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1. 发明授权

US11091452B2 Polymerizable compound, polymerizable composition, polymer, optically anisotropic body, and method for producing polymerizable compound 有权
公开(公告)号：US11091452B2
公开(公告)日：2021-08-17
申请号：US16595538
申请日：2019-10-08
申请人： ZEON CORPORATION
发明人： Kei Sakamoto , Satoshi Kiriki , Kumi Okuyama , Kanako Taira
IPC分类号： C07C243/18 , C07D277/82 , C07D417/12 , C07D277/84 , C07D513/04 , C08F20/36 , C07C243/16 , C07C243/20 , C07C243/14 , C07C69/753 , C08F22/24 , C09K19/04 , C08F28/06 , C08F22/14 , C08F22/20 , C08F20/68 , C08F22/26 , C08F22/22 , C08F26/06 , C07C251/86 , G02F1/137 , C07C249/16 , G02B5/30 , C08F22/10
摘要： A polymerizable compound has a practical low melting point, excellent solubility in a general-purpose solvent, and can produce an optical film at low cost, exhibits low reflected luminance, and achieves uniform conversion of polarized light over a wide wavelength band, an optically anisotropic article.

2. 发明申请

US20210077442A1 Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same 有权
公开(公告)号：US20210077442A1
公开(公告)日：2021-03-18
申请号：US16863459
申请日：2020-04-30
申请人： NeuroDerm, Ltd.
发明人： Oron Yacoby-Zeevi , Mara Nemas
IPC分类号： A61K31/198 , A61K9/00 , A61K31/12 , A61K31/277 , A61K47/22 , A61K47/18 , A61K9/08 , C07C243/18 , C07C279/14
摘要： Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.

3. 发明申请

US20170044117A1 SEMICARBAZIDE-SENSITIVE AMINE OXIDASE INHIBITORS FOR USE AS ANALGESICS IN TRAUMATIC NEUROPATHY AND NEUROGENIC INFLAMMATION 有权
标题翻译：二氧化硫敏感性胺氧化酶抑制剂用作TRAUMATIC NEUROPATHY和神经源性炎症中的治疗
公开(公告)号：US20170044117A1
公开(公告)日：2017-02-16
申请号：US15303794
申请日：2014-12-18
申请人： PÉCSI TUDOMÁNYEGYETEM
发明人： Zsuzsanna Andor TAMASIKNÉ HELYES , Valéria DEZSÖ-TÉKUS , Bálint SCHEICH , Péter MÁTYUS
IPC分类号： C07D263/32 , C07C243/18
CPC分类号： C07D263/32 , A61K31/15 , A61K31/404 , A61K31/417 , A61K31/50 , A61K31/513 , C07C243/18
摘要： The invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the treatment of hyperalgesia and allodynia implicated in traumatic neuropathy or neurogenic inflammation. Accordingly, the invention relates to a compound having SSAO/VAP-1 inhibitor activity for use in the inhibition of pathological activation and dysfunctions of peptidergic sensory nerves caused by mechanical damage or chemical activation of peptidergic sensory nerves in neurogenic inflammation.
摘要翻译：本发明涉及具有SSAO / VAP-1抑制剂活性的化合物，其用于治疗与创伤神经病变或神经源性炎症相关的痛觉过敏和异常性疼痛。因此，本发明涉及一种具有SSAO / VAP-1抑制剂活性的化合物，其用于抑制由神经源性炎症中的肽能感觉神经的机械损伤或化学活化引起的肽能感觉神经的病理活化和功能障碍。

