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1. 发明申请

US20230002333A1 ARYLAMIDE DERIVATIVE HAVING ANTITUMOR ACTIVITY 有权
公开(公告)号：US20230002333A1
公开(公告)日：2023-01-05
申请号：US17869226
申请日：2022-07-20
申请人： Chugai Seiyaku Kabushiki Kaisha
发明人： Yoshiaki Isshiki , Fumio Watanabe , Masaki Tomizawa , Kihito Hada , Kazuo Hattori , Kenichi Kawasaki , Ikumi Hyodo , Toshihiro Aoki
IPC分类号： C07D265/02 , C07D405/14 , C07D405/12 , C07C317/50 , C07C69/76 , C07D213/74 , C07F5/02 , C07D213/73 , C07C307/02 , C07F7/08 , C07D305/06 , C07D307/93 , C07D307/14 , C07D309/14 , C07D309/08 , C07D333/72 , C07D409/12 , C07C39/26 , C07C211/55 , C07D213/80 , C07D471/04 , C07C333/20
摘要： The present disclosure provides, for example, a compound represented by general formula (6) below or a pharmaceutically acceptable salt thereof, or a pharmaceutically acceptable solvate of the compound or salt: wherein X1, X2, X3 and X4 are each independently —CR2═ or —N═, R2 is, for example, a halogen atom, R1 is, for example, —S(═O)2—NH—R8, R8 is, for example, a C1-6 alkyl group, R3 is, for example, a hydrogen atom, R5 is, for example, a halogen atom, R6 is, for example, a hydrogen atom, and R4 is, for example, a cyclopropyl group. The compounds, salts or solvates provided by the present disclosure exhibit high RAF/MEK complex-stabilizing activity and can be used for the treatment or prevention of cell proliferative disorders, particularly cancers.

2. 发明申请

US20200369820A1 KETONE-CONTAINING CONTROLLED RADICAL INITIATORS FOR POLYMERIZATION REACTIONS 审中-公开
公开(公告)号：US20200369820A1
公开(公告)日：2020-11-26
申请号：US15733412
申请日：2019-02-13
申请人： 3M INNOVATIVE PROPERTIES COMPANY
发明人： Kevin M. Lewandowski , Stephen B. Roscoe , Babu N. Gaddam , Bryan T. Whiting , John L. Battiste , George W. Griesgraber
IPC分类号： C08F293/00 , C08F265/06 , C09J4/06 , C09J153/00 , C09J133/08 , C07C329/16 , C07C333/20
摘要： Controlled radical initiators that are ketone-containing dithiocarbamate or ketone-containing dithiocarbonate compounds are used to form polymeric materials that have a single polymeric block or multiple polymeric blocks. Reaction mixtures containing controlled radical initiators and various ethylenically unsaturated monomers, polymeric materials formed from the reaction mixtures, crosslinkable compositions containing the polymeric materials, crosslinked compositions formed from the crosslinkable compositions, and articles containing the polymeric materials, the crosslinkable compositions, or the crosslinked compositions are provided.

3. 发明授权

US09283416B2 Star-shaped hyperbranched polymer with triethanolamine core, carboxylate lateral group and dithiocarboxylate end group, and preparing method as well as application thereof 有权
公开(公告)号：US09283416B2
公开(公告)日：2016-03-15
申请号：US14681051
申请日：2015-04-07
申请人： Tongji University
发明人： Bingru Zhang , Fengting Li , Zhipeng Tian
IPC分类号： A62D3/33 , C07C213/06 , C07C213/08 , C07C227/06 , C07C333/20 , C07C333/16 , A62D101/08
CPC分类号： A62D3/33 , A62D2101/08 , A62D2101/24 , A62D2101/43 , C07C213/06 , C07C213/08 , C07C227/06 , C07C333/16 , C07C333/20
摘要： A star-shaped hyperbranched polymer with a triethanolamine core, a carboxylate lateral group and a dithiocarboxylate end group has a formula of N[CH2CH2OCOCH2CH2(COOM)N(CSSM)CH2CH2N(CSSM)2]3, wherein M is Na+, NH4+ or K+. The star-shaped hyperbranched polymer has an effectively stabilization effect on heavy metals in MSWI fly ash. A method thereof for stabilizing is simple, low in dosage, cheap and without secondary pollution. Therefore, heavy metals leaching concentration in fly ash stabilized production is lower than a limit of Chinese national standard. Furthermore, acid and alkali resistance thereof is sufficient, which decreases a long-term pollution risk in natural environment.

