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1. 发明申请

US20230133011A1 MULTIFUNCTIONAL CYTOPROTECTANT FOR TREATMENT OF PATHOGENIC PROCESSES MEDIATED BY OXIDATIVE STRESS AND TOXIC ELECTROPHILES 有权
公开(公告)号：US20230133011A1
公开(公告)日：2023-05-04
申请号：US17816980
申请日：2022-08-02
申请人： MONTEFIORE MEDICAL CENTER
发明人： Richard M. LOPACHIN , Terrence GAVIN , Brian GEOHAGEN
IPC分类号： A61K31/12 , A61K31/167 , A61K31/495 , A61K31/05 , A61K31/095 , A61K31/36 , A61P39/06 , A01N1/02 , A61K31/381 , A61K31/402 , A61K31/5375 , C07C49/80 , C07C49/807 , C07C49/825 , C07C49/84 , C07C233/33 , C07C323/22 , C07D207/04 , C07D207/325 , C07D295/112 , C07D333/22
摘要： Methods, filters and compositions are disclosed for treating toxicity due to oxidative stress and toxic electrophiles.

2. 发明申请

US20230066836A1 Antioxidant Extracts and Compositions 有权
公开(公告)号：US20230066836A1
公开(公告)日：2023-03-02
申请号：US17789893
申请日：2020-12-22
申请人： NextFerm Technologies Ltd.
发明人： Gai Ben-Dor , Yael Lifshitz , Avi Yosef , Tzafra Cohen , Arkadiy Haikin , Masha Fridman , Marina Khutorian , Sivan Mor Danan
IPC分类号： A61K36/07 , A61K31/122 , A61K33/34 , A61K33/00 , A61K33/30 , A61K31/198 , A61P39/06
摘要： The present invention relates to processes for preparing antioxidant liquid extracts and compositions and uses of such antioxidant liquid extracts and compositions. Also provided are novel antioxidant liquid extracts and compositions comprising astaxanthin. The antioxidant liquid extracts and compositions inter alia exhibit high antioxidant activity.

3. 发明授权

US11559518B2 Endoplasmic reticulum stress regulator comprising benzothiazoimidazolyl compound 有权
公开(公告)号：US11559518B2
公开(公告)日：2023-01-24
申请号：US16955545
申请日：2018-12-25
申请人： ER Stress Research Institute, Inc.
发明人： Seiichi Oyadomari
IPC分类号： A61K31/429 , A61K31/454 , A61K31/5377 , A61P39/06 , C07D513/04
摘要： A compound of general formula (1) [wherein: R1 and R2, which are the same or different, each represent a hydrogen atom, a halogen atom, a lower alkyl group, a lower cycloalkyl group, a lower alkanoyl group, a halogen substituted lower alkyl group, a lower alkoxy group, a halogen substituted lower alkoxy group, a cyano group, a cross-linked methylenedioxy group, an ethylenedioxy group, a propylenedioxy group, a lower alkylthio group, a lower alkylsulfonyl group, a carboxyl group, a lower alkoxycarbonyl group, a lower alkylamide group, a lower alkylamino alkylene amide group, an amino group, an alkylamino group, a hydroxy group, a functional group represented by general formula (2), or a functional group represented by general formula (3) —CONH(CH2)p—R3 (2) [wherein R3 represents a di-lower alkylamino group, a morpholino group, a piperidino group, a 2-methyl-piperidino group, or a 2-oxo-pyrrolidinyl group; p represents an integer from 2 to 6]; [wherein, R4 represents a lower alkyl group]; m and n each represent an integer from 0 to 3; the term lower represents a carbon number of 1 to 6; and the halogen atom represents a fluorine, chlorine or bromine atom] can inhibit endoplasmic reticulum stress to a greater extent as compared to known chemical chaperones. The compound thus can be used suitably as an agent for preventing, ameliorating or treating various diseases that are caused by endoplasmic reticulum stress.

