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    • 7. 发明授权
    • Methods for inducing anti-anxiety and calming effects in animals and humans
    • 诱发动物和人类抗焦虑和镇定作用的方法
    • US07794761B2
    • 2010-09-14
    • US11178998
    • 2005-07-11
    • Nancy J. ShelbyMitchell T. GodfreyMark J. Rosenfeld
    • Nancy J. ShelbyMitchell T. GodfreyMark J. Rosenfeld
    • A61K36/89A61K31/428A61K31/538
    • A61K31/428A61K31/423A61K31/538A61K36/88
    • Phenolic compounds with a phenolic molecule to which are covalently linked an oxygen-containing group, a nitrogen or another oxygen containing group, and a C1-C4 alkoxy group, or their precursor compounds, obtainable from monocotyledonous plants, or by chemical synthesis, have been found to calm and/or reduce anxiety and related behaviors and states in humans and animals. Additional chemical compounds of the present invention may include benzoxazinoids-cyclic hydroxyamic acids, lactams, and corresponding glucosides, which may serve as precursors to phenolic compounds. The phenolic compounds and precursors of phenolic compounds of the present invention, at concentrations suitable for human and animal therapeutic use, may be obtained from monocotyledonous plants such as corn in their early growth states which are timely harvested for optimum yield.
    • 已经将含有氧的基团,氮原子或另一个含氧基团的共价连接的酚类分子和可以从单子叶植物得到的C1-C4烷氧基或它们的前体化合物或化学合成的酚类化合物 发现平静和/或减少人类和动物中的焦虑和相关行为和状态。 本发明的另外的化合物可包括可用作酚类化合物的前体的苯并嗪类 - 环状羟基酸,内酰胺和相应的葡糖苷。 本发明的酚类化合物和酚类化合物的前体在适于人类和动物治疗用途的浓度下可以从它们的早期生长状态的单子叶植物如玉米中获得,这些植物被及时收获以获得最佳产量。
    • 8. 发明授权
    • Flavopereirine and alstonine combinations in the treatment and prevention of prostate cancer
    • 黄曲霉素和阿司匹林组合治疗和预防前列腺癌
    • US07341749B2
    • 2008-03-11
    • US11132183
    • 2005-05-19
    • John L. HallSylvie P. Beljanski
    • John L. HallSylvie P. Beljanski
    • A61K36/00A61K36/89A61K31/535A61K31/50
    • A61K36/24A61K31/475A61K2300/00
    • A method and composition for preventing prostate cancer and/or reducing PSA levels and/or alleviating the symptoms of BPH (Benign Prostatic Hyperplasia) or PIN (prostatic intraepithelial neoplasia) by administration of an effective amount of a mixture of flavopereirine and alstonine. A method and composition for treating low-grade prostate cancer and preventing the onset of metastatic disease and/or reducing the doubling time of PSA levels in men with positive biopsies showing relatively low Gleason scores and morphologies characteristic of non-invasive, slow-progressing prostate cancer. The flavopereirine and alstonine can be in the form of natural extracts derived from Pao Pereira and Rauwolfia Vomitoria, respectively. Alternatively, these two active compounds can be administered in purified form. The composition can be in included in a kit along with instructions for use in a treatment regimen.
    • 通过施用有效量的黄曲霉素和阿尔斯汀的混合物,预防前列腺癌和/或降低PSA水平和/或减轻BPH(良性前列腺增生症)或PIN(前列腺上皮内瘤变)症状的方法和组合物。 用于治疗低级前列腺癌并预防转移性疾病发作和/或减少具有阳性活组织检查的男性PSA水平倍增时间的方法和组合物显示出相对较低的格列森评分和非侵入性,缓慢进展的前列腺特征的形态 癌症。 黄曲霉素和阿司匹林可以分别是由派佩雷拉(Pao Pereira)和萝维(Rauwolfia Vomitoria)衍生的天然提取物。 或者,这两种活性化合物可以以纯化形式施用。 组合物可以包含在试剂盒中以及用于治疗方案的说明书中。