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1. 发明申请

US20220080040A1 SERUM FREE INTRACELLULAR PATHOGEN VACCINE 有权
公开(公告)号：US20220080040A1
公开(公告)日：2022-03-17
申请号：US17414156
申请日：2019-12-20
申请人： Intervet Inc.
发明人： Joseph Koumans , Petter Frost , Maria Forlenza
IPC分类号： A61K39/205 , A61K39/12 , A61K39/145 , A61K39/02 , A61K39/005 , A61K39/002 , A61K35/16 , A61P31/12 , A23K50/80 , A23K10/16 , A23K20/147 , A23K10/18 , A23K10/24
摘要： A vaccine composition comprising a virus antigen wherein the composition comprises less than 5% serum, wherein the virus antigen is a whole virus or derived from a whole virus, the vaccine composition reduces, prevents or avoids cross-stitch spinal deformity in the treated animal. Said vaccine composition for use in a method of treating a disease caused by the intracellular pathogen in an animal and reducing, preventing or avoiding cross-stitch spinal deformity in the treated animal. In cross-stitch vertebra the intervertebral space is completely collapsed. A vaccine composition for use as defined above wherein the animal is a fish. In an embodiment the pathogen is salmon alpha virus (SAV).

2. 发明授权

US11096999B2 Treatment and prevention of malaria 有权
公开(公告)号：US11096999B2
公开(公告)日：2021-08-24
申请号：US15500269
申请日：2015-07-30
申请人： OXFORD UNIVERSITY INNOVATION LIMITED
发明人： Simon Draper , Matthew Higgins , Katherine Wright , Alexander Douglas
IPC分类号： A61K39/015 , A61K39/00 , A61K39/02 , C07K16/20 , A61K39/005 , C07K14/445 , C12N7/00 , C12N15/115
摘要： There are provided antigens, vectors encoding the antigens, and antibodies and other binding compounds to the antigens and uses thereof in the prevention or treatment of malaria. In particular, compositions are provided comprising fragments of Reticulocyte-binding protein Homologue 5 (PfRH5). In particular, the invention provides fragments of PfRH5 rationally designed on the basis of the PfRH5 crystal structure, wherein said fragments which lack disordered regions, particularly the flexible N-terminal region and/or flexible central linker.

3. 发明申请

US20200147148A1 LIVE ATTENUATED PARASITIC VACCINE 审中-公开
公开(公告)号：US20200147148A1
公开(公告)日：2020-05-14
申请号：US16675842
申请日：2019-11-06
申请人： Ohio State Innovation Foundation
发明人： Bradford McGwire
IPC分类号： A61K35/68 , C12N1/10 , A61K39/005
摘要： Disclosed herein is an avirulent live vaccine that involves a recombinant protozoan from the order Trypanosomatida having a knocked out or silenced cyclophilin gene, wherein the cyclophilin gene comprises T. cruzi cyclophilin 19 (TcCyp19) gene, or an orthologue thereof. Also disclosed is a method or inducing a protective immune response in a subject that involves administering to the subject a vaccine disclosed herein. Also disclosed is a method of treating or preventing Chagas disease, African trypanosomiasis, and/or leishmaniasis in a subject that involves administering to the subject a vaccine disclosed herein.

4. 发明授权

US10525124B2 Mixed allergen compositions and methods for using the same 有权
公开(公告)号：US10525124B2
公开(公告)日：2020-01-07
申请号：US16171874
申请日：2018-10-26
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Kari C. Nadeau
IPC分类号： A61K36/00 , A61K39/00 , A61K39/35 , A61K39/36 , A61K39/38 , A61K9/00 , A61K31/59 , A61K39/005 , A61K45/06 , A61K47/10 , A61K47/44 , A61K47/46 , A61K35/60 , A61K35/747 , A61K9/14 , A61K31/375 , A61K31/593 , A61K35/00
摘要： Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin. Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.

5. 发明申请

US20190060444A1 MIXED ALLERGEN COMPOSITIONS AND METHODS FOR USING THE SAME 审中-公开
公开(公告)号：US20190060444A1
公开(公告)日：2019-02-28
申请号：US16171874
申请日：2018-10-26
申请人： The Board of Trustees of the Leland Stanford Junior University
发明人： Kari C. Nadeau
IPC分类号： A61K39/35 , A61K31/59 , A61K35/60 , A61K35/747 , A61K39/005 , A61K9/00 , A61K47/10 , A61K47/44 , A61K47/46 , A61K45/06 , A61K35/00 , A61K39/00
CPC分类号： A61K39/35 , A61K9/0053 , A61K9/148 , A61K31/375 , A61K31/59 , A61K31/593 , A61K35/60 , A61K35/747 , A61K39/005 , A61K45/06 , A61K47/10 , A61K47/44 , A61K47/46 , A61K2035/115 , A61K2039/54 , A61K2039/542 , A61K2039/545 , A61K2039/55 , A61K2039/57 , A61K2039/572 , A61K2039/575 , A61K2039/70 , A61K2300/00
摘要： Mixed allergen compositions of two or more different allergens are provided. In some instances, the mixed allergen compositions include: a nut allergen; an animal allergen; and at least one of: a non-nut plant allergen; a biotic agent; and a vitamin Also provided are methods of administering the mixed allergen compositions to a subject. The mixed allergen compositions find use in a variety of applications, including health maintenance, immune balance, gut balance, immune support, health improvement and therapeutic applications.

