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1. 发明申请

US20230037322A1 Cytotoxic Actin-Targeting Compounds 有权
公开(公告)号：US20230037322A1
公开(公告)日：2023-02-09
申请号：US17849949
申请日：2022-06-27
申请人： Queen's University at Kingston
发明人： Rebecca Grange , John Allingham , Andrew Craig , P. Andrew Evans , Madhu Aeluri
IPC分类号： A61K31/45 , A61K31/221 , A61K31/25 , A61K31/341 , A61K31/397 , A61K31/4015 , A61K45/06 , A61K47/36 , C07C235/28 , C07C321/10 , C07D205/08 , C07D207/27 , C07D211/76 , C07D307/46
摘要： A class of compounds useful in pharmaceutical compositions and methods for treating or preventing cancer is described. Analogs of Mycalolide B have been prepared and tested in breast and ovarian cancer cell lines. The compounds show utility for inhibition of survival and proliferation of tumor cells. The compounds have been shown to disrupt actin.

2. 发明申请

US20190315701A1 NOVEL EICOSANOID DERIVATIVES 审中-公开
公开(公告)号：US20190315701A1
公开(公告)日：2019-10-17
申请号：US16363022
申请日：2019-03-25
申请人： MAX-DELBRUECK-CENTRUM FUER MOLEKULARE MEDIZIN , BOARD OF REGENTS OF UNIVERSITY OF TEXAS SYSTEM
发明人： Wolf-Hagen Schunck , Gerd Wallukat , Robert Fischer , Cosima ARNOLD , Dominik N. Mueller , Narender PULI , John R. FALCK
IPC分类号： C07D303/38 , C07C233/49 , C07C235/28 , C07C275/14 , C07C233/47 , C07C275/16 , C07C235/76 , C07C275/20 , C07C233/09
摘要： The present invention provides compounds (n-3 PUFA derivatives) of formula (I): that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.

3. 发明申请

US20190127313A1 ANTIMICROBIAL AGENTS 审中-公开
公开(公告)号：US20190127313A1
公开(公告)日：2019-05-02
申请号：US16094617
申请日：2017-04-21
申请人： THE UNIVERSITY OF WARWICK
发明人： Gregory Leonard CHALLIS , Daniel John GRIFFITHS , Joleen Solange Liesbet MASSCHELEIN
IPC分类号： C07C69/732 , C12P7/64 , C07C69/738 , C07C235/28 , A61K31/232 , C12P13/02
摘要： The invention provides novel compounds of formula (I) and their pharmaceutically acceptable salts, metabolites, isomers (e.g. stereoisomers) and prodrugs. Such compounds are effective in the treatment of infections caused by Gram-negative bacteria such as Acinetobacter baumannii. In formula (I), X is O, NR (where R is either H or C1-3 alkyl, e.g. CH3), or CH2; R3 is H, F, CI, Br, I, or CH3; R4 is H, or OH; R5 and R6 are independently selected from H and OH, or R5 and R6 together are ═O; R7 is H, F, CI, Br, I, or CH3; R8 is H, OH, or —OC(O)NR′2 (where each R′ is independently H or C1-3 alkyl, e.g. CH3), preferably R8 is H, OH or —OC(O)NH2; R9 is a 5- or 6-membered, saturated or unsaturated, carbocyclic ring optionally substituted by one or more substituents, or R9 is an optionally substituted straight-chained or branched C1-6 alkyl group (e.g. C1-3 alkyl group); R10 is a straight-chained or branched C1-8 alkyl group (e.g. C1-6 alkyl group), a C4-6 cycloalkyl group, or an optionally substituted aryl or heteroaryl group; and each --- independently represents an optional bond (i.e. each of C2-C3, C4-C5, C6-C7, C8-C9, C10-C11 and C18-C19 are independently either C—C (single) or C═C (double) bonds).

4. 发明申请

US20160326128A1 NOVEL EICOSANOID DERIVATIVES 审中-公开
标题翻译：新型异氰脲酸衍生物
公开(公告)号：US20160326128A1
公开(公告)日：2016-11-10
申请号：US15007354
申请日：2016-01-27
申请人： Max-Delbrueck-Centrum fuer Molekulare Medizin , Board of Regents of University of Texas System
发明人： Wolf-Hagen SCHUNCK , Gerd WALLUKAT , Robert FISCHER , Cosima ARNOLD , Dominik N. MUELLER , Narender PULI , John R. FALCK
IPC分类号： C07D303/38 , C07C235/76 , C07C235/28 , C07C275/20 , C07C233/49
CPC分类号： C07D303/38 , C07C233/09 , C07C233/47 , C07C233/49 , C07C235/28 , C07C235/76 , C07C275/14 , C07C275/16 , C07C275/20
摘要： The present invention provides compounds (n-3 PUFA derivatives) of formula (I): that modulate conditions associated with cardiac damage, especially cardiac arrhythmias.
摘要翻译：调节与心脏损伤相关的病症，特别是心律失常。

