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1. 发明授权

US07045659B2 Process for the synthesis of monochloramine 有权
标题翻译：合成一氯胺的方法
公开(公告)号：US07045659B2
公开(公告)日：2006-05-16
申请号：US10691943
申请日：2003-10-23
申请人： Henri Delalu , Cécile Duriche , Jacques Berthet , Pierre Le Gars
发明人： Henri Delalu , Cécile Duriche , Jacques Berthet , Pierre Le Gars
IPC分类号： C01B21/09 , C07C239/04 , A01N59/00
CPC分类号： C01B21/091
摘要： The invention relates to a process for the synthesis of monochloramine by reaction of an ammonium chloride solution with a sodium hypochlorite solution. The sodium hypochlorite solution is basified beforehand with an inorganic base and the ratio of the concentration of ammonium chloride in the reaction medium to the concentration of sodium hypochlorite in the reaction medium is between 1 and 1.5. This ratio is preferably equal to 1.1.
摘要翻译：本发明涉及通过氯化铵溶液与次氯酸钠溶液的反应合成一氯胺的方法。次氯酸钠溶液预先用无机碱碱化，反应介质中氯化铵浓度与次氯酸钠浓度之比在1〜1.5之间。该比率优选等于1.1。

2. 发明授权

US08835507B2 Adamantane derivatives possessing anti-viral and anti-microbial activity 有权
标题翻译：金刚烷衍生物具有抗病毒和抗微生物活性
公开(公告)号：US08835507B2
公开(公告)日：2014-09-16
申请号：US13768316
申请日：2013-02-15
申请人： B. Vithal Shetty
发明人： B. Vithal Shetty
IPC分类号： A61K31/13 , C07C211/38 , C07C239/04
CPC分类号： C07C239/04 , C07C211/38 , C07C2603/74
摘要： The present invention relates to adamantane derivatives that are active as antiviral and anti-microbial agents; antiviral or antibacterial compositions comprising adamantane derivatives or pharmaceutically acceptable salts thereof; and methods of preventing or treating viral or bacterial infections in mammalian hosts through the administration of adamantine derivatives or their salts or pharmaceutical compositions comprising the same. In particular, viral infections prevented or treated by the methods of the present invention may include, but are not limited to, those caused by arenavirus or one or more pox viruses, such as vaccinia and/or variola.
摘要翻译：本发明涉及作为抗病毒和抗微生物剂活性的金刚烷衍生物; 包含金刚烷衍生物或其药学上可接受的盐的抗病毒或抗菌组合物; 以及通过施用金刚烷衍生物或其盐或包含其的药物组合物来预防或治疗哺乳动物宿主中的病毒或细菌感染的方法。特别地，通过本发明的方法预防或治疗的病毒感染可以包括但不限于由斑马鱼病毒或一种或多种痘病毒如牛痘和/或天花引起的病毒感染。

3. 发明授权

US6002002A Anti-ischaemic hydroxylamine derivatives and pharmaceutical compositions 失效
标题翻译：抗缺血性羟胺衍生物和药物组合物
公开(公告)号：US6002002A
公开(公告)日：1999-12-14
申请号：US914115
申请日：1998-05-13
申请人： Laszlo Urogdi , Ede Marvanyos , Mihaly Barabas , Laszlo Jaszlits , Katalin Biro , Andrea Jednakovits , Erzsebet Radvanyne , Maria Kurthy , Istvanne Udvardy Nagy
发明人： Laszlo Urogdi , Ede Marvanyos , Mihaly Barabas , Laszlo Jaszlits , Katalin Biro , Andrea Jednakovits , Erzsebet Radvanyne , Maria Kurthy , Istvanne Udvardy Nagy
IPC分类号： C07D295/08 , A61K31/17 , A61K31/27 , A61K31/445 , A61K31/495 , A61K31/535 , A61K31/5375 , A61P9/08 , A61P9/10 , C07C275/64 , C07D213/75 , C07D295/088 , C07D295/092 , C07D211/08 , C07C239/04 , C07D241/04 , C07D265/30
CPC分类号： C07D213/75 , C07C275/64 , C07D295/088
摘要： The present invention provides novel hydroxylamine derivatives represented by the general formula: wherein:X is O, --NH, or a group of formula NR', wherein R and R' are independently selected from alkyl, cycloalkyl, phenylalkyl, phenyl optionally substituted with halo, haloalkyl,alkyl, alkoxy or nitro; and a N-containing heterocyclic ring;R.sup.1 is H or alkanoyl,R.sup.2 is H or hydroxy optionally acylated with alkanoyl, andR.sup.3 is a group of the formula --NR.sup.4 R.sup.5 wherein R.sup.4 and R.sup.5 are independently selected fromH, alkyl, and a group of the formula --CO--NH--R wherein R is as defined above, orwherein R.sup.4 and R.sup.5 when taken together form a 5- to 7-membered heterocyclic ring which may optionally contain one additional hetero atom selected from nitrogen, oxygen and sulfur and which is optionally substituted with alkyl or phenylalkyl.Also provided are pharmaceutically acceptable acid addition salts of the compounds defined above, as well as pharmaceutical compositions containing the compounds or their acid addition salts as active ingredients. The compounds of the invention have been shown to have anti-ischemic effects.
摘要翻译： PCT No.PCT / HU96 / 00033 Sec。 371日期1998年5月13日 102（e）1998年5月13日PCT PCT 1996年6月14日PCT公布。出版物WO97 / 00251 日本1997年1月3日本发明提供由以下通式表示的新型羟胺衍生物：其中：X为O，-NH或式NR'基团，其中R和R'独立地选自烷基，环烷基，苯基烷基，任选被卤素，卤代烷基，烷基，烷氧基或硝基取代的苯基; 和含N的杂环; R1是H或烷酰基，R2是H或羟基，任选地被烷酰基酰化，R3是式-NR4R5的基团，其中R4和R5独立地选自H，烷基和式-CO-NH-R的基团其中R如上所定义，或者其中R 4和R 5一起形成5至7元杂环，其可以任选地含有一个选自氮，氧和硫的另外的杂原子，并且其任选被烷基或苯基烷基取代。还提供了上述化合物的药学上可接受的酸加成盐，以及含有化合物或其酸加成盐作为活性成分的药物组合物。已经显示本发明的化合物具有抗缺血作用。