4. 发明授权

US09168237B2 Adamantyl derivatives as therapeutic agents 有权
标题翻译：金刚烷基衍生物作为治疗剂
公开(公告)号：US09168237B2
公开(公告)日：2015-10-27
申请号：US14254397
申请日：2014-04-16
申请人： Women & Infants' Hospital of Rhode Island
发明人： Richard G. Moore , Rakesh K. Singh
IPC分类号： A01N37/00 , A61K31/21 , A61K31/198 , C07C333/20 , C07C331/20 , A61K31/26 , A61K31/27 , A61K45/06
CPC分类号： A61K31/198 , A61K31/26 , A61K31/27 , A61K45/06 , C07C331/20 , C07C333/20 , C07C2103/74 , C07C2603/74 , A61K2300/00 , A61K31/16
摘要： The present invention relates to adamantyl derivatives and their anti-cancer activity. Compounds of formulae I and II are provided as well as related methods of treatment and methods of synthesis.
摘要翻译：本发明涉及金刚烷基衍生物及其抗癌活性。提供式I和II的化合物以及相关的治疗方法和合成方法。

5. 发明申请

US20140371483A1 PROCESS FOR PREPARING METHYLENE BIS-(DIALKYLAMINO-DITHIOFORMATE) IN ONE STEP 有权
标题翻译：在一步中制备甲基双 - （二氨基亚氨基二取代基）的方法
公开(公告)号：US20140371483A1
公开(公告)日：2014-12-18
申请号：US14307849
申请日：2014-06-18
申请人： CHINA PETROLEUM & CHEMICAL CORPORATION , RESEARCH INSTITUTE OF NANJING CHEMICAL INDUSTRIAL GROUP
发明人： Zhiyong HE , Wei Huang , Weiwei Kong , Lei Ren , Junyan Ping
IPC分类号： C07C333/20
CPC分类号： C07C333/20
摘要： A process for preparing methylene bis-(dialkylamino-dithioformate) in one step includes: simultaneously feeding all or part of four raw materials: dialkylamine, an aqueous solution of sodium hydroxide, dichloromethane and carbon disulfide through a constant-flow pump into a continuous flow reactor; performing the reactions in the continuous flow reactor under a temperature of 10 to 100° C. and with a residence time of 10 to 100 s; simply separating of the obtained reaction products to give the final product. The process synthesizes the product in one step by using the continuous flow reactor. The rapid mass transfer and heat transfer in the continuous flow reactor promote the main reaction, reduce side reactions, improve the product color, and shorten the operation time. Moreover, the yield is relatively high and the quality of the final product meets the requirements.
摘要翻译：在一个步骤中制备亚甲基双 - （二烷基氨基 - 二硫代甲酸酯）的方法包括：通过恒流泵同时进料四种原料的全部或部分：二烷基胺，氢氧化钠的水溶液，二氯甲烷和二硫化碳进入连续流反应堆; 在连续流动反应器中在10〜100℃的温度下进行反应，停留时间为10〜100秒; 简单地分离得到的反应产物得到最终产物。该方法通过使用连续流动反应器在一个步骤中合成产物。连续流动反应器中的快速传质和传热促进了主要反应，减少副反应，提高了产品颜色，缩短了操作时间。此外，产量相对较高，最终产品的质量符合要求。

