专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US11370780B2 Additive for imparting ultraviolet absorbency and/or high refractive index to matrix, and resin member using same 有权
$Additive for imparting ultraviolet absorbency and/or high refractive index to matrix, and resin member using same$
公开(公告)号：US11370780B2
公开(公告)日：2022-06-28
申请号：US16394302
申请日：2019-04-25
申请人： Miyoshi Oil & Fat Co., Ltd. , Tokai Optical Co., Ltd.
发明人： Koji Kawai , Kotaro Kaneko , Nobuhiro Kaneko , Yuichi Shishino , Kuniyoshi Okamoto
IPC分类号： C07D249/18 , C08K5/37 , C08K5/3475 , C07D403/12 , C08K5/372 , C09K3/00 , C08L101/00 , C07C49/84 , C07C69/94 , C07C321/26 , C07C321/28 , C07D249/20 , C07D251/24
摘要： Provided is an additive for imparting ultraviolet absorbency, or an additive for imparting a high refractive index, which has satisfactory compatibility with a resin serving as a matrix and can maintain high transparency even if added in high concentrations. Also provided is an additive with which the function of imparting both ultraviolet absorbency and a high refractive index can be realized by means of one kind of additive. This additive is represented by the following Formula (I): wherein at least one of R1a to R9a is a monovalent sulfur-containing group represented by the following Formula (i-1) or Formula (i-2): R10amSH (i-1) R11anSR12a—SpR13a (i-2) wherein R10a to R12a each represent a divalent hydrocarbon group or the like; and R13a represents a monovalent hydrocarbon group or the like.

2. 发明授权

US11186568B2 Additive for imparting ultraviolet absorbency and/or high refractive index to matrix, and resin member using same 有权
$Additive for imparting ultraviolet absorbency and/or high refractive index to matrix, and resin member using same$
公开(公告)号：US11186568B2
公开(公告)日：2021-11-30
申请号：US16394298
申请日：2019-04-25
申请人： Miyoshi Oil & Fat Co., Ltd. , Tokai Optical Co., Ltd.
发明人： Koji Kawai , Kotaro Kaneko , Nobuhiro Kaneko , Yuichi Shishino , Kuniyoshi Okamoto
IPC分类号： C07C321/26 , C07D403/12 , C08K5/3475 , C08K5/37 , C08K5/372 , C09K3/00 , C08L101/00 , C07C49/84 , C07C69/94 , C07C321/28 , C07D249/20 , C07D251/24
摘要： Provided is an additive for imparting ultraviolet absorbency, or an additive for imparting a high refractive index, which has satisfactory compatibility with a resin serving as a matrix and can maintain high transparency even if added in high concentrations. Also provided is an additive with which the function of imparting both ultraviolet absorbency and a high refractive index can be realized by means of one kind of additive. This additive is represented by the following Formula (I): wherein at least one of R1a to R9a is a monovalent sulfur-containing group represented by the following Formula (i-1) or Formula (i-2): R10amSH (i-1) R11anSR12a—SpR13a (i-2) wherein R10a to R12a each represent a divalent hydrocarbon group or the like; and R13a represents a monovalent hydrocarbon group or the like.

