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1. 发明授权

US12059335B2 Device for guided bone and tissue regeneration 有权
公开(公告)号：US12059335B2
公开(公告)日：2024-08-13
申请号：US16999057
申请日：2020-08-20
申请人： Osteogenics Biomedical, Inc.
发明人： Barry K. Bartee , Chad M. Bartee , Istvan Urban
IPC分类号： A61F2/28 , A61B17/06 , A61B17/08 , A61B17/84 , A61B17/86 , A61C8/02 , A61F2/00 , A61L27/18 , A61L27/56 , A61L31/02
CPC分类号： A61F2/0063 , A61B17/06166 , A61B17/08 , A61B17/84 , A61B17/846 , A61B17/86 , A61C8/0006 , A61F2/28 , A61F2/2846 , A61L27/18 , A61L27/56 , A61L31/022 , A61F2002/0068 , A61F2002/2835 , A61F2210/0004 , A61F2210/0076 , A61F2250/0052 , A61L2430/02 , A61L2430/36
摘要： This disclosure describes a membrane configured to guide bone and tissue regeneration for a bone defect. The membrane may comprise a first layer, a second layer, one or more perforations, a binder, and/or other components. The first layer of the membrane may be configured to contact bone. The first layer may include pores configured to promote ingrowth of bone regenerating cells into the first layer. In some implementations, the first layer may be a continuous sheet of microporous material without large perforations. The second layer may be configured to substantially prevent fibrous connective tissue from growing into the bone defect. The second layer may comprise a relatively dense structure. The second layer may be fixedly coupled to the first layer. In some implementations, the perforations may comprise co-axial through-holes having common dimensions through the first layer and the second layer. The perforations may be configured to enhance ossification.

2. 发明公开

US20240207075A1 Absorbable Iron-Based Instrument 审中-公开
公开(公告)号：US20240207075A1
公开(公告)日：2024-06-27
申请号：US17802448
申请日：2020-05-27
申请人： BIOTYX MEDICAL (SHENZHEN) CO., LTD.
发明人： Dong Bian , Wenjiao Lin
IPC分类号： A61F2/82 , A61L31/02 , A61L31/08 , A61L31/10 , A61L31/16
CPC分类号： A61F2/82 , A61L31/022 , A61L31/088 , A61L31/10 , A61L31/16 , A61F2250/0031 , A61F2250/0036 , A61F2250/0054 , A61F2250/0067
摘要： Disclosed is an absorbable iron-based instrument (10). The absorbable iron-based instrument includes an iron-based matrix (100), a zinc-containing protective layer (200), a corrosion-promoting layer (300) and a drug controlled-release layer (400); the iron-based matrix (100) is provided with an outer wall (110), an inner wall (120) and a side wall (130); the zinc-containing protective layer (200) covers at least the outer wall (110) and the inner wall (120) of the iron-based matrix (100); the corrosion-promoting layer (300) fully covers the zinc-containing protective layer (200); the drug controlled-release layer (400) partially covers at least the corrosion-promoting layer (300); the corrosion-promoting layer (300) and the drug controlled-release layer (400) each contain degradable polymers; the weight-average molecular weight of the degradable polymers in the corrosion-promoting layer (300) is greater than the weight-average molecular weight of the degradable polymers in the drug controlled-release layer (400); and the thickness ratio of a portion of the zinc-containing protective layer (200) that is located at the inner wall (120) to a portion of the corrosion-promoting layer (300) that is located at the inner wall (120) is greater than the thickness ratio of a portion of the zinc-containing protective layer (200) that is located at the outer wall (110) to a portion of the corrosion-promoting layer (300) that is located at the outer wall (110). The corrosion behavior of the absorbable iron-based instrument (10) meets the requirements of clinical use, and the occurrence of adverse histological reactions is rare or avoided.

3. 发明授权

US12011175B2 Vaso-occlusive devices with in-situ stiffening 有权
公开(公告)号：US12011175B2
公开(公告)日：2024-06-18
申请号：US17984128
申请日：2022-11-09
申请人： Stryker Corporation , Stryker European Holdings I, LLC
发明人： Hancun Chen
IPC分类号： A61B17/12 , A61L31/02 , A61B17/00
CPC分类号： A61B17/1215 , A61B17/12031 , A61B17/12109 , A61B17/12113 , A61B17/1214 , A61B17/12168 , A61B17/12177 , A61L31/022 , A61B2017/00831 , A61B2017/00867 , A61B2017/00964 , A61L2430/36
摘要： A vaso-occlusive device is constructed out of dissimilar metallic materials that are in contact or otherwise in close proximity with one another, thereby causing the device to undergo galvanic corrosion when exposed to an electrolytic medium, such as blood or other body fluid, wherein one of the dissimilar metallic materials is zirconium or zirconium alloy to create a corrosive product including zirconia having a relatively high hardness, a relatively high fracture toughness, and a relatively high stability when the device is implanted in a vasculature site, such as an aneurysm.