6. 发明申请

US20050124816A1 Method for producing halogenated 2-(3-butenylsulphanyl)-1,3-thiazoles 有权
标题翻译：卤代2-（3-丁烯基硫烷基）-1,3-噻唑的制备方法
公开(公告)号：US20050124816A1
公开(公告)日：2005-06-09
申请号：US10501115
申请日：2003-01-03
申请人： Alexander Straub
发明人： Alexander Straub
IPC分类号： C07D277/20 , A01N43/78 , C07C331/04 , C07C333/00 , C07C333/20 , C07D277/36 , C07D277/16
CPC分类号： A01N43/78 , C07C331/04 , C07C333/20 , C07D277/36
摘要： The present invention relates to a process for preparing compounds of the formula (I) where R is H or F, by (a) reacting a compound of the formula (II) where X is halogen, mesylate or tosylate with a thiocyanate, (b) reacting the resultant product with H2S or one of its salts to give a dithiocarbamate, and (c) reacting the dithiocarbamate with acetaldehyde, chloroacetaldehyde or an acetal thereof, and further relates to intermediates used in this process.
摘要翻译：本发明涉及制备其中R为H或F的式（I）化合物的方法，通过以下步骤：使式（II）化合物（其中X为卤素，甲磺酸酯基或甲苯磺酸酯）与硫氰酸酯反应，（b））使所得产物与H 2 S或其盐之一反应，得到二硫代氨基甲酸酯，和（c）使二硫代氨基甲酸酯与乙醛，氯乙醛或其缩醛反应，并且还涉及此中使用的中间体处理。

7. 发明申请

US20050038280A1 Associative thickeners for aqueous systems 有权
标题翻译：用于水性体系的缔合增稠剂
公开(公告)号：US20050038280A1
公开(公告)日：2005-02-17
申请号：US10923271
申请日：2004-08-20
申请人： John Lai , Shui-Jen Hsu
发明人： John Lai , Shui-Jen Hsu
IPC分类号： C07C329/00 , C07C329/16 , C07C329/18 , C07C333/20 , C07C333/24 , C08F2/38 , C08F20/18 , C08G75/28 , C07C329/14
CPC分类号： C07C333/24 , C07C329/00 , C07C329/16 , C07C329/18 , C07C333/20 , C08F2/38 , C08F2/44 , C08F20/18 , C08G75/28 , C08K5/38 , C08L33/02 , C09D7/43
摘要： Thiocarbonate compounds which, in one embodiment, are utilized as a rheology modifier or associative thickener. The thiocarbonate compounds thicken or increase the viscosity of a composition, preferably an aqueous composition when used in an effective amount. In one preferred embodiment, the thiocarbonate compounds include at least one hydrophilic group containing repeat unit such as derived from acrylic acid, and at least one hydrophobic group to enhance association with other compounds and thus increase viscosity of a composition. Aqueous composition comprising a latex and thiocarbonate associative thickeners are described.
摘要翻译：在一个实施方案中，其用作流变改性剂或缔合增稠剂的硫代碳酸酯化合物。当以有效量使用时，硫代碳酸酯化合物增稠或增加组合物的粘度，优选水性组合物。在一个优选的实施方案中，硫代碳酸酯化合物包括至少一个含有亲水基团的重复单元，例如衍生自丙烯酸的至少一个疏水基团，以增强与其它化合物的缔合，从而提高组合物的粘度。描述了包含胶乳和硫代碳酸酯缔合增稠剂的水性组合物。