3. 发明授权

US09994515B2 Aryl naphthyl methanone oxime(s) and process for preparation thereof 有权
公开(公告)号：US09994515B2
公开(公告)日：2018-06-12
申请号：US14915194
申请日：2014-08-29
申请人： Council of Scientific & Industrial Research
发明人： Sabyasachi Sanyal , Atul Kumar , Naibedya Chattopadhyay , Jawahar Lal , Arun Kumar Trivedi , Dipak Datta , Srikanta Kumar Rath , Tahseen Akhtar , Shailendra Kumar Dhar Dwivedi , Manisha Yadav , Bandana Chakravarti , Abhishek Kumar Singh , Jay Sharan Mishra , Nidhi Singh , Anil Kumar Tripathi
IPC分类号： C07C251/48 , C07C251/58 , C07C251/60 , C07C55/07 , C07C57/15 , C07C59/255 , C07C59/265 , C07C249/08 , C07C319/02 , C07C321/26 , C07D295/088
CPC分类号： C07C251/48 , C07C55/07 , C07C57/15 , C07C59/255 , C07C59/265 , C07C249/08 , C07C251/58 , C07C251/60 , C07C319/02 , C07C321/26 , C07D295/088
摘要： The present invention relates to substituted aryl naphthyl methanone oximes of general formula (I), their process for preparation and their derivatives, salts, pharmaceutical composition thereof and their use in treatment of chronic myelogenous leukemia, acute myelogenous leukemia, lymphoma, multiple myeloma, solid tumor forming cell-lines including such as breast cancer, endometrial cancer colon cancer, prostate cancer and killing of drug resistant cancer stem cells, as subject in need thereof.

4. 发明授权

US09585853B2 Use of 1,3-diphenylprop-2-en-1-one derivatives for treating liver disorders 有权
标题翻译：使用1,3-二苯基丙-2-烯-1-酮衍生物治疗肝脏疾病
公开(公告)号：US09585853B2
公开(公告)日：2017-03-07
申请号：US14933335
申请日：2015-11-05
申请人： GENFIT
发明人： Raphael Darteil , Rémy Hanf , Dean Hum , Ingrid Dufour
IPC分类号： A61K31/192 , C07C321/26 , A61K45/06 , A61K38/28 , A61K31/155 , A61K31/216 , A61K31/222 , A61K31/381 , A61K31/426
CPC分类号： A61K31/192 , A61K9/20 , A61K31/155 , A61K31/216 , A61K31/222 , A61K31/381 , A61K31/426 , A61K38/28 , A61K45/06 , C07C321/26 , A61K2300/00
摘要： The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as aminotransferases. The 1,3-diphenylprop-2-en-1-one derivatives of General Formula (I) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease.
摘要翻译：本发明提供1,3-二苯基丙-2-烯-1-酮衍生物和包含其的用于治疗肝脏疾病的药物组合物，特别是那些需要降低生物化学标记如氨基转移酶的血浆水平的那些。通式（I）的1,3-二苯基丙-2-烯-1-酮衍生物具有肝保护性质，可用于治疗涉及肝细胞的病理破坏，炎症，变性和/或增殖的肝脏疾病的方法，如肝纤维化或脂肪肝病。

5. 发明申请

US20150051145A1 USE OF 1,3-DIPHENYLPROP-2-EN-1-ONE DERIVATIVES FOR TREATING LIVER DISORDERS 有权
标题翻译：用于治疗肝脏疾病的1,3-二苯基丙-2-烯-1-酮衍生物的应用
公开(公告)号：US20150051145A1
公开(公告)日：2015-02-19
申请号：US14523191
申请日：2014-10-24
申请人： Genfit
发明人： Raphael DARTEIL , Rémy Hanf , Dean Hum , Ingrid Dufour
IPC分类号： C07C321/26 , A61K45/06 , A61K31/192
CPC分类号： A61K31/192 , A61K9/20 , A61K31/155 , A61K31/216 , A61K31/222 , A61K31/381 , A61K31/426 , A61K38/28 , A61K45/06 , C07C321/26 , A61K2300/00
摘要： The invention provides 1,3-diphenylprop-2-en-1-one derivatives and pharmaceutical compositions comprising the same for treating liver disorders, in particular those requiring the reduction of plasma level of biochemical markers such as aminotransferases. The 1,3-diphenylprop-2-en-1-one derivatives of General Formula (I) have hepatoprotective properties and can be used in methods for treating liver disorders involving the pathological disruption, inflammation, degeneration, and/or proliferation of liver cells, such as liver fibrosis or fatty liver disease.
摘要翻译：本发明提供1,3-二苯基丙-2-烯-1-酮衍生物和包含其的用于治疗肝脏疾病的药物组合物，特别是那些需要降低生物化学标记如氨基转移酶的血浆水平的那些。通式（I）的1,3-二苯基丙-2-烯-1-酮衍生物具有肝保护性质，可用于治疗涉及肝细胞的病理破坏，炎症，变性和/或增殖的肝脏疾病的方法，如肝纤维化或脂肪肝病。

