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1. 发明授权

US06834205B2 Automatic shock lead gain adjuster 失效
公开(公告)号：US06834205B2
公开(公告)日：2004-12-21
申请号：US10760897
申请日：2004-01-20
申请人： Jason W. Eberle , LeAnne Marie Mackey
发明人： Jason W. Eberle , LeAnne Marie Mackey
IPC分类号： A61N1362
CPC分类号： A61N1/372 , A61N1/3704 , Y10S128/902
摘要： A system and method for automatically adjusting the gain for a shock lead system in an implantable medical device is provided. The system and method operate when, after a pre-selected period of time, the gain has not been programmed. The system and method then automatically produce and set the gain for the shock lead system. The system and method poll and determine a maximum value for the output of the shock lead system amplifier and produce a new gain value to scale the output to facilitate providing useful data that is large enough to separate signal from noise but small enough to avoid clipping.

2. 发明授权

US06766194B1 Dynamic control of overdrive pacing based on degree of randomness within heart rate 失效
公开(公告)号：US06766194B1
公开(公告)日：2004-07-20
申请号：US10017935
申请日：2001-12-12
申请人： Mark W. Kroll
发明人： Mark W. Kroll
IPC分类号： A61N1362
CPC分类号： A61N1/3622
摘要： A degree of randomness associated with the heart rate of the patient is determined based on an analysis of electrical heart signals. The degree of randomness may be determined, for example, based on a degree of entropy or a chaos dimensionality associated with heart rate. If the degree of randomness falls below a threshold value, indicating that the heart rate may be too coherent, a warning signal is generated indicating a significant risk of onset of a tachyarrhythmia. To prevent the tachyarrhythmia from occurring, overdrive pacing is initiated or, if already initiated, the overdrive pacing is made more aggressive. In a related technique, chaotic pacing is performed to ensure a sufficient heart rate variability.

3. 发明授权

US06760623B2 Cardiac rhythm management system with staggered pulses for coordination therapy 有权
公开(公告)号：US06760623B2
公开(公告)日：2004-07-06
申请号：US10087181
申请日：2002-03-01
申请人： Jeffrey E. Stahmann , Andrew P. Kramer , Julio C. Spinelli
发明人： Jeffrey E. Stahmann , Andrew P. Kramer , Julio C. Spinelli
IPC分类号： A61N1362
CPC分类号： A61N1/3627 , A61N1/3622 , A61N1/368 , A61N1/3684 , A61N1/3716
摘要： A cardiac rhythm management system for coordination therapy includes a pulse generator to generate pacing and discharging of recharge pulses. A pulse delivery controller coupled to the pulse generator, times the delivery of the pacing and discharging of recharge pulses in a desired sequence. A therapy circuit coupled to the pulse delivery controller, receives the timed pulses from the pulse delivery controller and delivers the timed pulses to one or more electrodes disposed in or around a heart to communicate the timed pacing and discharging of recharge pulses to different sites of a heart, to avoid any interactions resulting from the electric fields surrounding the electrodes during a multiple site pacing required by the coordination therapy.

4. 发明授权

US06754525B1 Reduction of defibrillation requirements through active pre-shock pacing with depolarization verification 失效
标题翻译：通过有效的预激动起搏降低除颤需求，并进行去极化验证
公开(公告)号：US06754525B1
公开(公告)日：2004-06-22
申请号：US10033740
申请日：2001-12-27
申请人： Rose Anne Province , Patrick D. Wolf
发明人： Rose Anne Province , Patrick D. Wolf
IPC分类号： A61N1362
CPC分类号： A61N1/3962 , A61N1/3925
摘要： An implantable cardiac stimulation device is equipped with a sensor to obtain information indicative of tissue depolarization. The device's processor is programmed to analyze the information to determine a suitable pacing pulse regimen and/or to trigger a cardioversion level stimulus.
摘要翻译：可植入心脏刺激装置配备有传感器以获得指示组织去极化的信息。设备的处理器被编程为分析信息以确定合适的起搏脉冲方案和/或触发心脏复律水平刺激。