4. 发明申请

US20220387392A1 METHODS AND COMPOSITIONS RELATED TO THE USE OF ERGOTHIONEINE 有权
公开(公告)号：US20220387392A1
公开(公告)日：2022-12-08
申请号：US17760056
申请日：2021-02-03
申请人： Steven CHEN , Priscilla SAMUEL , Elsa Cecilia COLLUM , BLUE CALIFORNIA
发明人： Steven CHEN , Priscilla SAMUEL , Elsa Cecilia COLLUM
IPC分类号： A61K31/4172 , A61P25/28 , A61P39/06 , A61P31/14 , A01N1/02
摘要： Provided herein are compositions comprising ergothioneine (e.g., a natural form of purified L-ergothioneine) and methods of using such compositions, e.g., for improving cell viability, maintaining telomere length, or treating telomere-related disorders. In some embodiments, the ergothioneine has a purity of at least or about 98%.

5. 发明申请

US20220378074A1 METHOD FOR PRODUCING HOP PROCESSED PRODUCT 有权
公开(公告)号：US20220378074A1
公开(公告)日：2022-12-01
申请号：US17878314
申请日：2022-08-01
申请人： SUNTORY HOLDINGS LIMITED
发明人： Takako Inui , Hiroo Matsui
IPC分类号： A23L33/105 , C12C3/00 , A61K36/85 , A61P39/06 , A61P3/06 , A61K36/185
摘要： There is a method for producing a hop processed product. The hop processed product is for use in foodstuff for anti-adipocyte differentiation or for antioxidation. It contains 50% by weight or more, preferably 60% by weight or more, and more preferably 70% by weight or more, of hop flowers (EM) showing hues satisfying that a value of a* is less than −0.5 in accordance with a CIE Lab color space, and preferably that a value of h is 90° or more in accordance with a CIE Lch color space. The hop processed product of the present invention has excellent action of anti-adipocyte differentiation or antioxidant action, so that the hop processed product can be expected to have effects in, for example, “anti-metabolic syndrome,” “anti-aging,” “anti-obesity,” and the like.

6. 发明授权

US11484563B2 Compositions and methods for activating cellular signaling pathways 有权
公开(公告)号：US11484563B2
公开(公告)日：2022-11-01
申请号：US17148441
申请日：2021-01-13
申请人： LifeVantage Corporation
发明人： Brian Dixon , Christina Beer , Qiana Martinez
IPC分类号： A61K36/9066 , A61K36/81 , A61K36/82 , A61K36/53 , A61K36/87 , A61K36/63 , A61K36/31 , A61K31/221 , A61K31/352 , A61K31/385 , A61K31/122 , A61K31/198 , A61K31/165 , A61K31/465 , A61K33/34 , A61K31/05 , A61K36/9062 , A61K31/353 , A61K9/48 , A61P39/06 , A61K9/20 , A61K9/00 , A61K36/28 , A61K31/455 , A61K31/522 , A61K36/68 , A61K31/30 , A61K31/357 , A61K36/22
摘要： Compositions and methods for increasing stress response and improving health and slowing the aging process in a user. A composition includes one or more of a first group consisting of milk thistle, ashwagandha, green tea, bacopa monnieri, and turmeric. The composition includes one or more of a second group consisting of acetyl-L-carnitine, quercetin, lipoic acid, coenzyme Q10, cysteine, and grape. The composition includes one or more of a third group consisting of wasabi, theacrine, copper, nicacin, cysteine, and olive extract.

7. 发明申请

US20220265724A1 CELL THERAPEUTIC AGENT FOR ANTI-INFLAMMATORY OR DAMAGED TISSUE REGENERATION COMPRISING PRUSSIAN BLUE NANOPARTICLES, AND METHOD FOR PREPARING THE SAME 有权
公开(公告)号：US20220265724A1
公开(公告)日：2022-08-25
申请号：US17571116
申请日：2022-01-07
申请人： Gwangju Institute of Science and Technology
发明人： Giyoong TAE , Abhishek Sahu , Hee Seok YANG , Jin JEON
IPC分类号： A61K35/28 , A61K9/14 , A61K33/26 , A61P39/06
摘要： An embodiment of the present invention provides a cell therapeutic agent for anti-inflammatory or damaged tissue regeneration comprising Prussian blue nanoparticles and cells, and a method for preparing the same. According to an embodiment of the present invention, there is an effect capable of providing a cell therapeutic agent having improved therapeutic performance and improved oxidative stress resistance, engraftment rate and viability at a damage site through the introduction of Prussian blue nanoparticles having ROS scavenging ability and anti-inflammatory properties, and a method for preparing the same.