4. 发明授权

US12005155B2 High-modulus alloy for medical devices 有权
公开(公告)号：US12005155B2
公开(公告)日：2024-06-11
申请号：US17113635
申请日：2020-12-07
申请人： Warsaw Orthopedic, Inc.
发明人： James Davidson , William Rezach , Rodney Ballard
IPC分类号： A61L31/02 , A61L27/04 , A61L27/50 , A61L31/14 , C22C27/00 , C22C27/04
CPC分类号： A61L27/047 , A61L27/50 , A61L31/022 , A61L31/14 , C22C27/00 , C22C27/04 , A61L2430/12 , A61L2430/22 , A61L2430/38
摘要： Medical devices, such as implants, having a high-modulus alloy. The alloy includes a biocompatible refractory-metal-based alloy having multiple refractory metals. The alloy has an elastic modulus above about 300 GPa. The alloy comprises 30-35% tungsten, 60% molybdenum, and 5-10% niobium. The alloy is absent of rhenium.

5. 发明授权

US11986195B2 Device and a thrombectomy apparatus for extraction of thrombus from a blood vessel 有权
公开(公告)号：US11986195B2
公开(公告)日：2024-05-21
申请号：US17274973
申请日：2019-10-16
申请人： ANACONDA BIOMED, SL
发明人： Ignacio Cortiñas Villazón , Ane Lizarazu González , Ofir Arad Hadar , Iñaki Galve Murillo
IPC分类号： A61B17/221 , A61L31/02 , A61L31/10 , A61B17/22
CPC分类号： A61B17/221 , A61L31/022 , A61L31/10 , A61B2017/22079 , A61B2017/2212
摘要： A device, a thrombectomy apparatus and a method for extraction of thrombus from a blood vessel are disclosed. The device comprises a segment changing its shape from a retracted position in a compressed state to an extended and expanded position. The segment is formed by a mesh of at least two sets of helicoidal filaments turning respectively in opposite directions and being intertwined. The mesh comprises two distinct tubular sections. The mesh of the first section has helicoidal filaments with a braiding angle providing radial forces higher than in the second section, thus the first section becomes appositioned against the inner wall of the blood vessel. The second section comprises two sub-sections. The first sub-section has a conical shape and comprises a braiding angle changing at its proximal and distal ends to provide radial strength to maintain the conical shape and to stop a proximal blood flow during the removal of the thrombus.

6. 发明公开

US20240157170A1 MULTI-LAYER PORTABLE THERAPEUTIC INFRARED HEATING SYSTEM AND DEVICE 审中-公开
公开(公告)号：US20240157170A1
公开(公告)日：2024-05-16
申请号：US18350356
申请日：2022-11-11
申请人： HigherDOSE LLC
发明人： Mary Kathleen Kaps , Lauren Berlingeri , Dong Hak Lee
IPC分类号： A61N5/06 , A61F7/00 , A61L31/02 , A61L31/14 , A61N2/00
CPC分类号： A61N5/0625 , A61F7/0097 , A61L31/028 , A61L31/14 , A61N2/002 , A61N2/004 , A61F2007/0071 , A61F2007/0088 , A61F2007/0095 , A61N1/16 , A61N2005/066
摘要： A multi-layer portable therapeutic infrared heating system comprises a heating wire layer configured to generate far-infrared radiation (FIR) when the multi-layer portable therapeutic infrared heating system is connected with an alternating current power supply; two charcoal layers positioned on either side of the heating wire layer and configured to absorb extremely low frequency (ELF) radiation associated with the FIR; grounding mechanism configured to transfer the ELF radiation absorbed by the two charcoal layers to a pin and ground the multi-layer portable therapeutic infrared heating system; and a multi-layer mixture layer configured to at least additionally reduce the ELF radiation.