6. 发明申请

US20100210631A1 SUBSTITUTED 2-[2-(PHENYL) ETHYLAMINO] ALKANEAMIDE DERIVATIVES AND THEIR USE AS SODIUM AND/OR CALCIUM CHANNEL MODULATORS 有权
标题翻译：取代的2- [2-（苯基）乙酰胺]烷基胺衍生物及其作为钠和/或钙通道调节剂的用途
公开(公告)号：US20100210631A1
公开(公告)日：2010-08-19
申请号：US12663926
申请日：2008-05-14
申请人： Piero Melloni , Alessandra Restivo , Emanuela Izzo , Simona Francisconi , Elena Colombo , Cibele Sabido-David
发明人： Piero Melloni , Alessandra Restivo , Emanuela Izzo , Simona Francisconi , Elena Colombo , Cibele Sabido-David
IPC分类号： A61K31/551 , C07C237/20 , A61K31/165 , C07C321/26 , A61P25/00 , A61P25/28 , A61P25/16 , A61P9/10 , A61P25/18 , A61P25/22 , A61P25/30 , A61P25/24 , A61K31/445 , A61K31/519 , A61P29/00
CPC分类号： A61K31/381 , A61K31/137 , A61K31/165 , A61K31/40 , A61K31/4515 , A61K31/519 , A61K31/5513 , C07C237/06 , C07C237/08 , C07C237/20 , C07C317/28 , C07C321/26 , C07C323/25 , C07C327/42 , C07C327/44 , C07D207/16 , C07D295/182 , C07D333/20
摘要： Substituted 2-[2-(phenyl)ethylamino]alkaneamide derivatives, pharmaceutically acceptable salts thereof, and pharmaceutical compositions containing them are useful as sodium and/or calcium channel modulators for preventing, alleviating and curing pathologies wherein the above mechanisms play a pathological role. The compounds may be particularly used for the prevention, alleviation, and curing of, for example, neurological, cognitive, psychiatric, inflammatory, urogenital, and gastrointestinal diseases.
摘要翻译：取代的2- [2-（苯基）乙基氨基]烷酰胺衍生物，其药学上可接受的盐和含有它们的药物组合物可用作用于预防，减轻和治愈其中上述机制发挥病理作用的病症的钠和/或钙通道调节剂。这些化合物可以特别用于预防，缓解和治愈例如神经，认知，精神，炎症，泌尿生殖和胃肠道疾病。

7. 发明申请

US20100147770A1 FUNCTIONALIZED CARBON SORBENT AND PROCESS FOR SELECTIVE CAPTURE OF PRESELECTED METALS 审中-公开
标题翻译：功能碳分子和选择性捕获金属的方法
公开(公告)号：US20100147770A1
公开(公告)日：2010-06-17
申请号：US12334311
申请日：2008-12-12
申请人： Glen E. Fryxell , William D. Samuels
发明人： Glen E. Fryxell , William D. Samuels
IPC分类号： C07C321/26 , C07C25/22 , B01J19/00 , C07C381/02 , C02F1/28
CPC分类号： B01D15/00 , B01D15/08 , B01J20/0288 , B01J20/20 , B01J20/28064 , B01J20/28066 , B01J20/28078 , B01J20/286 , B01J20/3204 , B01J20/3217 , B01J20/3219 , B01J20/3246 , B01J20/3248 , B01J20/3253 , B01J2220/54 , C01B32/372
摘要： A composition and process are described that provide for selective capture of targeted materials, including metals and chemical targets. The composition includes an activated carbon scaffold that is chemically modified to include ligands with a high affinity for selective capture of metals and chemical targets. The invention finds use, e.g., as heavy metal sorbents, as catalyst supports, in analytical applications such as ion chromatography, and in devices such as analytical instruments and chemical sensors.
摘要翻译：描述了组合物和方法，其提供靶物质的选择性捕获，包括金属和化学靶。该组合物包括经化学修饰以包括对选择性捕获金属和化学靶具有高亲和力的配体的活性炭支架。在分析应用如离子色谱法和诸如分析仪器和化学传感器的装置中，本发明可用作例如重金属吸附剂，作为催化剂载体。

