inhibitor comprising wood creosote as the active ingredient is provided.

3. 发明申请

US20210369674A1 HEALTH MANAGEMENT COMPOSITIONS AND METHODS OF MAKING AND USING THEREOF 有权
公开(公告)号：US20210369674A1
公开(公告)日：2021-12-02
申请号：US16322497
申请日：2017-08-03
申请人： Seattle Gummy Company
发明人： Feng Wan
IPC分类号： A61K31/4045 , A23L33/125 , A23L33/175 , A23L33/16 , A23L33/105 , A23L33/12 , A23L33/155 , A61K31/205 , A61K31/385 , A61K36/258 , A61K31/616 , A61K31/12 , A61K36/9066 , A61K36/88 , A61K36/9068 , A61K36/28 , A61K36/484 , A61K31/165 , A61K36/52 , A61K36/49 , A61K36/87 , A61K31/122 , A61K31/047 , A61K36/45 , A61K31/01 , A61K36/815 , A61K36/481 , A61K36/16 , A61K35/10 , A61K31/706 , A61K31/7004 , A61K31/07 , A61K31/375 , A61K31/593 , A61K31/355 , A61K31/51 , A61K31/525 , A61K31/4415 , A61K31/714 , A61K31/519 , A61K31/197 , A61K47/42 , A61K47/36 , A61K9/06 , A61K38/45 , A61K33/06 , A61K9/00
摘要： The nutraceutical composition includes a neuroprotecting composition, an anti-inflammatory composition, a cardiovascular protecting composition, an antioxidant composition, and a gelling component in a sufficient amount to provide a cohesive gelled product.

4. 发明授权

US11077162B2 Heart-protective plant preparation for preventing and improving coronary heart disease 有权
公开(公告)号：US11077162B2
公开(公告)日：2021-08-03
申请号：US17120162
申请日：2020-12-12
申请人： SHANDONG UNIVERSITY OF TECHNOLOGY
发明人： Yuanda Song , Syed Ammar , Shaoqi Li , Wu Yang
IPC分类号： A61K36/9068 , A61K9/00 , A61K9/14 , A61K9/48 , A61K36/22 , A61K36/287 , A61K36/31 , A61K36/45 , A61K36/49 , A61K36/52 , A61K36/537 , A61K36/54 , A61K36/60 , A61K36/63 , A61K36/71 , A61K36/738 , A61K36/889 , A61K36/8962
摘要： The present disclosure provides a natural plant preparation, including extracts of the following parts of plants: roots of Salvia miltiorrhiza Bunge, Juglans regia, Aesculus hippocastanum L. and Zingiber officinale Rosc., barks of Cinnamomum cassia Presl, seeds of Sesamum indicum, Carica papaya L., Nigella damascena L. and Punica granatum L., leaves of Centaurea cyanus L., resin of Pistacia Lentiscus, drupes of Cocos nucifera L., beans of Theobroma cacao L., dried pulp and kernels of Phoenix dactylifera L., dried pulp of Olea europaea, Ficus carica Linn., Walnut and Vaccinium Spp, cloves of Allium sativum, and petals of Rosa sp. The present disclosure further provides a method for preparing a plant preparation, including treating the above parts of plants with ethanol.

5. 发明授权

US10842774B2 Inhibited expression of PD-L1 and enhanced expression of PD-1 有权
公开(公告)号：US10842774B2
公开(公告)日：2020-11-24
申请号：US16653308
申请日：2019-10-15
申请人： IN Ingredients, Inc.
发明人： Augustin T. Romero , Bolin Qin
IPC分类号： A61K36/00 , A61K31/357 , A61K36/53 , A61K36/9066 , A61K36/63 , A61K36/73 , A61K31/353 , A61K31/7048 , A61K36/49 , A61K36/54 , A61K9/00
CPC分类号： A61K31/357 , A61K31/353 , A61K31/7048 , A61K36/49 , A61K36/53 , A61K36/54 , A61K36/63 , A61K36/73 , A61K36/9066 , A61K9/0019 , A61K9/0053 , A61K36/53 , A61K2300/00 , A61K36/54 , A61K2300/00 , A61K36/9066 , A61K2300/00 , A61K36/63 , A61K2300/00 , A61K36/73 , A61K2300/00
摘要： Processes for treating an autoimmune disease or condition by decreasing expression of a CD274 gene and/or a PD-L1 protein and increasing expression of a PDCD1 gene and/or a PD-1 protein in a subject in need of such expression changes are provided. The processes include administering to the subject a composition including at least 0.5% of cinnamtannin D-1 and/or cinnamtannin B-1. The processes further include decreasing expression of a CD274 gene and/or a PD-L1 protein and increasing expression of a PDCD1 gene and/or a PD-1 protein in the subject by the step of administering at the desired concentration or for the desired time wherein the composition may increase or decrease the relative expression levels of the genes or proteins while simultaneously ameliorating, preventing, or modulating a cardiac event in the subject.