5. 发明授权

US06732501B2 Ventricular connector 有权
公开(公告)号：US06732501B2
公开(公告)日：2004-05-11
申请号：US10184481
申请日：2002-06-26
申请人： Long Sheng Yu , Peter Piferi , Steven M. Parnis
发明人： Long Sheng Yu , Peter Piferi , Steven M. Parnis
IPC分类号： A61N1362
CPC分类号： A61M1/10 , A61M1/1008 , A61M1/101 , A61M1/1025 , A61M1/122 , A61M1/3659
摘要： A ventricular apex connector for quick connection and disconnection of an inflow tube of a ventricular assist device, comprising a sewing ring, a cylindrical ring, gripping pins, a spring ring and a sealing O-ring is provided. The cylindrical ring defines two openings, diametrically opposed to each other, in its walls. Gripping pins, comprising rods with gripping pads, are placed in the openings in the cylindrical ring so that the gripping pads are at rest within the inner circumference of the cylindrical ring. The spring ring is placed around the cylindrical ring and the rods of the gripping pads, which extend out of the outer wall of the cylindrical ring, are welded to the spring ring. The gripping pins are thus biased towards each other by the force of the spring ring. When the spring ring is squeezed, at points away from the gripping pin connection points, the deformation of the spring ring causes the gripping pads to be pulled out towards the inner wall of the cylindrical ring. An inflow tube of a heart pump may then be inserted into the ventricular apex connector, and upon the release of the spring ring, the inflow tube is sealedly held within the ventricle of the heart. In an embodiment an adapter sleeve may be attached to the inflow tube. In a further embodiment, the inflow tube may include an inner sleeve that is slidably and rotatably mounted therein. The inflow tube may have a bend at an end.

6. 发明授权

US06728575B2 Method and circuit for detecting cardiac rhythm abnormalities using a differential signal from a lead with a multi-electrode tip 失效
标题翻译：使用来自具有多电极尖端的引线的差分信号来检测心律异常的方法和电路
公开(公告)号：US06728575B2
公开(公告)日：2004-04-27
申请号：US09999131
申请日：2001-11-30
申请人： Sven-Erik Hedberg
发明人： Sven-Erik Hedberg
IPC分类号： A61N1362
CPC分类号： A61N1/3956
摘要： A cardiac lead has an end adapted for contact with cardiac tissue that has a number of dot-like electrodes which are separated from each other by electrically insulating material, and which are positioned at respective locations adapted for simultaneous contact with the cardiac tissue. The dot-like electrodes produce respective unipolar signals. At least one difference signal from the unipolar signals of a pair of the dot-like electrodes. The difference signal is edited in circuitry of a cardiac assist device and is compared to a threshold. If the threshold is exceeded, a signal indicating a cardiac rhythm abnormality, such as fibrillation, is generated for triggering electrical therapy delivered to the cardiac tissue by the cardiac assist device.
摘要翻译：心脏引线具有适于与具有多个点状电极的心脏组织接触的端部，其通过电绝缘材料彼此分离，并且位于适于与心脏组织同时接触的各个位置处。点状电极产生相应的单极信号。来自一对点状电极的单极信号的至少一个差分信号。差分信号在心脏辅助装置的电路中编辑并与阈值进行比较。如果超过阈值，则产生指示心律失常（例如原纤维化）的信号，用于触发由心脏辅助装置递送至心脏组织的电疗。

7. 发明授权

US06711439B1 Evoked response variability as an indicator of autonomic tone and surrogate for patient condition 有权
标题翻译：诱发反应变异性作为患者状况的自主神经和代谢指标
公开(公告)号：US06711439B1
公开(公告)日：2004-03-23
申请号：US10077663
申请日：2002-02-14
申请人： Kerry Bradley , Euljoon Park , Laurence S. Sloman
发明人： Kerry Bradley , Euljoon Park , Laurence S. Sloman
IPC分类号： A61N1362
CPC分类号： A61N1/371 , A61B5/4035
摘要： Modern implantable cardiac stimulation devices include processing and data storage capabilities that may be exploited to track myocardial condition and autonomic tone. Implantable devices have a capability to measure and store electrogram information over a period of time in a relatively large capacity memory, with advances in technology allowing increases in memory size. The evoked response varies in amplitude and morphology with changes in autonomic tone, ventricular filling, paced rate, and other parameters. The implantable cardiac device can be configured to sense and accurately quantify the evoked response, derive parameters from the quantified evoked response, store the parameters over long time periods, and derive variability statistics from the parameters to assist in tracking the patient's condition over time, and guiding the patient's therapy.
摘要翻译：现代可植入心脏刺激装置包括可被利用来追踪心肌状况和自主神经紧张的处理和数据存储能力。可移植设备具有在相对大容量存储器中在一段时间内测量和存储电描记图信息的能力，技术的进步允许存储器大小增加。诱发反应的幅度和形态随着自主神经调节，心室充盈，起搏率和其他参数的变化而变化。可植入心脏装置可被配置为感测并准确量化诱发反应，从量化的诱发反应导出参数，在长时间段内存储参数，并从参数中导出可变性统计数据，以帮助随时间跟踪患者的状况，以及指导患者的治疗。