4. 发明申请

US20160272672A1 PHOTOLABILE LINKER FOR THE SOLID-PHASE SYNTHESIS OF HYDRAZIDES AND PYRANOPYRAZOLES 有权
标题翻译：用于水合物和吡咯烷酮的固相合成的PHOLOLABILE连接器
公开(公告)号：US20160272672A1
公开(公告)日：2016-09-22
申请号：US14916547
申请日：2014-09-11
申请人： DANMARKS TEKNISKE UNIVERSITET
发明人： Thomas E. NIELSEN , Katrine QVORTRUP
IPC分类号： C07K1/12 , C07C281/02 , C07K5/097 , C07K5/065 , C07D491/052 , C07K5/087 , C07K5/083 , C07D233/64 , C07K7/06 , C07K1/04 , C07C243/18
CPC分类号： C07K1/124 , C07B2200/11 , C07C243/18 , C07C281/02 , C07D233/64 , C07D491/052 , C07K1/042 , C07K5/06078 , C07K5/0806 , C07K5/0808 , C07K5/0812 , C07K5/0823 , C07K7/06 , Y02P20/55
摘要： The photolabile hydrazine linker of the present invention is based on the o-nitro-veratryl group, which is capable of releasing hydrazide derivatives upon UV irradiation. The linker allows for a new solid-phase peptide synthesis (SPPS) strategy which is fully orthogonal to the most commonly used protecting groups and chemical methods in SPPS and shows excellent compatibility with peptide composition, notably the 20 naturally occurring a-amino acid residues (even in their side-chain protected form) are accepted in the C-terminal of the peptide hydrazides. Furthermore, the linker unit can be applied to synthesize combinatorial libraries of biological interesting heterocyclic compounds, such as pyranopyrazoles.
摘要翻译：本发明的光不稳定肼接头基于邻硝基藜芦基，其能够在UV照射时释放酰肼衍生物。该接头允许与SPPS中最常用的保护基和化学方法完全正交的新型固相肽合成（SPPS）策略，并且与肽组合物，特别是20种天然存在的α-氨基酸残基（特别是即使在其侧链保护形式）也被肽酰肼的C末端所接受。此外，接头单元可以用于合成生物感兴趣的杂环化合物如吡喃吡唑的组合文库。

5. 发明申请

US20160151317A1 Continuous Administration of Dopa Decarboxylase Inhibitors and Compositions for Same 有权
标题翻译：连续给予多巴脱羧酶抑制剂和组合物
公开(公告)号：US20160151317A1
公开(公告)日：2016-06-02
申请号：US14789214
申请日：2015-07-01
申请人： NeuroDerm, Ltd.
发明人： Oron Yacoby-Zeevi , Mara Nemas
IPC分类号： A61K31/198 , A61K31/277 , A61K9/00 , A61K9/08 , C07C243/18 , C07C279/14
CPC分类号： A61K31/198 , A61K9/0014 , A61K9/0019 , A61K9/0053 , A61K9/08 , A61K31/12 , A61K31/15 , A61K31/277 , A61K47/183 , A61K47/22 , C07C243/18 , C07C279/14 , A61K2300/00
摘要： Disclosed herein are compositions that include for example the arginine salt of carbidopa, and methods for treating neurological or movement diseases or disorders such as restless leg syndrome, Parkinson's disease, secondary parkinsonism, Huntington's disease, Parkinson's like syndrome, PSP, MSA, ALS, Shy-Drager syndrome and conditions resulting from brain injury including carbon monoxide or manganese intoxication, using substantially continuous administration of carbidopa or salt thereof together with administration of levodopa.
摘要翻译：本文公开了包括例如卡比多巴的精氨酸盐的组合物，以及用于治疗神经或运动疾病或障碍的方法，例如不宁腿综合征，帕金森病，继发性帕金森综合征，亨廷顿舞蹈病，帕金森氏综合症，PSP，MSA，ALS，害羞由脑损伤（包括一氧化碳或锰中毒引起的） - 使用基本上连续施用卡比多巴或其盐以及施用左旋多巴的情况。