8. 发明授权

US6084118A Sunscreening composition comprising natural products of a marine hydroid and derivatives thereof 失效
标题翻译：防晒组合物包含海洋水解物的天然产物及其衍生物
公开(公告)号：US6084118A
公开(公告)日：2000-07-04
申请号：US928554
申请日：1997-09-12
申请人： Niels L. Lindquist
发明人： Niels L. Lindquist
IPC分类号： A61K8/46 , A61K8/49 , A61K8/98 , A61Q17/04 , C07C333/20 , C07D277/36 , C07C381/00
CPC分类号： A61K8/49 , A61K8/46 , A61K8/987 , A61Q17/04 , C07C333/20 , C07D277/36
摘要： The invention relates to novel UVB/UVA-absorbing chromophores that are present in the natural products of a marine hydroid, and derivatives thereof, useful as sunscreening agents. Furthermore, the present invention relates to methods for protecting skin from the damaging effects of solar ultraviolet radiation. This method comprises topically applying to the skin an effective coating of a sunscreen composition of the present invention. Additional embodiments of the invention use these natural UV-absorbing compounds, or derivative thereof, as additives as a means of providing UV-protective plastics, paints, and waxes.
摘要翻译：本发明涉及存在于海洋水体的天然产物中的新型UVB / UVA吸收发色团及其衍生物，其可用作防晒剂。此外，本发明涉及保护皮肤免受太阳紫外线辐射的破坏作用的方法。该方法包括将本发明的防晒组合物的有效涂层局部施用于皮肤。本发明的另外的实施方案使用这些天然的紫外线吸收化合物或其衍生物作为添加剂作为提供防UV塑料，油漆和蜡的方法。

9. 发明授权

US5744629A Process for manufacturing methylene-bis (dibutyl-dithiocarbamate) with ASTM colour less than 2 失效
标题翻译：制造亚甲基双（二丁基 - 二硫代氨基甲酸盐）的方法，ASTM颜色小于2
公开(公告)号：US5744629A
公开(公告)日：1998-04-28
申请号：US595286
申请日：1996-02-02
申请人： Bela Jover , Janos Forstner , Jozsef Petro , Szabolcs Szoboszlay , Imre Fekete , Karoly Csergo , Gyula Sztreharszki , Gyula Raksi , Janos Kiss , Ferenc Miko , Jeno Baladincz , Jozsef Toth
发明人： Bela Jover , Janos Forstner , Jozsef Petro , Szabolcs Szoboszlay , Imre Fekete , Karoly Csergo , Gyula Sztreharszki , Gyula Raksi , Janos Kiss , Ferenc Miko , Jeno Baladincz , Jozsef Toth
IPC分类号： C07C271/12 , C07C333/20 , C10M135/18 , C07C57/04
CPC分类号： C07C333/20 , C10M135/18 , C10M2219/066
摘要： The invention relates to improved manufacture of methylene bis-(dibutyl-dithiocarbamate) with ASTM coulour less than 2, by reacting aqueous solutions of dibutyl amine and sodium hydroxide with carbon disulfide, treating the obtained reaction product with methylene dichloride, followed by vacuum stripping, phase separation and filtration of the precipitated sodium chloride. According to the invention, during reaction with carbon disulfide the temperature of the mixture is kept at or below 15.degree. C. and the vacuum stripping is performed in two steps, first between 45.degree. C. and 100.degree. C. and at a pressure of 5-50 kPa, then phase separation is carried out at a temperature between 35.degree. C. and 50.degree. C., followed by stripping the separated organic phase in vacuum also at a temperature between 45.degree. C. and 100.degree. C. and at a pressure of 5-50 kPa.
摘要翻译：本发明涉及通过使二丁基胺和氢氧化钠的水溶液与二硫化碳反应，用二氯甲烷二氯化物处理所得反应产物，然后真空汽提，改进了ASTM库仑小于2的二（二丁基二硫代氨基甲酸）亚甲基酯的制备，沉淀氯化钠的相分离和过滤。根据本发明，在与二硫化碳反应期间，将混合物的温度保持在15℃或低于15℃，真空汽提分两步进行，首先在45℃至100℃之间， 5-50kPa，然后在35℃至50℃的温度下进行相分离，然后在45℃至100℃的温度下真空除去分离的有机相，并在压力为5-50 kPa。