5. 发明申请

US20150031878A1 DERIVATIVES OF DOCOSAHEXAENOYLETHANOLAMIDE AND USES THEREOF 有权
标题翻译：苯并二氢叶酸的衍生物及其用途
公开(公告)号：US20150031878A1
公开(公告)日：2015-01-29
申请号：US14387410
申请日：2013-03-15
申请人： The United States of America, as represented by the Secretary, Department of Health and Human Serv
发明人： Hee-Yong Kim , Juan Jose Marugan , Erika E. Englund , Samarjit Patnaik
IPC分类号： C07D495/04 , C07D213/40 , C07D319/20 , C07D205/04 , C07C235/28 , C07D295/13
CPC分类号： C07D495/04 , C07C233/09 , C07C233/13 , C07C233/20 , C07C233/23 , C07C233/31 , C07C233/38 , C07C233/49 , C07C235/28 , C07C255/29 , C07C2601/04 , C07C2601/14 , C07D205/04 , C07D213/40 , C07D235/14 , C07D295/13 , C07D295/135 , C07D295/185 , C07D307/52 , C07D309/04 , C07D319/20 , C07D333/20
摘要： The invention provides derivatives of DEA which have increased potency and hydrolysis resistance as compared to DEA, and compositions thereof, as well as methods of using these derivatives to promote neurogenesis, neurite growth and/or length, and/or promote synaptogenesis.
摘要翻译：本发明提供了与DEA相比具有增强的耐药性和耐水解性的DEA衍生物及其组合物，以及使用这些衍生物促进神经发生，神经突生长和/或长度和/或促进突触发生的方法。

6. 发明授权

US07875746B2 Photosensitive composition, compound for use in the photosensitive composition and pattern forming method using the photosensitive composition 有权
标题翻译：感光组合物，用于感光组合物的化合物和使用感光组合物的图案形成方法
公开(公告)号：US07875746B2
公开(公告)日：2011-01-25
申请号：US11438728
申请日：2006-05-23
申请人： Kenji Wada
发明人： Kenji Wada
IPC分类号： C07C303/38 , C07C307/02 , C07C311/01 , C07C311/02 , C07C311/11 , C07C311/14 , C07C235/02 , C07C235/04 , C07C235/26 , C07C235/28 , C07C235/30 , C07C237/02
CPC分类号： C07C311/48 , C07D211/22 , C07D211/46 , C07D211/58 , C07D213/82 , C07D233/64 , C07D295/033 , C07D295/18 , C07D295/26 , C07D323/00 , C07D333/46 , C07D401/04 , G03F7/0045 , G03F7/0046 , G03F7/0382 , G03F7/0392
摘要： A photosensitive composition comprising: (A) a compound capable of generating a compound having a specific structure upon irradiation with actinic rays or radiation, a pattern forming method using the photosensitive composition, and a compound capable of generating a compound having a specific structure upon irradiation with actinic rays or radiation.
摘要翻译：一种光敏组合物，其包含：（A）能够在用光化射线或辐射照射时产生具有特定结构的化合物的化合物，使用该感光性组合物的图案形成方法和能够在照射时产生具有特定结构的化合物的化合物与光化射线或辐射。

7. 发明授权

US06900354B2 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives 失效
标题翻译： 3-苯基 - 丙酰胺基，3-苯基 - 丙烯酰胺基和3-苯基 - 丙炔酰氨基衍生物
公开(公告)号：US06900354B2
公开(公告)日：2005-05-31
申请号：US10613785
申请日：2003-07-03
申请人： Synese Jolidon , Rosa Maria Rodriguez Sarmiento , Andrew William Thomas , Wolfgang Wostl , Rene Wyler
发明人： Synese Jolidon , Rosa Maria Rodriguez Sarmiento , Andrew William Thomas , Wolfgang Wostl , Rene Wyler
IPC分类号： A61K31/165 , A61K31/275 , A61P25/28 , A61P43/00 , C07C231/02 , C07C231/12 , C07C235/06 , C07C235/28 , C07C235/34 , C07C255/54 , C07C233/09
CPC分类号： C07C255/54 , C07C235/34
摘要： The invention relates to 3-phenyl-propionamido, 3-phenyl-acrylamido and 3-phenyl-propynamido derivatives, for example, deriviatives of the formula wherein A is selected from R1, R3, R4, R5, R6, R7, R21, R22, R23, R24, and n are as defined herein or pharmaceutically acceptable salts thereof. The invention also relates to processes for preparation of such compounds, compositions containing them, and the use of such derivatives as MAO-B inhibitors. The invention further relates to methods for treating or preventing Alzheimer's disease and senile dementia by administering compounds of the invention.
摘要翻译：本发明涉及3-苯基 - 丙酰胺基，3-苯基 - 丙烯酰氨基和3-苯基 - 丙炔酰氨基衍生物，例如下式的衍生物：其中A选自R 1，R 3， R 4，R 5，R 6，R 6，R 7，R 21， R 22，R 23，R 24和n如本文所定义或其药学上可接受的盐。本发明还涉及这种化合物的制备方法，含有它们的组合物，以及这样的衍生物如MAO-B抑制剂的用途。本发明还涉及通过施用本发明的化合物治疗或预防阿尔茨海默病和老年痴呆的方法。