6. 发明申请

US20140045903A1 Bioavailable Diacylhydrazine Ligands for Modulating the Expression of Exogenous Genes via an Ecdysone Receptor Complex 审中-公开
标题翻译：用于通过蜕皮激素受体复合物调节外源基因表达的生物可利用的二酰基肼配体
公开(公告)号：US20140045903A1
公开(公告)日：2014-02-13
申请号：US13954376
申请日：2013-07-30
申请人： Intrexon Corporation
发明人： Robert Eugene HORMANN , David W. Potter , Orestes Chortyk , Colin M. Tice , Glenn Richard Carlson , Andrew Meyer , Thomas R. Opie
IPC分类号： C07D319/18 , C07D213/87 , C07C243/18
CPC分类号： C07C241/04 , A61K31/166 , A61K31/222 , A61K31/357 , A61K31/404 , A61K31/415 , A61K31/4184 , A61K31/455 , A61K31/4965 , C07C243/18 , C07C243/24 , C07C243/38 , C07C251/08 , C07C251/38 , C07C255/66 , C07C281/10 , C07C309/59 , C07C315/02 , C07C317/44 , C07C317/46 , C07D209/42 , C07D213/81 , C07D213/82 , C07D213/86 , C07D213/87 , C07D231/14 , C07D231/56 , C07D235/06 , C07D235/24 , C07D237/24 , C07D239/52 , C07D241/24 , C07D271/12 , C07D317/68 , C07D319/08 , C07D319/18 , C07D319/20 , C07D405/12 , C12N9/0069 , C12N15/635 , C12P21/00 , Y02A50/471
摘要： The present invention relates to non-steroidal ligands for use in nuclear receptor-based inducible gene expression system and a method to modulate exogenous gene expression in which an ecdysone receptor complex comprising a DNA binding domain; a ligand binding domain; a transactivation domain; and a ligand is contacted with a DNA construct comprising: the exogenous gene and a response element; wherein the exogenous gene is under the control of the response element and binding of the DNA binding domain to the response element in the presence of the ligand results in activation or suppression of the gene.
摘要翻译：本发明涉及用于基于核受体的可诱导基因表达系统的非甾体配体和调节外源基因表达的方法，其中包含DNA结合结构域的蜕皮激素受体复合物; 配体结合域; 反式激活域并且配体与包含以下的DNA构建体接触：外源基因和应答元件; 其中外源基因处于响应元件的控制之下，并且在配体存在下DNA结合结构域与响应元件的结合导致基因的激活或抑制。

7. 发明申请

US20120148682A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER 审中-公开
公开(公告)号：US20120148682A1
公开(公告)日：2012-06-14
申请号：US13144682
申请日：2010-01-14
申请人： David H. Young , Steven Howard Shaber , Gerald Shaber , Cruz Avila-Adame , Nneka T. Breaux , James M. Ruiz , Thomas L. Siddall , Jeffery D. Webster
发明人： David H. Young , Steven Howard Shaber , Gerald Shaber , Cruz Avila-Adame , Nneka T. Breaux , James M. Ruiz , Thomas L. Siddall , Jeffery D. Webster
IPC分类号： A01N59/20 , A01P3/00 , C07F1/08 , C07C243/18
CPC分类号： A01N33/26 , A01N31/00 , A01N31/04 , A01N33/00 , A01N59/00 , A01N59/16 , A01N59/20 , C07C251/86 , C07C323/36 , A01N37/28 , A01N37/38 , A01N37/40 , A01N37/44 , A01N37/48 , A01N43/30 , A01N2300/00
摘要： The present invention relates to the use of hydrazone compounds and copper for controlling the growth of fungi.

8. 发明申请

US20120021065A1 FUNGICIDAL COMPOSITIONS INCLUDING HYDRAZONE DERIVATIVES AND COPPER 失效
公开(公告)号：US20120021065A1
公开(公告)日：2012-01-26
申请号：US13144679
申请日：2010-01-14
申请人： David H. Young , Steven Howard Shaber , Cruz Avila-Adame , Nneka T. Breaux , James M. Ruiz , Thomas L. Siddall , Jeffery D. Webster
发明人： David H. Young , Steven Howard Shaber , Cruz Avila-Adame , Nneka T. Breaux , James M. Ruiz , Thomas L. Siddall , Jeffery D. Webster
IPC分类号： A01N59/20 , C07C255/66 , A01P3/00 , C07C243/18
CPC分类号： A01N33/26 , A01N31/00 , A01N31/04 , A01N33/00 , A01N59/00 , A01N59/16 , A01N59/20 , C07C251/86 , C07C323/36 , A01N37/28 , A01N37/38 , A01N37/40 , A01N37/44 , A01N37/48 , A01N43/30 , A01N2300/00
摘要： The present invention relates to the use of hydrazone compounds and copper for controlling the growth of fungi.