6. 发明申请

US20190201427A1 COMPOSITIONS CONTAINING TANNIC ACIDS AND USES THEREOF 审中-公开
公开(公告)号：US20190201427A1
公开(公告)日：2019-07-04
申请号：US16298804
申请日：2019-03-11
申请人： SyneuRx International (Taiwan) Corp.
发明人： Guochuan Emil Tsai , Ching-Cheng Wang , Tien-Lan Hsieh , Yi-Wen Mao
IPC分类号： A61K31/7024 , C07H13/08 , A61P11/00 , A61P25/16 , C07H1/08 , A23L33/105 , A61K36/49 , A61K36/48 , A61K36/22 , A61K36/185 , A61K45/06 , A61K38/26 , A61K36/87 , A61K36/82 , A61P1/16 , A23L33/10 , A23L33/00 , A61P5/50 , A61P25/28 , A61P25/30 , A61P9/00 , A61P11/06 , A61P25/18 , A61P25/24
CPC分类号： A61K31/7024 , A23L33/10 , A23L33/105 , A23L33/30 , A23V2002/00 , A61K31/00 , A61K36/185 , A61K36/22 , A61K36/48 , A61K36/49 , A61K36/82 , A61K36/87 , A61K38/26 , A61K45/06 , A61P1/16 , A61P5/50 , A61P9/00 , A61P11/00 , A61P11/06 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , A61P25/30 , C07H1/08 , C07H13/08 , Y02A50/411 , A61K2300/00
摘要： Compositions (e.g., pharmaceutical compositions, nutraceutical compositions or medical food compositions) comprising tannic acids, particularly tannic acids which are D-amino acid oxidase inhibitor with superior potency, purity and safety profile; and uses thereof for treating CNS disorder and obesity disorders including diabetes, hyperglycemia, hyperlipidemia or hypercholesterolemia.

7. 发明授权

US10016475B2 Composition for preventing, improving, or treating immune diseases comprising natural extracts as active ingredients 有权
公开(公告)号：US10016475B2
公开(公告)日：2018-07-10
申请号：US14404631
申请日：2013-05-29
申请人： KOREA FOOD RESEARCH INSTITUTE
发明人： Dong-Hwa Shon , Hee-Soon Shin , Min-Jung Bae , Ok-Hee Chai , Chang-Yuil Kang , Dae-Woon Choi , Gye-Young Choi , Jeong-Hae Rho , Jeong-Ryong Do
IPC分类号： A01N65/00 , A61K36/00 , A61K36/73 , A61K36/708 , A61K36/84 , A61K36/39 , A61K36/482 , A61K36/738 , A61K36/185 , A61K36/49 , A61K36/47 , A61K36/532 , A23L33/105
CPC分类号： A61K36/708 , A23L33/105 , A23V2002/00 , A61K36/185 , A61K36/39 , A61K36/47 , A61K36/482 , A61K36/49 , A61K36/532 , A61K36/738 , A61K36/84 , A61K2300/00
摘要： The present invention provides a composition for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, an antihistamine composition, and an anti-inflammatory composition. The present invention provides a method for preventing, improving, or treating Th1-mediated immune diseases or Th2-mediated immune diseases, a method for inhibiting the release of histamine, and a method for preventing, improving, or treating inflammatory disorders. The composition according to the present invention has excellent inhibitory activities for IL-4 generation, the degranulation of mast cells, COX-2, 15-NOX, and the passing of allergens from through an intestinal epithelial cell layer, or an excellent Treg cell inducing activity. Further, the present invention provides a detailed mechanism of action of a natural substance and a food-drived antiallergenic substance, and provides stability, a reduction in production costs, and improved convenience of use by using a natural substance as a material.