6. 发明授权

US10213500B2 Multicomponent or monocomponent vaccine to be used against chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure 有权
公开(公告)号：US10213500B2
公开(公告)日：2019-02-26
申请号：US15492365
申请日：2017-04-20
申请人： Carlos de Baeremaecker Barros
发明人： Carlos de Baeremaecker Barros
IPC分类号： A61K39/005 , A61K39/002 , A61K39/00
摘要： A monocomponent vaccine effective to moderate the clinical consequences of Chages disease, capable of stimulating an immune response against the trans-sialidase virulence factor of the Trypanosoma cruzi parasite. The vaccine active ingredient is an immunogenic component with a polynucleotide encoding one or more polypeptide(s) which includes a C-terminal region composed of at least two repetitive units of amino acids, with a polypeptide with trans-sialidase activity of Trypanosoma cruzi fused to the C-terminal region. The vaccine further comprises an aluminum oxide adjuvant that does not inhibit trans-sialidase enzymatic activity of the immunogen portion.

7. 发明申请

US20170290896A1 MULTICOMPONENT OR MONOCOMPONENT VACCINE TO BE USED AGAINST CHAGAS DISEASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCEDURE FOR THE OBTENTION OF IMMUNOGEN OF SAID VACCINES, AND NUCLEIC ACID USED IN SAID PROCEDURE 审中-公开
公开(公告)号：US20170290896A1
公开(公告)日：2017-10-12
申请号：US15492365
申请日：2017-04-20
申请人： Carlos de Baeremaecker Barros
发明人： Carlos de Baeremaecker Barros
IPC分类号： A61K39/005 , A61K39/002
CPC分类号： A61K39/005 , A61K39/00 , A61K39/002 , A61K2039/53 , A61K2039/55505 , A61K2039/55522 , A61K2039/55527 , Y02A50/414
摘要： A monocomponent vaccine effective to moderate the clinical consequences of Chages disease, capable of stimulating an immune response against the trans-sialidase virulence factor of the Trypanosoma cruzi parasite. The vaccine active ingredient is an immunogenic component with a polynucleotide encoding one or more polypeptide(s) which includes a C-terminal region composed of at least two repetitive units of amino acids, with a polypeptide with trans-sialidase activity of Trypanosoma cruzi fused to the C-terminal region. The vaccine further comprises an aluminum oxide adjuvant that does not inhibit trans-sialidase enzymatic activity of the immunogen portion.

8. 发明授权

US09662378B2 Multicomponent or monocomponent vaccine to be used against Chagas disease, pharmaceutical compositions containing them, procedure for the obtention of immunogen of said vaccines, and nucleic acid used in said procedure 有权
公开(公告)号：US09662378B2
公开(公告)日：2017-05-30
申请号：US14529454
申请日：2014-10-31
申请人： Carlos de Baeremaecker Barros
发明人： Carlos de Baeremaecker Barros
IPC分类号： A61K39/02 , A61K39/005 , A61K39/00
CPC分类号： A61K39/005 , A61K39/00 , A61K39/002 , A61K2039/53 , A61K2039/55505 , A61K2039/55522 , A61K2039/55527 , Y02A50/414
摘要： A vaccine against the Chagas disease, capable of stimulating the immune response against the trans-sialidase virulence factor of the Trypanosoma cruzi parasite, which is a multicomponent vaccine comprising: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions codifying one or more immunogenic polypeptides, or a monocomponent vaccine comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions codifying one or more immunogenic polypeptides derived from Trypanosoma cruzi and pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.