8. 发明申请

US20220257621A1 CANCER CELL PROLIFERATION SUPPRESSION AGENT AND COMPOSITION FOR SUPPRESSING PROLIFERATION OF CANCER CELLS 有权
公开(公告)号：US20220257621A1
公开(公告)日：2022-08-18
申请号：US17610190
申请日：2020-05-08
申请人： SHOWA DENKO K.K.
发明人： Yuko NAKAGAMI , Go FUKADA , Eiko KATO
IPC分类号： A61K31/702 , A61K31/355 , A61K31/7016 , A61P35/00 , A61P39/06
摘要： A cancer cell proliferation suppression agent containing, as an active ingredient, an inositol derivative in which a sugar is bound to inositol is provided. Furthermore, a composition for suppressing proliferation of cancer cells containing the above-mentioned cancer cell proliferation suppression agent and a pharmaceutically acceptable carrier is provided.

9. 发明授权

US11413269B2 Compositions for improved NRF2 activation and methods of their use 有权
公开(公告)号：US11413269B2
公开(公告)日：2022-08-16
申请号：US15757270
申请日：2016-09-02
申请人： PATHWAYS BIOSCIENCE, LLC
发明人： Brooks Michael Hybertson , Joe Milton McCord
IPC分类号： A61K36/53 , A61K36/81 , A61K36/906 , A61K36/00 , A61K31/366 , A61K31/12 , A61K31/352 , A61K36/9068 , A61K36/28 , A61K36/68 , A61K31/365 , A61P39/06 , A61P29/00 , A61K31/192 , A61K31/585
摘要： Disclosed here are compositions and methods for preventing or treating certain health conditions associated with inflammation or oxidative stress. These compositions are prepared from ingredients containing phytochemicals that activate the Nrf2 pathways. Synergistic effects of the different phytochemicals are also disclosed.

10. 发明申请

US20220226418A1 FINE BAMBOO POWDER AND PREPARATION METHOD THEREFOR AND USE THEREOF 有权
公开(公告)号：US20220226418A1
公开(公告)日：2022-07-21
申请号：US17589963
申请日：2022-02-01
申请人： Senlong Bio-Tech Co., Ltd.
发明人： Ying ZHANG , Shiyao FU , Luolian HUANG
IPC分类号： A61K36/899 , A23L33/22 , A23L33/105 , A23L33/00 , A23P10/40 , A61P39/06 , A61P1/16 , A61P37/06 , A61P3/06 , A61P3/10 , A61P1/00 , A61P19/10 , A23B7/02 , A23B7/06 , A23B7/154 , A23B7/157 , A23L3/3517 , A23L3/358 , A23L3/54 , A61K31/192 , A61K31/198 , A61K31/7048 , A61K31/7076
摘要： A MATZHU is prepared by using leaves of Gramineae (Graminae) and Bambusoideae plant as raw materials, and has a stable emerald color, and has an average powder particle size of 800 to 10,000 meshes, and has a total amount of dietary fiber of ≥60%, a content of lignin of ≥20% and a content of minerals of ≥7%, and comprises at least three or more bamboo leaf characteristic components, such as orientin, isoorientin, vitexin, isovitexin, adenosine, δ-hydroxylysine and p-coumaric acid. The method for the MATZHU preparation comprises, in turn, performing blanching and color protection, drying and superfine grinding the raw materials. By utilizing the thermal stability and the light stability of the MATZHU, the MATZHU may be used as a raw food material, a functional ingredient, or a dietary supplement.

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