10. 发明授权

US5723469A Amino-acid amide derivatives, agricultural or horticultural fungicides, and method for producing the same 失效
标题翻译：氨基酸酰胺衍生物，农业或园艺杀真菌剂及其制备方法
公开(公告)号：US5723469A
公开(公告)日：1998-03-03
申请号：US678299
申请日：1996-07-11
申请人： Masaru Shibata , Kazuhiko Sugiyama , Norihisa Yonekura , Junetsu Sakai , Yoshiyuki Kojima , Shigeru Hayashi
发明人： Masaru Shibata , Kazuhiko Sugiyama , Norihisa Yonekura , Junetsu Sakai , Yoshiyuki Kojima , Shigeru Hayashi
IPC分类号： C07K5/00 , A01N37/46 , A01N47/12 , A01N47/24 , A01P3/00 , C07C1/32 , C07C271/22 , C07C271/34 , C07C271/54 , C07C317/22 , C07C317/28 , C07C323/20 , C07C323/41 , C07C323/62 , C07C333/04 , C07C333/20 , C07D213/30 , C07D213/64 , C07D213/68 , C07D239/34 , C07D307/42 , C07D307/80 , C07D307/81 , C07D333/16 , C07D333/56 , C07K1/107 , C07K5/103 , A61K31/505 , A61K31/44 , C07D213/02
CPC分类号： C07D213/30 , A01N47/12 , C07C271/22 , C07C271/34 , C07C271/54 , C07C317/22 , C07C317/28 , C07C323/20 , C07C323/41 , C07C323/62 , C07C333/04 , C07C333/20 , C07D213/64 , C07D213/68 , C07D239/34 , C07D307/42 , C07D307/80 , C07D307/81 , C07D333/16 , C07D333/56 , C07C2101/08 , C07C2101/14 , C07C2101/16
摘要： The present invention provides an agricultural or horticultural fungicide including an effective amount of an amino-acid derivative represented by the formula: ##STR1## wherein R.sup.1 represents a lower alkyl group (optionally having at least one same or different substituent of a halogen atom, an alkoxy group, and a cyano group), R.sup.2 represents an ethyl group, or an n-propyl group, R.sup.3 represents a hydrogen atom or a lower alkyl group, R.sup.4 represents a hydrogen atom, R.sup.5, R.sup.6, and R.sup.7 independently represent a hydrogen atom or a lower alkyl group, R.sup.8 represents a hydrogen atom, or a lower alkyl group, Z.sup.1 and Z.sup.2 independently represent an oxygen atom or a sulfur atom, Z.sup.3 represents an oxygen atom, or a sulfur atom, Q represents a phenyl group, m represents an integer from 0 to 2, and n represents 0 or 1. The amino-acid amide derivatives according to the present invention exhibit superior control of cucumber downy mildew (Pseudoperonospora cubensis), tomato late blight (Phytophthora infestans), and grape downy mildew (Plasmopara viticola), and are effective for potato late blight (Phytophthora infestans). In addition, the agricultural or horticultural fungicides of the present invention are also characterized in that they are not harmful chemicals and exhibit excellent characteristics such as systemic action, residual activity, and persistence after rain-fall.
摘要翻译：本发明提供农业或园艺杀真菌剂，其包括有效量的由下式表示的氨基酸衍生物：其中R 1表示低级烷基（任选地具有至少一个相同或不同的卤素取代基原子，烷氧基和氰基），R 2表示乙基或正丙基，R 3表示氢原子或低级烷基，R 4表示氢原子，R 5，R 6和R 7分别表示氢原子或低级烷基，R8表示氢原子或低级烷基，Z1和Z2独立地表示氧原子或硫原子，Z3表示氧原子或硫原子，Q表示苯基，m表示0〜2的整数，n表示0或1.本发明的氨基酸酰胺衍生物显示出对黄瓜霜霉病（Pseudoperonospora cubensis），番茄晚疫病（致病疫霉），和葡萄霜霉病（Plasmopara viticola），对马铃薯晚疫病（致病疫霉）有效。此外，本发明的农业或园艺杀真菌剂的特征还在于它们不是有害的化学物质，并且在雨下降后具有优异的特性，例如全身作用，残留活性和持久性。

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