8. 发明申请

US20040014816A1 Novel aliphatic compounds, process for their preparation and their usage 失效
标题翻译：新型脂肪族化合物，其制备方法及其用途
公开(公告)号：US20040014816A1
公开(公告)日：2004-01-22
申请号：US10398921
申请日：2003-04-11
发明人： Tadakazu Tamai , Masazumi Nishikawa , Kenji Mori
IPC分类号： A61K031/16 , C07C235/28
CPC分类号： C07C235/08
摘要： The present invention provides an aliphatic compound represented by the following formula (I) or pharmacologically acceptable salts thereof: 1 where n denotes an integer of 1 to 11, and 1 denotes an integer of 1 to 16, the aliphatic compound being an optical isomer of the (2R,3S,2nullS) configuration when the 8-position thereof is a double bond, or an optical isomer of the (2S,3R,2nullRS) configuration when the 8-position is a single bond; methods for producing the compound or pharmacologically acceptable salts thereof; and uses of the compound in the treatment of cardiovascular diseases (e.g. arteriosclerosis, cardiac diseases), cancer, rheumatism, diabetic retinopathy, and respiratory diseases.
摘要翻译：本发明提供由下式（I）表示的脂族化合物或其药理学上可接受的盐：其中n表示1至11的整数，1表示1至16的整数，脂族化合物是（2S，3R，2'RS）构型的双键时的（2R，3S，2'S）构型或（2S，3R，2'RS）构型的旋光异构体; 制备化合物或其药理学上可接受的盐的方法; 以及该化合物在治疗心血管疾病（例如动脉硬化，心脏病），癌症，风湿病，糖尿病性视网膜病和呼吸系统疾病中的用途。

9. 发明申请

US20030109626A1 Fluorine-containing compounds and polymers derived therefrom 失效
标题翻译：含氟化合物和衍生自其的聚合物
公开(公告)号：US20030109626A1
公开(公告)日：2003-06-12
申请号：US10173915
申请日：2002-06-18
发明人： David Bradley , Jing Ji Ma , Haridasan K. Nair , David Nalewajek , Leonard M. Stachura , George Samuels , Michael Van Der Puy
IPC分类号： C08F214/18 , C07C329/04 , C07C235/28
CPC分类号： D06M15/21 , C07C69/653 , C07C233/20 , C08F20/22 , C08F20/28 , D06M15/277 , D06M2200/12
摘要： Provided are fluorine-containing compounds, and polymers derived therefrom, for use in compositions used for treating textile substrates. Also provided are methods of making fluorine-containing compounds and polymers derived therefrom, compositions comprising the compounds and/or polymers of the present invention, methods of treating substrates, and the treated products derived therefrom.
摘要翻译：提供含氟化合物及其衍生的聚合物，用于处理织物基材的组合物中。还提供了制备含氟化合物和由其衍生的聚合物的方法，包含本发明的化合物和/或聚合物的组合物，处理底物的方法和由其衍生的处理产物。

10. 发明授权

US6020510A Cytoprotective compounds 失效
公开(公告)号：US6020510A
公开(公告)日：2000-02-01
申请号：US17511
申请日：1998-02-02
申请人： Richard C. Franson , Raphael M. Ottenbrite
发明人： Richard C. Franson , Raphael M. Ottenbrite
IPC分类号： A61K31/22 , A61K31/00 , A61K31/23 , A61K31/231 , A61K31/24 , A61P7/00 , A61P7/02 , A61P9/00 , A61P9/10 , A61P17/00 , A61P17/04 , A61P29/00 , A61P33/00 , A61P37/00 , A61P37/08 , A61P39/00 , A61P39/02 , A61P43/00 , C07C69/732 , C07C219/08 , C07C229/16 , C07C233/38 , C07C235/28 , C07C309/14 , C07C309/15 , C07C69/58
CPC分类号： C07C309/15 , C07C219/08 , C07C229/16 , C07C233/38 , C07C235/28 , C07C309/14 , C07C69/732
摘要： The present invention provides compositions and methods for protecting cells from injury due to intrinsic membrane lysis, oxidation and/or invasion by destructive agents. Even more particularly, the present invention provides compositions and methods for treating or prophylactically inhibiting phospholipase mediated injury, injury due to oxidation, and inflammation. In a very specific sense, this invention provides compositions and methods of making these compositions that are inhibitors of phospholipase.

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