8. 发明授权

US07579379B2 CETP activity inhibitors 有权
标题翻译： CETP活性抑制剂
公开(公告)号：US07579379B2
公开(公告)日：2009-08-25
申请号：US11833859
申请日：2007-08-03
申请人： Hisashi Shinkai , Kimiya Maeda , Hiroshi Okamoto
发明人： Hisashi Shinkai , Kimiya Maeda , Hiroshi Okamoto
IPC分类号： A61K31/167 , C07C53/44 , C07C231/02 , C07C237/40 , C07C321/26
CPC分类号： C07D307/10 , A61K31/164 , A61K31/18 , A61K31/33 , A61K31/341 , A61K31/381 , A61K31/40 , A61K31/435 , A61K31/44 , C07C311/14 , C07C311/15 , C07C311/21 , C07C323/40 , C07C323/41 , C07C323/42 , C07C327/30 , C07C329/10 , C07C329/20 , C07C333/04 , C07C333/08 , C07C333/10 , C07C2601/02 , C07C2601/04 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07C2602/08 , C07C2602/22 , C07C2602/28 , C07C2603/74 , C07D211/34 , C07D213/80 , C07D213/81 , C07D307/68 , C07D333/38 , Y02P20/55
摘要： The present invention provides a CETP activity inhibitor comprising as an active ingredient a compound represented by the formula (I): wherein R represents a straight chain or branched alkyl group; a straight chain or branched alkenyl group; a lower haloalkyl group; a substituted or unsubstituted cycloalkyl group; a substituted or unsubstituted cycloalkenyl group; a substituted or unsubstituted cycloalkylalkyl group; a substituted or unsubstituted aryl group, or a substituted or unsubstituted heterocyclic group, X1, X2, X3, and X4 may be the same or different and each represents a hydrogen atom, a halogen atom, a lower alkyl group, a lower haloalkyl group; a lower alkoxy group; a cyano group; a nitro group; an acyl group; or an aryl group, Y represents —CO— or —SO2—, and Z represents a hydrogen atom or a mercapto-protecting group, or a prodrug compound, a pharmaceutically acceptable salt, or hydrate or solvate thereof. The compounds represented by the formula (I) can increase HDL and at the same time decrease LDL through selective inhibition of CETP activity and, therefore, is expected to be useful as a new type of a preventive or therapeutic agent for atherosclerosis or hyperlipidemia.
摘要翻译：本发明提供一种CETP活性抑制剂，其包含由式（I）表示的化合物作为活性成分：其中R表示直链或支链烷基; 直链或支链烯基; 低级卤代烷基; 取代或未取代的环烷基; 取代或未取代的环烯基; 取代或未取代的环烷基烷基; 取代或未取代的芳基或取代或未取代的杂环基，X 1，X 2，X 3和X 4可以相同或不同，各自表示氢原子，卤素原子，低级烷基，低级卤代烷基。低级烷氧基; 氰基; 硝基; 酰基; 或芳基，Y表示-CO-或-SO 2 - ，Z表示氢原子或巯基保护基，或前药化合物，其药学上可接受的盐或水合物或溶剂化物。由式（I）表示的化合物可以增加HDL，同时通过选择性抑制CETP活性降低LDL，因此预期可用作动脉粥样硬化或高脂血症的新型预防或治疗剂。

