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1. 发明申请

US20220354947A1 METHODS FOR PROVIDING POLYMERIC SYNTHETIC NANOCARRIERS FOR GENERATING ANTIGEN-SPECIFIC TOLERANCE IMMUNE RESPONSES 有权
公开(公告)号：US20220354947A1
公开(公告)日：2022-11-10
申请号：US17552392
申请日：2021-12-16
申请人： Selecta Biosciences, Inc.
发明人： David H. Altreuter , Aaron P. Griset , Roberto A. Maldonado
IPC分类号： A61K39/385 , A61K39/35 , G01N33/50 , G01N33/569 , A61K39/00 , A61K9/127 , A61K9/51 , A61K38/38 , A61K47/50 , A61K47/52 , A61K47/54 , A61K47/59 , A61K47/64 , A61K47/69 , B82Y5/00 , A61K39/36 , A61K31/192 , A61K9/14 , A61K38/13 , A61K38/18
摘要： Disclosed are synthetic nanocarrier compositions that provide controlled release of immunosuppressants as well as related methods. The synthetic nanocarrier compositions may also include antigen in some embodiments.

2. 发明申请

US20220280647A1 Hydrophobic Peptide Salts for Extended Release Compositions 有权
公开(公告)号：US20220280647A1
公开(公告)日：2022-09-08
申请号：US17634034
申请日：2020-08-12
申请人： BIOMARIN PHARMACEUTICAL INC.
发明人： Jake Ang , Sunil Kumar Battu , Joshua Laber , Karol Estrada , Jonathan LeBowitz , Joyce Chou
IPC分类号： A61K47/52 , A61K47/54 , A61K9/00 , A61K9/14 , A61P19/00
摘要： The present disclosure, relates, in general, to hydrophobic salts of hydrophilic peptides that form low solubility materials in aqueous solutions and are capable of extended or sustained release of the peptide component when administered to a subject. Hydrophobic salts of C-type natriuretic peptides and uses thereof are also disclosed.

3. 发明申请

US20220241419A1 Highly dispersible zinc phthalocyanine-silica nanotubes and preparation method therefor 有权
公开(公告)号：US20220241419A1
公开(公告)日：2022-08-04
申请号：US17617540
申请日：2020-06-02
申请人： Sang Ho Lee
发明人： Sang Ho Lee
IPC分类号： A61K41/00 , A61K47/52 , A61K47/69
摘要： The present disclosure relates to highly dispersible zinc phthalocyanine-silica nanotubes and a preparation method thereof. More particularly, the present disclosure relates to highly dispersible zinc phthalocyanine-silica nanotubes capable of improving the dispersibility of zinc phthalocyanine so that the zinc phthalocyanine can be easily absorbed in the body, and to a method of preparing highly dispersible zinc phthalocyanine nanotubes. The present disclosure proposes a highly dispersible zinc phthalocyanine-silica nanotube and a method of preparing sample. The method includes a first step of mixing a template with a alcohol solution to prepare a nanotube solution containing a nanotube template, a second step of adding a zinc phthalocyanine (ZnPc) solution to the nanotube solution and stirring the resulting mixture to prepare a zinc phthalocyanine-silica nanotube solution, a third step of adding a silica precursor to the zinc phthalocyanine-nanotube solution and stirring the resulting mixture to induce silication, thereby preparing a zinc phthalocyanine-silica nanotube solution, and a fourth step of filtering and drying the zinc phthalocyanine-silica nanotube to prepare zinc phthalocyanine nanotube powder. Further proposed is a method of preparing the zinc phthalocyanine powder.

4. 发明授权

US11344571B2 NO containing compositions 有权
公开(公告)号：US11344571B2
公开(公告)日：2022-05-31
申请号：US16568560
申请日：2019-09-12
申请人： University Court of the University of St. Andrews
发明人： Morven Duncan , Stewart Warrender , Russell Edward Morris , Damiano Cattaneo
IPC分类号： A61K33/00 , A61K8/19 , A61K9/14 , A61K31/155 , A61K31/496 , A61K47/52 , B01J20/22 , B01J20/28
摘要： Disclosed are metal organic framework materials (MOFs), comprising an extra-framework NO releasing compound within the internal pores and/or channels of the MOF, the NO-releasing compounds and their preparation and uses. The MOFs and NO-releasing compounds are capable of releasing NO on application of an external stimulus and may provide materials with multiple modes of antibacterial and/or drug action.

5. 发明申请

US20220071927A1 IRON/SHIKONIN NANO-COMPOSITE AND USE THEREOF AND METHOD FOR PREPARING THE SAME BY SUPERMOLECULAR SELF-ASSEMBLY 有权
公开(公告)号：US20220071927A1
公开(公告)日：2022-03-10
申请号：US17335565
申请日：2021-06-01
申请人： Jilin University
发明人： Hao Zhang , Wenjie Feng , Yi Liu , Lening Zhang , Wanrui Shi
IPC分类号： A61K31/122 , A61K47/52 , A61K9/14 , A61P35/00
摘要： An iron/shikonin nano-composite and a use thereof, and a method for preparing the same by supermolecular self-assembly, belonging to the technical field of functional materials. The composite consists of shikonin and ferric ions, wherein shikonin is coordinated with the ferric ions, and the hydroxyl and carbonyl groups in shikonin are coordinated with the ferric irons to form a complex, which is then assembled by π-π stacking and hydrophobic interactions to form a nano-composite which exhibits glutathione response. The composite is obtained by the following steps: adding an aqueous solution of a ferric salt and an organic solvent solution of shikonin in sequence into water while stirring at ambient temperature, continuously stirring at ambient temperature, and centrifuging the resulting mixture to purify, thereby obtaining an iron/shikonin nano-composite in the resulting solution.