8. 发明授权

US06708062B2 Pacemaker having adaptive arrhythmia detection windows 有权
标题翻译：起搏器具有适应性心律失常检测窗口
公开(公告)号：US06708062B2
公开(公告)日：2004-03-16
申请号：US10003935
申请日：2001-10-30
申请人： James H. Ericksen , Martin A. Rossing , Fareed Assad
发明人： James H. Ericksen , Martin A. Rossing , Fareed Assad
IPC分类号： A61N1362
CPC分类号： A61N1/3622
摘要： Methods for improving detection of arrhythmias by adaptively increasing arrhythmia detection intervals. One method includes increasing the V2V, the overall cardiac cycle length, thereby decreasing the pacing rate in the presence of ventricular safety paces (VSPs). Another method includes shortening the trigger interval following the atrial pace event, during which time the pacemaker will detect V-sense events, while leaving the A2V VSP interval unchanged, at the end of which any required VSP will be generated. In yet another method, the interval from A-pace to V-pace, the PAV interval, is shortened, while leaving the overall V2V cycle interval unchanged. This increases the ventricular to artial V2A interval, increasing the detection window for arthythmias. The PAV interval can be shortened in response to a recent history of VSP events.
摘要翻译：通过自适应地增加心律失常检测间隔来改善心律失常检测的方法。一种方法包括增加V2V，整个心脏周期长度，从而降低在心室安全步伐（VSP）存在的起搏速率。另一种方法包括缩短心房起搏事件之后的触发间隔，在此期间，起搏器将检测V感测事件，同时保持A2V VSP间隔不变，在其结束时将生成任何所需的VSP。在另一种方法中，缩短了从A速到V步的间隔，PAV间隔，同时保持V2V周期的整体间隔不变。这将心室增加到术语V2A间隔，增加了心律失常的检测窗口。可以根据最近的VSP事件历史来缩短PAV间隔。

9. 发明授权

US06671551B2 Cardiac rhythm management system with user interface indicating energy of pacing pulses 失效
标题翻译：具有指示起搏脉冲能量的用户界面的心律管理系统
公开(公告)号：US06671551B2
公开(公告)日：2003-12-30
申请号：US10021861
申请日：2001-12-17
申请人： Vickie L. Conley , Allan T. Koshiol
发明人： Vickie L. Conley , Allan T. Koshiol
IPC分类号： A61N1362
CPC分类号： A61N1/37247 , A61N1/371 , G06F19/00 , G06F19/3418
摘要： An implantable cardiac rhythm management system includes a user interface, such as an external programmer, for performing therapy energy threshold tests. The threshold tests allow the caregiver to determine the threshold energy at which paces capture the heart, i.e., cause a resulting contraction of the heart chamber to which the paces are delivered. The programmer provides recorded indications of the energy corresponding to each paced event, so that the caregiver can easily determine the point at which capture was lost. This recorded representation of pacing energy makes it easy for the caregiver to determine proper pacing thresholds to be used to ensure adequate pacing, while minimizing energy drain to prolong the useful life of the implanted device.
摘要翻译：植入式心律管理系统包括用于执行治疗能量阈值测试的诸如外部编程器的用户界面。阈值测试允许护理人员确定步态捕获心脏的阈值能量，即导致心脏腔室的递送收缩。程序员提供与每个节奏对应的能量的记录指示，使得看护者可以容易地确定捕获丢失的点。记录起搏能量的表现使护理人员能够轻松地确定适当的起搏阈值，以确保充分起搏，同时最大限度地减少能量消耗以延长植入器械的使用寿命。

10. 发明授权

US06662050B2 Notification of programmed state of medical device 有权
公开(公告)号：US06662050B2
公开(公告)日：2003-12-09
申请号：US09921455
申请日：2001-08-03
申请人： Walter H. Olson
发明人： Walter H. Olson
IPC分类号： A61N1362
CPC分类号： A61N1/37258
摘要： An implantable medical device, such as an implantable cardioverter/defibrillator (ICD) issues a notification when it has been left in a programmed state for some time, possibly inadvertently. The patient or another person may then initiate a course of corrective action, such as programming the device to an appropriate state.

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