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1. 发明授权

US11648324B2 Lipids and lipid nanoparticle formulations for delivery of nucleic acids 有权
公开(公告)号：US11648324B2
公开(公告)日：2023-05-16
申请号：US17317517
申请日：2021-05-11
申请人： Acuitas Therapeutics, Inc.
发明人： Steven M. Ansell , Xinyao Du
IPC分类号： A61K48/00 , A61K9/127 , C07C219/06 , C07C229/16 , C07C233/18 , C07C255/24 , C12N9/02 , A61K47/18 , C07C229/12
CPC分类号： A61K48/0033 , A61K9/127 , A61K47/18 , C07C219/06 , C07C229/12 , C07C229/16 , C07C233/18 , C07C255/24 , C12N9/0069 , C12Y113/12007
摘要： Compounds are provided having the following structure:

or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

2. 发明授权

US11420935B2 Bicyclic compounds 有权
公开(公告)号：US11420935B2
公开(公告)日：2022-08-23
申请号：US16849728
申请日：2020-04-15
申请人： Vivace Therapeutics, Inc.
发明人： Andrei W. Konradi , Tracy Tzu-Ling Tang Lin
IPC分类号： C07C235/66 , C07C311/51 , C07D217/24 , C07D217/26 , C07D401/12 , C07D213/40 , C07C255/24 , C07D333/70 , C07D305/08 , C07D305/06 , C07D241/12 , C07D233/64 , C07D257/04 , C07D213/73 , C07D213/61
摘要： Provided herein are compounds and pharmaceutical compositions comprising said compounds that are useful for treating deseases, such as cancers. Specific cancers include those that are mediated by YAP/TAZ or those that are modulated by the interaction between YAP/TAZ and TEAD.

3. 发明申请

US20220072155A1 NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS 有权
公开(公告)号：US20220072155A1
公开(公告)日：2022-03-10
申请号：US17317517
申请日：2021-05-11
申请人： Acuitas Therapeutics, Inc.
发明人： Steven M. Ansell , Xinyao Du
IPC分类号： A61K48/00 , A61K9/127 , C07C219/06 , C07C229/16 , C07C233/18 , C07C255/24 , C12N9/02 , A61K47/18 , C07C229/12
摘要： Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

4. 发明申请

US20190314524A1 NOVEL LIPIDS AND LIPID NANOPARTICLE FORMULATIONS FOR DELIVERY OF NUCLEIC ACIDS 审中-公开
公开(公告)号：US20190314524A1
公开(公告)日：2019-10-17
申请号：US16184782
申请日：2018-11-08
申请人： Acuitas Therapeutics, Inc.
发明人： Steven M. Ansell , Xinyao Du
IPC分类号： A61K48/00 , C07C255/24 , C07C233/18 , C07C229/16 , C07C219/06 , A61K47/18 , C12N9/02 , C07C229/12 , A61K9/127
摘要： Compounds are provided having the following structure: or a pharmaceutically acceptable salt, tautomer or stereoisomer thereof, wherein R1, R2, R3, L1, L2, G1, G2 and G3 are as defined herein. Use of the compounds as a component of lipid nanoparticle formulations for delivery of a therapeutic agent, compositions comprising the compounds and methods for their use and preparation are also provided.

5. 发明授权

US10442756B2 Compounds and compositions for intracellular delivery of therapeutic agents 有权
公开(公告)号：US10442756B2
公开(公告)日：2019-10-15
申请号：US15846084
申请日：2017-12-18
申请人： ModernaTX, Inc.
发明人： Kerry E. Benenato , Mark Cornebise
IPC分类号： C07C229/12 , A61K9/127 , C07C271/20 , C07C279/12 , C07C279/28 , C07C279/32 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D207/27 , C07D277/38 , C07C275/14 , C07C279/24 , C07C311/05 , C07C229/16 , C07C335/08 , C07C233/36 , C07C233/72 , C07C263/20 , C07C235/10 , C07C255/24 , C07F9/09 , A61K9/16 , A61K38/18 , A61K48/00 , C07K14/505 , A61K9/00 , A61K47/54 , A61K47/69 , C07C227/16 , A61K9/51 , A61K31/7105 , A61K38/17 , C07C227/18
摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