9. 发明申请

US20080009630A1 Photogenerated reagents 有权
标题翻译：光生试剂
公开(公告)号：US20080009630A1
公开(公告)日：2008-01-10
申请号：US11648717
申请日：2006-12-29
申请人： Xiaolian Gao , Zhou Xiaochuan , Wu Yao , Jean Pellois
发明人： Xiaolian Gao , Zhou Xiaochuan , Wu Yao , Jean Pellois
IPC分类号： C07D221/00 , C07C271/08 , C07C321/26 , C07C69/63 , C07D207/325
CPC分类号： C07H21/00 , C07B2200/11 , C07C205/42 , C07C227/20 , C07C243/34 , C07C329/10 , C07C2603/18 , C07D257/04 , C07D295/205 , C07D317/52 , C07D317/62 , C07F9/2408 , C07F9/2429 , C07C229/36
摘要： This invention describes reagent precursors and methods for chemical and biochemical reactions. These reagent precursors that can be activated in solution upon irradiation to generate reagents required for the subsequent chemical reactions. Specifically, photogenerated reagents (PGR) are useful for controlling parallel combinatorial synthesis and various chemical and biochemical reactions.
摘要翻译：本发明描述了用于化学和生化反应的试剂前体和方法。这些试剂前体可以在照射时在溶液中活化，以产生后续化学反应所需的试剂。具体来说，光生试剂（PGR）可用于控制平行组合合成和各种化学和生化反应。

10. 发明申请

US20020040157A1 3-amino-2-mercaptobenzoic acid derivatives and processes for their preparation 有权
标题翻译： 3-氨基-2-巯基苯甲酸衍生物及其制备方法
公开(公告)号：US20020040157A1
公开(公告)日：2002-04-04
申请号：US09963046
申请日：2001-09-25
发明人： Walter Kunz , Beat Jau
IPC分类号： C07C327/26 , C07C321/26
CPC分类号： C07D285/14 , C07C323/63 , C07C327/26 , C07C335/22 , C07D277/82
摘要： Compounds of the formula I 1 and disulfides thereof and salts thereof are important intermediate products for the preparation of compounds having a microbicidal and plant-immunizing action, of the formula III 2 In the compounds of the formulae I and III: X is halogen, n is 0,1,2 or 3; Z is CN, COnullA or CSnullA, A is hydrogen, halogen, OR1, SR2 and N(R3)R4; R1 to R4 are hydrogen, a substituted or unsubstituted, open-chain, saturated or unsaturated hydrocarbon radical containing not more than 8 carbon atoms, a substituted or unsubstituted cyclic, saturated or unsaturated hydrocarbon radical containing not more than 10 carbon atoms, substituted or unsubstituted benzyl or phenethyl, a substituted or unsubstituted alkanoyl group containing not more than 8 carbon atoms, a substituted or unsubstituted benzoyl group or a substituted or unsubstituted heterocyclyl radical; or R3 and R4, together with the nitrogen atom to which they are bonded, are a 5- or 6-membered, substituted or unsubstituted heterocyclic radical having 1-3 heteroatoms O, S and/or N. Processes for the preparation of compounds of the formula I are described.
摘要翻译：式I化合物及其二硫化物及其盐是制备具有式III的杀微生物和植物免疫作用的化合物的重要中间产物。在式I和III化合物中：X为卤素，n为0 ，1,2或3; Z是CN，CO-A或CS-A，A是氢，卤素，OR1，SR2和N（R3）R4; R 1至R 4为氢，取代或未取代的含有不超过8个碳原子的开链，饱和或不饱和烃基，取代或未取代的含有不多于10个碳原子的环状，饱和或不饱和烃基，取代或未取代的苄基或苯乙基，取代或未取代的不超过8个碳原子的烷酰基，取代或未取代的苯甲酰基或取代或未取代的杂环基; 或R 3和R 4与它们所键合的氮原子一起是具有1-3个杂原子O，S和/或N的5或6元取代或未取代的杂环基。用于制备描述了式I。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式