4. 发明申请

US20130231391A1 ADAMANTANE DERIVATIVES POSSESSING ANTI-VIRAL AND ANTI-MICROBIAL ACTIVITY 有权
标题翻译：抵抗抗病毒和抗微生物活性的ADAMANTANE衍生物
公开(公告)号：US20130231391A1
公开(公告)日：2013-09-05
申请号：US13768316
申请日：2013-02-15
申请人： B. Vithal SHETTY
发明人： B. Vithal SHETTY
IPC分类号： C07C239/04 , C07C211/38
CPC分类号： C07C239/04 , C07C211/38 , C07C2603/74
摘要： The present invention relates to adamantane derivatives that are active as antiviral and anti-microbial agents; antiviral or antibacterial compositions comprising adamantane derivatives or pharmaceutically acceptable salts thereof; and methods of preventing or treating viral or bacterial infections in mammalian hosts through the administration of adamantine derivatives or their salts or pharmaceutical compositions comprising the same. In particular, viral infections prevented or treated by the methods of the present invention may include, but are not limited to, those caused by arenavirus or one or more pox viruses, such as vaccinia and/or variola.
摘要翻译：本发明涉及作为抗病毒和抗微生物剂活性的金刚烷衍生物; 包含金刚烷衍生物或其药学上可接受的盐的抗病毒或抗菌组合物; 以及通过施用金刚烷衍生物或其盐或包含其的药物组合物来预防或治疗哺乳动物宿主中的病毒或细菌感染的方法。特别地，通过本发明的方法预防或治疗的病毒感染可以包括但不限于由斑马鱼病毒或一种或多种痘病毒如牛痘和/或天花引起的病毒感染。

5. 发明授权

US5789617A Neopentyl difluoroamino compounds for use in energetic formulations 失效
标题翻译：用于能量制剂的新戊基二氟氨基化合物
公开(公告)号：US5789617A
公开(公告)日：1998-08-04
申请号：US939172
申请日：1992-09-02
申请人： Thomas G. Archibald , Gerald E. Manser
发明人： Thomas G. Archibald , Gerald E. Manser
IPC分类号： C07C239/04 , C07C243/02 , C07C247/04 , C07D205/04 , C07D239/04 , C07C211/03
CPC分类号： C07C247/04 , C07C239/04 , C07C243/02 , C07D205/04 , C07D239/04
摘要： This invention relates to novel neopentyl difluoroamino compounds which are useful as plasticizers and oxidizers in energetic formulations, such as propellants, explosives, and gasifiers. These neopentyl difluoroamino compounds can be prepared either: (1) by the direct fluorination of amine derivatives containing energetic pendant groups; or (2) by first preparing NF.sub.2 -derivatives and then substituting these derivatives with energetic pendant groups. In particular, mono- and bis-(difluoroaminomethyl) oxetanes are synthesized and further reacted to yield the corresponding dinitrate esters. It has been discovered that these NF.sub.2 -dinitrate esters are very useful as energetic plasticizers in high-energy formulations.
摘要翻译：本发明涉及新型新戊基二氟氨基化合物，其可用作能量制剂中的增塑剂和氧化剂，例如推进剂，爆炸物和气化器。这些新戊基二氟氨基化合物可以制备成：（1）通过直接氟化含有能量侧基的胺衍生物; 或（2）首先制备NF2衍生物，然后用能量侧基代替这些衍生物。特别地，合成单 - 和二 - （二氟氨基甲基）氧杂环丁烷并进一步反应以产生相应的硝酸酯。已经发现，这些NF2-硝酸酯在高能量配方中作为能量增塑剂非常有用。