6. 发明申请

US20220008554A1 NOVEL NANOPARTICLES OF ANTIRETROVIRAL DRUGS, THEIR PREPARATION AND THEIR USE FOR THE TREATMENT OF VIRAL INFECTIONS 有权
公开(公告)号：US20220008554A1
公开(公告)日：2022-01-13
申请号：US17294149
申请日：2019-11-14
申请人： CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE , INSTITUT PASTEUR , UNIVERSITE PARIS-SACLAY
发明人： Hervé HILLAIREAU , Elias FATTAL , Giovanna GIACALONE , Héla SAIDI , Marie-Lise GOUGEON , Marion QUAILLET , Sarah PALLARA
IPC分类号： A61K47/69 , A61K9/00 , A61K38/16 , A61K31/4985 , A61K31/505 , A61K31/7072 , A61K47/52 , A61K9/51 , A61P31/12
摘要： The present application relates to nanoparticles including an antiretroviral drug and chitosan and optionally one or more metal cation, their use for treating viral infections, their process of preparation and the pharmaceutical compositions including the same.

7. 发明授权

US11167035B2 Insulin compositions and method of making a composition 有权
公开(公告)号：US11167035B2
公开(公告)日：2021-11-09
申请号：US14332906
申请日：2014-07-16
申请人： Novo Nordisk A/S
发明人： Svend Havelund , Frantisek Hubalek , Helle Birk Olsen , Ib Jonassen , Thomas Hoeg-Jensen , Anne Plum , Ulla Ribel-Madsen
IPC分类号： A61K9/62 , A61K47/52 , A61K38/28 , C07K14/62
摘要： The invention is related to insulin compositions with a high content of zinc atoms per six molecules of acylated insulin. The insulin is an acylated insulin and may be mixed with a further insulin analogue such as the rapid acting insulin Asp B28 human insulin.

8. 发明申请

US20210128598A1 Radiation-Sterilized Biodegradable Drug Delivery Compositions 有权
公开(公告)号：US20210128598A1
公开(公告)日：2021-05-06
申请号：US17074619
申请日：2020-10-19
申请人： Durect Corporation
发明人： Michael Sekar , SuIl Yum , Felix Theeuwes , William Van Osdol
IPC分类号： A61K31/7052 , A61K38/26 , A61K38/27 , A61K45/06 , A61K31/198 , A61K47/52 , A61K47/64 , A61K41/17 , A61K38/17 , A61K38/22 , C07K14/575 , C07K14/61 , A61K9/00 , A61K9/16 , A61K9/19 , A61L2/00
摘要： The present disclosure is directed to a method of making a composition by combining a vehicle, e.g., a single phase vehicle, and an insoluble component comprising a beneficial agent, and sterilizing the composition using ionizing radiation prior to use, wherein the beneficial agent is stable following exposure to a sterilizing dose of ionizing radiation. Related compositions and methods are provided.

9. 发明申请

US20210100907A1 DRUG DELIVERY SYSTEMS COMPRISING A NEUROTROPHIC AGENT, AN APOPTOSIS SIGNALING FRAGMENT INHIBITOR (FAS) OR FAS LIGAND (FASL) INHIBITOR, A TUMOR NECROSIS FACTOR-ALPHA (TNF-ALPHA) OR TNF RECEPTOR INHIBITOR, A MITOCHONDRIAL PEPTIDE, AN OLIGONUCLEOTIDE, A CHEMOKINE INHIBITOR, OR A CYSTEINE-ASPARTIC PROTEASE INHIBITOR 有权
公开(公告)号：US20210100907A1
公开(公告)日：2021-04-08
申请号：US17125776
申请日：2020-12-17
申请人： Cella Therapeutics, LLC
发明人： Rhett M. Schiffman , Lukas Scheibler
IPC分类号： A61K47/52 , A61K38/10 , A61K38/08 , A61K47/60 , A61K45/06
摘要： This disclosure relates to a drug delivery system comprising a neurotrophic agent, an apoptosis signaling fragment inhibitor (FAS) or FAS-ligand (FASL) inhibitor, a tumor necrosis factor-α (TNF-α) or TNF receptor (TNFR) inhibitor, a mitochondrial peptide, an oligonucleotide, a chemokine inhibitor, or a cysteine-aspartic protease (caspase) inhibitor, including any combination of these compounds and, optionally, a sustained delivery component. This type of drug delivery system can be used to treat a medical condition such as an inherited or age-related choroid, retina, optic nerve disorder, or optic nerve degeneration; an otic disorder; a neurologic or CNS disorder; or a related condition; or a condition related to occlusion or obstruction of a blood vessel or blood circulation such as a stroke, myocardial or renal infarction. Medicaments, methods of manufacturing medicaments, kits, and other related products or methods are also described.

10. 发明申请

US20210085702A1 Use of Oligosaccharide Compounds for Treating Wounds of Arteriopathic Diabetic Patients 有权
公开(公告)号：US20210085702A1
公开(公告)日：2021-03-25
申请号：US16613474
申请日：2018-05-16
申请人： Urgo Recherche Innovation et Developpement
发明人： Serge Bohbot
IPC分类号： A61K31/7016 , A61K47/52 , A61K9/70 , A61P17/02
摘要： The subject of the present invention is a synthetic polysulfated oligosaccharide having 1 to 4 monosaccharide units, salts thereof, and complexes thereof, for use thereof for treating diabetic foot ulcer in arteriopathic patients.

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