9. 发明申请

US20150056243A1 MULTICOMPONENT OR MONOCOMPONENT VACCINE TO BE USED AGAINST CHAGAS DISEASE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM, PROCEDURE FOR THE OBTENTION OF IMMUNOGEN OF SAID VACCINES, AND NUCLEIC ACID USED IN SAID PROCEDURE 审中-公开
标题翻译：用于灭菌疫苗的多种或多种单克隆疫苗，含有它们的药物组合物，阻止免疫原性免疫球蛋白的程序，以及按照程序使用的核酸
公开(公告)号：US20150056243A1
公开(公告)日：2015-02-26
申请号：US14529454
申请日：2014-10-31
申请人： Carlos de Baeremaecker Barros
发明人： Carlos de Baeremaecker Barros
IPC分类号： A61K39/005
CPC分类号： A61K39/005 , A61K39/00 , A61K39/002 , A61K2039/53 , A61K2039/55505 , A61K2039/55522 , A61K2039/55527 , Y02A50/414
摘要： A vaccine against the Chagas disease, capable of stimulating the immune response against the trans-sialidase virulence factor of the Trypanosoma cruzi parasite, which is a multicomponent vaccine comprising: (a) an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of thereof and (b) one or more polynucleotides including the regions codifying one or more immunogenic polypeptides, or a monocomponent vaccine comprising at least one component selected among an immunogenic portion formed by one or more recombinant or synthetic polypeptides or fractions of them and a group of polynucleotides including the regions codifying one or more immunogenic polypeptides derived from Trypanosoma cruzi and pharmaceutical compositions containing said multicomponent and monocomponent vaccines, the procedures for obtaining the immunogen portion of said vaccines and the nucleic acid used in the procedure.
摘要翻译：一种针对恰加斯病的疫苗，其能够刺激针对克氏锥虫寄生虫的唾液酸酶毒力因子的免疫应答，其是多组分疫苗，其包含：（a）由一种或多种重组或合成多肽或部分形成的免疫原性部分和（b）一种或多种多核苷酸，包括编码一种或多种免疫原性多肽的区域，或包含至少一种选自由一种或多种重组或合成多肽或其部分形成的免疫原性部分的组分的单组分疫苗和一组包括编码一种或多种衍生自克氏锥虫的免疫原性多肽的区域的多核苷酸和含有所述多组分和单组分疫苗的药物组合物，获得所述疫苗的免疫原部分的程序和该方法中使用的核酸。

10. 发明授权

US08114412B2 T. cruzi-derived neurotrophic agents and methods of use therefor 有权
标题翻译：来自克氏锥虫的神经营养因子及其使用方法
公开(公告)号：US08114412B2
公开(公告)日：2012-02-14
申请号：US11365743
申请日：2006-02-28
申请人： Marina Chuenkova , Miercio A. Pereira
发明人： Marina Chuenkova , Miercio A. Pereira
IPC分类号： A61K38/00 , A61K39/005
CPC分类号： A61K38/47 , A61K35/68 , C12N9/2402 , C12Y302/01018 , Y02A50/414 , A61K2300/00
摘要： The invention relates to T. cruzi trans-sialidase (TS) and to the neurotrophic and IL-6 secretion-inducing activities of the protein. TS, neurotrophic variants and/or neurotrophic peptides based upon the sequence of TS can be administered to a mammal to directly or indirectly provide neurotrophic support for neurons. A mammalian neurotrophic factor (e.g., CNTF, LIF) can be co-administered with the TS, neurotrophic variant and/or neurotrophic peptide. TS, IL-6 secretion-inducing variants and/or IL-6 secretion-inducing peptides based upon the sequence of TS can be administered to a mammal to induce the secretion of IL-6. TS, active variants and/or active peptides can be administered to a mammal having an acquired or congenital condition characterized by neuronal degeneration or to a mammal that has experienced trauma to the brain, spinal cord or peripheral nerves. The invention also relates to neurotrophic and IL-6 secretion-inducing variants of TS and to neurotrophic and IL-6 secretion-inducing peptides. The invention also relates to compositions comprising TS, active variants thereof and/or active peptides and a physiologically acceptable carrier.
摘要翻译：本发明涉及克氏锥虫唾液酸酶（TS）和蛋白质的神经营养和IL-6分泌诱导活性。可以将基于TS序列的TS，神经营养变体和/或神经营养肽施用于哺乳动物以直接或间接地为神经元提供神经营养支持。哺乳动物神经营养因子（例如，CNTF，LIF）可以与TS，神经营养变体和/或神经营养肽共同施用。基于TS序列的TS，IL-6分泌诱导变体和/或IL-6分泌诱导肽可以给予哺乳动物以诱导IL-6的分泌。 TS，活性变体和/或活性肽可以被给予具有以神经元变性为特征的获得性或先天性病症的哺乳动物或经历对脑，脊髓或周围神经的创伤的哺乳动物。本发明还涉及TS的神经营养和IL-6分泌诱导变体，以及神经营养和IL-6分泌诱导肽。本发明还涉及包含TS，其活性变体和/或活性肽和生理上可接受的载体的组合物。

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