6. 发明授权

US10273194B2 Process to conserve cyano-function and improve performance of low molecular weight nitrification inhibitors to improve fertilizer efficiency 有权
公开(公告)号：US10273194B2
公开(公告)日：2019-04-30
申请号：US15854319
申请日：2017-12-26
申请人： Gary David McKnight , Randall Linwood Rayburn , Wei Xu
发明人： Gary David McKnight , Randall Linwood Rayburn , Wei Xu
IPC分类号： C05C11/00 , C05C9/00 , C05G3/00 , C08L61/32 , C08L61/02 , C08L61/28 , C05F11/08 , C08G12/28 , C01C3/16 , G01J3/42 , C07C255/24
摘要： Disclosed are compositions and methods of making a liquid fertilizer additive of biodegradable polymers and/or oligomers comprised of utilizing a non-aqueous polar, aprotic organo liquid (NAPAOL) as the reaction medium for the reaction of aldehyde(s) with cyano-containing nitrification inhibitors that have one or more groups that react with the aldehyde(s) wherein said reactive groups are selected from the group consisting of a) primary and secondary amines, b) amides, c) thiols, d) hydroxyls and e) phenol.

7. 发明申请

US20190016669A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
公开(公告)号：US20190016669A1
公开(公告)日：2019-01-17
申请号：US16148822
申请日：2018-10-01
申请人： ModernaTX, Inc.
发明人： Kerry E. BENENATO , Mark CORNEBISE
IPC分类号： C07C229/12 , C07C227/16 , C07C271/20 , A61K9/00 , A61K9/127 , C07C227/18 , A61K48/00 , A61K38/17 , A61K31/7105 , A61K9/51 , A61K9/16 , A61K47/69 , A61K47/54 , C07K14/505 , A61K38/18 , C07F9/09 , C07C255/24 , C07C235/10 , C07C233/36 , C07C335/08 , C07C229/16 , C07C311/05 , C07C279/24 , C07C275/14 , C07D277/38 , C07D207/27 , C07D271/10 , C07D271/06 , C07D265/33 , C07D263/20 , C07D249/04 , C07D233/72 , C07C279/32 , C07C279/28 , C07C279/12
CPC分类号： C07C229/12 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/0033 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

8. 发明申请

US20180201572A1 COMPOUNDS AND COMPOSITIONS FOR INTRACELLULAR DELIVERY OF THERAPEUTIC AGENTS 审中-公开
公开(公告)号：US20180201572A1
公开(公告)日：2018-07-19
申请号：US15846084
申请日：2017-12-18
申请人： ModernaTX, Inc.
发明人： Kerry E. BENENATO
IPC分类号： C07C229/12 , A61K9/00 , C07K14/505 , C07F9/09 , C07D277/38 , C07D271/10 , C07D271/06 , C07D265/33 , C07D263/20 , C07D249/04 , C07D233/72 , C07D207/27 , C07C335/08 , C07C311/05 , C07C279/32 , C07C279/28 , C07C279/24 , C07C279/12 , C07C275/14 , C07C271/20 , C07C255/24 , C07C235/10 , C07C233/36 , C07C229/16 , A61K48/00 , A61K47/69 , A61K47/54 , A61K38/18 , A61K9/16 , A61K9/127
CPC分类号： C07C229/12 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/0033 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