8. 发明授权

US09717757B1 Composition and method to treat and prevent muscle cramping 有权
公开(公告)号：US09717757B1
公开(公告)日：2017-08-01
申请号：US13729102
申请日：2012-12-28
申请人： Samuel N. Gasque, Jr.
发明人： Samuel N. Gasque, Jr.
IPC分类号： A61K33/38 , A61K31/122 , A61K31/352 , A61K31/4166 , A61K31/716 , A61K33/06 , A61K33/14 , A61K36/28 , A61K36/49 , A61K36/88
CPC分类号： A61K33/38 , A61K31/122 , A61K31/352 , A61K31/4166 , A61K31/716 , A61K33/06 , A61K33/14 , A61K36/28 , A61K36/49 , A61K36/80 , A61K36/87 , A61K36/88 , A61K36/886 , A61K2300/00
摘要： A method of treating muscle cramps and muscle pain, and to relieve swelling in and around muscles after strenuous physical activity is provided, whereby an aqueous composition is applied topically to the skin overlying the affected muscles, the composition has dissolved, suspended or dispersed therein (a) an anti-inflammatory agent; (b) an agent that stimulates or promotes cell growth; and (c) an agent that enhances or stimulates the skin's immune system, wherein components (a), (b) and (c) are different.

9. 发明申请

US20170106027A1 COMPOSITIONS AND METHODS OF IMPROVING PERFORMANCE AND INTESTINAL HEALTH OF POULTRY 审中-公开
公开(公告)号：US20170106027A1
公开(公告)日：2017-04-20
申请号：US15295753
申请日：2016-10-17
申请人： Kemin Industries, Inc.
发明人： Rachel Tonda , Jon Kieran Rubach , Sally Moore , Mitchell Poss
IPC分类号： A61K35/742 , A61K31/7034 , A61K36/48 , A61K36/49 , A61K36/22
CPC分类号： A61K35/742 , A23K10/18 , A23K20/111 , A23K50/75 , A61K31/7024 , A61K31/7034 , A61K36/22 , A61K36/48 , A61K36/49 , A61K2300/00
摘要： Gut health in poultry is improved by providing an efficacious amount of extracts of tannic acid via feed or via drinking water. The extracts of tannic acid are also effective when the poultry are infected with coccidiosis and/or necrotic enteritis. In alternative embodiments, an efficacious amount of Bacillus coagulans is also included.

10. 发明申请

US20160051611A1 Topical Pharmaceutical Bases for Wound and Scar Treatment 有权
标题翻译：伤口和疤痕治疗专题药物基地
公开(公告)号：US20160051611A1
公开(公告)日：2016-02-25
申请号：US14831621
申请日：2015-08-20
申请人： Professional Compounding Centers of America (PCCA)
发明人： Daniel Banov
IPC分类号： A61K36/58 , A61Q19/00 , A61K45/06 , A61K8/97 , A61K36/49 , A61K36/185
CPC分类号： A61K36/58 , A61K9/0014 , A61K36/185 , A61K36/49 , A61K45/06 , A61L15/40 , A61L26/0057 , A61K2300/00
摘要： The present disclosure refers to topical pharmaceutical bases that include a synergistic combination of pracaxi oil, andiroba oil, copaiba balsam, and ucuuba butter. Further, these topical pharmaceutical bases are proposed for treating skin conditions in mammals, such as, for example wounds and scars. The topical pharmaceutical bases provide healing, moisturizing, anti-inflammatory, antibacterial, and antifungal effect. Additionally, the topical pharmaceutical bases enable an effective administration of specific active pharmaceutical ingredients (APIs), thereby improving treatment outcomes. Topical pharmaceutical compositions including the topical pharmaceutical bases increase the residence time of APIs within a wound or scar, thereby improving the penetration of APIs into the affected area. Also, the topical pharmaceutical bases provide relatively uniform distribution of the APIs within the topical pharmaceutical compositions. Further, the topical pharmaceutical compositions release APIs slowly, thereby enhancing treatment effectiveness.
摘要翻译：本公开内容涉及包括普拉卡西油，安罗巴油，康帕巴香脂和ucuuba黄油的协同组合的局部药物基质。此外，这些局部药物基础被提出用于治疗哺乳动物的皮肤病症，例如伤口和疤痕。局部药物基础提供愈合，保湿，抗炎，抗菌和抗真菌作用。此外，局部药物基质能够有效地施用特定的活性药物成分（API），从而改善治疗结果。包括局部药物基质的局部药物组合物增加了API在伤口或疤痕内的停留时间，从而改善了API渗透到受影响区域中。此外，局部药物基质提供了在局部药物组合物内的相对均匀的API分布。此外，局部药物组合物缓慢释放API，从而提高治疗效果。

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