7. 发明授权

US11980410B2 Composite scaffolds for thermal ablation of metastatic cancer cells 有权
公开(公告)号：US11980410B2
公开(公告)日：2024-05-14
申请号：US16152769
申请日：2018-10-05
申请人： Regents of the University of Minnesota
发明人： Samira M. Azarin , Francisco Pelaez , Navid Manuchehrabadi , John C. Bischof
IPC分类号： A61B18/08 , A61F7/00 , A61L31/02 , A61L31/10 , A61L31/14 , A61B18/00
CPC分类号： A61B18/08 , A61F7/00 , A61L31/022 , A61L31/10 , A61L31/14 , A61L31/146 , A61B2018/00065 , A61B2018/00077 , A61B2018/00113 , A61B2018/00136 , A61B2018/00577 , A61B2018/087 , A61F2007/009 , A61L2400/08 , A61L2400/18 , A61L31/10 , C08L67/04
摘要： A device includes an electrically conductive or electrically semiconductive material and a biocompatible porous scaffold around the electrically conductive or electrically semiconductive material. The biocompatible porous scaffold includes a biocompatible polymer and pores configured to capture metastatic cells.

8. 发明公开

US20240138809A1 ACOUSTIC MATCHING LAYER MATERIAL, ACOUSTIC MATCHING SHEET, COMPOSITION FOR ACOUSTIC MATCHING LAYER MATERIAL, ACOUSTIC WAVE PROBE, ACOUSTIC WAVE MEASUREMENT APPARATUS, AND MANUFACTURING METHOD OF ACOUSTIC WAVE PROBE 审中-公开
公开(公告)号：US20240138809A1
公开(公告)日：2024-05-02
申请号：US18396973
申请日：2023-12-27
申请人： FUJIFILM Corporation
发明人： Kazushi Furukawa , Yoshihiro Nakai
IPC分类号： A61B8/00 , A61L31/02 , A61L31/06 , A61L31/12 , A61L31/14
CPC分类号： A61B8/4281 , A61L31/022 , A61L31/06 , A61L31/128 , A61L31/14
摘要： Provided are an acoustic matching layer material containing a curing reaction product obtained by reacting an epoxy resin (A) having an epoxy equivalent weight of 140 or less with at least one of a curing agent (B-1) which is a monomer or a curing catalyst (B-2), and metal particles (C) having a density of 4.5 g/cm3 or more and less than 10 g/cm3 at 20° C., in which a content of particles (D) having a density of less than 4.5 g/cm3 at 20° C. is less than 5% by mass; an acoustic matching sheet; a composition for an acoustic matching layer material; an acoustic wave probe; an acoustic wave measurement apparatus; and a manufacturing method of an acoustic wave probe.

9. 发明授权

US11969519B1 Implant comprising magnesium alloy and a method for preparing thereof 有权
公开(公告)号：US11969519B1
公开(公告)日：2024-04-30
申请号：US18324388
申请日：2023-05-26
申请人： Bioretec Oy
发明人： Timo Lehtonen , Kimmo Lähteenkorva , Anna-Maija Haltia , Christopher Stahle
IPC分类号： A61L27/00 , A61F2/28 , A61F2/30 , A61L27/04 , A61L27/44 , A61L27/58 , A61L31/02 , A61L31/14 , C22C1/02 , C22C23/00 , C22F1/06
CPC分类号： A61L27/047 , A61L27/042 , A61L27/446 , A61L27/58 , A61L31/022 , A61L31/148 , C22C1/02 , C22C23/00 , C22F1/06 , A61L2420/02
摘要： The present application provides an orthopedic implant or a part thereof, comprising biodegradable magnesium alloy comprising magnesium and Ca in the range of 0.550-0.700 wt %, Zn in the range of 0.400-0.700 wt %, and Fe 50 ppm or less, the biodegradable magnesium alloy consisting of two phases comprising a first phase comprising magnesium and Zn and a second phase less noble than the first phase, the second phase comprising Mg2Ca precipitates larger than nano-sized. The present application also provides a method for preparing the biodegradable magnesium alloy, a method for preparing the orthopedic implant or the part thereof, and a method for treating a subject in need of therapy for a medical condition of a bone.

10. 发明授权

US11963864B2 Method and system for reducing pulmonary flow 有权
公开(公告)号：US11963864B2
公开(公告)日：2024-04-23
申请号：US16741233
申请日：2020-01-13
申请人： Varun Shetty
发明人： Varun Shetty
IPC分类号： A61F2/06 , A61F2/82 , A61F2/958 , A61L31/04 , A61F2/95 , A61L31/02
CPC分类号： A61F2/06 , A61F2/958 , A61L31/048 , A61F2002/068 , A61F2/9522 , A61F2250/001 , A61L31/022
摘要： A method and system discloses a medical device comprising a pre-crimped stent mounted on an inflatable means for inflating the pre-crimped stent. The pre-crimped stent mounted on an inflatable means further includes a membrane with a centrally positioned opening with a second expandable diameter, wherein the membrane covers one end of the pre-crimped stent, thereby reducing pulmonary flow in a pulmonary artery.

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