9. 发明授权

US07750042B2 Paclitaxel enhancer compound 失效
标题翻译：紫杉醇增强剂化合物
公开(公告)号：US07750042B2
公开(公告)日：2010-07-06
申请号：US12077729
申请日：2008-03-20
申请人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono , Zhi-Qiang Xia
发明人： Keizo Koya , Lijun Sun , Shoujun Chen , Noriaki Tatsuta , Yaming Wu , Mitsunori Ono , Zhi-Qiang Xia
IPC分类号： A61K31/335 , A61K31/20 , C07C327/38 , C07C243/18
CPC分类号： C07D307/68 , A45D2008/006 , A61K31/337 , A61K31/505 , A61K31/53 , A61K31/5377 , A61K47/58 , C07C327/56 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07D209/42 , C07D209/44 , C07D213/83 , C07D261/18 , C07D333/38 , C07D333/68
摘要： One embodiment of the present invention is a compound represented by the Structural Formula (I): Y is a covalent bond of a substituted or unsubstituted straight chained hydrocarbyl group. In addition, Y, taken together with both >C═Z groups to which it is bonded, is a substituted or unsubstituted aromatic group. Preferably, Y is a covalent bond or —C(R7R8)—. R1 is an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, or a substituted non-aromatic heterocyclic group, R2-R4 are independently —H, an aliphatic group, a substituted aliphatic group, a non-aromatic heterocyclic group, a substituted non-aromatic heterocyclic group, an aryl group or a substituted aryl group, or R1 and R3 taken together with the carbon and nitrogen atoms to which they are bonded, and/or R2 and R4 taken together with the carbon and nitrogen atoms to which they are bonded, form a non-aromatic heterocyclic ring optionally fused to an aromatic ring. R5-R6 are independently —H, an aliphatic group, a substituted aliphatic group, an aryl group or a substituted aryl group. R7 and R8 are each independently —H, an aliphatic or substituted aliphatic group, or R7 is —H and R8 is a substituted or unsubstituted aryl group, or, R7 and R8, taken together, are a C2-C6 substituted or unsubstituted alkylene group. Z is ═O or ═S. Also disclosed are pharmaceutical compositions comprising the compound of the present invention and a pharmaceutically acceptable carrier or diluent.
摘要翻译：本发明的一个实施方案是由结构式（I）表示的化合物：Y是取代或未取代的直链烃基的共价键。此外，Y与它所键合的两个> C = Z基团一起是取代或未取代的芳族基团。优选Y为共价键或-C（R 7 R 8） - 。 R1是脂肪族基团，取代脂肪族基团，非芳族杂环基团或取代的非芳族杂环基团，R2-R4独立地是-H，脂肪族基团，取代的脂肪族基团，非芳香族杂环基，取代的非芳族杂环基，芳基或取代的芳基，或者R 1和R 3与它们所键合的碳原子和氮原子一起，和/或R 2和R 4与碳和氮原子一起形成与芳环稠合的非芳族杂环。 R5-R6独立地是-H，脂族基团，取代的脂族基团，芳基或取代的芳基。 R 7和R 8各自独立地为-H，脂族或取代的脂族基团，或者R 7为-H且R 8为取代或未取代的芳基，或者R 7和R 8一起为C 2 -C 6取代或未取代的亚烷基。 Z为═O或═S。还公开了包含本发明化合物和药学上可接受的载体或稀释剂的药物组合物。

10. 发明授权

US07544838B2 Ligands for estrogen related receptors and methods for synthesis of said ligands 有权
标题翻译：雌激素相关受体的配体和合成所述配体的方法
公开(公告)号：US07544838B2
公开(公告)日：2009-06-09
申请号：US11336515
申请日：2006-01-20
申请人： Barry Forman , Donna Yu
发明人： Barry Forman , Donna Yu
IPC分类号： C07C243/18
CPC分类号： C07D333/44 , C07C249/16 , C07D207/335 , C07D207/34 , C07D251/46 , C07D307/52 , C07D333/22 , C07C251/86
摘要： Estrogen-Related Receptor (ERR) modulating compounds and methods for synthesis of said compounds are described.
摘要翻译：描述了雌激素相关受体（ERR）调节化合物和合成所述化合物的方法。

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