9. 发明授权

US09868691B2 Compounds and compositions for intracellular delivery of therapeutic agents 有权
公开(公告)号：US09868691B2
公开(公告)日：2018-01-16
申请号：US15476253
申请日：2017-03-31
申请人： MODERNATX, Inc.
发明人： Kerry E. Benenato
IPC分类号： A61K9/51 , A61K48/00 , C07C229/12 , A61K9/127 , C07C271/20 , C07C279/12 , C07C279/28 , C07C279/32 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D207/27 , C07D277/38 , C07C275/14 , C07C279/24 , C07C311/05 , C07C229/16 , C07C335/08 , C07C233/36 , C07C235/10 , C07C255/24 , C07F9/09 , A61K9/16 , A61K38/18 , C07K14/505 , A61K9/00 , A61K47/54 , A61K47/69
CPC分类号： C07C229/12 , A61K9/0019 , A61K9/0043 , A61K9/0073 , A61K9/127 , A61K9/1271 , A61K9/1272 , A61K9/1617 , A61K9/1641 , A61K9/5123 , A61K9/5146 , A61K31/7105 , A61K38/1725 , A61K38/1816 , A61K47/543 , A61K47/6911 , A61K48/00 , A61K48/0033 , A61K48/005 , C07C227/16 , C07C227/18 , C07C229/16 , C07C233/36 , C07C235/10 , C07C255/24 , C07C271/20 , C07C275/14 , C07C279/12 , C07C279/24 , C07C279/28 , C07C279/32 , C07C311/05 , C07C335/08 , C07C2601/02 , C07C2601/04 , C07C2601/14 , C07C2601/18 , C07D207/27 , C07D233/72 , C07D249/04 , C07D263/20 , C07D265/33 , C07D271/06 , C07D271/10 , C07D277/38 , C07F9/091 , C07K14/505
摘要： The disclosure features novel lipids and compositions involving the same. Nanoparticle compositions include a novel lipid as well as additional lipids such as phospholipids, structural lipids, and PEG lipids. Nanoparticle compositions further including therapeutic and/or prophylactics such as RNA are useful in the delivery of therapeutic and/or prophylactics to mammalian cells or organs to, for example, regulate polypeptide, protein, or gene expression.

10. 发明申请

US20160023996A1 Cancer Chemotherapeutic Agent/Formulation, Manufacture and Use Thereof 有权
标题翻译：癌症化疗药物/制剂，制造和使用
公开(公告)号：US20160023996A1
公开(公告)日：2016-01-28
申请号：US14428836
申请日：2013-09-27
申请人： BOSE INSTITUTE , WEST BENGAL STATE UNIVERSITY
发明人： Subhrangsu Chatterjee , Anirban Bhunia , Deba Prasad Mandal , Shamee Bhattacharjee
IPC分类号： C07C255/24 , A61K9/00 , C07C253/30
CPC分类号： C07C255/24 , A61K9/0019 , A61K31/275 , C07C251/24 , C07C253/30
摘要： A cancer chemotherapeutic agent that is particularly kinase suppressing and/or any other signaling pathway interfering agents and pharmaceutical formulations/compositions involving the same and its process of manufacture is provided. A potential the cancer chemotherapeutic agent is provided which apart from stated anticancer activity as a proven kinase suppressing and/or any other signaling pathway interfering agent could also involve specific potential binding affinity towards the intramolecular G-Quadruplex DNA structure and/or other potential quadruplex forming sequences over duplex DNA structures favours further diverse end use and application including but not limited to antiaging, antiangiogenic, antiproliferative, antitumor, antibiotic, antiviral, antifungal and multiple anticancer therapeutics, and also possesses favourable cytotoxicity values towards uncontrollably proliferative cells by inducing apoptosis irrespective of cells' p53 status, without being cytotoxic to normal cells.
摘要翻译：提供特别是激酶抑制和/或任何其它信号传导途径干扰剂和涉及其的药物制剂/组合物及其制备方法的癌症化学治疗剂。提供癌症化学治疗剂的潜力，除了作为已证实的激酶抑制和/或任何其他信号传导途径干扰剂的所述抗癌活性外，还可以涉及对分子内G-四链体DNA结构和/或其他潜在的四联体形成的特异性潜在结合亲和力双链DNA结构上的序列有利于进一步多样化的最终用途和应用，包括但不限于抗衰老，抗血管生成，抗增殖，抗肿瘤，抗生素，抗病毒，抗真菌和多重抗癌治疗剂，并且还通过诱导凋亡而对不受控制的增殖细胞具有有利的细胞毒性值，细胞的p53状态，而不对正常细胞具有细胞毒性。

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