6. 发明授权

US3329721A Synthesis of hydroxydifluoroamino alkanes 失效
标题翻译：羟基二氟氨基烷烃的合成
公开(公告)号：US3329721A
公开(公告)日：1967-07-04
申请号：US34553564
申请日：1964-02-17
申请人： ROBERTO FRANCISCO Q
发明人： ROBERTO FRANCISCO Q
IPC分类号： C07C239/04
CPC分类号： C07C239/04

7. 发明授权

US09248117B2 Substituted N,N-dihaloamines as antimicrobials 有权
标题翻译：取代的N，N-二卤代胺作为抗微生物剂
公开(公告)号：US09248117B2
公开(公告)日：2016-02-02
申请号：US13276145
申请日：2011-10-18
申请人： Rakesh K. Jain , Timothy Shiau , Charles Francavilla , Eddy Low , Eric Douglas Turtle , Donogh John Roger O'Mahony
发明人： Rakesh K. Jain , Timothy Shiau , Charles Francavilla , Eddy Low , Eric Douglas Turtle , Donogh John Roger O'Mahony
IPC分类号： A61K31/131 , C07C211/02 , A61K31/4166 , C07C239/04 , C07C317/28 , C07H15/04
CPC分类号： A61K31/4166 , C07C239/04 , C07C317/28 , C07H15/04
摘要： The present application describes compounds of Formula I: which are antimicrobial agents, including antibacterial, disinfectant, antifungal, germicidal and/or antiviral agents.
摘要翻译：本申请描述了式I的化合物：其是抗微生物剂，包括抗菌剂，消毒剂，抗真菌剂，杀菌剂和/或抗病毒剂。

8. 发明申请

US20050065115A1 N,N-dihalogenated amino acids and derivatives 有权
标题翻译： N，N-二卤代氨基酸及其衍生物
公开(公告)号：US20050065115A1
公开(公告)日：2005-03-24
申请号：US10920636
申请日：2004-08-17
申请人： Mansour Bassiri , Ramin Najafi , Lu Wang , Jane Yang
发明人： Mansour Bassiri , Ramin Najafi , Lu Wang , Jane Yang
IPC分类号： A01N41/08 , A01N59/00 , A61K20060101 , A61K31/13 , A61K31/195 , A61K31/66 , A61K31/69 , C07C239/04 , C07C309/14
CPC分类号： C07C239/04 , A01N41/08 , A01N59/00 , C07C309/14
摘要： The present invention relates to active bactericidal, antibacterial, anti-infective, antimicrobial, sporicidal, disinfectant, antifungal and antiviral compounds and compositions and to new uses of these compositions in therapy. This specification also describes methods of use for the new compounds and compositions. The specification further describes methods for preparing these compounds.
摘要翻译：本发明涉及活性杀菌，抗细菌，抗感染，抗微生物，杀芽孢，消毒剂，抗真菌和抗病毒化合物和组合物以及这些组合物在治疗中的新用途。本说明书还描述了新化合物和组合物的使用方法。本说明书还描述了制备这些化合物的方法。

9. 发明授权

US5753701A N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters as novel safe agents for water disinfection 失效
标题翻译： N-氯-N-甲基葡糖胺和N-氯-N-甲基葡糖胺酯作为水消毒的新型安全剂
公开(公告)号：US5753701A
公开(公告)日：1998-05-19
申请号：US736913
申请日：1996-10-25
申请人： Anwar A. Hussain , Bassam Tashtoush , Lewis W. Dittert
发明人： Anwar A. Hussain , Bassam Tashtoush , Lewis W. Dittert
IPC分类号： A01N37/12 , C07C239/04 , G01N33/534 , C07C219/06 , A01N37/04
CPC分类号： A01N37/12 , C07C239/04 , G01N33/534
摘要： The present invention relates to N-chloro-N-methyl glucamine and N-chloro-N-methyl glucamine esters, and their use as agents for water disinfection and as mild oxidizing agents for the radiolabeling of oxidation-sensitive biomolecules.
摘要翻译：本发明涉及N-氯-N-甲基葡糖胺和N-氯-N-甲基葡糖胺酯，以及它们作为水消毒剂和用作放射性标记氧化敏感生物分子的温和氧化剂的用途。

10. 发明授权

US09409863B2 Process for preparing chloroamines 有权
标题翻译：制备氯胺的方法
公开(公告)号：US09409863B2
公开(公告)日：2016-08-09
申请号：US14379133
申请日：2013-02-13
申请人： BAYER INTELLECTUAL PROPERTY GMBH
发明人： Mark James Ford
IPC分类号： C07D211/92 , C07C239/04
CPC分类号： C07D211/92 , C07C239/04
摘要： The present application relates to a process for preparing chloroamines which can be used as precursors for syntheses of fine chemicals and active ingredients from pharmaceuticals and/or agriculture, by reaction of secondary amines of the formula (II) with chlorine gas in the presence of an aqueous alkali metal or alkaline earth metal oxide base.
摘要翻译：本申请涉及一种制备氯胺的方法，其可以用作由药物和/或农业合成精细化学品和活性成分的前体，通过式（II）的仲胺与氯气在碱金属或碱土金属氧化物碱。

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